Abstract:
:Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the growing number of immunocompromised children at risk for IFD, this disease continues to be associated with significant morbidity and death and with increased financial burden to the health care system. Therefore, it is important to understand the contemporary epidemiology of IFD. Incidence rates of IFD in children are affected by geographical, population, and time variability. There is an ongoing effort to constantly document and update the incidence of IFD and species distribution among different pediatric populations as a means to direct preventative, diagnostic, and therapeutic resources to the most appropriate subset of patients. Children with a hematologic malignancy or a primary or secondary immunodeficiency, those undergoing solid organ or hematopoietic stem cell transplantation, and premature neonates are the major subsets of pediatric patients at risk of developing IFD. In this review, we focus on fungal disease epidemiology with a specific emphasis on the 2 most common pediatric IFDs, IC and invasive aspergillosis (IA).
journal_name
J Pediatric Infect Dis Socjournal_title
Journal of the Pediatric Infectious Diseases Societyauthors
Pana ZD,Roilides E,Warris A,Groll AH,Zaoutis Tdoi
10.1093/jpids/pix046subject
Has Abstractpub_date
2017-09-01 00:00:00pages
S3-S11issue
suppl_1eissn
2048-7193issn
2048-7207pii
4100187journal_volume
6pub_type
杂志文章,评审abstract:BACKGROUND:Children who develop malaria after returning to a setting in which the disease is not endemic are at high risk for critical delays in diagnosis and initiation of antimalarial therapy. We assessed the clinical impact of the implementation of malaria rapid diagnostic testing (RDT) on the management of children...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piz022
更新日期:2020-07-13 00:00:00
abstract::Coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barré syndrome (GBS), followed by 5 adult Italian patients and anoth...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa086
更新日期:2020-09-17 00:00:00
abstract::The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice. Attention to 5 major areas hold the promise of making new antibiotics available for use in chil...
journal_title:Journal of the Pediatric Infectious Diseases Society
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更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:This study was designed to determine whether an automated hospital-based influenza vaccination screening program leveraging the electronic medical record (EMR) increases vaccination rates. METHODS:We performed a retrospective cohort study of all children ≥6 months old admitted to medical, surgical, rehabili...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit044
更新日期:2014-03-01 00:00:00
abstract::Frontline clinicians caring for hospitalized children typically knew the indication for antimicrobial therapy but less often knew the current day or planned duration of therapy or of plans for intravenous to oral conversion. Night shift clinicians were less likely to know day of therapy and duration of therapy than da...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piv026
更新日期:2016-12-01 00:00:00
abstract::Among newborns with congenital cytomegalovirus (CMV) infection from China, there was no difference in CMV viral load in saliva specimens dried and stored at room temperature compared with those kept wet and stored cold, even after longer storage time for the former than the later (74 vs 58 days, P = .02). ...
journal_title:Journal of the Pediatric Infectious Diseases Society
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doi:10.1093/jpids/piy048
更新日期:2018-08-17 00:00:00
abstract:Background:Pseudomonas aeruginosa is a common cause of healthcare-associated infection. Multidrug-resistant (MDR) (>3 classes) and carbapenem-resistant (CR) P aeruginosa are significant threats globally. We used a large reference-laboratory database to study the epidemiology of P aeruginosa in children in the United St...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piw064
更新日期:2017-11-24 00:00:00
abstract:BACKGROUND:As antiretroviral therapy (ART) allows the world's 2.3 million human immunodeficiency virus (HIV)-infected children to grow and thrive, these children need to be informed of their HIV status. Neither the prevalence of disclosure to children nor its impact has been evaluated in most resource-limited settings....
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit024
更新日期:2013-06-01 00:00:00
abstract::Children with healthcare-associated Clostridium difficile infection were identified. The incidence increased from 3.2/10,000 patient days in 2007 to 5.2/10,000 patient days in 2011 (p < 0.001). Of 169 isolates, the most common North American Pulsed-Field (NAP) types were NAP4 (n = 43; (25.4%), and NAP1 (n = 25;14.8%) ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piv011
更新日期:2015-12-01 00:00:00
abstract:Background:Trichosporonosis is an emerging and often fatal opportunistic fungal infection in immunocompromised patients, particularly those with hematologic malignancy, but data in children are lacking. Methods:We report here 3 cases of invasive infection caused by Trichosporon asahii in pediatric patients with acute ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/pix031
更新日期:2018-08-17 00:00:00
abstract::Recent guidelines recommend empiric vancomycin dosing of 60 mg/kg per day and consideration of higher trough concentrations (15-20 mcg/mL) in children with invasive infections. In this study, we report a retrospective review evaluating the dose/trough relationship and predicted area under the curve in pediatric patien...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis083
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Egypt has the highest prevalence of hepatitis C virus (HCV) infection. Anti-HCV antibodies were detectable in 3% of children in Upper Egypt. Our aim was to evaluate the efficacy of ledipasvir/sofosbuvir for chronic HCV genotype 4 in adolescents with/without hematological disorders and to determine the effect...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa006
更新日期:2020-02-15 00:00:00
abstract:Introduction:Antimicrobial use is decreasing across freestanding children's hospitals, predominantly in institutions with antimicrobial stewardship programs (ASPs) in place. A highly effective ASP should effect a greater decrease in use than predicted by existing trends. Antimicrobial stewardship programs depend on cli...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piw054
更新日期:2017-11-24 00:00:00
abstract:BACKGROUND:Prevention strategies for cytomegalovirus (CMV) in pediatric transplant recipients are sparsely reported. A hybrid strategy that combines prophylaxis with preemptive therapy using serial CMV viral load monitoring is an emerging option. We report our clinical outcomes with a hybrid strategy in pediatric heart...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis056
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, st...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piy035
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Single-nucleotide polymorphisms (SNPs) in the fucosyltransferase genes FUT2 and FUT3 have been associated with susceptibility to various infectious and inflammatory disorders. FUT variations influence the expression of human histo-blood group antigens (HBGAs) (H-type 1 and Lewis), which are highly expressed ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piy085
更新日期:2019-12-27 00:00:00
abstract:BACKGROUND:The 2017-2018 influenza season was of high severity. Circulating influenza strains change periodically, making it important to determine vaccine effectiveness on an annual basis, especially for susceptible populations. The primary aim of our study was to estimate the effectiveness of the influenza vaccine am...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piz077
更新日期:2020-09-17 00:00:00
abstract::The reduction in human immunodeficiency virus (HIV) transmission through breastmilk with maternal combination antiretroviral therapy (cART) has led many pregnant women living with HIV and healthcare providers to question exclusive formula feeding in resource-rich settings. Here, we describe cART prophylaxis in 3 breas...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piz003
更新日期:2020-04-30 00:00:00
abstract:Background:Lower procalcitonin (PCT) concentrations are associated with reduced risk of bacterial community-acquired pneumonia (CAP) in adults, but data in children are limited. Methods:We analyzed serum PCT concentrations from children hospitalized with radiographically confirmed CAP enrolled in the Centers for Disea...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piw091
更新日期:2018-02-19 00:00:00
abstract:BACKGROUND:Respiratory viruses cause significant morbidity and death in infants; 99% of such deaths occur in resource-limited settings. Risk factors for initial and repeated respiratory viral infections in young infants in resource-limited settings have not been well described. METHODS:From 2011 to 2014, a birth cohor...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piy107
更新日期:2020-02-28 00:00:00
abstract::Chronic granulomatous disease (CGD) is a congenital disorder characterized by recurrent life-threatening bacterial and fungal infections and development of severe inflammation secondary to a congenital defect in 1 of the 5 phagocyte oxidase (phox) subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxi...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/piy015
更新日期:2018-05-09 00:00:00
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journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Although long treatment courses of outpatient antimicrobials are often used in pediatric patients, few data exist regarding the frequency of adverse events (AEs) associated with these medications. METHODS:We performed a retrospective cohort study of all patients seen in the Infectious Diseases clinic at a t...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piu037
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:A moderate to severe (M/S) influenza clinical endpoint has been proposed in children, defined as fever >39°C, otitis media, lower respiratory tract infection, or serious extrapulmonary manifestations. The objective of the study was to evaluate the M/S measure against clinically relevant outcomes including ho...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piz075
更新日期:2020-09-17 00:00:00
abstract::Children presenting to an emergency department following an animal bite were found to be at risk for infection if they had puncture wounds, crush wounds, or were bitten by a cat. Of the infected wounds that were cultured, methicillin-resistant Staphylococcus aureus was not isolated as a pathogen. ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis096
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Rotavirus is the most common cause of infectious diarrhea in children worldwide. Recent studies have described changes in the burden of all-cause gastroenteritis; however, there are limited data on the clinical and economic impact of rotavirus vaccine on cases of laboratory-confirmed rotavirus disease. METH...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis058
更新日期:2012-12-01 00:00:00
abstract::Pneumonia, most often caused by a respiratory virus, is common in childhood. Mycoplasma pneumoniae also is detected frequently, particularly in older children in the era of pneumococcal conjugate vaccination. Despite recommendations for β-lactam antibiotics, macrolide antibiotics, including erythromycin, clarithromyci...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/pix083
更新日期:2018-02-19 00:00:00
abstract:BACKGROUND:While fluoroquinolones are commonly used in adults, the use in children has been low. Since 2000, there were 3 US Food and Drug Administration (FDA) Boxed warnings regarding fluoroquinolones (2008, 2013, and 2016). Our objective was to describe the use of fluoroquinolones in children and assess the impact of...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa156
更新日期:2020-12-30 00:00:00
abstract:OF KEY POINTS:Although relatively rare, invasive meningococcal disease continues to be a health concern, especially in young children. This systematic review clearly delineates both the near- and long-term morbidities that can occur after, and persist beyond, the period of acute illness. BACKGROUND:Although rare, inva...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
abstract::Coronaviruses contribute to the burden of respiratory diseases in children, frequently manifesting in upper respiratory symptoms considered to be part of the "common cold." Recent epidemics of novel coronaviruses recognized in the 21st century have highlighted issues of zoonotic origins of transmissible respiratory vi...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/piaa037
更新日期:2020-04-30 00:00:00