Abstract:
:Stromal interaction molecule (STIM)-1 and -2 are multi-domain, single-pass transmembrane proteins involved in sensing changes in compartmentalized calcium (Ca2+) levels and transducing this cellular signal to Orai1 channel proteins. Our understanding of the molecular mechanisms underlying STIM signaling has been dramatically improved through available X-ray crystal and solution NMR structures. This high-resolution structural data has revealed that intricate intramolecular and intermolecular protein-protein interactions are involved in converting STIMs from the quiescent to activation-competent states. This review article summarizes the current high resolution structural data on specific EF-hand, sterile α motif and coiled-coil interactions which drive STIM function in the activation of Orai1 channels. Further, the work discusses the effects of post-translational modifications on the structure and function of STIMs. Future structural studies on larger STIM:Orai complexes will be critical to fully defining the molecular bases for STIM function and how post-translational modifications influence these mechanisms.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Novello MJ,Zhu J,Feng Q,Ikura M,Stathopulos PBdoi
10.1016/j.ceca.2018.04.006subject
Has Abstractpub_date
2018-07-01 00:00:00pages
88-94eissn
0143-4160issn
1532-1991pii
S0143-4160(18)30059-9journal_volume
73pub_type
杂志文章,评审相关文献
CELL CALCIUM文献大全abstract::Fluorescence imaging of calcium ions (Ca(2+)) has become an essential technique for investigation of signaling pathways involving Ca(2+) as a second messenger. But, Ca(2+) signaling is involved in many biological phenomena, and therefore simultaneous visualization of Ca(2+) and other biomolecules (multicolor imaging) ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2016.06.002
更新日期:2016-10-01 00:00:00
abstract::Cardiogenesis depends on a tightly regulated balance between proliferation and differentiation of cardiac progenitor cells (CPCs) and their cardiomyocyte descendants. While exposure of early mouse embryos to Ca(2+) channel antagonists has been associated with abnormal cardiac morphogenesis, less is known about the con...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2014.02.018
更新日期:2014-05-01 00:00:00
abstract::Relative to mammals, the neuroendocrine control of pituitary growth hormone (GH) secretion and synthesis in teleost fish involves numerous stimulatory and inhibitory regulators, many of which are delivered to the somatotrophs via direct innervation. Among teleosts, how multifactorial regulation of somatotroph function...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2011.11.001
更新日期:2012-03-01 00:00:00
abstract::As pivotal players in cellular metabolism, mitochondria have a double-faceted role in the final decision of cell fate. This is true for all cell types, but it is even more important and intriguing in the cancer setting. Mitochondria regulate cell fate in many diverse ways: through metabolism, by producing ATP and othe...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2020.102308
更新日期:2020-12-01 00:00:00
abstract::This investigation concentrates on the change in Ca(2+) concentration ([Ca(2+)]) caused by ryanodine in U373 MG cells. This cell type from a human astrocytoma is a unique cellular model because it only expresses the type 3 ryanodine receptor (RyR3), which is generally the least abundant isoform. In the presence of phy...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2004.02.004
更新日期:2004-11-01 00:00:00
abstract::Receptors for extracellular nucleotides (the P2X-calcium channels and the phospholipase C-coupled P2Y receptors) play key roles in pain signaling, but little is known on their function in trigeminal ganglia, whose hyperactivation leads to the development of migraine pain. Here we characterize calcium signaling via P2X...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2007.10.003
更新日期:2008-06-01 00:00:00
abstract::We present a new method for ratiometric Ca2+ measurements using indicators with excitation spectra in the visible range of wavelengths. Laser-scanning confocal microscopy was used to record intracellular Ca(2+)-signals with high temporal and spatial resolution in single cardiac myocytes. The patch-clamp technique was ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(93)90040-d
更新日期:1993-05-01 00:00:00
abstract::It is well known that in different tissues, dihydropyridines bind at nanomolar concentrations to a receptor and block voltage-operated Ca2+ channels. In studies reported here, Harderian gland tissue homogenates from intact male hamsters exhibited significant dihydropyridine binding (Bmax = 1700 fmoles/mg protein) of h...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(92)90036-r
更新日期:1992-10-01 00:00:00
abstract::The mammalian ryanodine receptor Ca2+ release channel (RyR) has a single conserved high affinity calmodulin (CaM) binding domain. However, the skeletal muscle RyR1 is activated and cardiac muscle RyR2 is inhibited by CaM at submicromolar Ca2+. This suggests isoform-specific domains are involved in RyR regulation by Ca...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2017.05.013
更新日期:2017-09-01 00:00:00
abstract::Ca2+ signals are known to mediate an array of cellular functions including secretion, contraction, and conductivity changes. In spite of the obvious role of Ca2+ in signalling, the control of Ca2+ within cells is known to be a complex phenomenon involving a number of distinct active and passive transport systems funct...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/0143-4160(89)90062-6
更新日期:1989-07-01 00:00:00
abstract::Cooling can induce Ca(2+) signaling via activation of temperature-sensitive ion channels such as TRPM8, TRPA1 and ryanodine receptor channels. Here we have studied the mechanism of cooling-evoked Ca(2+) signaling in mouse olfactory ensheathing cells (OECs), a specialized type of glial cells in the olfactory nerve laye...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2012.04.017
更新日期:2012-08-01 00:00:00
abstract::In human embryonic kidney (HEK) cells stably transfected with green fluorescent protein targeted to the endoplasmic reticulum (ER), elevation of intracellular Ca2+ ([Ca2+]i) altered ER morphology, making it appear punctate. Electron microscopy revealed that these punctate structures represented circular and branched r...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1054/ceca.2000.0108
更新日期:2000-03-01 00:00:00
abstract::Endothelin-1 (ET-1), a potent vasoactive peptide with a pathogenic role in vascular diseases, has been shown to induce the activation of ERK1/2, PKB and the expression of a transcriptional regulator, the early growth response 1 (Egr-1), key mediators of hypertrophic and proliferative responses in vascular smooth muscl...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2013.10.002
更新日期:2013-12-01 00:00:00
abstract::Ca(2+) signals control DNA synthesis and repair, gene transcription, and other cell functions that occur within the nucleus. The nuclear envelope can store Ca(2+) and release it into the nucleus via either the inositol 1,4,5-trisphosphate receptor (InsP3R) or the ryanodine receptor (RyR). Furthermore, many cell types ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2005.09.010
更新日期:2006-01-01 00:00:00
abstract::Here we report on the feasibility of using replication deficient adenoviruses to modify signal transduction systems in epithelia. We constructed two viruses, one expressing a dominant negative mutant of the alpha-subunit of Gq (Ad-EF1-dnG alpha q) and the other expressing the wild-type alpha-subunit of Gq (Ad-EF1-wtG ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(98)90077-x
更新日期:1998-08-01 00:00:00
abstract::Cellular redox status is maintained by the balance between series of antioxidant systems and production of reactive oxygen/nitrogenous species. Cells utilize this redox balance to mediate diverse physiological functions. Transient receptor potential (TRP) channels are non-selective cation channels that act as biosenso...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2016.02.009
更新日期:2016-08-01 00:00:00
abstract::The secretion of adrenocorticotrophin (ACTH) from corticotropes is a key component in the endocrine response to stress. The resting potential of corticotropes is set by the basal activities of TWIK-related K(+) (TREK)-1 channel. Corticotrophin-releasing hormone (CRH), the major ACTH secretagogue, closes the background...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2011.12.007
更新日期:2012-03-01 00:00:00
abstract::The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2+) channel to regulate IP(3)-mediated Ca(2+) release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and al...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/j.ceca.2011.05.011
更新日期:2011-09-01 00:00:00
abstract::Muscarinic acetylcholine (ACh) receptors activate the phospholipase C signal transduction pathway to promote the formation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and the consequent elevation of cytoplasmic calcium (Ca2+). The inositol phosphate and Ca(2+)-mobilization responses to ACh were analyzed in Xenopus ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(93)90090-s
更新日期:1993-10-01 00:00:00
abstract::The sternal epithelium of Porcellio scaber was used as a novel model to study the subcellular elemental distribution in control and Ca(2+)-transporting stages in situ. The anterior sternal epithelium (ASE) is specialized for transport of cuticular Ca to sternal CaCO(3) deposits during premolt, and from these deposits ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/s0143-4160(02)00060-x
更新日期:2002-06-01 00:00:00
abstract::N,N'-dicyclohexylcarbodiimide (DCCD) and 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide (CMCD) inhibited calmodulin-dependent Ca2(+)+Mg2(+)-ATPase activity in erythrocyte ghost membranes. The extent of the inhibition caused by carbodiimides strongly depended on their hydrophobicity. Hydrophobic DCCD was a more potent...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(90)90004-e
更新日期:1990-04-01 00:00:00
abstract::Here, we report a novel role for the cysteine protease calpain in store-operated calcium entry. Several structurally and mechanistically unrelated inhibitors of calpain inhibited Ca2+ entry activated in human platelets by thapsigargin-evoked Ca2+ store depletion or the physiological agonist thrombin, whereas inhibitor...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2006.05.008
更新日期:2007-02-01 00:00:00
abstract::Here we examine the potential coupling between the synthesis of secretory proteins and the sensitivity of exocytosis to the concentration of free Ca(2+) in the cytosol ([Ca(2+)](i)) in plant cell. We therefore monitor in tobacco protoplasts the excursion of the membrane capacitance in response to an elevation of [Ca(2...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2012.05.011
更新日期:2012-09-01 00:00:00
abstract::The effect of furosemide and ouabain on the intracellular concentration of Ca2+ was studies in myocardial cell cultures using Fura-2, a fluorescent agent, as an intracellular Ca2+ indicator. Introduction of 200 microM ouabain to the cultured cells increased the intracellular calcium concentration from an average of 23...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(95)90004-7
更新日期:1995-08-01 00:00:00
abstract::Intracellular Ca(2+)-transport ATPases exert a pivotal role in the endoplasmic reticulum and in the compartments of the cellular secretory pathway by maintaining a sufficiently high lumenal Ca(2+) (and Mn(2+)) concentration in these compartments required for an impressive number of vastly different cell functions. At ...
journal_title:Cell calcium
pub_type: 杂志文章,评审
doi:10.1016/s0143416002001847
更新日期:2002-11-01 00:00:00
abstract::Pituitary neuropeptide oxytocin is increasingly recognised as a cardiovascular hormone, in addition to its many regulatory roles in other organ systems. Studies in atrial and ventricular myocytes from the neonatal and adult rats have identified synthesis of oxytocin and the expression of oxytocin receptors in these ce...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2019.102099
更新日期:2019-12-01 00:00:00
abstract::R24571 a derivative of the antimycotic miconazole, appears to be 5 to 8 times more potent than trifluoperazine in its ability to inhibit the calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum vesicles. The cAMP-dependent protein kinase mediated phosphorylation of cardiac sarcoplasmic reticulum was ...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(83)90039-8
更新日期:1983-04-01 00:00:00
abstract::Apparent calcium stability constants and the purity of Ca-chelating agents were evaluated using Ca(2+)-selective electrodes by the double-log optimization method [Oiki S. Yamamoto T. Okada Y. (1994) Cell Calcium, 15, 199-208]. The method was amended to allow evaluation of the free Ca2+ concentrations contaminating ele...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(94)90060-4
更新日期:1994-03-01 00:00:00
abstract::NAADP (nicotinic acid adenine dinucleotide phosphate) is a recently discovered second messenger, and as such, we have much yet to learn about its functions in health and disease. A bottleneck in this basic research is due to NAADP, like all second messengers, being charged to prevent it from leaking out of cells. This...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/j.ceca.2007.08.006
更新日期:2008-06-01 00:00:00
abstract::When the concentrations of either calcium or of magnesium in the culture medium were increased from the normal 0.6 and 1.0 mM to 1.8 and 2.5 mM respectively mitotic activity of rat thymic lymphocytes increased. Very high (10(-4)M) ouabain concentrations abolished these mitogenic actions whilst lower (10(-7) and 10(-11...
journal_title:Cell calcium
pub_type: 杂志文章
doi:10.1016/0143-4160(83)90044-1
更新日期:1983-02-01 00:00:00