New findings from the Bipolar Collaborative Network: clinical implications for therapeutics.

Abstract:

:In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.

journal_name

Curr Psychiatry Rep

authors

Post RM,Altshuler LL,Frye MA,Suppes T,McElroy S,Keck PE Jr,Leverich GS,Kupka R,Nolen WA,Grunze H

doi

10.1007/s11920-006-0056-5

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

489-97

issue

6

eissn

1523-3812

issn

1535-1645

journal_volume

8

pub_type

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