Abstract：
:Bipolar depression is considered the most difficult-to-treat phase of bipolar disorder, in relation to its pervasiveness and efficacy and/or tolerability limitations of available treatments. Indeed, most mood stabilizers and atypical antipsychotics are not as effective in ameliorating depressive compared with manic symptoms, and entail substantial tolerability limitations. However, the use of antidepressants is highly controversial, as their efficacy appears less robust in bipolar compared with unipolar depression. In addition, antidepressants, in spite of generally having adequate somatic tolerability, in BD may be associated with a higher risk of manic/hypomanic switch, suicidality and rapid cycling. Among alternative pharmacological strategies, compounds with stimulant and pro-dopaminergic effects, such as methylphenidate, modafinil, armodafinil and pramipexole, have showed potential antidepressant activity, even though their use in clinical practice has been limited by the paucity of controlled evidence. This article seeks to review available evidence about the use of the aforementioned compounds in the treatment of bipolar depression. Findings from reviewed studies suggested that pro-dopaminergic compounds, such as pramipexole and stimulants/stimulant-like agents, deserve consideration as adjunctive therapies in bipolar depressed patients, at least in some subgroups of patients. Nevertheless, caution regarding their use is recommended as further clinical trials with larger samples and longer follow-up periods are necessary to clarify the roles of these medications in bipolar depression.
journal_name
Curr Psychiatry Repjournal_title
Current psychiatry reportsauthors
Dell'Osso B,Ketter TA,Cremaschi L,Spagnolin G,Altamura ACdoi
10.1007/s11920-013-0378-zsubject
Has Abstractpub_date
2013-08-01 00:00:00pages
378issue
8eissn
1523-3812issn
1535-1645journal_volume
15pub_type
杂志文章,评审abstract：:The comorbidity of anxiety disorders with pain has received little research attention even though recent studies show that these disorders are as likely to co-occur with chronic pain conditions as depressive disorder. Comorbid anxiety has implications for the impact and outcome of pain conditions. Even though it may b...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-008-0051-0
更新日期：2008-08-01 00:00:00
abstract：:Stratification by age at onset has been useful for genetic studies across all of medicine. For the past 20 years, the National Institute of Mental Health has been systematically recruiting patients with onset of schizophrenia before age 13 years. Examination of familial transmission of known candidate risk genes was c...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-009-0024-y
更新日期：2009-04-01 00:00:00
abstract：:Acute mania is frequently a medical emergency requiring hospitalization for behavioral control, rapid resolution of irritability, agitation, de-escalation of mood, and decreasing of risk-taking behavior. Lithium efficacy in the management of acute mania was reported in 1949 and approved by the US Food and Drug Adminis...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-006-0058-3
更新日期：2006-12-01 00:00:00
abstract：PURPOSE OF REVIEW:To provide an overview of the selection process and annual updates of the child mental health measures within the Child Core Set, describe national and statewide adherence rates, and summarize findings from a systematic literature review examining measure adherence rates and whether adherence is assoc...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-0986-3
更新日期：2019-01-31 00:00:00
abstract：:Anorexia nervosa is a debilitating illness that affects mostly females and their families. Multiple physiologic disturbances are present and can be life-threatening. Nutritional rehabilitation is the foremost initial treatment goal. Assessment skills include understanding the physiologic, developmental, and psychiatri...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0174-y
更新日期：2011-04-01 00:00:00
abstract：:Child maltreatment is a serious problem in US society, affecting approximately three million children. Children and adolescents exposed to child abuse and neglect experience high rates of post-traumatic stress disorder (PTSD). In addition, they are at risk for comorbid mental illness. Biologic stress systems affected ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-003-0027-z
更新日期：2003-06-01 00:00:00
abstract：:Anxiety symptoms and disorders have long been described in schizophrenia. This article reviews the epidemiology, phenomenology, and neurobiologic underpinnings of comorbid anxiety symptoms and disorders in schizophrenia. Recent literature was obtained by Medline searches using key words relating to schizophrenia and a...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0074-0
更新日期：2004-08-01 00:00:00
abstract：:Attention-deficit hyperactivity disorder (ADHD) and substance use disorders (SUDs) may have common etiologies. ADHD is more prevalent in patients with substance use disorders, and this pattern is consistent across different substances of abuse. Individuals with SUDs and ADHD exhibit significant variations in their cli...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0769-7
更新日期：2017-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Neuroactive steroid hormones, such as estradiol and progesterone, likely play a role in the pathophysiology of female-specific psychiatric disorders such as premenstrual dysphoric disorder (PMDD) and postpartum depression and may contribute to the marked sex differences observed in the incidence and p...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0906-y
更新日期：2018-05-18 00:00:00
abstract：:Manic symptoms frequently occur in patients with comorbid medical disorders and present a diagnostic and treatment challenge. Manic symptoms may be due to an independent psychiatric illness, may be induced or precipitated by a medical condition, or may result from medication or substance use. The presence of manic sym...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-007-0024-8
更新日期：2007-06-01 00:00:00
abstract：:Researchers have estimated the cost of treating substance abuse and its effects on medical care and social service expenses, but have rarely used the methods developed to evaluate medical care interventions. When outcomes are expressed as quality-adjusted life years, substance abuse treatment may be compared with othe...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-999-0027-8
更新日期：1999-12-01 00:00:00
abstract：:Insomnia is one of the most common complaints of US armed service members. Diagnosis and treatment of insomnia in active duty and veteran populations are often complicated by comorbid disorders experienced by military personnel, such as post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). Cognitive ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-015-0622-9
更新日期：2015-10-01 00:00:00
abstract：PURPOSE OF REVIEW:We discuss recent evidence around the identification and response to domestic and sexual violence in primary care for perpetrators and victims, in the context of feminist social media movements such as #MeToo. RECENT FINDINGS:There is no recent research on identification and response to perpetrators ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-0991-6
更新日期：2019-02-08 00:00:00
abstract：:The central characteristics of borderline personality disorder (BPD) are bound to be associated with the development and maintenance of couple dysfunction. Although seven of the nine diagnostic criteria of BPD in the DSM-IV-TR refer directly to interpersonal functioning, very few empiric studies have addressed the exa...
journal_title：Current psychiatry reports
pub_type： 杂志文章
doi：10.1007/s11920-009-0009-x
更新日期：2009-02-01 00:00:00
abstract：:There has been a recent acceleration in the development and testing of programs for computer-assisted cognitive-behavioral therapy (CCBT). Programs are now available for treatment of depression, anxiety disorders, and other psychiatric conditions. Technology for delivery of CCBT includes multimedia programs, virtual r...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0152-4
更新日期：2010-12-01 00:00:00
abstract：:Psychotic symptoms are common in both the manic and depressive phases of bipolar disorder. More than half of patients with bipolar disorder will experience psychotic symptoms in their lifetime. Grandiose delusions are the most common type of psychotic symptom, but any kind of psychotic symptom, including thought disor...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0069-4
更新日期：2000-08-01 00:00:00
abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder characterized by inattention, impulsivity, and/or hyperactivity in children and adults. Putative environmental risk factors for ADHD include toxin and prenatal smoke exposure, low socioeconomic status, and parental marital instability and disc...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-009-0058-1
更新日期：2009-10-01 00:00:00
abstract：PURPOSE OF REVIEW:The objective of this review is to describe the extent to which (1) obstetric settings are currently screening for mental health and substance use disorders and social determinants of health (SDoH), and (2) screening is followed by systematic approaches for ensuring an adequate response to positive sc...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-020-01182-z
更新日期：2020-09-16 00:00:00
abstract：:Children's and adolescent's use of computer games and videogames is becoming highly popular and has increased dramatically over the last decade. There is growing evidence of high prevalence of addiction to computer games and videogames among children, which is causing concern because of its harmful consequences. There...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0311-x
更新日期：2012-10-01 00:00:00
abstract：:"Food addiction" is an emerging area, and behavioral and biological overlaps have been observed between eating and addictive disorders. Potential misconceptions about applying an addiction framework to problematic eating behavior may inhibit scientific progress. Critiques of "food addiction" that focus on descriptive ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-015-0563-3
更新日期：2015-04-01 00:00:00
abstract：PURPOSE OF REVIEW:This article aims to review select applications of Transcranial Magnetic Stimulation (TMS) that have significant relevance in geriatric psychiatry. RECENT FINDINGS:Small study sizes and parameter variability limit the generalizability of many TMS studies in geriatric patients. Additionally, geriatric...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0866-2
更新日期：2018-02-10 00:00:00
abstract：:Human neurodevelopment is the result of genetic and environmental interactions. This paper examines the role of prenatal nutrition relative to psychiatric disorders and explores the relationship among nutrients, mood changes, and mood disorders. Epidemiologic studies have found that adults who were born with a normal,...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0006-z
更新日期：2004-12-01 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of this study was to review the literature on perinatal intimate partner violence, focusing on recent knowledge to guide mental health professionals on the best approaches to identify and treat women exposed to perinatal intimate partner violence. RECENT FINDINGS:Risk factors have been br...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0778-6
更新日期：2017-05-01 00:00:00
abstract：PURPOSE OF REVIEW:As rates of suicide continue to rise, there is urgent need for innovative approaches to better understand, predict, and care for those at high risk of suicide. Numerous mobile and sensor technology solutions have already been proposed, are in development, or are already available today. This review se...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0914-y
更新日期：2018-06-28 00:00:00
abstract：:The present review examines the moderating role of ideology on the effects of war, armed conflict, and terrorism on youth. Ideology is an important factor given the central role played by religio-political ideology and nationalism in present-day conflicts. Ideologies or worldviews represent cognitive frameworks that i...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-016-0684-3
更新日期：2016-05-01 00:00:00
abstract：:The conflict between French nosology and international classifications is mainly linked to the French concepts of chronic hallucinatory psychosis and bouffée délirante. However, these discrepancies are now largely reduced by the evolution of the recent versions of international classifications. The term chronic halluc...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-003-0040-2
更新日期：2003-07-01 00:00:00
abstract：PURPOSE OF REVIEW:To highlight an emerging understanding of burnout and physician mental health. This review will provide a discussion of conceptual and diagnostic issues of the burnout syndrome with its relevance to psychiatry, and how psychiatry may interface with other medical disciplines to provide support in creat...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1100-6
更新日期：2019-10-15 00:00:00
abstract：PURPOSE OF REVIEW:This review provides an overview of the state of research on alliance ruptures and resolutions in the treatment of personality disorders (PDs). We discuss frequently used instruments to measure alliance ruptures and resolutions. We discuss the effectiveness of rupture resolution processes and highligh...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-020-01212-w
更新日期：2020-12-11 00:00:00
abstract：PURPOSE OF REVIEW:Phenibut (β-phenyl-γ-aminobutyric acid) is a psychoactive GABA analogue currently being marketed online as an anxiolytic and nootropic dietary supplement. Its use is growing in popularity, but its pharmacological activity is well beyond that of a conventional nutritional supplement, and similar to tha...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1009-0
更新日期：2019-03-09 00:00:00
abstract：PURPOSE OF REVIEW:This review delineates issues in the conceptualization and operationalization of eating disorder recovery, highlights recent findings about recovery (since 2016), and proposes future directions. RECENT FINDINGS:A longstanding problem in the field is that there are almost as many different definitions...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-018-0932-9
更新日期：2018-08-09 00:00:00
