Neuroimaging the Menstrual Cycle and Premenstrual Dysphoric Disorder.

Abstract:

:Knowledge of gonadal hormone-related influences on human brain anatomy, function, and chemistry is scarce. The present review scrutinized organizational and functional neuroimaging correlates of the menstrual cycle and premenstrual dysphoric disorder (PMDD). Supportive evidence of cyclic short-term structural and functional brain plasticity in response to gonadal hormonal modulation is provided. The paucity of studies, sparsity and discordance of findings, and weaknesses in study design at present hinder the drawing of firm conclusions. Ideal study designs should comprise high-resolution multimodal neuroimaging (e.g., MRI, DTI, rs-fMRI, fMRI, PET), hormones, genetic, and behavioral longitudinal assessments of healthy women and PMDD patients at critical time points of the menstrual cycle phase (i.e., early follicular phase, late follicular phase, mid-luteal phase) in a counter-balanced setup. Studies integrating large-scale brain network structural, functional, and molecular neuroimaging, as well as treatment data, will deepen the understanding of neural state, disorder, and treatment markers.

journal_name

Curr Psychiatry Rep

authors

Comasco E,Sundström-Poromaa I

doi

10.1007/s11920-015-0619-4

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

77

issue

10

eissn

1523-3812

issn

1535-1645

journal_volume

17

pub_type

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