Abstract：
:Naturally occurring plasmids have medical importance given that they frequently code for virulence or antibiotic resistance. In many cases, plasmids impose a fitness cost to their hosts, meaning that the growth rate of plasmid-bearing cells is lower than that of plasmid-free cells. However, this does not fit with the fact that plasmids are ubiquitous in nature nor that plasmids and their hosts adapt to each other very fast - as has been shown in laboratory evolutionary assays. Even when plasmids are costly, they seem to largely interact in such a way that the cost of two plasmids is lower than the cost of one of them alone. Moreover, it has been argued that transfer rates are too low to compensate for plasmid costs and segregation. Several mechanisms involving interactions between plasmids and other replicons could overcome this limitation, hence contributing to the maintenance of plasmids in bacterial populations. We examine the importance of these mechanisms from a clinical point of view, particularly the spread of antibiotic resistance genes.
journal_name
Plasmidjournal_title
Plasmidauthors
Gama JA,Zilhão R,Dionisio Fdoi
10.1016/j.plasmid.2018.09.009subject
Has Abstractpub_date
2018-09-01 00:00:00pages
82-88eissn
0147-619Xissn
1095-9890pii
S0147-619X(18)30023-4journal_volume
99pub_type
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