Inflammatory biomarkers in depression: an opportunity for novel therapeutic interventions.

Abstract:

:Currently available antidepressants are effective in less than two thirds of depressed patients, with even lower remission rates in the context of co-morbid medical illness. A rapidly expanding evidence base suggests that maladaptive inflammatory immune responses may be a common pathophysiology underlying depression, particularly in the presence of a general medical condition. The inflammatory hypothesis of depression marks a significant shift away from monoamine-based approaches and is a major step towards developing novel treatments that directly target causal factors of depression. Many antidepressants exert anti-inflammatory effects and there is an emerging literature documenting the efficacy of anti-inflammatory agents as adjunctive treatments for depression. Identification of inflammatory biomarkers in depression will require a re-conceptualization of both the diagnostic phenomenology and the experimental approaches to studying multi-determined psychiatric disorders. In addition to their application in diagnosis, predicting prognosis, and monitoring severity and response to treatment, inflammatory biomarkers may serve as novel therapeutic targets in the treatment of depression.

journal_name

Curr Psychiatry Rep

authors

Li M,Soczynska JK,Kennedy SH

doi

10.1007/s11920-011-0210-6

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

316-20

issue

5

eissn

1523-3812

issn

1535-1645

journal_volume

13

pub_type

杂志文章
  • Genetic abnormalities of chromosome 22 and the development of psychosis.

    abstract::A microdeletion at chromosome 22q11 is the most frequently known interstitial deletion found in humans, occurring in approximately one of every 4000 live births. Its occurrence is associated with a characteristic facial dysmorphology, a range of congenital abnormalities, and psychiatric problems, especially schizophre...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-004-0062-4

    authors: Williams NM,Owen MJ

    更新日期:2004-06-01 00:00:00

  • Neuroimaging in pedophilia.

    abstract::Paraphilia is a set of disorders characterized by abnormal sexual desires. Perhaps most discussed amongst them, pedophilia is a complex interaction of disturbances of the emotional, cognitive and sexual experience. Using new imaging techniques such as functional magnetic resonance imaging, neural correlates of emotion...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-013-0351-x

    authors: Wiebking C,Northoff G

    更新日期:2013-04-01 00:00:00

  • Neuropsychiatric aspects of frontotemporal dementias.

    abstract::Frontotemporal dementia (FTD) is a clinically distinct disorder that is under-recognized. A primary focus of recent research has been to delineate neuropsychiatric features that best discriminate FTD from other dementias, and to identify test instruments that elicit differentiating characteristics most effectively. Ad...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-999-0015-z

    authors: Snowden JS,Neary D

    更新日期:1999-10-01 00:00:00

  • Bipolar disorder in late life: future directions in efficacy and effectiveness research.

    abstract::There is a dearth of knowledge regarding the diagnosis and treatment of bipolar disorder in late life. Based on a review of the current research on bipolar disorder in late life, emerging areas of research were identified: 1) methodological challenges in diagnosing bipolar disorder; 2) a lack of guidelines for the tre...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-005-0018-3

    authors: Kilbourne AM

    更新日期:2005-03-01 00:00:00

  • Pain and depression: an integrative review of neurobiological and psychological factors.

    abstract::The comorbidity of pain and depression has been well established in the literature and is associated with a greater burden to the individual and society than either condition alone. The relationship between pain and depression is quite complex and multiple factors must be considered when trying to disentangle the pain...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-013-0421-0

    authors: Goesling J,Clauw DJ,Hassett AL

    更新日期:2013-12-01 00:00:00

  • Schizophrenia and genetics: new insights.

    abstract::There is consistent evidence that the principal etiology of schizophrenia involves predisposing genetic factors. Recent years have seen several new insights in the genetics of schizophrenia. Several chromosomal regions show significant evidence that they contain schizophrenia susceptibility genes. A clinically relevan...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-996-0051-x

    authors: Bassett AS,Chow EW,Weksberg R,Brzustowicz L

    更新日期:2002-08-01 00:00:00

  • Epidemiological and Clinical Gender Differences in OCD.

    abstract:PURPOSE OF REVIEW:This review highlights recent research regarding gender differences in OCD, with a focus on prevalence, course of illness, symptom presentation, comorbidity, and treatment response. RECENT FINDINGS:Overall, findings remain mixed. OCD may be more common among males in childhood, but is more common amo...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-019-1015-2

    authors: Mathes BM,Morabito DM,Schmidt NB

    更新日期:2019-04-23 00:00:00

  • Sex Differences in Trauma-Related Psychopathology: a Critical Review of Neuroimaging Literature (2014-2017).

    abstract:PURPOSE OF REVIEW:Sex differences in the epidemiology and clinical presentation of trauma-related psychopathology have long been documented. Multiple underlying mechanisms have been examined, both psychosocial and biological. Among the most promising biological mechanisms are neural substrates of trauma-related psychop...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-017-0854-y

    authors: Helpman L,Zhu X,Suarez-Jimenez B,Lazarov A,Monk C,Neria Y

    更新日期:2017-11-08 00:00:00

  • Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: initial lessons from the treatment for adolescents with depression study.

    abstract::Adolescents with major depressive disorder (MDD), their families and clinicians experience significant challenges when weighing the potential risks versus benefits of available choices in the treatment of MDD. Although MDD is highly prevalent in adolescents and is associated with marked suffering, impairment and risk ...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-005-0063-y

    authors: Pathak S,Kratochvil CJ,Rogers GM,Silva S,Vitiello B,Weller EB,March JS

    更新日期:2005-12-01 00:00:00

  • Ecological Momentary Assessment and Mood Disorders in Children and Adolescents: a Systematic Review.

    abstract:PURPOSE OF REVIEW:The aim of the present review is to systematically examine published data regarding ecological momentary assessment (EMA) in children and adolescents with mood disorders. RECENT FINDINGS:EMA is increasingly used to collect participant's information in their real environment and in real time. There ar...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章

    doi:10.1007/s11920-018-0913-z

    authors: Baltasar-Tello I,Miguélez-Fernández C,Peñuelas-Calvo I,Carballo JJ

    更新日期:2018-08-01 00:00:00

  • Using interpersonal therapy (IPT) with older adults today and tomorrow: a review of the literature and new developments.

    abstract::Interpersonal psychotherapy (IPT) has been shown to be an efficacious evidence-based treatment for major depression in combination with antidepressant medication, as a maintenance treatment in combination with medication, and as monotherapy (with placebo). After reviewing the salient features of IPT that make it a goo...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-008-0005-6

    authors: Miller MD

    更新日期:2008-02-01 00:00:00

  • Ethical issues in schizophrenia research.

    abstract::Ethical issues in the field of schizophrenia research have become a focus of intense debate in the past year. The publication of the final report of the National Bioethics Advisory Commission (NBAC) coupled with recent media reports have catapulted these issues into international view. Major questions have been raised...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章

    doi:10.1007/s11920-999-0005-1

    authors: Zipursky RB

    更新日期:1999-10-01 00:00:00

  • Alliance Ruptures and Resolutions in Personality Disorders.

    abstract:PURPOSE OF REVIEW:This review provides an overview of the state of research on alliance ruptures and resolutions in the treatment of personality disorders (PDs). We discuss frequently used instruments to measure alliance ruptures and resolutions. We discuss the effectiveness of rupture resolution processes and highligh...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-020-01212-w

    authors: Schenk N,Fürer L,Zimmermann R,Steppan M,Schmeck K

    更新日期:2020-12-11 00:00:00

  • Altered brain reward circuits in eating disorders: chicken or egg?

    abstract::The eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) are severe psychiatric disorders with high mortality. Our knowledge about the neurobiology of eating disorders is very limited, and the question remains whether alterations in brain structure or function in eating disorders are state related, remnants...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-013-0396-x

    authors: Frank GK

    更新日期:2013-10-01 00:00:00

  • Coping and Social Support in Children Exposed to Mass Trauma.

    abstract::The goal of this paper was to critically evaluate the literature on children coping with mass trauma published between the years 2011 and 2014 and to emphasize interesting and important findings with the aim of proposing a new comprehensive model for better understanding the process of coping with these events in this...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-015-0576-y

    authors: Braun-Lewensohn O

    更新日期:2015-06-01 00:00:00

  • Nutrients, neurodevelopment, and mood.

    abstract::Human neurodevelopment is the result of genetic and environmental interactions. This paper examines the role of prenatal nutrition relative to psychiatric disorders and explores the relationship among nutrients, mood changes, and mood disorders. Epidemiologic studies have found that adults who were born with a normal,...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-004-0006-z

    authors: Casper RC

    更新日期:2004-12-01 00:00:00

  • Defining psychosis: the evolution of DSM-5 schizophrenia spectrum disorders.

    abstract::Descriptions of mental illness exist throughout recorded history. However, until the mid-twentieth century, there was no standard nosology or diagnostic standard for mental disorders. This limited understanding of these disorders and development of better treatments. As conditions such as dementia praecox and schizoph...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-013-0409-9

    authors: Bhati MT

    更新日期:2013-11-01 00:00:00

  • HIV in adolescents: what we know and what we need to know.

    abstract::HIV, the cause of AIDS, has infected more than 65 million people worldwide, including 1 million children. An estimated 39.5 million people are living with HIV. As of 2006, 4.3 million were newly infected, with 2.8 million occurring in sub-Saharan Africa. Rates of infection have risen more than 50% in Eastern Europe an...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-008-0020-7

    authors: Benton TD,Ifeagwu JA

    更新日期:2008-04-01 00:00:00

  • Mania in the medically ill.

    abstract::Manic symptoms frequently occur in patients with comorbid medical disorders and present a diagnostic and treatment challenge. Manic symptoms may be due to an independent psychiatric illness, may be induced or precipitated by a medical condition, or may result from medication or substance use. The presence of manic sym...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-007-0024-8

    authors: Arora M,Daughton J

    更新日期:2007-06-01 00:00:00

  • Disturbed Sleep and Postpartum Depression.

    abstract::The perinatal period introduces a myriad of changes. One important but often overlooked change is an increased reporting of sleep disturbance. Although casually regarded as a consequence of pregnancy or postpartum, there is emerging evidence implicating significant sleep disturbance, characterized by insomnia symptoms...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-016-0705-2

    authors: Okun ML

    更新日期:2016-07-01 00:00:00

  • Update on Addressing Mental Health and Burnout in Physicians: What Is the Role for Psychiatry?

    abstract:PURPOSE OF REVIEW:To highlight an emerging understanding of burnout and physician mental health. This review will provide a discussion of conceptual and diagnostic issues of the burnout syndrome with its relevance to psychiatry, and how psychiatry may interface with other medical disciplines to provide support in creat...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-019-1100-6

    authors: McFarland DC,Hlubocky F,Riba M

    更新日期:2019-10-15 00:00:00

  • Impact of molecular medicine on neuropsychiatry: the clinician's perspective.

    abstract::Clinical neuropsychiatry has traditionally relied on individual practitioner experience or the apprentice-training model for formulating cases and choosing treatment. Scientifically-based diagnostic criteria and treatment algorithms have been lacking in the overlap area between psychiatry and neurology, owing largely ...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-996-0026-y

    authors: Ryan JM,Loy R,Tariot PN

    更新日期:2001-10-01 00:00:00

  • Depression and dysphoria effects on the interpersonal perception of negative and positive moods and caring relationships: effects of antidepressants, amphetamine, and methylphenidate.

    abstract::An inverse relationship exists between an individual's degree of negative affect and the interpersonal perception of friendliness, sympathy and empathy, acceptance, warmth, regard, and genuineness, and the converse relationship persists for the perception of sadness and anger. Thus, a "negative interpersonal bias" exi...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-003-0084-3

    authors: Janowsky DS

    更新日期:2003-12-01 00:00:00

  • Sex Doll Ownership: An Agenda for Research.

    abstract:PURPOSE OF REVIEW:The topic of sex doll ownership is becoming an increasingly discussed issue from both a social and legal perspective. This review aims to examine the veracity of the existing psychological, sexological, and legal literature in relation to doll ownership. RECENT FINDINGS:Strong views exist across the ...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-020-01177-w

    authors: Harper CA,Lievesley R

    更新日期:2020-08-15 00:00:00

  • Behavioral Responses in Youth Exposed to Natural Disasters and Political Conflict.

    abstract:PURPOSE OF REVIEW:The aim of this review was to focus solely on youths' behavioral responses to natural disasters and political conflicts in order to fully understand their impact and scope. RECENT FINDINGS:Recent studies in the field of trauma have shown that theoretical conceptions have moved away from a narrow focu...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-019-1030-3

    authors: Nuttman-Shwartz O

    更新日期:2019-04-29 00:00:00

  • Artificial Intelligence for Mental Health and Mental Illnesses: an Overview.

    abstract:PURPOSE OF REVIEW:Artificial intelligence (AI) technology holds both great promise to transform mental healthcare and potential pitfalls. This article provides an overview of AI and current applications in healthcare, a review of recent original research on AI specific to mental health, and a discussion of how AI can s...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-019-1094-0

    authors: Graham S,Depp C,Lee EE,Nebeker C,Tu X,Kim HC,Jeste DV

    更新日期:2019-11-07 00:00:00

  • Internet interventions for mental health and addictions: current findings and future directions.

    abstract::Over the last several years, there has been a substantial increase in the number of publications reporting on Internet interventions for mental health and addictions. This paper provides a summary of the recent research on Internet interventions for the most common mental health and addictions concerns-depression, anx...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-014-0521-5

    authors: Cunningham JA,Gulliver A,Farrer L,Bennett K,Carron-Arthur B

    更新日期:2014-12-01 00:00:00

  • Personality disorder classification: stuck in neutral, how to move forward?

    abstract::An "Alternative DSM-5 Model for Personality Disorders" was published in Sect. III of DSM-5, while the identical categories and criteria from DSM-IV for the personality disorders (PDs) are in Sect. II. Given strong shifts from categorical diagnoses toward dimensional representations in psychiatry, how did the PDs end u...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-014-0480-x

    authors: Skodol AE

    更新日期:2014-10-01 00:00:00

  • New findings from the Bipolar Collaborative Network: clinical implications for therapeutics.

    abstract::In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than ...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-006-0056-5

    authors: Post RM,Altshuler LL,Frye MA,Suppes T,McElroy S,Keck PE Jr,Leverich GS,Kupka R,Nolen WA,Grunze H

    更新日期:2006-12-01 00:00:00

  • Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature.

    abstract::Since its earliest descriptions, schizophrenia has been thought to be clinically heterogeneous. Symptomatic features and subtypes tend to aggregate in families, suggesting that genetic factors contribute to individual differences in illness presentation. Over the past 5 years, evidence from genetic linkage and associa...

    journal_title:Current psychiatry reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11920-008-0028-z

    authors: Fanous AH,Kendler KS

    更新日期:2008-04-01 00:00:00