Abstract：
:Substance use disorder is a chronic condition of compulsive drug seeking and use that is mediated by stable changes in central reward pathways. Repeated use of abused drugs causes persistent alterations in gene expression responsible for the long-term behavioral and structural changes. Recently, it has been suggested that epigenetic mechanisms are responsible in part for these drug-induced changes in gene expression. One of the alluring aspects of epigenetic regulation of gene expression is that epigenetic mechanisms may provide transient and potentially stable conditions that in turn may ultimately participate in the molecular mechanisms required for neuronal changes subserving long-lasting changes in behavior. This review describes epigenetic mechanisms of gene regulation and then discusses the emerging role of epigenetics in drug-induced plasticity and behavior. Understanding these mechanisms that establish and maintain drug-dependent plasticity changes may lead to deeper understanding of substance use disorders as well as novel approaches to treatment.
journal_name
Curr Psychiatry Repjournal_title
Current psychiatry reportsauthors
McQuown SC,Wood MAdoi
10.1007/s11920-010-0099-5subject
Has Abstractpub_date
2010-04-01 00:00:00pages
145-53issue
2eissn
1523-3812issn
1535-1645journal_volume
12pub_type
杂志文章,评审abstract：:By design or by default, primary care providers (PCPs)are frequently the vanguard in the fight against suicide. Recent studies have highlighted programs to improve screening and prevention of suicidality in the medical home, particularly among high-risk patients, such as adolescents, the elderly, and veterans. Increas...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0286-7
更新日期：2012-08-01 00:00:00
abstract：:HIV, the cause of AIDS, has infected more than 65 million people worldwide, including 1 million children. An estimated 39.5 million people are living with HIV. As of 2006, 4.3 million were newly infected, with 2.8 million occurring in sub-Saharan Africa. Rates of infection have risen more than 50% in Eastern Europe an...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-008-0020-7
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-016-0710-5
更新日期：2016-08-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-996-0026-y
更新日期：2001-10-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-014-0544-y
更新日期：2015-02-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-007-0024-8
更新日期：2007-06-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0069-4
更新日期：2000-08-01 00:00:00
abstract：PURPOSE OF REVIEW:We discuss recent evidence around the identification and response to domestic and sexual violence in primary care for perpetrators and victims, in the context of feminist social media movements such as #MeToo. RECENT FINDINGS:There is no recent research on identification and response to perpetrators ...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-0991-6
更新日期：2019-02-08 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1100-6
更新日期：2019-10-15 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-006-0062-7
更新日期：2006-08-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1009-0
更新日期：2019-03-09 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-010-0108-8
更新日期：2010-06-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-000-0007-5
更新日期：2000-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Sex differences in cognitive function are well documented yet few studies had adequate numbers of women and men living with HIV (WLWH; MLWH) to identify sex differences in neurocognitive impairment (NCI) and the factors contributing to NCI. Here, we review evidence that WLWH may be at greater risk for...
journal_title：Current psychiatry reports
pub_type： 杂志文章
doi：10.1007/s11920-019-1089-x
更新日期：2019-09-14 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0782-x
更新日期：2017-06-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-008-0076-4
更新日期：2008-12-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-004-0033-9
更新日期：2004-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Sex differences in the epidemiology and clinical presentation of trauma-related psychopathology have long been documented. Multiple underlying mechanisms have been examined, both psychosocial and biological. Among the most promising biological mechanisms are neural substrates of trauma-related psychop...
journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-017-0854-y
更新日期：2017-11-08 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-015-0563-3
更新日期：2015-04-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
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更新日期：2003-10-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
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更新日期：2019-08-13 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1086-0
更新日期：2019-09-14 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-011-0231-1
更新日期：2011-12-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-012-0260-4
更新日期：2012-06-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章
doi：10.1007/s11920-009-0009-x
更新日期：2009-02-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-008-0051-0
更新日期：2008-08-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章
doi：10.1007/s11920-011-0210-6
更新日期：2011-10-01 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
doi：10.1007/s11920-019-1019-y
更新日期：2019-03-22 00:00:00
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journal_title：Current psychiatry reports
pub_type： 杂志文章,评审
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更新日期：2002-10-01 00:00:00
