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NATURE文献大全abstract::In 2001 the Intergovernmental Panel on Climate Change projected the contribution to sea level rise from the Greenland ice sheet to be between -0.02 and +0.09 m from 1990 to 2100 (ref. 1). However, recent work has suggested that the ice sheet responds more quickly to climate perturbations than previously thought, parti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05168
更新日期:2006-09-21 00:00:00
abstract::Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III tumours (sometimes referred to as lower-grade gliomas). Genetic tumour profiling is used to classify disease and guide therapy1,2, but involves brain surgery for ti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0882-3
更新日期:2019-01-01 00:00:00
abstract::Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature17038
更新日期:2016-01-21 00:00:00
abstract::Salmonella enterica serovar Typhi (S. Typhi) differs from most other salmonellae in that it causes a life-threatening systemic infection known as typhoid fever. The molecular bases for its unique clinical presentation are unknown. Here we find that the systemic administration of typhoid toxin, a unique virulence facto...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12377
更新日期:2013-07-18 00:00:00
abstract::One of the main unanswered questions in solar physics is why the Sun's outer atmosphere is hotter than its surface. Theory predicts abundant production of high-frequency (10-50 mHz) acoustic waves in subsurface layers of the Sun, and such waves are believed by many to constitute the dominant heating mechanism of the c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03695
更新日期:2005-06-16 00:00:00
abstract::A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a protein-conducting channel, allowing polypeptides to be transferred across or integrated into membranes. We report the crystal structure of the complex from Methanococcus jannaschii at a resolution of 3.2 A. The structure suggests ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02218
更新日期:2004-01-01 00:00:00
abstract::The induction of polyarthritis in rats by intradermal immunisation with homologous or heterologous type II collagen incomplete or incomplete Freund's adjuvant was reported recently by Trentham et al. We have now produced a similar disease in certain strains of mice. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283666a0
更新日期:1980-02-14 00:00:00
abstract::How the brain selects appropriate sensory inputs and suppresses distractors is unknown. Given the well-established role of the prefrontal cortex (PFC) in executive function, its interactions with sensory cortical areas during attention have been hypothesized to control sensory selection. To test this idea and, more ge...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15398
更新日期:2015-10-29 00:00:00
abstract::The superposition principle is a fundamental tenet of quantum mechanics. It allows a quantum system to be 'in two places at the same time', because the quantum state of a physical system can simultaneously include measurably different physical states. The preparation and use of such superposed states forms the basis o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08005
更新日期:2009-05-28 00:00:00
abstract::Insulin resistance occurs in a variety of conditions, including diabetes, obesity and essential hypertension, but its underlying molecular mechanisms are unclear. In type 2 (non-insulin-dependent) diabetes mellitus, it is insulin-resistance in skeletal muscle, the chief site of insulin-mediated glucose disposal in hum...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335632a0
更新日期:1988-10-13 00:00:00
abstract::BINDING of the TATA-binding protein (TBP) to the TATA box is required for transcription from many eukaryotic promoters in gene expression. Regulation of this binding is therefore likely to be an important determinant of promoter activity. Incorporation of the TATA sequence into nucleosomes dramatically reduces transcr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/370481a0
更新日期:1994-08-11 00:00:00
abstract::Although it is well established that family members resemble each other in intelligence , the extent to which this results from either shared genes or a shared environment remains controversial, perhaps especially since the relevant evidence presented by Burt has been shown probably to have been fabricated. The influe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/309620a0
更新日期:1984-06-14 00:00:00
abstract::Genetic-environmental interactions probably underlie spontaneous human autoimmune disorders, a category of complex traits thought to include multiple sclerosis (MS). The geographical distribution and familial aggregation of this disease have often been ascribed to the role of infectious agents, but there is no consens...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/377150a0
更新日期:1995-09-14 00:00:00
abstract::Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cells. Once activated, they proliferate vigorously, generating effector cells that can migrate to B-cell areas or to inflamed tissues. A fraction of primed T lymphocytes persists as circulating memory ce...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/44385
更新日期:1999-10-14 00:00:00
abstract::Rapid warming over the past 50 years on the Antarctic Peninsula is associated with the collapse of a number of ice shelves and accelerating glacier mass loss. In contrast, warming has been comparatively modest over West Antarctica and significant changes have not been observed over most of East Antarctica, suggesting ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11391
更新日期:2012-09-06 00:00:00
abstract::Much of our current knowledge about mitochondria has come from studying patients who have respiratory chain disorders. These disorders comprise a large collection of individually rare syndromes, each presenting in a unique and often devastating way. In recent years, there has been great progress in defining their gene...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature11707
更新日期:2012-11-15 00:00:00
abstract::Direct dating of ductile shear zones and calculation of uplift/exhumation rates can be done using various radiometric dating techniques. But radiometric dating of shallow crustal faulting, which occurs in the crust's brittle regime, has remained difficult because the low temperatures typical of shallow crusted faults ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35084053
更新日期:2001-07-12 00:00:00
abstract::Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338225a0
更新日期:1989-03-16 00:00:00
abstract::Juxtaposition between endoplasmic reticulum (ER) and mitochondria is a common structural feature, providing the physical basis for intercommunication during Ca(2+) signalling; yet, the molecular mechanisms controlling this interaction are unknown. Here we show that mitofusin 2, a mitochondrial dynamin-related protein ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07534
更新日期:2008-12-04 00:00:00
abstract::A fascinating question in biology is how molecular changes in developmental pathways lead to macroevolutionary changes in morphology. Mutations in homeotic (Hox) genes have long been suggested as potential causes of morphological evolution, and there is abundant evidence that some changes in Hox expression patterns co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature716
更新日期:2002-02-21 00:00:00
abstract::Enhancers are DNA sequences that stimulate transcription from eukaryotic promoters. This stimulatory effect can be exerted over large distances and from a position either 5' or 3' of a promoter. Enhancers have been found in the genomes of many viruses, and in some cellular genes such as those encoding immunoglobulin h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322383a0
更新日期:1986-07-24 00:00:00
abstract::Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. Here we show that the Wnt signalling pathway has an important role in this process. Overexpression of activated beta-catenin expands t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01593
更新日期:2003-05-22 00:00:00
abstract::The evolutionary biologist "studies the steps by which the miraculous adaptations so characteristic of every aspect of the organic world have evolved". But the general nature of such adaptive steps is still unclear. Evolution is often thought to be random and dependent on unpredictable events. In this light, one might...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35095046
更新日期:2001-09-20 00:00:00
abstract::Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1-4. However, how adult-born neurons regulate dentate gyrus information processing to protect from stress-induced anxiety-like be...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0262-4
更新日期:2018-07-01 00:00:00
abstract::Neutrophils activated by the formyl peptide f-Met-Leu-Phe transiently accumulate a small subset of highly polar inositol lipids. A similar family of lipids also appear in many other cells in response to a range of growth factors and activated oncogenes, and are presumed to be the direct or indirect products of 3-phosp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351033a0
更新日期:1991-05-02 00:00:00
abstract::It has been suggested that the initiation step in mouse skin carcinogenesis involves an alteration in epidermal-differentiation, as mouse basal keratinocytes exposed to initiators resist the arrest of cell growth that is normally associated with the induction of terminal differentiation by calcium ions. The growth of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314459a0
更新日期:1985-04-04 00:00:00
abstract::Courtship rituals serve to reinforce reproductive barriers between closely related species. Drosophila melanogaster and Drosophila simulans exhibit reproductive isolation, owing in part to the fact that D. melanogaster females produce 7,11-heptacosadiene, a pheromone that promotes courtship in D. melanogaster males bu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0322-9
更新日期:2018-07-01 00:00:00
abstract::The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertil...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13413
更新日期:2014-06-05 00:00:00
abstract::Quantum superposition lies at the heart of quantum mechanics and gives rise to many of its paradoxes. Superposition of de Broglie matter waves' has been observed for massive particles such as electrons, atoms and dimers, small van der Waals clusters, and neutrons. But matter wave interferometry with larger objects has...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/44348
更新日期:1999-10-14 00:00:00
abstract::Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptid...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12942
更新日期:2014-03-06 00:00:00