Evaluation of a hydrogel membrane on bone regeneration in furcation periodontal defects in dogs.

Abstract:

:The aim of the study was to evaluate bone regeneration using a canine model with surgically created periodontal defects filled for 12 weeks using a stratified biomaterial consisting in a biphasic calcium phosphate (BCP) covered with a crosslinking hydrogel acting as polymer membrane of silated hydroxypropyl methylcellulose (Si-HPMC) as the tested new concept. Bilateral, critical-sized, defects were surgically created at the mandibular premolar teeth of six adult beagle dogs. The defects were randomly allocated and: (i) left empty for spontaneous healing or filled with: (ii) BCP and a collagen membrane; (iii) BCP and hydrogel Si-HPMC membrane. At 12 weeks, the experimental conditions resulted in significantly enhanced bone regeneration in the test BCP/Si-HPMC group. Within the limits of this study, we suggest that the hydrogel Si-HPMC may act as an occlusive barrier to protect bone area from soft connective tissue invasion and then effectively contribute to enhance bone regeneration.

journal_name

Dent Mater J

journal_title

Dental materials journal

authors

Struillou X,Fruchet A,Rakic M,Badran Z,Rethore G,Sourice S,Fellah BH,LE Guehennec L,Gauthier O,Weiss P,Soueidan A

doi

10.4012/dmj.2017-238

subject

Has Abstract

pub_date

2018-09-30 00:00:00

pages

825-834

issue

5

eissn

0287-4547

issn

1881-1361

journal_volume

37

pub_type

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