What's New With the Old Coronaviruses?

abstract：BACKGROUND:Shiga toxin (Stx)-producing Escherichia coli (STECs) are the most common cause of acute renal failure in children. The present study evaluated a 10-year STEC polymerase chain reaction screening regimen in children. METHODS:All routine stool culture specimens from patients below 10 years of age (n = 10 342) ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Matussek A,Einemo IM,Jogenfors A,Löfdahl S,Löfgren S

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:In November 2020, the US Food and Drug Administration (FDA) provided Emergency Use Authorizations (EUA) for two novel virus-neutralizing monoclonal antibody therapies, bamlanivimab, and REGN-COV2 (casirivimab plus imdevimab), for the treatment of mild to moderate COVID-19 in adolescents and adults in specifi...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Wolf J,Abzug MJ,Wattier RL,Sue PK,Vora SB,Zachariah P,Dulek DE,Waghmare A,Olivero R,Downes KJ,James SH,Pinninti SG,Yarbrough A,Aldrich ML,MacBrayne CE,Soma VL,Grapentine SP,Oliveira CR,Hayes M,Kimberlin DW,Jones S

更新日期：2021-01-03 00:00:00

abstract：BACKGROUND:Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics. METHODS:We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diag...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Wangrangsimakul T,Greer RC,Chanta C,Nedsuwan S,Blacksell SD,Day NPJ,Paris DH

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012-2019 based on national surveillance. METHO...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Kang HJ,Yoon Y,Lee YP,Kim HJ,Lee DY,Lee JW,Hyeon JY,Yoo JS,Lee S,Kang C,Choi W,Han MG

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, st...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Simon TD,Kronman MP,Whitlock KB,Browd SR,Holubkov R,Kestle JRW,Kulkarni AV,Langley M,Limbrick DD,Luerssen TG,Oakes J,Riva-Cambrin J,Rozzelle C,Shannon CN,Tamber M,Wellons Iii JC,Whitehead WE,Mayer-Hamblett N,Hydroceph

更新日期：2019-07-01 00:00:00

abstract：Background:Pseudomonas aeruginosa is a common cause of healthcare-associated infection. Multidrug-resistant (MDR) (>3 classes) and carbapenem-resistant (CR) P aeruginosa are significant threats globally. We used a large reference-laboratory database to study the epidemiology of P aeruginosa in children in the United St...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Logan LK,Gandra S,Mandal S,Klein EY,Levinson J,Weinstein RA,Laxminarayan R,Prevention Epicenters Program, US Centers for Disease Control and Prevention.

更新日期：2017-11-24 00:00:00

abstract：:We conducted a survey of pediatric members of the Emerging Infections Network regarding outpatient parenteral antimicrobial therapy (OPAT) practices and clinical decision making about OPAT initiation. We identified substantial variation in characteristics and resources of pediatric OPAT practices. Opportunities to imp...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Banerjee R,Beekmann SE,Doby EH,Polgreen PM,Rathore MH,Hersh AL

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Children who develop malaria after returning to a setting in which the disease is not endemic are at high risk for critical delays in diagnosis and initiation of antimalarial therapy. We assessed the clinical impact of the implementation of malaria rapid diagnostic testing (RDT) on the management of children...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Enane LA,Sullivan KV,Spyridakis E,Feemster KA

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Rotavirus is the most common cause of infectious diarrhea in children worldwide. Recent studies have described changes in the burden of all-cause gastroenteritis; however, there are limited data on the clinical and economic impact of rotavirus vaccine on cases of laboratory-confirmed rotavirus disease. METH...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Guerra AH,Stockmann C,Pavia AT,Hersh AL,Thorell EA,Weng HY,Korgenski K,Byington CL,Ampofo K

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Endothelial activation may contribute to development of severe disease from Plasmodium falciparum infection, but optimal markers of endothelial activation in severe malaria, the extent of endothelial activation in asymptomatic infection, and the effect of blood group O on endothelial activation have not been...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Park GS,Ireland KF,Opoka RO,John CC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Despite a high burden of staphylococcal skin disease in children and high incidence of Staphylococcus aureus bacteremia in adult Indigenous populations in northern Australia, there are few studies describing incidence or clinical information of invasive S aureus (ISA) infections in children. METHODS:We cond...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Engelman D,Hofer A,Davis JS,Carapetis JR,Baird RW,Giffard PM,Holt DC,Tong SY

更新日期：2014-12-01 00:00:00

abstract：:The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice. Attention to 5 major areas hold the promise of making new antibiotics available for use in chil...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Noel GJ,Nambiar S,Bradley J,Clinical Trials Transformation Initiative’s Pediatric Antibiotic Drug Development Program.

更新日期：2019-03-28 00:00:00

abstract：Background:Evaluation for neonatal sepsis routinely includes performing both aerobic and anaerobic blood cultures despite our lack of knowledge of the true incidence of anaerobic bacteremia in this age group and the consequences of not performing these paired cultures. Methods:We performed a retrospective review of al...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Messbarger N,Neemann K

更新日期：2018-08-17 00:00:00

abstract：:Across 12 consecutive influenza seasons in Utah, medically-attended visits for laboratory-confirmed influenza infection peaked first among older children (12-18 years). Peak activity in older children preceded that of children 0-4 years by more than 2 days and that of peak activity among adults ≥65 years by more than ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Stockmann C,Pavia AT,Hersh AL,Spigarelli MG,Castle B,Korgenski K,Byington CL,Ampofo K

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Data on human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection among children in Africa are limited. We evaluated the seroprevalence of both viruses among healthy, HIV-uninfected children and HIV-infected children in the Kilimanjaro region of northern Tanzania....

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Muro FJ,Fiorillo SP,Sakasaka P,Odhiambo C,Reddy EA,Cunningham CK,Buchanan AM

更新日期：2013-12-01 00:00:00

abstract：:Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occu...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Higa N,Pelz A,Birch D,Beck IA,Sils T,Samson P,Bwakura-Dangarembizi M,Bolton-Moore C,Capparelli E,Chadwick E,Frenkel LM

更新日期：2020-04-30 00:00:00

abstract：:Recent guidelines recommend empiric vancomycin dosing of 60 mg/kg per day and consideration of higher trough concentrations (15-20 mcg/mL) in children with invasive infections. In this study, we report a retrospective review evaluating the dose/trough relationship and predicted area under the curve in pediatric patien...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Chhim RF,Arnold SR,Lee KR

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Parainfluenza virus (PIV), a common pediatric pathogen, is associated with significant morbidity in immunocompromised (IC) hosts. DAS181, a novel sialidase fusion protein inhibitor, seems to be effective against PIV in vitro and in vivo; its use in IC children has not been evaluated. METHODS:Patients were d...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Waghmare A,Wagner T,Andrews R,Smith S,Kuypers J,Boeckh M,Moss R,Englund JA

更新日期：2015-06-01 00:00:00

abstract：Key points:The effectiveness of pentavalent rotavirus vaccine against rotavirus-associated hospitalization was more than 90% 4 years after introduction into the national immunization program in Finland. A major impact on hospitalization for all-cause gastroenteritis was observed also. Background:Rotavirus vaccination ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Hemming-Harlo M,Vesikari T,Uhari M,Renko M,Salminen M,Torcel-Pagnon L,Hartwig S,Simondon F,Bricout H

更新日期：2017-11-24 00:00:00

abstract：Background:Data on long-term toxicity of antiretroviral therapy (ART) in HIV-infected children are sparse. PENPACT-1 was an open-label trial in which HIV-infected children were assigned randomly to receive protease inhibitor (PI)- or nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based ART. Methods:We examined ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Melvin AJ,Warshaw M,Compagnucci A,Saidi Y,Harrison L,Turkova A,Tudor-Williams G,PENPACT-1 (PENTA 9\/PACTG 390\/ANRS 103) Study Team.

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:P1093 is an ongoing phase I/II multicenter open-label study of dolutegravir plus an optimized background regimen in age-defined pediatric cohorts; here we report the long-term safety and virologic efficacy outcomes for the oldest cohort. METHODS:The study enrolled human immunodeficiency virus type 1 (HIV-1)...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Viani RM,Ruel T,Alvero C,Fenton T,Acosta EP,Hazra R,Townley E,Palumbo P,Buchanan AM,Vavro C,Singh R,Graham B,Anthony P,George K,Wiznia A,P1093 Study Team .

更新日期：2020-04-30 00:00:00

abstract：Background:Children undergoing CIC frequently have positive urine culture results and receive many antimicrobial agents. Subsequently, this population is at high risk for infections caused by antimicrobial-resistant bacteria. Resistant pathogens, such as vancomycin-resistant Enterococcus (VRE), carbapenem-resistant Ent...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Forster CS,Courter J,Jackson EC,Mortensen JE,Haslam DB

更新日期：2017-11-24 00:00:00

abstract：:Frontline clinicians caring for hospitalized children typically knew the indication for antimicrobial therapy but less often knew the current day or planned duration of therapy or of plans for intravenous to oral conversion. Night shift clinicians were less likely to know day of therapy and duration of therapy than da...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Larru B,Sulieman SE,Localio R,Ross RK,Sharland M,Zaoutis TE,Gerber JS

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Single-nucleotide polymorphisms (SNPs) in the fucosyltransferase genes FUT2 and FUT3 have been associated with susceptibility to various infectious and inflammatory disorders. FUT variations influence the expression of human histo-blood group antigens (HBGAs) (H-type 1 and Lewis), which are highly expressed ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： King JR,Varadé J,Hammarström L

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Farmer C,Yehia BR,Fleishman JA,Rutstein R,Mathews WC,Nijhawan A,Moore RD,Gebo KA,Agwu AL,HIV Research Network.

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:In theory, active surveillance of methicillin-resistant Staphylococcus aureus (MRSA) reduces MRSA spread by identifying all MRSA-colonized patients and placing them under contact precautions. In October 2007, Illinois mandated active MRSA surveillance in all intensive care units, including neonatal intensive...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Lyles RD,Trick WE,Hayden MK,Lolans K,Fogg L,Logan LK,Shulman ST,Weinstein RA,Lin MY,Centers for Disease Control and Prevention, Prevention Epicenters Program.

更新日期：2016-12-01 00:00:00

abstract：OF KEY POINTS:Although relatively rare, invasive meningococcal disease continues to be a health concern, especially in young children. This systematic review clearly delineates both the near- and long-term morbidities that can occur after, and persist beyond, the period of acute illness. BACKGROUND:Although rare, inva...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Strifler L,Morris SK,Dang V,Tu HA,Minhas RS,Jamieson FB,Deeks SL,Crowcroft NS,Sander B

更新日期：2016-12-01 00:00:00

abstract：:Pythium insidiosum, also known as "swamp cancer," has been long known for its destructive effects on plants and animals. Infections with this fungus-like organism typically occur in temperate, tropical, and subtropical regions [ 1]. Human infection with P insidiosum, although exceedingly rare, is characterized by inva...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Kirzhner M,Arnold SR,Lyle C,Mendoza LL,Fleming JC

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Prevention strategies for cytomegalovirus (CMV) in pediatric transplant recipients are sparsely reported. A hybrid strategy that combines prophylaxis with preemptive therapy using serial CMV viral load monitoring is an emerging option. We report our clinical outcomes with a hybrid strategy in pediatric heart...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Lin A,Worley S,Brubaker J,Boyle G,Nasman C,Sabella C,Danziger-Isakov LA

更新日期：2012-12-01 00:00:00

abstract：:Actinomycetes are Gram-positive bacteria that can be part of the normal human flora of the gastrointestinal, pulmonary, and genital tract. Infections are rare, slowly progressing and most commonly affect the cervicofacial region. Actinomyces israelii is the most frequently isolated species but a number of other specie...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Walther K,Bruder E,Goldenberger D,Mayr J,Schaad UB,Ritz N

更新日期：2015-09-01 00:00:00