Abstract:
:Stimulation of polymorphonuclear leukocytes (PMN) by tetravalent concanavalin A (alpha-ConA) induces membrane depolarization preceding the onset of superoxide anion (O2-) production. Both divalent and monovalent ConA analogues were studied to evaluate the role of valence. Monovalent ConA (m-ConA) was inactive in stimulating O2- production and divalent derivatives were less active than native alpha-ConA. Similarly, membrane depolarization was dependent on the valency of ConA. m-ConA did not induce a marked change in membrane potential, whereas sustained depolarization occurred with multivalent ConA. The formation of multiple linked interactions between surface receptors may be an important early event in the activation of PMN by ConA.
journal_name
Cell Struct Functjournal_title
Cell structure and functionauthors
Kuroki M,Kamo N,Kobatake Y,Abe Y,Ishii Sdoi
10.1247/csf.11.199subject
Has Abstractpub_date
1986-06-01 00:00:00pages
199-204issue
2eissn
0386-7196issn
1347-3700journal_volume
11pub_type
杂志文章abstract::Under unfavorable conditions for growth, haploid myxoamoebae of Physarum polycephalum retracted their pseudopodia and changed their cell shape into disk-like form, after which they constructed the cell walls to form microcysts. These morphological changes of haploid cells were associated with changes in intracellular ...
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