Abstract：
:Experimental evidence demonstrates that collagen cross-linking in bone tissue significantly influences its deformation and failure behavior yet difficulties exist in determining the independent biomechanical effects of collagen cross-linking using in vitro and in vivo experiments. The aim of this study is to use a nano-scale composite material model of mineral and collagen to determine the independent roles of enzymatic and non-enzymatic cross-linking on the mechanical behavior of a mineralized collagen fibril. Stress-strain curves were obtained under tensile loading conditions without any collagen cross-links, with only enzymatic cross-links (modeled by cross-linking the end terminal position of each collagen domain), or with only non-enzymatic cross-links (modeled by random placement of cross-links within the collagen-collagen interfaces). Our results show enzymatic collagen cross-links have minimal effect on the predicted stress-strain curve and produce a ductile material that fails through debonding of the mineral-collagen interface. Conversely, non-enzymatic cross-links significantly alter the predicted stress-strain response by inhibiting collagen sliding. This inhibition leads to greater load transfer to the mineral, which minimally affects the predicted stress, increases modulus and decreases post-yield strain and toughness. As a consequence the toughness of bone that has more non-enzymatically mediated collagen cross-links will be drastically reduced.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Siegmund T,Allen MR,Burr DBdoi
10.1016/j.jbiomech.2008.02.017subject
Has Abstractpub_date
2008-01-01 00:00:00pages
1427-35issue
7eissn
0021-9290issn
1873-2380pii
S0021-9290(08)00086-9journal_volume
41pub_type
杂志文章abstract：:It is well accepted that the steady-state isometric force following active stretching of a muscle is greater than the steady-state isometric force obtained in a purely isometric contraction at the same length. This property of skeletal muscle has been called residual force enhancement (FE). Despite decades of research...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.06.007
更新日期：2008-08-28 00:00:00
abstract：:Soft tissue artefact (STA) and marker placement variability are sources of error when measuring the intrinsic kinematics of the foot. This study aims to demonstrate a non-invasive, combined ultrasound and motion capture (US/MC) technique to directly measure foot skeletal motion. The novel approach is compared to a sta...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.12.014
更新日期：2014-03-21 00:00:00
abstract：:The objective of this study was to examine the use of the continuous wavelet transform (CWT) on surface electromyographic (sEMG) signals acquired from the lower extremity muscles during gait in children with typical development (TD) and cerebral palsy (CP). This was done to explore the possibility of developing a quan...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2004.07.002
更新日期：2005-06-01 00:00:00
abstract：:It is well documented that most upper limb amputees utilize compensatory movement strategies to accomplish everyday tasks when using a prosthetic device and that musculoskeletal complaints (MSCs) are more common in this population. However, little information is available on how the loss of distal degrees of freedom (...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109843
更新日期：2020-07-17 00:00:00
abstract：:The topographical distributions of the zonal properties of articular cartilage over the medial tibia from an experimental osteoarthritis (OA) model were evaluated as a function of external loading by microscopic Magnetic Resonance Imaging (µMRI). T2 relaxation times and cartilage thicknesses were measured at 17.6 µm r...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.08.011
更新日期：2015-10-15 00:00:00
abstract：:Simulating and analysing eye movement is useful for assessing visual system contribution to discomfort with respect to body movements, especially in virtual environments where simulation sickness might occur. It can also be used in the design of eye prosthesis or humanoid robot eye. In this paper, we present two biome...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.02.006
更新日期：2018-04-11 00:00:00
abstract：:The problem of peristaltic transport of blood in a uniform and non-uniform tube has been investigated, under zero Reynolds number and long wavelength approximation. Blood is represented by a two-layered fluid model consisting of a central layer of suspension of all erythrocytes, etc., assumed to be a Casson fluid, and...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(84)90140-4
更新日期：1984-01-01 00:00:00
abstract：:It is clinically challenging to distinguish between ankle and subtalar joints instability in vivo. Understanding the changes in load-displacement at the ankle and subtalar joints after ligament injuries may detect specific changes in joint characteristics that cannot be detected by investigating changes in range of mo...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.10.033
更新日期：2019-01-03 00:00:00
abstract：:Static stretching is a major type of mechanical stimuli utilized during distraction osteogenesis (DO), a general surgical method for the lengthening of bone. The molecular signals that drive the regenerative process in DO include a variety of cytokines. Among these, bone morphogenic protein (BMP, -2 and -4) has been r...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.08.006
更新日期：2009-12-11 00:00:00
abstract：:Incomplete stent apposition (ISA, also known as malapposition) is a complication that affects day-to-day coronary stenting procedures. ISA is more prominent in complex arterial geometries, such as curvature, asa result of the limited conformability of coronary stents. These malapposed struts disturb the otherwise near...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.09.016
更新日期：2017-10-03 00:00:00
abstract：:Three-dimensional gait analysis (3D-GA) is commonly used to answer clinical questions of the form "which joints and what variables are most affected during when". When studying high-dimensional datasets, traditional dimension reduction methods (e.g. principal components analysis) require "data flattening", which may m...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.04.035
更新日期：2019-06-11 00:00:00
abstract：:Multiple osteochondral grafts can be used to resurface large joint defects in both humans and horses. In humans, immediate postoperative weight bearing can be prevented, however in the equine, it is unavoidable. Early weight bearing can create detrimental graft micromotion. The aim of this study was to investigate the...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.10.007
更新日期：2006-01-01 00:00:00
abstract：:Patient specific quantitative CT (QCT) imaging data together with the finite element (FE) method may provide an accurate prediction of a patient's femoral strength and fracture risk. Although numerous FE models investigating femoral fracture strength have been published, there is little consent on the effect of bounda...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.07.004
更新日期：2013-09-03 00:00:00
abstract：:Which of the elementary components (hydroxyapatite (HA) crystals, collagen, non-collagenous organic matter, water) do significantly contribute to the ultrastructural elastic stiffness magnitude and anisotropy of mineralized tissues; and how, i.e. through which shapes and assemblages (which micromechanical morphology)?...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(02)00080-5
更新日期：2002-09-01 00:00:00
abstract：:Total disc arthroplasty (TDA) can be used to replace a degenerated intervertebral disc in the spine. There are different designs of prosthetic discs, but one of the most common is a ball-and-socket combination. Contact between the bearing surfaces can result in high frictional torque, which can then result in wear and...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.11.045
更新日期：2012-02-02 00:00:00
abstract：:In this study, an experimental framework is described that allows pressurization of intact, human atherosclerotic carotid samples (inflation testing), in combination with ultrasound imaging. Eight fresh human carotid endarterectomy samples were successfully pressurized and tested. About 36 2-D (+t) ultrasound datasets...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.01.016
更新日期：2014-03-03 00:00:00
abstract：:Mechanical properties of skeletal muscles are often studied for controlled, electrically induced, maximal, or supra-maximal contractions. However, many mechanical properties, such as the force-length relationship and force enhancement following active muscle stretching, are quite different for maximal and sub-maximal,...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.12.002
更新日期：2007-01-01 00:00:00
abstract：:This article describes a method to simulate fusion of morselized cancellous bone. The morselized cancellous bone is mixed with an epoxy adhesive, in empirically determined proportions. The mixture is then impacted into a construct. When the epoxy cures, the morselized material fuses into a cohesive, contiguous structu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00032-x
更新日期：2001-06-01 00:00:00
abstract：:The purpose of this investigation was to determine how the moment arms and architecture of the wrist muscles influence their isometric moment-generating characteristics. A three-dimensional computer graphic model was developed that estimates the moment arms, maximum isometric forces, and maximum isometric flexion-exte...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(97)00015-8
更新日期：1997-07-01 00:00:00
abstract：:Biphasic properties of articular cartilage allow it to be an excellent bearing material and have been studied through several simplified experiments as well as finite element modelling. However, three-dimensional biphasic finite element (FE) models of the whole joint are rare. The current study was carried out to expe...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.02.140
更新日期：2011-05-17 00:00:00
abstract：:Accurate modeling of soft tissue motion effects relative to bone during impact requires knowledge of the mass of soft and rigid tissues in living people. Holmes et al., [2005. Predicting in vivo soft tissue masses of the lower extremity using segment anthropometric measures and DXA. Journal of Applied Biomechanics, 21...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.02.013
更新日期：2008-01-01 00:00:00
abstract：:Bone is a biological nanocomposite composed primarily of collagen and hydroxyapatite. The collagen molecules self-assemble to from a structure known as a fibril that comprises of about 85-95% of the total bone protein. In a fibril, the molecular level interactions at the interface between molecular collagen and hydrox...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.02.027
更新日期：2010-06-18 00:00:00
abstract：:The ability to quantitatively measure stability is essential to ensuring the safety of locomoting systems. While the response to perturbation directly reflects the stability of a motion, this experimental method puts human subjects at risk. Unfortunately, existing indirect methods for estimating stability from unpertu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.02.022
更新日期：2018-04-27 00:00:00
abstract：:Chondrocytes in articular cartilage are regularly subjected to compression and recovery due to dynamic loading of the joint. Previous studies have investigated the elastic and viscoelastic properties of chondrocytes using micropipette aspiration techniques, but in order to calculate cell properties, these studies have...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.11.006
更新日期：2006-01-01 00:00:00
abstract：:This study is aimed at the analysis of articular contact in a three-dimensional mathematical model of the human knee-joint. In particular the effect of articular contact on the passive motion characteristics is assessed in relation to experimentally obtained joint kinematics. Two basically different mathematical conta...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(91)90019-j
更新日期：1991-01-01 00:00:00
abstract：:A stereoradiographic method was developed to measure the three-dimensional shape of the rib cage in vivo in order to provide descriptive data and to study symmetry in the normal population. The method is also intended for use in description of rib asymmetry in scoliosis. Rib midlines were reconstructed from digitized ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(88)90127-3
更新日期：1988-01-01 00:00:00
abstract：:The present work displayed the first quantitative data of forces acting on tendons and pulleys during specific sport-climbing grip techniques. A three-dimensional static biomechanical model was used to estimate finger muscle tendon and pulley forces during the "slope" and the "crimp" grip. In the slope grip the finger...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.08.027
更新日期：2006-01-01 00:00:00
abstract：:In the context of reconciling the mechanical properties of trabecular bone measured from in vitro mechanical testing with the true in situ behavior, recent attention has focused on the "side-artifact" which results from interruption of the trabecular network along the sides of machined specimens. The objective of this...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.05.008
更新日期：2007-01-01 00:00:00
abstract：:Individuals with spastic cerebral palsy (SCP) exhibit restricted joint range of motion and increased joint stiffness due to structural alterations of their muscles. Little is known about which muscle-tendon structures are responsible for these alterations. The aim of this study was to compare the passive mechanics of ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.06.008
更新日期：2011-09-02 00:00:00
abstract：:Several studies have attributed the prevalence of low back pain (LBP) in helicopter pilots mainly to poor posture in-flight and whole-body vibration, with the latter hypothesis particularly related to a cyclic response of the erector spine (ES) muscle to vibration. This work aims to determine if helicopter vibration a...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00090-2
更新日期：2001-10-01 00:00:00
