Abstract：
:Twin studies have established that there are substantial genetic influences on alcoholism (0.5-0.6) in both men and women. Our knowledge of behaviors predisposing to alcoholism, including anxiety and impulsivity, is advancing rapidly through animal and human studies. Although alcoholism is often comorbid with other substance abuse and psychiatric disorders, recent studies have shown that, with the exception of nicotine, the heritability of alcoholism is largely substance-specific. Increasing understanding of the neurobiology of addiction has identified neural pathways in which genetic variation at candidate genes could influence vulnerability. Some functional variants of these genes have been identified. Recent linkage analyses in humans and rodents have pointed to genomic regions harboring genes that influence alcoholism. Refinement of clinical phenotypes and use of intermediate phenotypes will improve chances of gene identification. All these advances in the understanding of the genetics of alcoholism should facilitate the development of more accurately targeted therapies using molecular diagnostic approaches.
journal_name
Curr Psychiatry Repjournal_title
Current psychiatry reportsauthors
Enoch MA,Goldman Ddoi
10.1007/s11920-001-0012-3keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
144-51issue
2eissn
1523-3812issn
1535-1645journal_volume
3pub_type
杂志文章,评审abstract：:There is a dearth of knowledge regarding the diagnosis and treatment of bipolar disorder in late life. Based on a review of the current research on bipolar disorder in late life, emerging areas of research were identified: 1) methodological challenges in diagnosing bipolar disorder; 2) a lack of guidelines for the tre...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-005-0018-3
更新日期：2005-03-01 00:00:00
abstract：:The purposes of this paper are to provide an overview of the state of the science of sleep in children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of insomnia in children with ASD, and present a practice pathway for promoting optimal sleep. Approximately two thirds of children with ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0782-x
更新日期：2017-06-01 00:00:00
abstract：PURPOSE OF REVIEW:We review the existing literature on gene-environment interactions (G×E) and epigenetic changes primarily in borderline personality disorder (BPD) but also in antisocial, schizotypal, and avoidant personality disorders. RECENT FINDINGS:Research supports that susceptibility genes to BPD or its underly...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0934-7
更新日期：2018-08-09 00:00:00
abstract：:This review addresses issues related to the use of structured psychiatric diagnostic interviews in children and adolescents. Structured diagnostic interviews improve the diagnostic process by better organizing the collection of clinical data and eliminating biases when applying diagnostic criteria. Available interview...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0047-3
更新日期：2004-04-01 00:00:00
abstract：:The comorbidity of pain and depression has been well established in the literature and is associated with a greater burden to the individual and society than either condition alone. The relationship between pain and depression is quite complex and multiple factors must be considered when trying to disentangle the pain...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0421-0
更新日期：2013-12-01 00:00:00
abstract：:Viral encephalitis, a condition in which a virus infects the brain and produces an inflammatory response, affects approximately 20,000 individuals per year in the United States. The viral encephalidities include sporadic and epidemic acute viral encephalidities and subacute and chronic/progressive viral encephalitis o...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0024-x
更新日期：2004-10-01 00:00:00
abstract：:Schizophrenia is a serious psychiatric illness which is experienced by about 1 % of individuals worldwide and has a debilitating impact on perception, cognition, and social function. Over the years, several models/hypotheses have been developed which link schizophrenia to dysregulations of the dopamine, glutamate, and...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-016-0710-5
更新日期：2016-08-01 00:00:00
abstract：:Clinical neuropsychiatry has traditionally relied on individual practitioner experience or the apprentice-training model for formulating cases and choosing treatment. Scientifically-based diagnostic criteria and treatment algorithms have been lacking in the overlap area between psychiatry and neurology, owing largely ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-996-0026-y
更新日期：2001-10-01 00:00:00
abstract：:Bipolar disorder (BD) is one of the most potentially severe mental disorders. Literature data indicate that despite the current available treatments, a large proportion of patients do not achieve complete remission, with consequent residual symptoms and chronic impairment. We carried out a comprehensive review of new ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-011-0231-1
更新日期：2011-12-01 00:00:00
abstract：:Updated findings on the relationship between nicotine and depression are presented. Clinical and preclinical research on nicotine use and depression suggests that nicotine may have some properties in common with antidepressants. Updated findings involve the comorbidity of smoking and major depressive disorder (MDD), t...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-001-0040-z
更新日期：2001-12-01 00:00:00
abstract：:The concepts of healthcare reform and population health are shifting the emphasis from traditional, volume-based care to a model in which value, or quality, predominates. High quality care will be increasingly rewarded, with financial consequences for poor performance. This shift will be accelerated by the use of heal...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0369-0
更新日期：2013-07-01 00:00:00
abstract：:The comorbidity of anxiety disorders with pain has received little research attention even though recent studies show that these disorders are as likely to co-occur with chronic pain conditions as depressive disorder. Comorbid anxiety has implications for the impact and outcome of pain conditions. Even though it may b...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-008-0051-0
更新日期：2008-08-01 00:00:00
abstract：:Individuals with bipolar disorder experience twice the cardiovascular mortality expected from general population estimates. The metabolic syndrome is more common in those with bipolar disorder, with a prevalence ratio of 1.6, and includes many traditional cardiovascular risk factors, which may explain much of the elev...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-009-0072-3
更新日期：2009-12-01 00:00:00
abstract：:In the past three decades, there has been an exponential increase in the worldwide availability of Internet access and devices that are able to access online materials. This literature review investigated whether increased accessibility of Internet child pornography (CP) increases the risk of in-person child sexual ex...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-016-0707-0
更新日期：2016-08-01 00:00:00
abstract：:Researchers have estimated the cost of treating substance abuse and its effects on medical care and social service expenses, but have rarely used the methods developed to evaluate medical care interventions. When outcomes are expressed as quality-adjusted life years, substance abuse treatment may be compared with othe...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-999-0027-8
更新日期：1999-12-01 00:00:00
abstract：:Musical hallucinations have been described in numerous neurologic and psychiatric patients, but their pathophysiologic background is not understood. Analyzing the published cases, five subgroups can be separated according to their etiology: hypacusis, psychiatric disorders, focal brain lesions, epilepsy, and intoxicat...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-006-0024-0
更新日期：2006-06-01 00:00:00
abstract：PURPOSE OF REVIEW:With the current demographic shifts, the USA will soon become a "majority minority" country. While the population of the USA over the age of 65 years is projected to increase from 13.5% to 20% in 2030, racial and ethnic minority elderly, who are now 21% of the population, will increase to 44% by 2060....
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1082-4
更新日期：2019-09-14 00:00:00
abstract：:Drug treatment of patients with borderline personality disorder (BPD) is common but mostly not supported by evidence from high-quality research. This review summarises the current evidence up to August 2014 and also aims to identify research trends in terms of ongoing randomised controlled trials (RCTs) as well as res...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-014-0534-0
更新日期：2015-01-01 00:00:00
abstract：:Several international guidelines indicate stimulants, including methylphenidate (MPH), amphetamines and derivatives, modafinil, and armodafinil among the second-third-line choices for bipolar depression. Efficacy of stimulants has been also reported for the management of residual depressive symptoms such as fatigue an...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0758-x
更新日期：2017-01-01 00:00:00
abstract：:In May 2013 the APA will release DSM-5, which will restructure the diagnostic classification for autism spectrum disorders (ASDs) into a single category. The proposed changes in DSM-5 aim to better reflect the current state of research by consistently identifying the core features in social/communication and restricti...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0327-2
更新日期：2012-12-01 00:00:00
abstract：:The term paraphrenia refers to a condition characterized by a strong delusional component with preservation of thought and personality. Most affected patients are women. Although a late age at onset (> 60 years) has been proposed in the literature, evidence for this assertion remains debatable. Deterioration of cognit...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0108-8
更新日期：2010-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The aim of this review was to focus solely on youths' behavioral responses to natural disasters and political conflicts in order to fully understand their impact and scope. RECENT FINDINGS:Recent studies in the field of trauma have shown that theoretical conceptions have moved away from a narrow focu...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1030-3
更新日期：2019-04-29 00:00:00
abstract：:The eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) are severe psychiatric disorders with high mortality. Our knowledge about the neurobiology of eating disorders is very limited, and the question remains whether alterations in brain structure or function in eating disorders are state related, remnants...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0396-x
更新日期：2013-10-01 00:00:00
abstract：:Relapse is a highly prevalent phenomenon in addiction. This paper examines the new research on identifying biological factors that contribute to addiction relapse risk. Prospective studies examining relapse risk are reviewed, and clinical, biological, and neural factors that predict relapse risk are identified. Clinic...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-011-0224-0
更新日期：2011-10-01 00:00:00
abstract：:A large number of studies have examined both the epidemiology and neuropsychiatric manifestations of dementia among older adults. However, there is a relative dearth of studies focusing on ethnic minority elders in the United States. This article reviews the existing empiric literature in the area of ethnicity and dem...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0040-4
更新日期：2000-02-01 00:00:00
abstract：:Interest in the relationship between cannabis use and psychosis has increased dramatically in recent years, in part because of concerns related to the growing availability of cannabis and potential risks to health and human functioning. There now exists a plethora of scientific articles addressing this issue, but few ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-015-0657-y
更新日期：2016-02-01 00:00:00
abstract：:Social media tools such as blogs, microblogs, social networking sites, podcasts, and video-sharing sites are now ubiquitous. These tools enable instantaneous interactions with a global community of individuals, including medical professionals, learners, and patients. An understanding of social media tools and how they...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-015-0635-4
更新日期：2015-12-01 00:00:00
abstract：:This paper reviews recent evidence on the value of phallometric (i.e., erectile) measures of sex offenders plus earlier crucial papers. Distinctions are made between types of measuring devices with the volumetric instrument appearing to be the most sensitive. Considering the meaning of responses it is concluded that a...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0428-6
更新日期：2014-01-01 00:00:00
abstract：PURPOSE OF REVIEW:I summarize recent developments in understanding the phenomenology of memory in PTSD, describe the most prominent theoretical models, and outline new forms of treatment aimed at modifying the traumatic memory. RECENT FINDINGS:Intrusive memories that have the quality of being relived in the present ha...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0950-7
更新日期：2018-08-28 00:00:00
abstract：:The existence of a group of psychoses that are symptomatologically and prognostically different from schizophrenia and affective psychotic disorders is supported by clinical and epidemiologic evidence. Although such "atypical" psychoses account for up to 10% of all psychotic disorders, their aetiology, pathophysiology...
journal_title：Current psychiatry reports
pub_type： 历史文章,杂志文章
doi：10.1007/s11920-001-0029-7
更新日期：2001-08-01 00:00:00
