Affinity maturation of humanized anti-epidermal growth factor receptor antibody using a modified phage-based open sandwich selection method.

abstract：:After prolonged stay in an intensive care unit (ICU) patients often complain about cognitive impairments that affect health-related quality of life after discharge. The aim of this proof-of-concept study was to test the feasibility and effects of controlled visual and acoustic stimulation in a virtual reality (VR) set...

journal_title：Scientific reports

authors： Gerber SM,Jeitziner MM,Wyss P,Chesham A,Urwyler P,Müri RM,Jakob SM,Nef T

更新日期：2017-10-16 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship bet...

journal_title：Scientific reports

authors： Ntasis VF,Panousis NI,Tektonidou MG,Dermitzakis ET,Boumpas DT,Bertsias GK,Nikolaou C

更新日期：2020-10-06 00:00:00

abstract：:The onset of inversion in the metal-oxide-semiconductor field-effect transistor (MOSFET) takes place when the surface potential is approximately twice the bulk potential. In contrast, the conduction threshold in accumulation mode transistors, such as the oxide thin film transistor (TFT), has remained ambiguous in view...

journal_title：Scientific reports

authors： Lee S,Nathan A

更新日期：2016-03-02 00:00:00

abstract：:P-type doping in high Al-content AlGaN alloys is a main challenge for realizing AlGaN-based deep ultraviolet optoelectronics devices. According to the first-principles calculations, Mg activation energy may be reduced so that a high hole concentration can be obtained by introducing nanoscale (AlN)5/(GaN)1 superlattice...

journal_title：Scientific reports

authors： Wang X,Wang W,Wang J,Wu H,Liu C

更新日期：2017-03-14 00:00:00

abstract：:In the presence of a lateral periodic potential modulation, two-dimensional electrons may exhibit interesting phenomena, such as a graphene-like energy-momentum dispersion, Bloch oscillations, or the Hofstadter butterfly band structure. To create a sufficiently strong potential modulation using conventional semiconduc...

journal_title：Scientific reports

authors： Lu TM,Laroche D,Huang SH,Chuang Y,Li JY,Liu CW

更新日期：2016-02-11 00:00:00

abstract：:Measuring the Parathyroid hormone (PTH) levels assists in the investigation and management of patients with parathyroid disorders. Rapid PTH monitoring is a valid tool for accurate assessment intraoperatively. Rapid Electro-Analytical Device (READ) is a point-of-care device that uses impedance change between target an...

journal_title：Scientific reports

authors： Tanak AS,Muthukumar S,Hashim IA,Prasad S

更新日期：2020-11-02 00:00:00

abstract：:Hereditary tyrosinemia type 1 (HT1) is a severe inborn error of metabolism, impacting the tyrosine catabolic pathway with a high incidence of hepatocellular carcinoma (HCC). Using a HT1 murine model, we investigated the changes in profiles of circulating and hepatic miRNAs. The aim was to determine if plasma miRNAs co...

journal_title：Scientific reports

authors： Angileri F,Morrow G,Scoazec JY,Gadot N,Roy V,Huang S,Wu T,Tanguay RM

更新日期：2016-06-10 00:00:00

abstract：:There are a number of psychological phenomena in which dramatic emotional responses are evoked by seemingly innocuous perceptual stimuli. A well known example is the 'uncanny valley' effect whereby a near human-looking artifact can trigger feelings of eeriness and repulsion. Although such phenomena are reasonably well...

journal_title：Scientific reports

authors： Moore RK

更新日期：2012-01-01 00:00:00

abstract：:Thin waveguides such as graded-index lenses and fiber bundles are often used as imaging probes for high-resolution endomicroscopes. However, strong back-reflection from the end surfaces of the probes makes it difficult for them to resolve weak contrast objects, especially in the reflectance-mode imaging. Here we propo...

journal_title：Scientific reports

authors： Yoon C,Kang M,Hong JH,Yang TD,Xing J,Yoo H,Choi Y,Choi W

更新日期：2017-07-26 00:00:00

abstract：:Hirschsprung disease (HSCR) is a common cause of functional colonic obstruction in children. The currently available genetic testing is often inadequate as it mainly focuses on RET and several other genes, accounting for only 15-20% of cases. To identify novel, potentially pathogenic variants, we isolated a panel of g...

journal_title：Scientific reports

authors： Zhang Z,Li Q,Diao M,Liu N,Cheng W,Xiao P,Zou J,Su L,Yu K,Wu J,Li L,Jiang Q

更新日期：2017-11-01 00:00:00

abstract：:It is of paramount importance to improve the control over large area growth of high quality molybdenum disulfide (MoS2) and other types of 2D dichalcogenides. Such atomically thin materials have great potential for use in electronics, and are thought to make possible the first real applications of spintronics. Here in...

journal_title：Scientific reports

authors： Ionescu R,Campbell B,Wu R,Aytan E,Patalano A,Ruiz I,Howell SW,McDonald AE,Beechem TE,Mkhoyan KA,Ozkan M,Ozkan CS

更新日期：2017-07-25 00:00:00

abstract：:LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technology has largely been confined to anatomic imaging with limited applications into functional or molecular imaging. Here, we report molecular imaging reactive oxygen and nitrogen species (RONS) with a near-infra...

journal_title：Scientific reports

authors： Hariri A,Zhao E,Jeevarathinam AS,Lemaster J,Zhang J,Jokerst JV

更新日期：2019-08-06 00:00:00

abstract：:Ten-year oncological experience of the University Medical Center Groningen with conventional laparotomy (C-RRRTM) and laparoscopy (L-RRRTM) is described concerning resection of residual retroperitoneal tumor masses (RRTM) in a large series of patients with advanced nonseminomatous testicular germ cell tumors (NSTGCT)....

journal_title：Scientific reports

authors： Öztürk Ç,Been LB,van Ginkel RJ,Gietema JA,Hoekstra HJ

更新日期：2019-11-01 00:00:00

abstract：:Nanodiamond (ND) has emerged as a promising carbon nanomaterial for therapeutic applications. In previous studies, ND has been reported to have outstanding biocompatibility and high uptake rate in various cell types. ND containing nitrogen-vacancy centers exhibit fluorescence property is called fluorescent nanodiamond...

journal_title：Scientific reports

authors： Huang YA,Kao CW,Liu KK,Huang HS,Chiang MH,Soo CR,Chang HC,Chiu TW,Chao JI,Hwang E

更新日期：2014-11-05 00:00:00

abstract：:Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chroni...

journal_title：Scientific reports

authors： Zhang W,Zhong W,Sun Q,Sun X,Zhou Z

更新日期：2017-08-21 00:00:00

abstract：:Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...

journal_title：Scientific reports

authors： Hu J,Shi Y,Wang C,Wan H,Wu D,Wang H,Peng X

更新日期：2018-02-16 00:00:00

abstract：:The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representi...

journal_title：Scientific reports

authors： Gehring TV,Luksys G,Sandi C,Vasilaki E

更新日期：2015-10-01 00:00:00

abstract：:Recent studies have shown inconsistent results regarding the value of desmoteplase for treating acute ischemic stroke (AIS) when administered within an extended time window. We performed a meta-analysis to explore the value of desmoteplase in AIS treatment. The MEDLINE, EMBASE, and Cochrane Library databases were sear...

journal_title：Scientific reports

authors： Shi L,Liang F,Li Y,Shao A,Zhou K,Yu J,Zhang J

更新日期：2016-09-27 00:00:00

abstract：:Duchenne muscular dystrophy, one of the most common lethal genetic disorders, is caused by mutations in the DMD gene and a lack of dystrophin protein. In most DMD patients and animal models, sporadic dystrophin-positive muscle fibres, called revertant fibres (RFs), are observed in otherwise dystrophin-negative backgro...

journal_title：Scientific reports

authors： Rodrigues M,Echigoya Y,Maruyama R,Lim KR,Fukada SI,Yokota T

更新日期：2016-12-07 00:00:00

abstract：:Melanoma patients with BRAF mutations respond to treatment with vemurafenib, thus creating a need for accurate testing of BRAF mutation status. We carried out a blinded study to evaluate various BRAF mutation testing methodologies in the clinical setting. Formalin-fixed, paraffin-embedded melanoma samples were macrodi...

journal_title：Scientific reports

authors： Richter A,Grieu F,Carrello A,Amanuel B,Namdarian K,Rynska A,Lucas A,Michael V,Bell A,Fox SB,Hewitt CA,Do H,McArthur GA,Wong SQ,Dobrovic A,Iacopetta B

更新日期：2013-01-01 00:00:00

abstract：:Soil microbial responses to fire are likely to change over the course of forest recovery. Investigations on long-term changes in bacterial dynamics following fire are rare. We characterized the soil bacterial communities across three different times post fire in a 2 to 152-year fire chronosequence by Illumina MiSeq se...

journal_title：Scientific reports

authors： Sun H,Santalahti M,Pumpanen J,Köster K,Berninger F,Raffaello T,Asiegbu FO,Heinonsalo J

更新日期：2016-08-30 00:00:00

abstract：:A major challenge in current exome sequencing in autosomal recessive (AR) families is the lack of an effective method to prioritize single-nucleotide variants (SNVs). AR families are generally too small for linkage analysis, and length of homozygous regions is unreliable for identification of causative variants. Vario...

journal_title：Scientific reports

authors： Imai A,Nakaya A,Fahiminiya S,Tétreault M,Majewski J,Sakata Y,Takashima S,Lathrop M,Ott J

更新日期：2015-07-06 00:00:00

abstract：:Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J...

journal_title：Scientific reports

authors： Kaushik A,Jayant RD,Nikkhah-Moshaie R,Bhardwaj V,Roy U,Huang Z,Ruiz A,Yndart A,Atluri V,El-Hage N,Khalili K,Nair M

更新日期：2016-05-04 00:00:00

abstract：:Comet assay is a widely used method, especially in the field of genotoxicity, to quantify and measure DNA damage visually at the level of individual cells with high sensitivity and efficiency. Generally, computer programs are used to analyze comet assay output images following two main steps. First, each comet region ...

journal_title：Scientific reports

authors： Hong Y,Han HJ,Lee H,Lee D,Ko J,Hong ZY,Lee JY,Seok JH,Lim HS,Son WC,Sohn I

更新日期：2020-11-03 00:00:00

abstract：:Multifunctional materials with more than two good properties are widely required in modern industries. However, some properties are often trade-off with each other by single microstructural designation. For example, nanostructured materials have high strength, but low ductility and thermal stability. Here by means of ...

journal_title：Scientific reports

authors： Zhang YS,Zhao YH,Zhang W,Lu JW,Hu JJ,Huo WT,Zhang PX

更新日期：2017-01-06 00:00:00

abstract：:The frontal lobes are essential for human volition and goal-directed behavior, yet their function remains unclear. While various models have highlighted working memory, reinforcement learning, and cognitive control as key functions, a single framework for interpreting the range of effects observed in prefrontal cortex...

journal_title：Scientific reports

authors： Alexander WH,Brown JW

更新日期：2018-03-01 00:00:00

abstract：:This research investigated the association between prolonged disposable diaper (DD) wearing in infancy and primary enuresis (PNE). As a case-control study, we collected data from 376 children with enuresis and 379 healthy children who were sex- and age-matched at three tertiary care institutions in mainland China from...

journal_title：Scientific reports

authors： Li X,Wen JG,Shen T,Yang XQ,Peng SX,Wang XZ,Xie H,Wu XD,Du YK

更新日期：2020-09-01 00:00:00

abstract：:Gibberellins (GAs) participate in controlling various aspects of basic plant growth responses. With the exception of bryophytes, GA signalling in land plants, such as lycophytes, ferns and angiosperms, is mediated via GIBBERELLIN-INSENSITIVE DWARF1 (GID1) and DELLA proteins. To explore whether this GID1-DELLA mechanis...

journal_title：Scientific reports

authors： Du R,Niu S,Liu Y,Sun X,Porth I,El-Kassaby YA,Li W

更新日期：2017-11-30 00:00:00

abstract：:The manipulation of superparamagnetic microbeads for lab-on-a-chip applications relies on the steering of microbeads across an altering stray field landscape on top of soft magnetic parent structures. Using ab initio principles, we show three-dimensional simulations forecasting the controlled movement of microbeads. S...

journal_title：Scientific reports

authors： Klingbeil F,Block F,Sajjad U,Holländer RB,Deshpande S,McCord J

更新日期：2020-05-29 00:00:00

abstract：:Early diagnosis of dementia including Alzheimer's disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild ...

journal_title：Scientific reports

authors： Kobayashi N,Shinagawa S,Niimura H,Kida H,Nagata T,Tagai K,Shimada K,Oka N,Shikimoto R,Noda Y,Nakajima S,Mimura M,Shigeta M,Kondo K

更新日期：2020-07-22 00:00:00