当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Upregulation of chemokine CXCL10 enhances chronic pulmonary inflammation in tree shrew collagen-induced arthritis.

Upregulation of chemokine CXCL10 enhances chronic pulmonary inflammation in tree shrew collagen-induced arthritis.

Abstract：

:Chronic pulmonary inflammation (CPI) gives rise to serious lung injuries in rheumatoid arthritis (RA) patients. However, the molecular mechanism underlying the pathogenesis of RA-associated CPI remains little understood. Here we established a novel tree shrew-based collagen-induced arthritis (TsCIA) model to study RA-associated CPI. Our results showed that typical CPI but not fibrosis developed pathologically in the TsCIA model. Furthermore, abnormal up-regulation of pulmonary chemokine CXCL10 was directly associated with lung damage. Specific blockage of CXCR3 (a CXCL10 receptor) significantly decreased the severity of CPI by decreasing the recruitment of inflammatory cells. Therefore, CXCL10 is proposed as a key player responsible for the development of TsCIA-associated CPI. Our findings also suggest that CXCR3 could be developed as a potential diagnosis biomarker for RA-associated CPI.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Gao B,Lin J,Jiang Z,Yang Z,Yu H,Ding L,Yu M,Cui Q,Dunavin N,Zhang M,Li M

doi

10.1038/s41598-018-28404-y

subject

Has Abstract

pub_date

2018-07-03 00:00:00

pages

9993

issue

1

issn

2045-2322

pii

10.1038/s41598-018-28404-y

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Publisher Correction: Syngeneic Mesenchymal Stem Cells Reduce Immune Rejection After Induced Pluripotent Stem Cell-Derived Allogeneic Cardiomyocyte Transplantation.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-67129-9

    authors： Yoshida S,Miyagawa S,Toyofuku T,Fukushima S,Kawamura T,Kawamura A,Kashiyama N,Nakamura Y,Toda K,Sawa Y

    更新日期：2020-06-17 00:00:00

  • The effects of playing music on mental health outcomes.

    abstract：:The association between active musical engagement (as leisure activity or professionally) and mental health is still unclear, with earlier studies reporting contrasting findings. Here we tested whether musical engagement predicts (1) a diagnosis of depression, anxiety, schizophrenia, bipolar or stress-related disorder...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49099-9

    authors： Wesseldijk LW,Ullén F,Mosing MA

    更新日期：2019-08-30 00:00:00

  • Frequency-noise measurements of optical frequency combs by multiple fringe-side discriminator.

    abstract：:The frequency noise of an optical frequency comb is routinely measured through the hetherodyne beat of one comb tooth against a stable continuous-wave laser. After frequency-to-voltage conversion, the beatnote is sent to a spectrum analyzer to retrive the power spectral density of the frequency noise. Because narrow-l...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16338

    authors： Coluccelli N,Cassinerio M,Gambetta A,Laporta P,Galzerano G

    更新日期：2015-11-09 00:00:00

  • Rapid and Sensitive SERS Detection of Bisphenol A Using Self-assembled Graphitic Substrates.

    abstract：:We have prepared and tested a new surface enhanced Raman scattering (SERS) substrate based on self-assembled graphitic sheets to detect bisphenol A (BPA) in plastic consumer goods. Transmission electron microscopy (TEM) and atomic-force microscopy (AFM) were used to characterize the structure of the graphitic sheets a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17030-9

    authors： Lin PY,Hsieh CW,Hsieh S

    更新日期：2017-12-01 00:00:00

  • Subcellular localisation modulates ubiquitylation and degradation of Ascl1.

    abstract：:The proneural transcription factor Ascl1 is a master regulator of neurogenesis, coordinating proliferation and differentiation in the central nervous system. While its expression is well characterised, post-translational regulation is much less well understood. Here we demonstrate that a population of chromatin-bound ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23056-4

    authors： Gillotin S,Davies JD,Philpott A

    更新日期：2018-03-15 00:00:00

  • Movement patterns of the grey field slug (Deroceras reticulatum) in an arable field.

    abstract：:We report the results of an experiment on radio-tracking of individual grey field slugs in an arable field and associated data modelling designed to investigate the effect of slug population density in their movement. Slugs were collected in a commercial winter wheat field in which a 5x6 trapping grid had been establi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74643-3

    authors： Ellis J,Petrovskaya N,Forbes E,Walters KFA,Petrovskii S

    更新日期：2020-10-21 00:00:00

  • Population genomics of two congeneric Palaearctic shorebirds reveals differential impacts of Quaternary climate oscillations across habitats types.

    abstract：:Intracontinental biotic divisions across the vast Palaearctic region are not well-characterized. Past research has revealed patterns ranging from a lack of population structure to deep divergences along varied lines of separation. Here we compared biogeographic patterns of two Palaearctic shorebirds with different hab...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54715-9

    authors： Tan HZ,Ng EYX,Tang Q,Allport GA,Jansen JJFJ,Tomkovich PS,Rheindt FE

    更新日期：2019-12-03 00:00:00

  • Publisher Correction: Fungal communities and their association with nitrogen-fixing bacteria affect early decomposition of Norway spruce deadwood.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-66769-1

    authors： Gómez-Brandón M,Probst M,Siles JA,Peintner U,Bardelli T,Egli M,Insam H,Ascher-Jenull J

    更新日期：2020-06-16 00:00:00

  • A novel proton transfer mechanism in the SLC11 family of divalent metal ion transporters.

    abstract：:In humans, the H+-coupled Fe2+ transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis. While X-ray diffraction has recently unveiled the structure of the bacterial homologue ScaDMT as a LeuT-fold transporter, the exact mechanism of H+-cotransport has remained elusive. Here, we used a combin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06446-y

    authors： Pujol-Giménez J,Hediger MA,Gyimesi G

    更新日期：2017-07-28 00:00:00

  • Loss of maternal annexin A5 increases the likelihood of placental platelet thrombosis and foetal loss.

    abstract：:Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy. We found significant reductions in litter size and foetal weight in Anxa5-null...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00827

    authors： Ueki H,Mizushina T,Laoharatchatathanin T,Terashima R,Nishimura Y,Rieanrakwong D,Yonezawa T,Kurusu S,Hasegawa Y,Brachvogel B,Pöschl E,Kawaminami M

    更新日期：2012-01-01 00:00:00

  • Erratum: Boolean Models of Biological Processes Explain Cascade-Like Behavior.

    abstract：:This corrects the article DOI: 10.1038/srep20067. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/srep46387

    authors： Chen H,Wang G,Simha R,Du C,Zeng C

    更新日期：2017-06-30 00:00:00

  • The impact of injury on apparent survival of whale sharks (Rhincodon typus) in South Ari Atoll Marine Protected Area, Maldives.

    abstract：:The whale shark (Rhincodon typus) is an endangered species with a declining global population. The South Ari Atoll Marine Protected Area (SAMPA), Maldives, is one of few locations globally where year-long residency of individuals occurs. This SAMPA aggregation appears to consist almost exclusively of immature males. D...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79101-8

    authors： Harvey-Carroll J,Stewart JD,Carroll D,Mohamed B,Shameel I,Zareer IH,Araujo G,Rees R

    更新日期：2021-01-13 00:00:00

  • Molecular cloning, expression and the adjuvant effects of interleukin-8 of channel catfish (Ictalurus Punctatus) against Streptococcus iniae.

    abstract：:Interleukin-8 (IL-8) as an important cytokine involving in inflammatory and immune response, has been studied as effective adjuvants for vaccines in mammals. However, there are fewer reports about the characterization and adjuvant effects of IL-8 in fish. In this study, cloning and sequence analysis of IL-8 coding reg...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29310

    authors： Wang E,Wang J,Long B,Wang K,He Y,Yang Q,Chen D,Geng Y,Huang X,Ouyang P,Lai W

    更新日期：2016-07-04 00:00:00

  • Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.

    abstract：:The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson's disease. Native monomeric αSyn exists in an intrinsically disordered ensemble of interconverting conformations, which has made its therapeutic targeting by small molecules highly challenging. Nonetheless, her...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52598-4

    authors： Tóth G,Neumann T,Berthet A,Masliah E,Spencer B,Tao J,Jobling MF,Gardai SJ,Bertoncini CW,Cremades N,Bova M,Ballaron S,Chen XH,Mao W,Nguyen P,Tabios MC,Tambe MA,Rochet JC,Junker HD,Schwizer D,Sekul R,Ott I,Ander

    更新日期：2019-11-18 00:00:00

  • Mechanical properties and microstructural change of W-Y2O3 alloy under helium irradiation.

    abstract：:A wet-chemical method combined with spark plasma sintering was used to prepare a W-Y2O3 alloy. High-temperature tensile tests and nano-indentation microhardness tests were used to characterize the mechanical properties of the alloy. After He-ion irradiation, fuzz and He bubbles were observed on the irradiated surface....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12755

    authors： Tan X,Luo L,Chen H,Zhu X,Zan X,Luo G,Chen J,Li P,Cheng J,Liu D,Wu Y

    更新日期：2015-07-31 00:00:00

  • Novel method for evaluating the indication for endoscopic papillectomy in patients with ampullary adenocarcinoma.

    abstract：:This study aimed to determine the clinicopathological features of the subtypes of ampullary carcinoma (AC) to explore the indications for endoscopic papillectomy (EP) in early AC. Fifty-seven patients with AC who underwent curative resection were retrospectively reviewed. The 0/IA stages were significantly more common...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79836-4

    authors： Yamamoto K,Itoi T,Nagata N,Sofuni A,Tsuchiya T,Ishii K,Tanaka R,Tonozuka R,Honjo M,Mukai S,Asai Y,Matsunami Y,Yamaguchi H,Matsubayashi J,Joyama E,Nagakawa Y

    更新日期：2021-01-12 00:00:00

  • Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2.

    abstract：:Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed dif...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06993-4

    authors： Fischer R,Marsal J,Guttà C,Eisler SA,Peters N,Bethea JR,Pfizenmaier K,Kontermann RE

    更新日期：2017-07-26 00:00:00

  • Novel Variations in Native Ethiopian Goat breeds PRNP Gene and Their Potential Effect on Prion Protein Stability.

    abstract：:Scrapie is a lethal neurodegenerative disease of sheep and goats caused by the misfolding of the prion protein. Variants such as M142, D145, S146, H154, Q211, and K222 were experimentally found to increase resistance or extend scrapie incubation period in goats. We aimed to identify polymorphisms in the Afar and Arsi-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63874-z

    authors： Teferedegn EY,Yaman Y,Ün C

    更新日期：2020-04-24 00:00:00

  • Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection.

    abstract：:Lactic acid bacteria (LAB) are the common probiotics. Here, we investigated the antiviral protective effects of heat-killed LAB strain Lactobacillus casei DK128 (DK128) on influenza viruses. Intranasal treatment of mice with DK128 conferred protection against different subtypes of influenza viruses by lessening weight...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17487-8

    authors： Jung YJ,Lee YT,Ngo VL,Cho YH,Ko EJ,Hong SM,Kim KH,Jang JH,Oh JS,Park MK,Kim CH,Sun J,Kang SM

    更新日期：2017-12-12 00:00:00

  • Black P/graphene hybrid: A fast response humidity sensor with good reversibility and stability.

    abstract：:Black phosphorus (BP) materials have attracted considerable attention owing to their ultra-sensitive humidity sensing characteristics because of the natural absorption of water (H2O) molecules on the BP surface caused by the specific 2D layer-crystalline structure. On the other hand, the BP-based humidity sensor is le...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10848-3

    authors： Phan DT,Park I,Park AR,Park CM,Jeon KJ

    更新日期：2017-09-05 00:00:00

  • Measurement of Two-Photon Absorption Cross Section of Metal Ions by a Mass Sedimentation Approach.

    abstract：:The photo-reduction of metal ions in solution induced by femtosecond laser is an important and novel method for fabricating three-dimensional metal microstructures. However, the nonlinear absorption cross section of metal ions remains unknown because its measurement is difficult. In the present study, a method based o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17712

    authors： Ma ZC,Chen QD,Han B,Liu XQ,Song JF,Sun HB

    更新日期：2015-12-11 00:00:00

  • Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl4-induced liver cirrhosis by protecting the intestinal barrier in rats.

    abstract：:Alterations in the gut microbiome have been reported in liver cirrhosis, and probiotic interventions are considered a potential treatment strategy. This study aimed to evaluate the effects and mechanisms of Lactobacillus salivarius LI01, Pediococcus pentosaceus LI05, Lactobacillus rhamnosus GG, Clostridium butyricum M...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07091-1

    authors： Shi D,Lv L,Fang D,Wu W,Hu C,Xu L,Chen Y,Guo J,Hu X,Li A,Guo F,Ye J,Li Y,Andayani D,Li L

    更新日期：2017-07-31 00:00:00

  • Central s-resistin deficiency ameliorates hypothalamic inflammation and increases whole body insulin sensitivity.

    abstract：:S-resistin, a non-secretable resistin isoform, acts as an intracrine factor that regulates adipocyte maduration, inflammatory and insulin response in 3T3-L1 cells. However, its intracellular function in vivo is still unknown. In this study, we analyze the central role of s-resistin, decreasing its hypothalamic express...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22255-3

    authors： Rodríguez M,Pintado C,Moltó E,Gallardo N,Fernández-Martos CM,López V,Andrés A,Arribas C

    更新日期：2018-03-02 00:00:00

  • Cyclophilin A is associated with peripheral artery disease and chronic kidney disease in geriatrics: The Tianliao Old People (TOP) study.

    abstract：:Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09937

    authors： Liu MC,Lee YW,Lee PT,Chang CS,Tai YL,Yu JR,Su XT,Hsu LW,Lin SH,Wu CH,Liu PY

    更新日期：2015-04-24 00:00:00

  • Graft revascularization is essential for non-invasive monitoring of transplanted islets with radiolabeled exendin.

    abstract：:Islet transplantation is a novel promising strategy to cure type 1 diabetes. However, the long-term outcome is still poor, because both function and survival of the transplant decline over-time. Non-invasive imaging methods have the potential to enable monitoring of islet survival after transplantation and the effects...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15521

    authors： Eter WA,Bos D,Frielink C,Boerman OC,Brom M,Gotthardt M

    更新日期：2015-10-22 00:00:00

  • Principles and development of collagen-mediated tissue fusion induced by laser irradiation.

    abstract：:The mechanism underlying tissue fusion mediated by laser irradiation remains unclear. We clarify the mechanisms underlying laser-mediated tissue fusion using a novel model. Microscopic examinations of morphological changes within the adventitia of a bovine carotid artery and a collagen sheet prepared from bovine dermi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45486-4

    authors： Sasaki S,Ikeda T,Okihara SI,Nishimura S,Nakadate R,Saeki H,Oki E,Mori M,Hashizume M,Maehara Y

    更新日期：2019-06-28 00:00:00

  • Unsupervised learning for large-scale corneal topography clustering.

    abstract：:Machine learning algorithms have recently shown their precision and potential in many different use cases and fields of medicine. Most of the algorithms used are supervised and need a large quantity of labeled data to achieve high accuracy. Also, most applications of machine learning in medicine are attempts to mimic ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73902-7

    authors： Zéboulon P,Debellemanière G,Gatinel D

    更新日期：2020-10-12 00:00:00

  • Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer's disease by interacting with APOE ε4.

    abstract：:Some studies have demonstrated interactions of AD-risk single nucleotide polymorphisms (SNPs) in non-APOE regions with APOE genotype. Nevertheless, no study reported interactions of expression quantitative trait locus (eQTL) for APOE with APOE genotype. In present study, we included 9286 unrelated AD patients and 8479...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26398-1

    authors： Zhang A,Zhao Q,Xu D,Jiang S

    更新日期：2018-05-23 00:00:00

  • Sex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite).

    abstract：:Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated the sex-related pharmacokinetics of metapristone in both rats and dogs, and explored the related ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17225-0

    authors： Chen W,Xiao Y,Chen J,Liu J,Shao J,Li T,Zhu Y,Ma J,Gao Y,Wang J,Xu J,Lu Y,Jia L

    更新日期：2017-12-07 00:00:00

  • Experience has a limited effect on humans' ability to predict the outcome of social interactions in children, dogs and macaques.

    abstract：:The ability to predict others' behaviour represents a crucial mechanism which allows individuals to react faster and more appropriately. To date, several studies have investigated humans' ability to predict conspecifics' behaviour, but little is known on our ability to predict behaviour in other species. Here, we aime...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78275-5

    authors： Donnier S,Kovács G,Oña LS,Bräuer J,Amici F

    更新日期：2020-12-04 00:00:00