Abstract：
:Since its earliest descriptions, schizophrenia has been thought to be clinically heterogeneous. Symptomatic features and subtypes tend to aggregate in families, suggesting that genetic factors contribute to individual differences in illness presentation. Over the past 5 years, evidence from genetic linkage and association studies has mounted to suggest that some susceptibility genes are etiologic factors for more or less specific illness subtypes. Furthermore, modifier genes may affect clinical features dimensionally only after a given patient is already affected with the illness. In this paper, we review recent findings supporting the existence of such "modifier" genes. To date, DTNBP1 has provided the greatest evidence of illness modification, as associations with negative and cognitive symptoms and worse outcome have been published in independent samples. Future directions include using whole-genome association studies to search for genetic modifiers of schizophrenia.
journal_name
Curr Psychiatry Repjournal_title
Current psychiatry reportsauthors
Fanous AH,Kendler KSdoi
10.1007/s11920-008-0028-zsubject
Has Abstractpub_date
2008-04-01 00:00:00pages
164-70issue
2eissn
1523-3812issn
1535-1645journal_volume
10pub_type
杂志文章,评审abstract：:There is consistent evidence that major depression is familial and population-based twin studies as well as hospital register-based twin studies find substantial heritability. However, there is also a large proportion of variation in liability left to be explained by nongenetic factors. Although there seems little dou...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0062-y
更新日期：2000-04-01 00:00:00
abstract：:Major depressive disorder (MDD) is a common psychiatric illness with high levels of morbidity and mortality. Despite intensive research during the past several decades, the neurobiological basis and pathophysiology of depressive disorders remain unknown. Genetic factors play important roles in the development of MDD, ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0150-6
更新日期：2010-12-01 00:00:00
abstract：:Rigorous research has recently identified a range of behavioral therapies that have been shown to be effective across the most prevalent types of substance dependence. This review summarizes the roles of behavioral therapies as contrasted with those of pharmacotherapies for substance use disorders and then provides an...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-005-0032-5
更新日期：2005-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Telemental health, which is treatment mediated by technology, is an increasingly common method of delivering mental health care. However, its impact on the therapeutic alliance is unclear. This review examines studies of telemental health and its impact on therapeutic alliance. RECENT FINDINGS:Findin...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1055-7
更新日期：2019-07-08 00:00:00
abstract：:Knowledge of gonadal hormone-related influences on human brain anatomy, function, and chemistry is scarce. The present review scrutinized organizational and functional neuroimaging correlates of the menstrual cycle and premenstrual dysphoric disorder (PMDD). Supportive evidence of cyclic short-term structural and func...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-015-0619-4
更新日期：2015-10-01 00:00:00
abstract：:Effective treatments for co-occurring schizophrenia and substance abuse have emerged over the past 15 years. They involve integration and melding of mental health and substance abuse treatments, helping people to acquire the skills and supports they need to manage both illnesses and to pursue functional goals, and a c...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-996-0037-8
更新日期：2001-10-01 00:00:00
abstract：:Manic symptoms frequently occur in patients with comorbid medical disorders and present a diagnostic and treatment challenge. Manic symptoms may be due to an independent psychiatric illness, may be induced or precipitated by a medical condition, or may result from medication or substance use. The presence of manic sym...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-007-0024-8
更新日期：2007-06-01 00:00:00
abstract：:There is a dearth of knowledge regarding the diagnosis and treatment of bipolar disorder in late life. Based on a review of the current research on bipolar disorder in late life, emerging areas of research were identified: 1) methodological challenges in diagnosing bipolar disorder; 2) a lack of guidelines for the tre...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-005-0018-3
更新日期：2005-03-01 00:00:00
abstract：:Viral encephalitis, a condition in which a virus infects the brain and produces an inflammatory response, affects approximately 20,000 individuals per year in the United States. The viral encephalidities include sporadic and epidemic acute viral encephalidities and subacute and chronic/progressive viral encephalitis o...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0024-x
更新日期：2004-10-01 00:00:00
abstract：:The Surgeon General's National Action Agenda highlighted key issues that challenge the public health system in appropriately meeting the mental health needs of children and their families. Among these issues included the need for screening and early identification, improving access to appropriate mental health care, s...
journal_title：Current psychiatry reports
pub_type： 杂志文章
doi：10.1007/s11920-002-0042-5
更新日期：2002-04-01 00:00:00
abstract：:The term paraphrenia refers to a condition characterized by a strong delusional component with preservation of thought and personality. Most affected patients are women. Although a late age at onset (> 60 years) has been proposed in the literature, evidence for this assertion remains debatable. Deterioration of cognit...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0108-8
更新日期：2010-06-01 00:00:00
abstract：:Musical hallucinations have been described in numerous neurologic and psychiatric patients, but their pathophysiologic background is not understood. Analyzing the published cases, five subgroups can be separated according to their etiology: hypacusis, psychiatric disorders, focal brain lesions, epilepsy, and intoxicat...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-006-0024-0
更新日期：2006-06-01 00:00:00
abstract：PURPOSE OF REVIEW:We review recent and growing evidence that provides support for a novel parasomnia, trauma associated sleep disorder (TASD). Based on these findings, we further develop the clinical and polysomnographic (PSG) characteristics of TASD. We also address factors that precipitate TASD, develop a differentia...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1066-4
更新日期：2019-08-13 00:00:00
abstract：:The purposes of this paper are to provide an overview of the state of the science of sleep in children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of insomnia in children with ASD, and present a practice pathway for promoting optimal sleep. Approximately two thirds of children with ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0782-x
更新日期：2017-06-01 00:00:00
abstract：:Bipolar disorder is marked by frequent recurrences, a course from childhood or early adulthood until death, marked increased rates of suicide, and substantial functional morbidity. Maintenance treatment is generally recommended to reduce the ravages of the illness. This article reviews the evidence that lithium, dival...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0007-5
更新日期：2000-12-01 00:00:00
abstract：:There is consistent evidence that the principal etiology of schizophrenia involves predisposing genetic factors. Recent years have seen several new insights in the genetics of schizophrenia. Several chromosomal regions show significant evidence that they contain schizophrenia susceptibility genes. A clinically relevan...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-996-0051-x
更新日期：2002-08-01 00:00:00
abstract：:Anorexia nervosa is a debilitating illness that affects mostly females and their families. Multiple physiologic disturbances are present and can be life-threatening. Nutritional rehabilitation is the foremost initial treatment goal. Assessment skills include understanding the physiologic, developmental, and psychiatri...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0174-y
更新日期：2011-04-01 00:00:00
abstract：PURPOSE OF REVIEW:As rates of suicide continue to rise, there is urgent need for innovative approaches to better understand, predict, and care for those at high risk of suicide. Numerous mobile and sensor technology solutions have already been proposed, are in development, or are already available today. This review se...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0914-y
更新日期：2018-06-28 00:00:00
abstract：:The concepts of healthcare reform and population health are shifting the emphasis from traditional, volume-based care to a model in which value, or quality, predominates. High quality care will be increasingly rewarded, with financial consequences for poor performance. This shift will be accelerated by the use of heal...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0369-0
更新日期：2013-07-01 00:00:00
abstract：:Delirium is an under-recognized, highly prevalent form of organ dysfunction in the intensive care unit (ICU). It is imperative to be aware of risk factors for delirium in the ICU, some of which are modifiable. In the last 5 years, a new tool for detecting delirium among critically ill patients has been validated and f...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-007-0006-x
更新日期：2007-02-01 00:00:00
abstract：:Anxiety symptoms and disorders have long been described in schizophrenia. This article reviews the epidemiology, phenomenology, and neurobiologic underpinnings of comorbid anxiety symptoms and disorders in schizophrenia. Recent literature was obtained by Medline searches using key words relating to schizophrenia and a...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0074-0
更新日期：2004-08-01 00:00:00
abstract：:Bipolar depression is considered the most difficult-to-treat phase of bipolar disorder, in relation to its pervasiveness and efficacy and/or tolerability limitations of available treatments. Indeed, most mood stabilizers and atypical antipsychotics are not as effective in ameliorating depressive compared with manic sy...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0378-z
更新日期：2013-08-01 00:00:00
abstract：:Attention-deficit hyperactivity disorder (ADHD) and substance use disorders (SUDs) may have common etiologies. ADHD is more prevalent in patients with substance use disorders, and this pattern is consistent across different substances of abuse. Individuals with SUDs and ADHD exhibit significant variations in their cli...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0769-7
更新日期：2017-03-01 00:00:00
abstract：:The present review examines the moderating role of ideology on the effects of war, armed conflict, and terrorism on youth. Ideology is an important factor given the central role played by religio-political ideology and nationalism in present-day conflicts. Ideologies or worldviews represent cognitive frameworks that i...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-016-0684-3
更新日期：2016-05-01 00:00:00
abstract：:Few treatments for eating disorders have established a base of empirical support, and those that have are still limited by high dropout rates and low abstinence rates. Thus, there is a critical need for innovative eating disorder treatments to fill this gap. The past decade has seen a surge in the development of novel...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0407-y
更新日期：2013-11-01 00:00:00
abstract：:Post-traumatic stress disorder (PTSD) is a disruptive, chronic, and relatively common disorder that is often difficult to treat. Many patients with PTSD are unresponsive, have only moderate or marginal responses, or have troubling side effects to first-line serotonin reuptake inhibitor treatment. Studies suggest that ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-007-0035-5
更新日期：2007-08-01 00:00:00
abstract：:An "Alternative DSM-5 Model for Personality Disorders" was published in Sect. III of DSM-5, while the identical categories and criteria from DSM-IV for the personality disorders (PDs) are in Sect. II. Given strong shifts from categorical diagnoses toward dimensional representations in psychiatry, how did the PDs end u...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-014-0480-x
更新日期：2014-10-01 00:00:00
abstract：:The cognitive model of OCD suggests that misinterpreting intrusive thoughts as unacceptable leads to increased anxiety and attempts to suppress or ignore the thoughts through avoidance or compulsive rituals. An insidious negative feedback loop develops as one's attention focuses on these thoughts and in turn the unwan...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-013-0357-4
更新日期：2013-05-01 00:00:00
abstract：:Research consistently indicates that in animals and adults, reduced central serotonergic (5-HT) function is associated with increased aggression. This relationship has been elucidated via cerebrospinal fluid monoamine metabolite levels, hormonal responses to pharmacologic challenge using serotonergic probes, platelet ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0052-0
更新日期：2000-04-01 00:00:00
abstract：:Animal models may be useful in investigating the fundamental mechanisms underlying psychiatric disorders, and may contribute to the development of new medications. A computerized literature search was used to collect studies on recently developed animal models for anxiety disorders. Particular cognitive-affective proc...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-003-0056-7
更新日期：2003-08-01 00:00:00
