SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis.

abstract：:Activity-dependent alteration of the transcriptional program is central for shaping neuronal connectivity. Constitutively expressed transcription factors orchestrate the initial response to neuronal stimulation and serve as substrates for second messenger-regulated kinase signalling cascades. The mitogen-activated pro...

journal_title：Scientific reports

authors： Blüthgen N,van Bentum M,Merz B,Kuhl D,Hermey G

更新日期：2017-03-28 00:00:00

abstract：:Biological hydrogen production is based on activity of specific enzymes called hydrogenases. Hydrogenases are oxygen sensitive metalloenzymes containing Ni and/or Fe atoms at the active site, catalyzing reversible reduction of protons. Generally, [Fe-Fe] hydrogenases prefer proton reduction to molecular hydrogen, a po...

journal_title：Scientific reports

authors： Mangayil R,Karp M,Lamminmäki U,Santala V

更新日期：2016-10-27 00:00:00

abstract：:Greenhouse gas (GHG) emissions from livestock grazing systems are contributing to global warming. To examine the influence of yak grazing systems on GHG fluxes and relationships between GHG fluxes and environmental factors, we measured carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) fluxes over three key s...

journal_title：Scientific reports

authors： Liu Y,Yan C,Matthew C,Wood B,Hou F

更新日期：2017-01-20 00:00:00

abstract：:Laparoscopic cholecystectomy (LC) is the standard technique for treatment of gallbladder disease. In case of acute cholecystitis we can identify preoperative factors associated with an increased risk of conversion and intraoperative complications. The aim of our study was to detect preoperative laboratory and radiolog...

journal_title：Scientific reports

authors： Di Buono G,Romano G,Galia M,Amato G,Maienza E,Vernuccio F,Bonventre G,Gulotta L,Buscemi S,Agrusa A

更新日期：2021-01-28 00:00:00

abstract：:Most published sleep studies use three species: human, house mouse, or Norway rat. The degree to which data from these species captures variability in mammalian sleep remains unclear. To gain insight into mammalian sleep diversity, we examined sleep architecture in the spiny basal murid rodent Acomys cahirinus. First,...

journal_title：Scientific reports

authors： Wang C,Guerriero LE,Huffman DM,Ajwad AA,Brooks TC,Sunderam S,Seifert AW,O'Hara BF

更新日期：2020-07-02 00:00:00

abstract：:The purpose of this study was to 1) identify microbial compositional changes on chicken carcasses during processing, 2) determine the antimicrobial efficacy of peracetic acid (PAA) and Amplon (blend of sulfuric acid and sodium sulfate) at a poultry processing pilot plant scale, and 3) compare microbial communities bet...

journal_title：Scientific reports

authors： Ae Kim S,Hong Park S,In Lee S,Owens CM,Ricke SC

更新日期：2017-02-23 00:00:00

abstract：:Obesity is characterized as the excessive accumulation of body fat and has a complex genetic foundation in humans including monogenic high-risk mutations and polygenic contributions. Domestic pigs represent a valuable model on an obesity-promoting high-caloric diet while constantly evaluated for body characteristics. ...

journal_title：Scientific reports

authors： Reyer H,Varley PF,Murani E,Ponsuksili S,Wimmers K

更新日期：2017-08-22 00:00:00

abstract：:The 6SA-CASSCF(10, 10)/6-31G (d, p) quantum chemistry method has been applied to perform on-the-fly trajectory surface hopping simulation with global switching algorithm and to explore excited-state intramolecular proton transfer reactions for the o-nitrophenol molecule within low-lying electronic singlet states (S0 a...

journal_title：Scientific reports

authors： Xu C,Yu L,Zhu C,Yu J,Cao Z

更新日期：2016-05-25 00:00:00

abstract：:Cotton leaf curl disease (CLCuD), caused by cotton leaf curl viruses (CLCuVs), is among the most devastating diseases in cotton. While the widely cultivated cotton species Gossypium hirsutum is generally susceptible, the diploid species G. arboreum is a natural source for resistance against CLCuD. However, the influen...

journal_title：Scientific reports

authors： Naqvi RZ,Zaidi SS,Akhtar KP,Strickler S,Woldemariam M,Mishra B,Mukhtar MS,Scheffler BE,Scheffler JA,Jander G,Mueller LA,Asif M,Mansoor S

更新日期：2017-11-21 00:00:00

abstract：:Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodime...

journal_title：Scientific reports

authors： Kawasaki Y,Sakimura A,Park CM,Tomaru R,Tanaka T,Ozawa T,Zhou Y,Narita K,Kishi H,Muraguchi A,Sakurai H

更新日期：2016-08-17 00:00:00

abstract：:High content of organic matter in the downstream of watersheds underscored the severity of non-point source (NPS) pollution. The major objectives of this study were to characterize and quantify dissolved organic matter (DOM) in watersheds affected by NPS pollution, and to apply self-organizing map (SOM) and parallel f...

journal_title：Scientific reports

authors： Zhang Y,Liang X,Wang Z,Xu L

更新日期：2015-11-03 00:00:00

abstract：:Understanding coupling of ferroic properties over grain boundaries and within clusters of grains in polycrystalline materials is hindered due to a lack of direct experimental methods to probe the behaviour of individual grains in the bulk of a material. Here, a variant of three-dimensional X-ray diffraction (3D-XRD) i...

journal_title：Scientific reports

authors： Daniels JE,Majkut M,Cao Q,Schmidt S,Wright J,Jo W,Oddershede J

更新日期：2016-03-09 00:00:00

abstract：:The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, c...

journal_title：Scientific reports

authors： Keshavarz M,Skill M,Hollenhorst MI,Maxeiner S,Walecki M,Pfeil U,Kummer W,Krasteva-Christ G

更新日期：2018-05-14 00:00:00

abstract：:The oxidative stress regulator Spx is ubiquitously found among Gram-positive bacteria. Previously, we reported identification of two Spx proteins in Streptococcus mutans - SpxA1 was the primary activator of oxidative stress genes whereas SpxA2 served a backup role. Here, we used RNA sequencing to uncover the scope of ...

journal_title：Scientific reports

authors： Kajfasz JK,Ganguly T,Hardin EL,Abranches J,Lemos JA

更新日期：2017-11-22 00:00:00

abstract：:The endocannabinoid 2-arachidonoylglycerol (2-AG) functions as a retrograde signaling molecule mediating synaptic transmission and plasticity at both inhibitory and excitatory synapses. However, little is known about whether 2-AG signaling is involved in homeostatic regulation of miniature synaptic events at excitator...

journal_title：Scientific reports

authors： Song Y,Zhang J,Chen C

更新日期：2015-11-06 00:00:00

abstract：:The aim of this of this meta-analysis was to examine the potential association between certain early repolarization (ER) characteristics and ventricular tachyarrhythmias (VTAs) in patients with acute myocardial infarction (AMI). We searched PubMed, Embase and Web of Science databases for records published until Decemb...

journal_title：Scientific reports

authors： Zhang Z,Letsas KP,Yang Y,Korantzopoulos P,Li G,Yan GX,Liu T

更新日期：2015-11-02 00:00:00

abstract：:Episodic ataxia is an autosomal dominant ion channel disorder characterized by episodes of imbalance and incoordination. The disease is genetically heterogeneous and is classified as episodic ataxia type 2 (EA2) when it is caused by a mutation in the CACNA1A gene, encoding the α1A subunit of the P/Q-type voltage-gated...

journal_title：Scientific reports

authors： Sintas C,Carreño O,Fernàndez-Castillo N,Corominas R,Vila-Pueyo M,Toma C,Cuenca-León E,Barroeta I,Roig C,Volpini V,Macaya A,Cormand B

更新日期：2017-05-31 00:00:00

abstract：:The marine world is incredibly rich in brilliant and intense colours. Photonic structures are found in many different species and provide extremely complex optical responses that cannot be achieved solely by pigments. In this study we examine the cuticular structure of the red alga Chondrus crispus (Irish Moss) using ...

journal_title：Scientific reports

authors： Chandler CJ,Wilts BD,Vignolini S,Brodie J,Steiner U,Rudall PJ,Glover BJ,Gregory T,Walker RH

更新日期：2015-07-03 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Jia Y,Tian Z,Shi X,Liu JP,Chen J,Liu X,Ye R,Ren Z,Tian J

更新日期：2019-11-21 00:00:00

abstract：:We study theoretically and numerically the kinetics of the coefficient of friction of an elastomer due to abrupt changes of sliding velocity. Numerical simulations reveal the same qualitative behavior which has been observed experimentally on different classes of materials: the coefficient of friction first jumps and ...

journal_title：Scientific reports

authors： Li Q,Dimaki A,Popov M,Psakhie SG,Popov VL

更新日期：2014-07-28 00:00:00

abstract：:Enzyme replacement therapies have revolutionized patient treatment for multiple rare lysosomal storage diseases but show limited effectiveness for addressing pathologies in "hard-to-treat" organs and tissues including brain and bone. Here we investigate the plant lectin RTB as a novel carrier for human lysosomal enzym...

journal_title：Scientific reports

authors： Acosta W,Ayala J,Dolan MC,Cramer CL

更新日期：2015-09-18 00:00:00

abstract：:Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action for many therapeutic antibodies. A therapeutic immunoglobulin (Ig) G1 monoclonal antibody lost more than half of its ADCC activity after heat stress at 40 °C for 4 months. Size-exclusion and ion-exchange chromatography were used t...

journal_title：Scientific reports

authors： Lu X,Machiesky LA,De Mel N,Du Q,Xu W,Washabaugh M,Jiang XR,Wang J

更新日期：2020-01-15 00:00:00

abstract：:IFI16 and AIM2 are important DNA sensors in antiviral immunity. To characterize these two molecules in a woodchuck model, which is widely used to study hepatitis B virus (HBV) infection, we cloned and analyzed the complete coding sequences (CDSs) of woodchuck IFI16 and AIM2, and found that AIM2 was highly conserved in...

journal_title：Scientific reports

authors： Yan Q,Li M,Liu Q,Li F,Zhu B,Wang J,Lu Y,Liu J,Wu J,Zheng X,Lu M,Wang B,Yang D

更新日期：2016-06-29 00:00:00

abstract：:Neuroblastoma is the most commonly diagnosed extracranial tumor in the first year of life. Approximately 9% of neuroblastoma patients present germline or somatic aberrations in the gene encoding for anaplastic lymphoma kinase (ALK). This increases in high-risk neuroblastomas, which have a 14% frequency of ALK aberrati...

journal_title：Scientific reports

authors： Cervantes-Madrid D,Szydzik J,Lind DE,Borenäs M,Bemark M,Cui J,Palmer RH,Hallberg B

更新日期：2019-12-18 00:00:00

abstract：:Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are informative for individual cancer types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integrative data s...

journal_title：Scientific reports

authors： Tan H,Bao J,Zhou X

更新日期：2015-07-27 00:00:00

abstract：:Extracellular data analysis has become a quintessential method for understanding the neurophysiological responses to stimuli. This demands stringent techniques owing to the complicated nature of the recording environment. In this paper, we highlight the challenges in extracellular multi-electrode recording and data an...

journal_title：Scientific reports

authors： Veerabhadrappa R,Lim CP,Nguyen TT,Berk M,Tye SJ,Monaghan P,Nahavandi S,Bhatti A

更新日期：2016-06-24 00:00:00

abstract：:To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick's limit. We find that in the biologically relevant range of parameters, if the imbalance between cell division and death is moderate or low (high de...

journal_title：Scientific reports

authors： Rodriguez-Brenes IA,Wodarz D,Komarova NL

更新日期：2015-12-09 00:00:00

abstract：:To date there are thirteen species validly assigned to the genus Anaerococcus. Most of the species in this genus are anaerobic and of human origin. Anaerococcus urinimassiliensis sp. nov., strain Marseille-P2143T is member of family Peptoniphilaceae, which was isolated from the urine of a 17-year-old boy affected by a...

journal_title：Scientific reports

authors： Morand A,Tall ML,Kuete Yimagou E,Ngom II,Lo CI,Cornu F,Tsimaratos M,Lagier JC,Levasseur A,Raoult D,Fournier PE

更新日期：2021-01-29 00:00:00

abstract：:Grain yield is a complicated trait, which is highly associated with biomass productivity. The cell wall is a central element of biomass, and its biogenesis contributes to plant architecture and development. However, the genetic link between cell-wall property and grain yield is largely unclear. Here, we report on iden...

journal_title：Scientific reports

authors： Xu Z,Li S,Zhang C,Zhang B,Zhu K,Zhou Y,Liu Q

更新日期：2017-10-02 00:00:00

abstract：:In populations of Drosophila larvae, both, an aggregation and a dispersal behavior can be observed. However, the mechanisms coordinating larval locomotion in respect to other animals, especially in close proximity and during/after physical contacts are currently only little understood. Here we test whether relevant in...

journal_title：Scientific reports

authors： Otto N,Risse B,Berh D,Bittern J,Jiang X,Klämbt C

更新日期：2016-08-11 00:00:00