Abstract：
:Relapse is a highly prevalent phenomenon in addiction. This paper examines the new research on identifying biological factors that contribute to addiction relapse risk. Prospective studies examining relapse risk are reviewed, and clinical, biological, and neural factors that predict relapse risk are identified. Clinical factors, patient-related factors, and subjective and behavioral measures such as depressive symptoms, stress, and drug craving all predict future relapse risk. Among biological measures, endocrine measures such as cortisol and cortisol/corticotropin (ACTH) ratio as a measure of adrenal sensitivity and serum brain-derived neurotrophic factor were also predictive of future relapse risk. Among neural measures, brain atrophy in the medial frontal regions and hyperreactivity of the anterior cingulate during withdrawal were identified as important in drug withdrawal and relapse risk. Caveats pertaining to specific drug abuse type and phase of addiction are discussed. Finally, significant implications of these findings for clinical practice are presented, with a specific focus on determining biological markers of relapse risk that may be used to identify those individuals who are most at risk of relapse in the clinic. Such markers may then be used to assess treatment response and develop specific treatments that will normalize these neural and biological sequelae so as to significantly improve relapse outcomes.
journal_name
Curr Psychiatry Repjournal_title
Current psychiatry reportsauthors
Sinha Rdoi
10.1007/s11920-011-0224-0subject
Has Abstractpub_date
2011-10-01 00:00:00pages
398-405issue
5eissn
1523-3812issn
1535-1645journal_volume
13pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:Artificial intelligence (AI) technology holds both great promise to transform mental healthcare and potential pitfalls. This article provides an overview of AI and current applications in healthcare, a review of recent original research on AI specific to mental health, and a discussion of how AI can s...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1094-0
更新日期：2019-11-07 00:00:00
abstract：PURPOSE OF REVIEW:We discuss recent evidence around the identification and response to domestic and sexual violence in primary care for perpetrators and victims, in the context of feminist social media movements such as #MeToo. RECENT FINDINGS:There is no recent research on identification and response to perpetrators ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-0991-6
更新日期：2019-02-08 00:00:00
abstract：:The term paraphrenia refers to a condition characterized by a strong delusional component with preservation of thought and personality. Most affected patients are women. Although a late age at onset (> 60 years) has been proposed in the literature, evidence for this assertion remains debatable. Deterioration of cognit...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0108-8
更新日期：2010-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this review is to provide a theoretical explanation and a review of the recent literature concerning the role of neuroactive steroids in perinatal depression, and to use this information to suggest future directions of research. RECENT FINDINGS:The bulk of the evidence on neuroactive s...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0937-4
更新日期：2018-08-09 00:00:00
abstract：PURPOSE OF REVIEW:We review recent and growing evidence that provides support for a novel parasomnia, trauma associated sleep disorder (TASD). Based on these findings, we further develop the clinical and polysomnographic (PSG) characteristics of TASD. We also address factors that precipitate TASD, develop a differentia...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1066-4
更新日期：2019-08-13 00:00:00
abstract：:The stress vulnerability model has proven to be a politically important model for two reasons. It has provided the framework that defines a temporal and dynamic process whereby a person's uniquely determined biopsychosocial vulnerability to schizophrenia symptoms interacts with his or her capacity to manage stress and...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0260-4
更新日期：2012-06-01 00:00:00
abstract：PURPOSE OF REVIEW:This review provides an overview of the state of research on alliance ruptures and resolutions in the treatment of personality disorders (PDs). We discuss frequently used instruments to measure alliance ruptures and resolutions. We discuss the effectiveness of rupture resolution processes and highligh...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-020-01212-w
更新日期：2020-12-11 00:00:00
abstract：PURPOSE OF REVIEW:We review recent empirical investigations about two core processes subtending impairments in interpersonal functioning and, more precisely, cooperative behaviors in personality disorders: Trust toward others and rejection sensitivity. The main contributions are about borderline and narcissistic person...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1059-3
更新日期：2019-07-01 00:00:00
abstract：PURPOSE OF REVIEW:To review the current literature on biobehavioral mechanisms involved in reactive aggression in a transdiagnostic approach. RECENT FINDINGS:Aggressive reactions are closely related to activations in the brain's threat circuitry. They occur in response to social threat that is experienced as inescapab...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-020-01208-6
更新日期：2020-11-12 00:00:00
abstract：:Manic symptoms frequently occur in patients with comorbid medical disorders and present a diagnostic and treatment challenge. Manic symptoms may be due to an independent psychiatric illness, may be induced or precipitated by a medical condition, or may result from medication or substance use. The presence of manic sym...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-007-0024-8
更新日期：2007-06-01 00:00:00
abstract：:Psychotic symptoms are common in both the manic and depressive phases of bipolar disorder. More than half of patients with bipolar disorder will experience psychotic symptoms in their lifetime. Grandiose delusions are the most common type of psychotic symptom, but any kind of psychotic symptom, including thought disor...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0069-4
更新日期：2000-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Anxiety disorders are the most prevalent mental disorders. Although prevalence estimates are lower in males than females, the disability associated with anxiety disorders has been increasing in males. This review focuses on recent research studying sex differences in anxiety disorders and associated s...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-020-01203-x
更新日期：2020-10-30 00:00:00
abstract：:The existence of a group of psychoses that are symptomatologically and prognostically different from schizophrenia and affective psychotic disorders is supported by clinical and epidemiologic evidence. Although such "atypical" psychoses account for up to 10% of all psychotic disorders, their aetiology, pathophysiology...
journal_title：Current psychiatry reports
pub_type： 历史文章,杂志文章
doi：10.1007/s11920-001-0029-7
更新日期：2001-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Marijuana use presents a unique challenge to bariatric surgery programs. We review the recent evidence examining marijuana use on outcomes following bariatric surgery. RECENT FINDINGS:Recent studies have not demonstrated an increased risk of short-term surgical complications or differences in up to 2...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-020-01218-4
更新日期：2021-01-12 00:00:00
abstract：:Clinical neuropsychiatry has traditionally relied on individual practitioner experience or the apprentice-training model for formulating cases and choosing treatment. Scientifically-based diagnostic criteria and treatment algorithms have been lacking in the overlap area between psychiatry and neurology, owing largely ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-996-0026-y
更新日期：2001-10-01 00:00:00
abstract：:The perinatal period introduces a myriad of changes. One important but often overlooked change is an increased reporting of sleep disturbance. Although casually regarded as a consequence of pregnancy or postpartum, there is emerging evidence implicating significant sleep disturbance, characterized by insomnia symptoms...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-016-0705-2
更新日期：2016-07-01 00:00:00
abstract：PURPOSE OF REVIEW:We review recent research addressing neurocognitive and information processing abnormalities in posttraumatic stress disorder (PTSD), including studies informing direction of causality. We additionally consider neurocognition in the context of co-morbid mild traumatic brain injury (TBI) and psychosoci...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0964-1
更新日期：2018-09-17 00:00:00
abstract：PURPOSE OF REVIEW:We review the existing literature on gene-environment interactions (G×E) and epigenetic changes primarily in borderline personality disorder (BPD) but also in antisocial, schizotypal, and avoidant personality disorders. RECENT FINDINGS:Research supports that susceptibility genes to BPD or its underly...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0934-7
更新日期：2018-08-09 00:00:00
abstract：:The present review examines the moderating role of ideology on the effects of war, armed conflict, and terrorism on youth. Ideology is an important factor given the central role played by religio-political ideology and nationalism in present-day conflicts. Ideologies or worldviews represent cognitive frameworks that i...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-016-0684-3
更新日期：2016-05-01 00:00:00
abstract：:Children's and adolescent's use of computer games and videogames is becoming highly popular and has increased dramatically over the last decade. There is growing evidence of high prevalence of addiction to computer games and videogames among children, which is causing concern because of its harmful consequences. There...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0311-x
更新日期：2012-10-01 00:00:00
abstract：:Bipolar depression is considered the most difficult-to-treat phase of bipolar disorder, in relation to its pervasiveness and efficacy and/or tolerability limitations of available treatments. Indeed, most mood stabilizers and atypical antipsychotics are not as effective in ameliorating depressive compared with manic sy...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0378-z
更新日期：2013-08-01 00:00:00
abstract：:Research consistently indicates that in animals and adults, reduced central serotonergic (5-HT) function is associated with increased aggression. This relationship has been elucidated via cerebrospinal fluid monoamine metabolite levels, hormonal responses to pharmacologic challenge using serotonergic probes, platelet ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0052-0
更新日期：2000-04-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of the present review was threefold: to address the current state of Animal-Assisted Interactions (AAI) within the military; to summarize recent literature (within the past three years) in the field of AAI; and to discuss trends in AAI research since 2014. RECENT FINDINGS:With regard to A...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0861-z
更新日期：2017-11-25 00:00:00
abstract：PURPOSE OF REVIEW:Circadian rhythms are a topic of growing interest in mental health, particularly in obsessive-compulsive disorder. However, the consistency of this link has not been carefully examined. Thus, the present review integrates findings from the past 5 years in order to determine the strength of such a rela...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1033-0
更新日期：2019-06-04 00:00:00
abstract：:By design or by default, primary care providers (PCPs)are frequently the vanguard in the fight against suicide. Recent studies have highlighted programs to improve screening and prevention of suicidality in the medical home, particularly among high-risk patients, such as adolescents, the elderly, and veterans. Increas...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0286-7
更新日期：2012-08-01 00:00:00
abstract：:Poststroke depression (PSD) is a form of geriatric depression that is associated with various negative outcomes. This article reviews existing research concerning the etiology, treatment, and prevention of PSD with particular emphasis on the development of a biopsychosocial conceptualization of PSD etiology and treatm...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-006-0078-z
更新日期：2006-02-01 00:00:00
abstract：:Insomnia is related to an increased risk of eating disorders, while eating disorders are related to more disrupted sleep. Insomnia is also linked to poorer treatment outcomes for eating disorders. However, over the last decade, studies examining sleep and eating disorders have relied on surveys, with no objective meas...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-016-0728-8
更新日期：2016-10-01 00:00:00
abstract：:Recently, the DSM-5 Personality Disorders Workgroup offered its proposed revision for borderline personality disorder (BPD) and other personality disorder types ( http://www.dsm5.org ). According to the workgroup, this revision reflects an attempt to address excessive comorbidity among personality disorders, place per...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0170-2
更新日期：2011-02-01 00:00:00
abstract：:Descriptions of mental illness exist throughout recorded history. However, until the mid-twentieth century, there was no standard nosology or diagnostic standard for mental disorders. This limited understanding of these disorders and development of better treatments. As conditions such as dementia praecox and schizoph...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0409-9
更新日期：2013-11-01 00:00:00
abstract：:HIV, the cause of AIDS, has infected more than 65 million people worldwide, including 1 million children. An estimated 39.5 million people are living with HIV. As of 2006, 4.3 million were newly infected, with 2.8 million occurring in sub-Saharan Africa. Rates of infection have risen more than 50% in Eastern Europe an...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-008-0020-7
更新日期：2008-04-01 00:00:00
