The Prevalence of Disclosure of HIV Status to HIV-Infected Children in Western Kenya.

Abstract:

BACKGROUND:As antiretroviral therapy (ART) allows the world's 2.3 million human immunodeficiency virus (HIV)-infected children to grow and thrive, these children need to be informed of their HIV status. Neither the prevalence of disclosure to children nor its impact has been evaluated in most resource-limited settings. METHODS:We conducted a prospective assessment of a random sample of HIV-infected children ages 6-14 years enrolled in HIV care at a large referral clinic in Eldoret, Kenya. Clinicians administered questionnaires to children and caregivers independently at routine clinic visits to assess disclosure status, ART adherence, stigma, and depression. Children's demographic and clinical characteristics were extracted from chart review. We calculated descriptive statistics and performed logistic regression to assess the association between disclosure and other characteristics. RESULTS:Two hundred seventy children-caregiver dyads completed questionnaires. The mean child age was 9.3 years (standard deviation 2.6); 49% were male, and 42% were orphans. 11.1% of children had been informed of their HIV status (N = 30). Of those under 10 years, 3.3% knew their status, whereas 9.2% of 10- to 12-year-olds and 39.5% of 13- to 14-year-olds knew they had HIV. Only age was significantly associated with disclosure status in both bivariate analyses (P < .0001) and multiple logistic regression (odds ratio 1.67, 95% confidence interval 1.36-2.05) when considering social demographics, disease stage variables, adherence, stigma measures, and depression. CONCLUSIONS:Rates of informing children in western Kenya of their HIV status are low, even among older children. Guiding families through developmentally appropriate disclosure processes should be a key facet of long-term pediatric HIV management.

authors

Turissini ML,Nyandiko WM,Ayaya SO,Marete I,Mwangi A,Chemboi V,Warui L,Vreeman RC

doi

10.1093/jpids/pit024

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

136-43

issue

2

eissn

2048-7193

issn

2048-7207

pii

pit024

journal_volume

2

pub_type

杂志文章
  • Evaluation of Discharge Antibiotic Prescribing at a Freestanding Children's Hospital: Opportunities for Stewardship.

    abstract::We conducted a retrospective study to evaluate suboptimal discharge antibiotic prescribing at a children's hospital and found that 27% of the prescriptions were suboptimal. Thirty-three percent of the patients who might have qualified for solid dosage forms received liquid dosages instead. Our findings suggest that op...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piy127

    authors: Olson J,Thorell EA,Hersh AL

    更新日期:2019-12-27 00:00:00

  • Epidemiology of Community-Acquired Pneumonia Hospitalizations and Associated Complications Before and After the Implementation of the Heptavalent Pneumococcal Conjugate Vaccine in Athens, Greece.

    abstract::We determined the rates of community-acquired pneumonia (CAP)-associated hospitalizations and complications in Athens, over a period covering 4 years before and 4 years after the implementation of the 7-valent pneumococcal vaccine (PCV7) in Greece. PCV7 had no impact on pediatric CAP rates, whereas there was an increa...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/pit088

    authors: Lagousi T,Papadatou I,Kopsidas I,Critselis E,Theodoridou M,Spoulou V

    更新日期:2015-09-01 00:00:00

  • Frequency of Multidrug-Resistant Organisms Cultured From Urine of Children Undergoing Clean Intermittent Catheterization.

    abstract:Background:Children undergoing CIC frequently have positive urine culture results and receive many antimicrobial agents. Subsequently, this population is at high risk for infections caused by antimicrobial-resistant bacteria. Resistant pathogens, such as vancomycin-resistant Enterococcus (VRE), carbapenem-resistant Ent...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piw056

    authors: Forster CS,Courter J,Jackson EC,Mortensen JE,Haslam DB

    更新日期:2017-11-24 00:00:00

  • Compassionate Use of Letermovir in a 2-Year-Old Immunocompromised Child With Resistant Cytomegalovirus Disease.

    abstract::Little information on the efficacy and pharmacokinetics of letermovir among immunocompromised children is currently available. We describe here the use of letermovir in a 2-year-old immunocompromised child with ganciclovir-resistant cytomegalovirus disease who required extracorporeal membrane oxygenation. Detailed inf...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piz033

    authors: Pérez Marín M,Decosterd LA,Andre P,Buclin T,Mercier T,Murray K,Rizzi M,Meylan P,Jaton-Ogay K,Opota O,Gengler C,Perez MH,Natterer J,Asner SA

    更新日期:2020-02-28 00:00:00

  • Viral Loads in Congenital Cytomegalovirus Infection From a Highly Immune Population.

    abstract::Among newborns with congenital cytomegalovirus (CMV) infection from China, there was no difference in CMV viral load in saliva specimens dried and stored at room temperature compared with those kept wet and stored cold, even after longer storage time for the former than the later (74 vs 58 days, P = .02). ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piy048

    authors: Xu A,Wang S,Zhang W,Wang X,Wang T,Liu X,Wang H,Ma W,Amin M,Dollard S,Wang C

    更新日期:2018-08-17 00:00:00

  • Failure of Syndrome-Based Diarrhea Management Guidelines to Detect Shigella Infections in Kenyan Children.

    abstract:BACKGROUND:Shigella is a leading cause of childhood diarrhea mortality in sub-Saharan Africa. Current World Health Organization guidelines recommend antibiotics for children in non cholera-endemic areas only in the presence of dysentery, a proxy for suspected Shigella infection. METHODS:To assess the sensitivity and s...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piv037

    authors: Pavlinac PB,Denno DM,John-Stewart GC,Onchiri FM,Naulikha JM,Odundo EA,Hulseberg CE,Singa BO,Manhart LE,Walson JL

    更新日期:2016-12-01 00:00:00

  • Quality Improvement Feature Series Article 3: Writing and Reviewing Quality Improvement Manuscripts.

    abstract::Achieving rapid and meaningful improvement in healthcare requires the dissemination of quality improvement project results via publication. Doing this well requires detailed descriptions of the complex interventions and of the context in which the improvement took place. This report builds on the first 2 articles in t...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/pix078

    authors: Schondelmeyer AC,Brower LH,Statile AM,White CM,Brady PW

    更新日期:2018-08-17 00:00:00

  • Infectious Causes of Acute Gastroenteritis in US Children Undergoing Allogeneic Hematopoietic Cell Transplant: A Longitudinal, Multicenter Study.

    abstract:BACKGROUND:Acute gastroenteritis (AGE) in hematopoietic cell transplant (HCT) patients causes significant morbidity and mortality. Data regarding the longitudinal assessment of infectious pathogens during symptomatic AGE and asymptomatic periods, particularly in children, are limited. We investigated the prevalence of ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piz063

    authors: Schuster JE,Johnston SH,Piya B,Dulek DE,Wikswo ME,McHenry R,Browne H,Gautam R,Bowen MD,Vinjé J,Payne DC,Azimi P,Selvarangan R,Halasa N,Englund JA

    更新日期:2020-09-17 00:00:00

  • Fucosyltransferase Gene Polymorphisms and Lewisb-Negative Status Are Frequent in Swedish Newborns, With Implications for Infectious Disease Susceptibility and Personalized Medicine.

    abstract:BACKGROUND:Single-nucleotide polymorphisms (SNPs) in the fucosyltransferase genes FUT2 and FUT3 have been associated with susceptibility to various infectious and inflammatory disorders. FUT variations influence the expression of human histo-blood group antigens (HBGAs) (H-type 1 and Lewis), which are highly expressed ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piy085

    authors: King JR,Varadé J,Hammarström L

    更新日期:2019-12-27 00:00:00

  • Role of Anaerobic Blood Cultures in Neonatal Bacteremia.

    abstract:Background:Evaluation for neonatal sepsis routinely includes performing both aerobic and anaerobic blood cultures despite our lack of knowledge of the true incidence of anaerobic bacteremia in this age group and the consequences of not performing these paired cultures. Methods:We performed a retrospective review of al...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/pix088

    authors: Messbarger N,Neemann K

    更新日期:2018-08-17 00:00:00

  • Association of Routine Chlamydia trachomatis Screening During Pregnancy and Seroprevalence of Chlamydial Infection in Children, 1991-2015.

    abstract::We performed a seroepidemiologic study of sera from children in Brooklyn, New York, before and after the implementation of prenatal chlamydial screening almost 20% of children aged ≤10 years in the prescreening group had anti-Chlamydia trachomatis immunoglobulin G compared with none in the postscreening group. ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piaa002

    authors: Banniettis N,Wisecup K,Boland L,Watanabe I,Hammerschlag MR,Kohlhoff S

    更新日期:2020-01-20 00:00:00

  • Age-Specific Patterns of Influenza Activity in Utah: Do Older School Age Children Drive the Epidemic?

    abstract::Across 12 consecutive influenza seasons in Utah, medically-attended visits for laboratory-confirmed influenza infection peaked first among older children (12-18 years). Peak activity in older children preceded that of children 0-4 years by more than 2 days and that of peak activity among adults ≥65 years by more than ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/pit004

    authors: Stockmann C,Pavia AT,Hersh AL,Spigarelli MG,Castle B,Korgenski K,Byington CL,Ampofo K

    更新日期:2014-06-01 00:00:00

  • Laboratory-Confirmed Rotavirus Disease in Utah Children: Clinical and Economic Impact of Rotavirus Vaccination.

    abstract:BACKGROUND:Rotavirus is the most common cause of infectious diarrhea in children worldwide. Recent studies have described changes in the burden of all-cause gastroenteritis; however, there are limited data on the clinical and economic impact of rotavirus vaccine on cases of laboratory-confirmed rotavirus disease. METH...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/pis058

    authors: Guerra AH,Stockmann C,Pavia AT,Hersh AL,Thorell EA,Weng HY,Korgenski K,Byington CL,Ampofo K

    更新日期:2012-12-01 00:00:00

  • What's New With the Old Coronaviruses?

    abstract::Coronaviruses contribute to the burden of respiratory diseases in children, frequently manifesting in upper respiratory symptoms considered to be part of the "common cold." Recent epidemics of novel coronaviruses recognized in the 21st century have highlighted issues of zoonotic origins of transmissible respiratory vi...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章,评审

    doi:10.1093/jpids/piaa037

    authors: Ogimi C,Kim YJ,Martin ET,Huh HJ,Chiu CH,Englund JA

    更新日期:2020-04-30 00:00:00

  • Ledipasvir/Sofosbuvir in Adolescents With Chronic Hepatitis C Genotype 4 With and Without Hematological Disorders: Virological Efficacy and Impact on Liver Stiffness.

    abstract:BACKGROUND:Egypt has the highest prevalence of hepatitis C virus (HCV) infection. Anti-HCV antibodies were detectable in 3% of children in Upper Egypt. Our aim was to evaluate the efficacy of ledipasvir/sofosbuvir for chronic HCV genotype 4 in adolescents with/without hematological disorders and to determine the effect...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piaa006

    authors: Makhlouf NA,Abdelmalek MO,Ibrahim ME,Abu-Faddan NH,Kheila AE,Mahmoud AA

    更新日期:2020-02-15 00:00:00

  • Successful Treatment of Parainfluenza Virus Respiratory Tract Infection With DAS181 in 4 Immunocompromised Children.

    abstract:BACKGROUND:Parainfluenza virus (PIV), a common pediatric pathogen, is associated with significant morbidity in immunocompromised (IC) hosts. DAS181, a novel sialidase fusion protein inhibitor, seems to be effective against PIV in vitro and in vivo; its use in IC children has not been evaluated. METHODS:Patients were d...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piu039

    authors: Waghmare A,Wagner T,Andrews R,Smith S,Kuypers J,Boeckh M,Moss R,Englund JA

    更新日期:2015-06-01 00:00:00

  • A Prospective, International Cohort Study of Invasive Mold Infections in Children.

    abstract:BACKGROUND:Invasive mold infections (IMIs) are a leading cause of mortality in immunocompromised children, yet there has never been an international epidemiologic investigation of pediatric IMIs. METHODS:This international, prospective cohort study was performed to characterize the epidemiology, antifungal therapy, an...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jpids/piu074

    authors: Wattier RL,Dvorak CC,Hoffman JA,Brozovich AA,Bin-Hussain I,Groll AH,Castagnola E,Knapp KM,Zaoutis TE,Gustafsson B,Sung L,Berman D,Halasa NB,Abzug MJ,Velegraki A,Sharma TS,Fisher BT,Steinbach WJ

    更新日期:2015-12-01 00:00:00

  • Factors Associated With Retention Among Non-Perinatally HIV-Infected Youth in the HIV Research Network.

    abstract:BACKGROUND:The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piu102

    authors: Farmer C,Yehia BR,Fleishman JA,Rutstein R,Mathews WC,Nijhawan A,Moore RD,Gebo KA,Agwu AL,HIV Research Network.

    更新日期:2016-03-01 00:00:00

  • Disseminated Tularemia: Finding the Needle in the Haystack.

    abstract::We report a case of disseminated tularemia in a previously healthy 8-month-old male. This case highlights an atypical presentation of tularemia with multisystem organ involvement. The diagnosis was complicated by concurrent primary cytomegalovirus infection. Bronchoalveolar lavage culture confirmed the diagnosis. The ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piaa066

    authors: Stringham S,Green Hines A,Attebery J,Darwin L,Wachholtz A,Deschamp A,Choudhry O,Neemann K

    更新日期:2020-06-14 00:00:00

  • Clinical Features and Outcomes of Children with Culture-Negative Septic Arthritis.

    abstract:BACKGROUND:Septic arthritis is a serious infection, but the results of blood and joint fluid cultures are often negative in children. We describe here the clinical features and management of culture-negative septic arthritis in children at our hospital and their outcomes. METHODS:We performed a retrospective review of...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piy034

    authors: Spyridakis E,Gerber JS,Schriver E,Grundmeier RW,Porsch EA,St Geme JW,Downes KJ

    更新日期:2019-07-01 00:00:00

  • Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome.

    abstract::We report here 18 cases of pediatric group A streptococcal toxic shock syndrome, associated clinical findings, and bacterial molecular genetic characteristics discovered through whole-genome sequencing. This comparative whole-genome sequencing revealed unique gene content (speK) and polymorphisms (dpiB) in emm87 group...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piy069

    authors: Deniskin R,Shah B,Muñoz FM,Flores AR

    更新日期:2019-07-01 00:00:00

  • Regional Epidemiology of Methicillin-Resistant Staphylococcus aureus Among Critically Ill Children in a State With Mandated Active Surveillance.

    abstract:BACKGROUND:In theory, active surveillance of methicillin-resistant Staphylococcus aureus (MRSA) reduces MRSA spread by identifying all MRSA-colonized patients and placing them under contact precautions. In October 2007, Illinois mandated active MRSA surveillance in all intensive care units, including neonatal intensive...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piv050

    authors: Lyles RD,Trick WE,Hayden MK,Lolans K,Fogg L,Logan LK,Shulman ST,Weinstein RA,Lin MY,Centers for Disease Control and Prevention, Prevention Epicenters Program.

    更新日期:2016-12-01 00:00:00

  • A Different Epidemiology of Enterovirus A and Enterovirus B Co-circulating in Korea, 2012-2019.

    abstract:BACKGROUND:Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012-2019 based on national surveillance. METHO...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piaa111

    authors: Kang HJ,Yoon Y,Lee YP,Kim HJ,Lee DY,Lee JW,Hyeon JY,Yoo JS,Lee S,Kang C,Choi W,Han MG

    更新日期:2020-11-05 00:00:00

  • Clinical Characteristics of Hospitalized Infants With Laboratory-Confirmed Pertussis in Guatemala.

    abstract:Background:Pertussis is an important cause of hospitalization and death in infants too young to be vaccinated (aged <2 months). Limited data on infant pertussis have been reported from Central America. The aim of this study was to characterize acute respiratory illnesses (ARIs) attributable to Bordetella pertussis amon...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/pix081

    authors: Phadke VK,McCracken JP,Kriss JL,Lopez MR,Lindblade KA,Bryan JP,Garcia ME,Funes CE,Omer SB

    更新日期:2018-12-03 00:00:00

  • Clinical Impact of Malaria Rapid Diagnostic Testing at a US Children's Hospital.

    abstract:BACKGROUND:Children who develop malaria after returning to a setting in which the disease is not endemic are at high risk for critical delays in diagnosis and initiation of antimalarial therapy. We assessed the clinical impact of the implementation of malaria rapid diagnostic testing (RDT) on the management of children...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piz022

    authors: Enane LA,Sullivan KV,Spyridakis E,Feemster KA

    更新日期:2020-07-13 00:00:00

  • Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity.

    abstract:BACKGROUND:Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics. METHODS:We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diag...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piz014

    authors: Wangrangsimakul T,Greer RC,Chanta C,Nedsuwan S,Blacksell SD,Day NPJ,Paris DH

    更新日期:2020-04-30 00:00:00

  • Risk of Repeated Admissions for Respiratory Syncytial Virus in a Cohort of >10 000 Hospitalized Children.

    abstract:BACKGROUND:The objective was to describe respiratory syncytial virus (RSV) hospitalizations in Alberta, Canada over a 13-year period with an emphasis on the incidence and risk factors for repeat hospitalizations attributable to new RSV infections. METHODS:This was a retrospective database analysis. The Alberta Health ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piaa077

    authors: Wong K,Robinson JL,Hawkes MT

    更新日期:2020-07-24 00:00:00

  • First 12 Months of Life for Infants in New York City, New York, With Possible Congenital Zika Virus Exposure.

    abstract:BACKGROUND:Our goal was to characterize the epidemiology and clinical significance of congenital Zika virus (ZIKV) exposure by prospectively following a cohort of infants with possible congenital exposure through their first year of life. METHODS:We included infants born in New York City between 2016 and 2017 who had ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piz027

    authors: Lee EH,Cooper H,Iwamoto M,Lash M,Conners EE,Bloch D,Clark S,Hrusa G,Kubinson H,Paladini M,McGibbon E,Rakeman JL,Fine AD,Limberger RJ,Liu D,Slavinski S,New York City Department of Health and Mental Hygiene Zika Working Gro

    更新日期:2020-07-13 00:00:00

  • Physician-to-Physician Electronic Consultation: A Tool for the Pediatric Infectious Diseases Specialist to Document Encounters and Quantify Effort.

    abstract::E-consults replace "curbside" interactions, facilitate provider-specialist communication, document within the medical record, and track relative value units (RVUs). Pediatric infectious diseases (PID) E-consults commonly relate to vaccines, exposures, diagnoses, and treatments. The documented RVU effort of 197 consecu...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章

    doi:10.1093/jpids/piaa041

    authors: Gonzalez BE,Sabella C,Esper FP,Daniels HL,Saracusa C,Boutros J,Foster CB

    更新日期:2020-05-05 00:00:00

  • Trichosporonosis in Pediatric Patients With a Hematologic Disorder.

    abstract:Background:Trichosporonosis is an emerging and often fatal opportunistic fungal infection in immunocompromised patients, particularly those with hematologic malignancy, but data in children are lacking. Methods:We report here 3 cases of invasive infection caused by Trichosporon asahii in pediatric patients with acute ...

    journal_title:Journal of the Pediatric Infectious Diseases Society

    pub_type: 杂志文章,评审

    doi:10.1093/jpids/pix031

    authors: Foster CE,Edwards MS,Brackett J,Schady DA,Healy CM,Baker CJ

    更新日期:2018-08-17 00:00:00