Base-free nickel-catalysed decarbonylative Suzuki-Miyaura coupling of acid fluorides.

abstract：:The mechanical environment crucially influences many cell functions. However, it remains largely mysterious how mechanical stimuli are transmitted into biochemical signals. Src is known to regulate the integrin-cytoskeleton interaction, which is essential for the transduction of mechanical stimuli. Using fluorescent r...

journal_title：Nature

authors： Wang Y,Botvinick EL,Zhao Y,Berns MW,Usami S,Tsien RY,Chien S

更新日期：2005-04-21 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Flaviviruses, when complexed with antibody at subneutralizing concentrations, show enhanced replication in human and simian peripheral blood leukocytes (ref. 1, and J.S.M.P. and J.S.P., unpublished observations) and in P388 D1 and other macrophage cell lines. A comparable phenomenon has been demonstrated with alphavir...

journal_title：Nature

authors： Peiris JS,Gordon S,Unkeless JC,Porterfield JS

更新日期：1981-01-15 00:00:00

abstract：:Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wid...

journal_title：Nature

authors： Heinig M,Petretto E,Wallace C,Bottolo L,Rotival M,Lu H,Li Y,Sarwar R,Langley SR,Bauerfeind A,Hummel O,Lee YA,Paskas S,Rintisch C,Saar K,Cooper J,Buchan R,Gray EE,Cyster JG,Cardiogenics Consortium.,Erdmann J,Heng

更新日期：2010-09-23 00:00:00

abstract：:The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic s...

journal_title：Nature

authors： Hochedlinger K,Jaenisch R

更新日期：2006-06-29 00:00:00

abstract：:The process of DNA recognition by the activated form of the restriction endonuclease from E. coli K involves three enzyme-DNA complexes which can be differentiated experimentally. These are: an initial complex formed at a nonspecific site; a recognition complex involving the host specificity site; and a cleavage compl...

journal_title：Nature

authors： Yuan R,Bickle TA,Ebbers W,Brack C

更新日期：1975-08-14 00:00:00

abstract：:The respiratory organs of terrestrial insects consist of tracheal tubes with external spiracular valves that control gas exchange. Despite their relatively high metabolic rate, many insects have highly discontinuous patterns of gas exchange, including long periods when the spiracles are fully closed. Two explanations ...

journal_title：Nature

authors： Hetz SK,Bradley TJ

更新日期：2005-02-03 00:00:00

abstract：:The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...

journal_title：Nature

authors： Knorr W,Prentice IC,House JI,Holland EA

更新日期：2005-01-20 00:00:00

abstract：:The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physiological effects suc...

journal_title：Nature

authors： Saxton RA,Chantranupong L,Knockenhauer KE,Schwartz TU,Sabatini DM

更新日期：2016-08-11 00:00:00

abstract：:Diatoms dominate the biomass of phytoplankton in nutrient-rich conditions and form the basis of some of the world's most productive marine food webs. The diatom nuclear genome contains genes with bacterial and plastid origins as well as genes of the secondary endosymbiotic host (the exosymbiont), yet little is known a...

journal_title：Nature

authors： Allen AE,Dupont CL,Oborník M,Horák A,Nunes-Nesi A,McCrow JP,Zheng H,Johnson DA,Hu H,Fernie AR,Bowler C

更新日期：2011-05-12 00:00:00

abstract：:Plants can have positive effects on each other. For example, the accumulation of nutrients, provision of shade, amelioration of disturbance, or protection from herbivores by some species can enhance the performance of neighbouring species. Thus the notion that the distributions and abundances of plant species are inde...

journal_title：Nature

authors： Callaway RM,Brooker RW,Choler P,Kikvidze Z,Lortie CJ,Michalet R,Paolini L,Pugnaire FI,Newingham B,Aschehoug ET,Armas C,Kikodze D,Cook BJ

更新日期：2002-06-20 00:00:00

abstract：:Important Ca2+ signals in the cytosol and organelles are often extremely localized and hard to measure. To overcome this problem we have constructed new fluorescent indicators for Ca2+ that are genetically encoded without cofactors and are targetable to specific intracellular locations. We have dubbed these fluorescen...

journal_title：Nature

authors： Miyawaki A,Llopis J,Heim R,McCaffery JM,Adams JA,Ikura M,Tsien RY

更新日期：1997-08-28 00:00:00

abstract：:Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)1-3. For most solid-state qubit technologies-for example, those using superconduc...

journal_title：Nature

authors： Yang CH,Leon RCC,Hwang JCC,Saraiva A,Tanttu T,Huang W,Camirand Lemyre J,Chan KW,Tan KY,Hudson FE,Itoh KM,Morello A,Pioro-Ladrière M,Laucht A,Dzurak AS

更新日期：2020-04-01 00:00:00

abstract：:Compared with atoms, molecules have a rich internal structure that offers many opportunities for technological and scientific advancement. The study of this structure could yield critical insights into quantum chemistry, new methods for manipulating quantum information, and improved tests of discrete symmetry violatio...

journal_title：Nature

authors： Rellergert WG,Sullivan ST,Schowalter SJ,Kotochigova S,Chen K,Hudson ER

更新日期：2013-03-28 00:00:00

abstract：:Environmental change is rapidly accelerating, and many species will need to adapt to survive1. Ensuring that protected areas cover populations across a broad range of environmental conditions could safeguard the processes that lead to such adaptations1-3. However, international conservation policies have largely negle...

journal_title：Nature

authors： Hanson JO,Rhodes JR,Butchart SHM,Buchanan GM,Rondinini C,Ficetola GF,Fuller RA

更新日期：2020-04-01 00:00:00

abstract：:A magnetic field penetrates a superconductor through an array of 'vortices', each of which carries one quantum of flux that is surrounded by a circulating supercurrent. In this vortex state, the resistivity is determined by the dynamical properties of the vortex 'matter'. For the high-temperature copper oxide supercon...

journal_title：Nature

authors： Bouquet F,Marcenat C,Steep E,Calemczuk R,Kwok WK,Welp U,Crabtree GW,Fisher RA,Phillips NE,Schilling A

更新日期：2001-05-24 00:00:00

abstract：:As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have shaped the evolution of innate immunity remains poorly understood. Here we characterize the...

journal_title：Nature

authors： Hagai T,Chen X,Miragaia RJ,Rostom R,Gomes T,Kunowska N,Henriksson J,Park JE,Proserpio V,Donati G,Bossini-Castillo L,Vieira Braga FA,Naamati G,Fletcher J,Stephenson E,Vegh P,Trynka G,Kondova I,Dennis M,Haniffa M,No

更新日期：2018-11-01 00:00:00

abstract：:Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has bee...

journal_title：Nature

authors： Johannessen CM,Boehm JS,Kim SY,Thomas SR,Wardwell L,Johnson LA,Emery CM,Stransky N,Cogdill AP,Barretina J,Caponigro G,Hieronymus H,Murray RR,Salehi-Ashtiani K,Hill DE,Vidal M,Zhao JJ,Yang X,Alkan O,Kim S,Harris JL

更新日期：2010-12-16 00:00:00

abstract：:Variations in atmospheric radiocarbon (14C) concentrations can be attributed either to changes in the carbon cycle--through the rate of radiocarbon removal from the atmosphere--or to variations in the production rate of 14C due to changes in solar activity or the Earth's magnetic field. The production rates of 10Be an...

journal_title：Nature

authors： Muscheler R,Beer J,Wagner G,Finkel RC

更新日期：2000-11-30 00:00:00

abstract：:Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its substrate AMP-activated protein kinase (AMPK), kinases that coordinate metabolism with cell growth. Deletion of the Lkb1 (also called Stk11) gene in m...

journal_title：Nature

authors： Nakada D,Saunders TL,Morrison SJ

更新日期：2010-12-02 00:00:00

abstract：:The best spectrographs are limited in stability by their calibration light source. Laser frequency combs are the ideal calibrators for astronomical spectrographs. They emit a spectrum of lines that are equally spaced in frequency and that are as accurate and stable as the atomic clock relative to which the comb is sta...

journal_title：Nature

authors： Wilken T,Curto GL,Probst RA,Steinmetz T,Manescau A,Pasquini L,González Hernández JI,Rebolo R,Hänsch TW,Udem T,Holzwarth R

更新日期：2012-05-30 00:00:00

abstract：:The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial com...

journal_title：Nature

authors： Mouse Genome Sequencing Consortium.,Waterston RH,Lindblad-Toh K,Birney E,Rogers J,Abril JF,Agarwal P,Agarwala R,Ainscough R,Alexandersson M,An P,Antonarakis SE,Attwood J,Baertsch R,Bailey J,Barlow K,Beck S,Berry E,Bir

更新日期：2002-12-05 00:00:00

abstract：:Promoters are DNA sequences that have an essential role in controlling gene expression. While recent whole cancer genome analyses have identified numerous hotspots of somatic point mutations within promoters, many have not yet been shown to perturb gene expression or drive cancer development. As such, positive selecti...

journal_title：Nature

authors： Perera D,Poulos RC,Shah A,Beck D,Pimanda JE,Wong JW

更新日期：2016-04-14 00:00:00

abstract：:Successful expression of genes transferred into distantly related species in which genetic functions have been maintained through evolution has been reported previously. In the case of the silkmoth Bombyx mori and the fruitfly Drosophila melanogaster, both of which produce chorions (eggshells), Bombyx chorion genes ar...

journal_title：Nature

authors： Bello B,Couble P

更新日期：1990-08-02 00:00:00

abstract：:In this Article, owing to an error during the production process, in Fig. 1a, the dark blue and light blue wedges were incorrectly labelled as 'G•C → T•A' and 'G•C → A•T', instead of 'C•G → T•A' and 'C•G → A•T', respectively. Fig. 1 has been corrected online. ...

journal_title：Nature

authors： Gaudelli NM,Komor AC,Rees HA,Packer MS,Badran AH,Bryson DI,Liu DR

更新日期：2018-07-01 00:00:00

abstract：:Recent studies in which cloned immunoglobulin genes were introduced into cultured cells have produced two significant findings. First, the genes are expressed after transfection into lymphoid cells but not non-lymphoid cells. Second, transcription of an immunoglobulin gene requires, in addition to the promoter region,...

journal_title：Nature

authors： Foster J,Stafford J,Queen C

更新日期：1985-05-30 00:00:00

abstract：:The determination of molecular masses from barometric sedimentation profiles, a main topic in ultracentrifugal analysis, is thought to be quantitatively correct for non-interacting particles. Whereas this expectation is justified for uncharged colloids or macromolecules at low volume fractions, early ultracentrifugati...

journal_title：Nature

authors： Raşa M,Philipse AP

更新日期：2004-06-24 00:00:00

abstract：:The Gulf Stream transports approximately 31 Sv (1 Sv = 10(6) m(3) s(-1)) of water and 1.3 x 10(15) W of heat into the North Atlantic ocean. The possibility of abrupt changes in Gulf Stream heat transport is one of the key uncertainties in predictions of climate change for the coming centuries. Given the limited length...

journal_title：Nature

authors： Lund DC,Lynch-Stieglitz J,Curry WB

更新日期：2006-11-30 00:00:00

abstract：:The well known trade-off between hardness and toughness (resistance to fracture) makes simultaneous improvement of both properties challenging, especially in diamond. The hardness of diamond can be increased through nanostructuring strategies1,2, among which the formation of high-density nanoscale twins - crystalline ...

journal_title：Nature

authors： Yue Y,Gao Y,Hu W,Xu B,Wang J,Zhang X,Zhang Q,Wang Y,Ge B,Yang Z,Li Z,Ying P,Liu X,Yu D,Wei B,Wang Z,Zhou XF,Guo L,Tian Y

更新日期：2020-06-01 00:00:00

abstract：:Dehydration embrittlement has been proposed to explain both intermediate- and deep-focus earthquakes in subduction zones. Because such earthquakes primarily occur at shallow depths or within the core of the subducting plate, dehydration at relatively low temperatures has been emphasized. However, recent careful reloca...

journal_title：Nature

authors： Zhang J,Green HW,Bozhilov K,Jin Z

更新日期：2004-04-08 00:00:00