Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update.

Abstract:

PURPOSE OF REVIEW:We review the existing literature on gene-environment interactions (G×E) and epigenetic changes primarily in borderline personality disorder (BPD) but also in antisocial, schizotypal, and avoidant personality disorders. RECENT FINDINGS:Research supports that susceptibility genes to BPD or its underlying traits may be expressed under certain environmental conditions such as physical or childhood sexual abuse. Epigenetic modifications of neurodevelopment- and stress-related genes are suggested to underlie the relationship between early life adversary and borderline personality disorder. Only limited studies have investigated the role of gene-environment interactions and epigenetic changes in the genesis of antisocial, schizotypal, and avoidant personality disorders. Considering the lack of pharmacological treatment for most personality disorders, the emerging evidence on the critical role of G×E and epigenetic changes in the genesis of personality disorders could help develop more biologically oriented therapeutic approaches. Future studies should explore the potential of this new therapeutic dimension.

journal_name

Curr Psychiatry Rep

authors

Bulbena-Cabre A,Bassir Nia A,Perez-Rodriguez MM

doi

10.1007/s11920-018-0934-7

subject

Has Abstract

pub_date

2018-08-09 00:00:00

pages

74

issue

9

eissn

1523-3812

issn

1535-1645

pii

10.1007/s11920-018-0934-7

journal_volume

20

pub_type

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