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A mechanical apparatus with microprocessor controlled stress profile for cyclic compression of cultured articular cartilage explants.

Abstract：

:An apparatus was designed for mechanical compression of cultured articular cartilage explants with acylindrical plain-ended loading head (diameter 2-5 mm) driven by a stepping motor. A load cell under the culture dish was applied for feedback regulation utilizing a microprocessor-based control unit. The operating programs allowed either continuous or cyclic loading, the latter with adjustable loading/resting ratio. The improvements in the present design compared with previously described apparatuses for similar purposes include: (1) the accurately controlled compression by a load cell and a rapid feedback circuit; (2) the wide range of selectable stresses (25 kPa-12.5 MPa) with both continuous and cyclic loading modes; (3) the ability to handle cycles as short as 1 s with 15 ms peak loading phase. Using a 4 s cycle and 0.5 MPa load for 1.5 h resulted in a significantly enhanced incorporation of radiosulphate in cultured bovine articular cartilage explants, suggesting a stimulation of proteoglycan synthesis. Light and scanning electron microscopic examinations revealed a slight depression and superficial alterations in cartilage structure at the impact site following high pressures. We expect that this apparatus will help in revealing how articular cartilage tissue and chondrocytes respond to external mechanical stimuli.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Parkkinen JJ,Lammi MJ,Karjalainen S,Laakkonen J,Hyvärinen E,Tiihonen A,Helminen HJ,Tammi M

doi

10.1016/0021-9290(89)90232-7

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

1285-91

issue

11-12

eissn

0021-9290

issn

1873-2380

pii

0021-9290(89)90232-7

journal_volume

22

pub_type

杂志文章

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