当前位置： SCI文献检索 > Journal of the Pediatric Infectious Diseases Society期刊下所有文献 > A Prospective, International Cohort Study of Invasive Mold Infections in Children.

A Prospective, International Cohort Study of Invasive Mold Infections in Children.

Abstract：

BACKGROUND:Invasive mold infections (IMIs) are a leading cause of mortality in immunocompromised children, yet there has never been an international epidemiologic investigation of pediatric IMIs. METHODS:This international, prospective cohort study was performed to characterize the epidemiology, antifungal therapy, and outcomes of pediatric IMIs. Children (≤18 years) with proven or probable IMIs were enrolled between August 2007 and May 2011 at 22 sites. Risk factors, underlying diagnoses, and treatments were recorded. Outcomes were assessed at 12 weeks after diagnosis using European Organization for Research and Treatment of Cancer/Mycoses Study Group response criteria. RESULTS:One hundred thirty-one pediatric patients with IMIs were enrolled; the most common IMI was invasive aspergillosis ([IA] 75%). Children with IA and those with other types of IMIs had similar underlying risk factors, except that children with IMIs caused by non-Aspergillus species were more likely to have received mold-active antifungal agents preceding diagnosis. The most commonly used antifungal classes after diagnosis were triazoles (82%) and polyenes (63%). Combination therapy was used in 53% of patients. Use of combination therapy was associated with an increased risk of adverse events (risk ratio, 1.98; 95% confidence interval, 1.06-3.68; P = .031), although there was no detectable difference in outcome. CONCLUSIONS:Although risk factors for IMIs are similar across specific subtypes, preceding antifungal therapy may be an important modifier. Combination antifungal therapy requires further study to determine its true risks and benefits.

journal_name

J Pediatric Infect Dis Soc

journal_title

Journal of the Pediatric Infectious Diseases Society

authors

Wattier RL,Dvorak CC,Hoffman JA,Brozovich AA,Bin-Hussain I,Groll AH,Castagnola E,Knapp KM,Zaoutis TE,Gustafsson B,Sung L,Berman D,Halasa NB,Abzug MJ,Velegraki A,Sharma TS,Fisher BT,Steinbach WJ

doi

10.1093/jpids/piu074

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

313-22

issue

4

eissn

2048-7193

issn

2048-7207

pii

piu074

journal_volume

4

pub_type

杂志文章,多中心研究

相关文献

Journal of the Pediatric Infectious Diseases Society文献大全
  • Age-Specific Patterns of Influenza Activity in Utah: Do Older School Age Children Drive the Epidemic?

    abstract：:Across 12 consecutive influenza seasons in Utah, medically-attended visits for laboratory-confirmed influenza infection peaked first among older children (12-18 years). Peak activity in older children preceded that of children 0-4 years by more than 2 days and that of peak activity among adults ≥65 years by more than ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pit004

    authors： Stockmann C,Pavia AT,Hersh AL,Spigarelli MG,Castle B,Korgenski K,Byington CL,Ampofo K

    更新日期：2014-06-01 00:00:00

  • Epidemiology of Community-Acquired Pneumonia Hospitalizations and Associated Complications Before and After the Implementation of the Heptavalent Pneumococcal Conjugate Vaccine in Athens, Greece.

    abstract：:We determined the rates of community-acquired pneumonia (CAP)-associated hospitalizations and complications in Athens, over a period covering 4 years before and 4 years after the implementation of the 7-valent pneumococcal vaccine (PCV7) in Greece. PCV7 had no impact on pediatric CAP rates, whereas there was an increa...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pit088

    authors： Lagousi T,Papadatou I,Kopsidas I,Critselis E,Theodoridou M,Spoulou V

    更新日期：2015-09-01 00:00:00

  • Patient and Treatment Characteristics by Infecting Organism in Cerebrospinal Fluid Shunt Infection.

    abstract：BACKGROUND:Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, st...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piy035

    authors： Simon TD,Kronman MP,Whitlock KB,Browd SR,Holubkov R,Kestle JRW,Kulkarni AV,Langley M,Limbrick DD,Luerssen TG,Oakes J,Riva-Cambrin J,Rozzelle C,Shannon CN,Tamber M,Wellons Iii JC,Whitehead WE,Mayer-Hamblett N,Hydroceph

    更新日期：2019-07-01 00:00:00

  • Primary and Repeated Respiratory Viral Infections Among Infants in Rural Nepal.

    abstract：BACKGROUND:Respiratory viruses cause significant morbidity and death in infants; 99% of such deaths occur in resource-limited settings. Risk factors for initial and repeated respiratory viral infections in young infants in resource-limited settings have not been well described. METHODS:From 2011 to 2014, a birth cohor...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piy107

    authors： Boonyaratanakornkit J,Englund JA,Magaret AS,Bu Y,Tielsch JM,Khatry SK,Katz J,Kuypers J,Shrestha L,LeClerq SC,Steinhoff MC,Chu HY

    更新日期：2020-02-28 00:00:00

  • Association of Routine Chlamydia trachomatis Screening During Pregnancy and Seroprevalence of Chlamydial Infection in Children, 1991-2015.

    abstract：:We performed a seroepidemiologic study of sera from children in Brooklyn, New York, before and after the implementation of prenatal chlamydial screening almost 20% of children aged ≤10 years in the prescreening group had anti-Chlamydia trachomatis immunoglobulin G compared with none in the postscreening group. ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piaa002

    authors： Banniettis N,Wisecup K,Boland L,Watanabe I,Hammerschlag MR,Kohlhoff S

    更新日期：2020-01-20 00:00:00

  • Inpatient Antimicrobial Stewardship in Pediatrics: A Systematic Review.

    abstract：BACKGROUND:The clinical and economic outcomes associated with pediatric antimicrobial stewardship programs (ASPs) and other supplemental antimicrobial stewardship (AS) interventions have not been well described or reviewed. METHODS:We performed a systematic review using PubMed to identify studies with any of the follo...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章,评审

    doi：10.1093/jpids/piu141

    authors： Smith MJ,Gerber JS,Hersh AL

    更新日期：2015-12-01 00:00:00

  • Fucosyltransferase Gene Polymorphisms and Lewisb-Negative Status Are Frequent in Swedish Newborns, With Implications for Infectious Disease Susceptibility and Personalized Medicine.

    abstract：BACKGROUND:Single-nucleotide polymorphisms (SNPs) in the fucosyltransferase genes FUT2 and FUT3 have been associated with susceptibility to various infectious and inflammatory disorders. FUT variations influence the expression of human histo-blood group antigens (HBGAs) (H-type 1 and Lewis), which are highly expressed ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piy085

    authors： King JR,Varadé J,Hammarström L

    更新日期：2019-12-27 00:00:00

  • Laboratory-Confirmed Rotavirus Disease in Utah Children: Clinical and Economic Impact of Rotavirus Vaccination.

    abstract：BACKGROUND:Rotavirus is the most common cause of infectious diarrhea in children worldwide. Recent studies have described changes in the burden of all-cause gastroenteritis; however, there are limited data on the clinical and economic impact of rotavirus vaccine on cases of laboratory-confirmed rotavirus disease. METH...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pis058

    authors： Guerra AH,Stockmann C,Pavia AT,Hersh AL,Thorell EA,Weng HY,Korgenski K,Byington CL,Ampofo K

    更新日期：2012-12-01 00:00:00

  • Seroprevalence of Hepatitis B and C Viruses Among Children in Kilimanjaro Region, Tanzania.

    abstract：BACKGROUND:Data on human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection among children in Africa are limited. We evaluated the seroprevalence of both viruses among healthy, HIV-uninfected children and HIV-infected children in the Kilimanjaro region of northern Tanzania....

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pit018

    authors： Muro FJ,Fiorillo SP,Sakasaka P,Odhiambo C,Reddy EA,Cunningham CK,Buchanan AM

    更新日期：2013-12-01 00:00:00

  • Clinical Characteristics of Hospitalized Infants With Laboratory-Confirmed Pertussis in Guatemala.

    abstract：Background:Pertussis is an important cause of hospitalization and death in infants too young to be vaccinated (aged <2 months). Limited data on infant pertussis have been reported from Central America. The aim of this study was to characterize acute respiratory illnesses (ARIs) attributable to Bordetella pertussis amon...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pix081

    authors： Phadke VK,McCracken JP,Kriss JL,Lopez MR,Lindblade KA,Bryan JP,Garcia ME,Funes CE,Omer SB

    更新日期：2018-12-03 00:00:00

  • Evidence of Endothelial Activation in Asymptomatic Plasmodium falciparum Parasitemia and Effect of Blood Group on Levels of von Willebrand Factor in Malaria.

    abstract：BACKGROUND:Endothelial activation may contribute to development of severe disease from Plasmodium falciparum infection, but optimal markers of endothelial activation in severe malaria, the extent of endothelial activation in asymptomatic infection, and the effect of blood group O on endothelial activation have not been...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pis010

    authors： Park GS,Ireland KF,Opoka RO,John CC

    更新日期：2012-03-01 00:00:00

  • Successful Treatment of Parainfluenza Virus Respiratory Tract Infection With DAS181 in 4 Immunocompromised Children.

    abstract：BACKGROUND:Parainfluenza virus (PIV), a common pediatric pathogen, is associated with significant morbidity in immunocompromised (IC) hosts. DAS181, a novel sialidase fusion protein inhibitor, seems to be effective against PIV in vitro and in vivo; its use in IC children has not been evaluated. METHODS:Patients were d...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piu039

    authors： Waghmare A,Wagner T,Andrews R,Smith S,Kuypers J,Boeckh M,Moss R,Englund JA

    更新日期：2015-06-01 00:00:00

  • Clinical Features and Outcomes of Children with Culture-Negative Septic Arthritis.

    abstract：BACKGROUND:Septic arthritis is a serious infection, but the results of blood and joint fluid cultures are often negative in children. We describe here the clinical features and management of culture-negative septic arthritis in children at our hospital and their outcomes. METHODS:We performed a retrospective review of...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piy034

    authors： Spyridakis E,Gerber JS,Schriver E,Grundmeier RW,Porsch EA,St Geme JW,Downes KJ

    更新日期：2019-07-01 00:00:00

  • First 12 Months of Life for Infants in New York City, New York, With Possible Congenital Zika Virus Exposure.

    abstract：BACKGROUND:Our goal was to characterize the epidemiology and clinical significance of congenital Zika virus (ZIKV) exposure by prospectively following a cohort of infants with possible congenital exposure through their first year of life. METHODS:We included infants born in New York City between 2016 and 2017 who had ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piz027

    authors： Lee EH,Cooper H,Iwamoto M,Lash M,Conners EE,Bloch D,Clark S,Hrusa G,Kubinson H,Paladini M,McGibbon E,Rakeman JL,Fine AD,Limberger RJ,Liu D,Slavinski S,New York City Department of Health and Mental Hygiene Zika Working Gro

    更新日期：2020-07-13 00:00:00

  • Assessment of Cytomegalovirus Hybrid Preventative Strategy in Pediatric Heart Transplant Patients.

    abstract：BACKGROUND:Prevention strategies for cytomegalovirus (CMV) in pediatric transplant recipients are sparsely reported. A hybrid strategy that combines prophylaxis with preemptive therapy using serial CMV viral load monitoring is an emerging option. We report our clinical outcomes with a hybrid strategy in pediatric heart...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pis056

    authors： Lin A,Worley S,Brubaker J,Boyle G,Nasman C,Sabella C,Danziger-Isakov LA

    更新日期：2012-12-01 00:00:00

  • Epidemiology of Invasive Fungal Disease in Children.

    abstract：:Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the grow...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章,评审

    doi：10.1093/jpids/pix046

    authors： Pana ZD,Roilides E,Warris A,Groll AH,Zaoutis T

    更新日期：2017-09-01 00:00:00

  • Breastfeeding by Women Living With Human Immunodeficiency Virus in a Resource-Rich Setting: A Case Series of Maternal and Infant Management and Outcomes.

    abstract：:The reduction in human immunodeficiency virus (HIV) transmission through breastmilk with maternal combination antiretroviral therapy (cART) has led many pregnant women living with HIV and healthcare providers to question exclusive formula feeding in resource-rich settings. Here, we describe cART prophylaxis in 3 breas...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piz003

    authors： Nashid N,Khan S,Loutfy M,MacGillivray J,Yudin MH,Campbell DM,Barozzino T,Baqi M,Read SE,Bitnun A

    更新日期：2020-04-30 00:00:00

  • What's New With the Old Coronaviruses?

    abstract：:Coronaviruses contribute to the burden of respiratory diseases in children, frequently manifesting in upper respiratory symptoms considered to be part of the "common cold." Recent epidemics of novel coronaviruses recognized in the 21st century have highlighted issues of zoonotic origins of transmissible respiratory vi...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章,评审

    doi：10.1093/jpids/piaa037

    authors： Ogimi C,Kim YJ,Martin ET,Huh HJ,Chiu CH,Englund JA

    更新日期：2020-04-30 00:00:00

  • Invasive Fungal Disease in Pediatric Solid Organ Transplant Recipients.

    abstract：Background:Solid organ transplant (SOT) recipients are at risk for invasive fungal disease (IFD). Data on IFD burden in pediatric patients are limited. We aimed to determine the incidence and outcome of IFD in a large cohort of pediatric patients who underwent SOT. Methods:A single-center cohort of pediatric patients ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pix041

    authors： Saxena S,Gee J,Klieger S,Kajon A,Petersen H,Zaoutis T,Fisher B

    更新日期：2018-08-17 00:00:00

  • Disseminated Tularemia: Finding the Needle in the Haystack.

    abstract：:We report a case of disseminated tularemia in a previously healthy 8-month-old male. This case highlights an atypical presentation of tularemia with multisystem organ involvement. The diagnosis was complicated by concurrent primary cytomegalovirus infection. Bronchoalveolar lavage culture confirmed the diagnosis. The ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piaa066

    authors： Stringham S,Green Hines A,Attebery J,Darwin L,Wachholtz A,Deschamp A,Choudhry O,Neemann K

    更新日期：2020-06-14 00:00:00

  • Role of Anaerobic Blood Cultures in Neonatal Bacteremia.

    abstract：Background:Evaluation for neonatal sepsis routinely includes performing both aerobic and anaerobic blood cultures despite our lack of knowledge of the true incidence of anaerobic bacteremia in this age group and the consequences of not performing these paired cultures. Methods:We performed a retrospective review of al...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pix088

    authors： Messbarger N,Neemann K

    更新日期：2018-08-17 00:00:00

  • Automated Screening of Hospitalized Children for Influenza Vaccination.

    abstract：BACKGROUND:This study was designed to determine whether an automated hospital-based influenza vaccination screening program leveraging the electronic medical record (EMR) increases vaccination rates. METHODS:We performed a retrospective cohort study of all children ≥6 months old admitted to medical, surgical, rehabili...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pit044

    authors： Pollack AH,Kronman MP,Zhou C,Zerr DM

    更新日期：2014-03-01 00:00:00

  • The Prevalence of Disclosure of HIV Status to HIV-Infected Children in Western Kenya.

    abstract：BACKGROUND:As antiretroviral therapy (ART) allows the world's 2.3 million human immunodeficiency virus (HIV)-infected children to grow and thrive, these children need to be informed of their HIV status. Neither the prevalence of disclosure to children nor its impact has been evaluated in most resource-limited settings....

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pit024

    authors： Turissini ML,Nyandiko WM,Ayaya SO,Marete I,Mwangi A,Chemboi V,Warui L,Vreeman RC

    更新日期：2013-06-01 00:00:00

  • Infections Within the First Month After Pediatric Lung Transplantation: Epidemiology and Impact on Outcomes.

    abstract：BACKGROUND:Despite successes in lung transplantation, with infection as the leading cause of death in the first year following lung transplantation, there remains a lag in survival compared with other solid organ transplants. Infections that occur early after transplantation may impact short- and long-term outcomes in ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piaa050

    authors： Onyearugbulem C,Coss-Bu J,Gazzaneo MC,Melicoff E,Das S,Lam F,Mallory GB,Munoz FM

    更新日期：2020-06-13 00:00:00

  • Vancomycin Dosing Practices, Trough Concentrations, and Predicted Area Under the Curve in Children With Suspected Invasive Staphylococcal Infections.

    abstract：:Recent guidelines recommend empiric vancomycin dosing of 60 mg/kg per day and consideration of higher trough concentrations (15-20 mcg/mL) in children with invasive infections. In this study, we report a retrospective review evaluating the dose/trough relationship and predicted area under the curve in pediatric patien...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pis083

    authors： Chhim RF,Arnold SR,Lee KR

    更新日期：2013-09-01 00:00:00

  • Hepatic, Renal, Hematologic, and Inflammatory Markers in HIV-Infected Children on Long-term Suppressive Antiretroviral Therapy.

    abstract：Background:Data on long-term toxicity of antiretroviral therapy (ART) in HIV-infected children are sparse. PENPACT-1 was an open-label trial in which HIV-infected children were assigned randomly to receive protease inhibitor (PI)- or nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based ART. Methods:We examined ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pix050

    authors： Melvin AJ,Warshaw M,Compagnucci A,Saidi Y,Harrison L,Turkova A,Tudor-Williams G,PENPACT-1 (PENTA 9\/PACTG 390\/ANRS 103) Study Team.

    更新日期：2017-09-01 00:00:00

  • Guillain-Barré Syndrome Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Detection and Coronavirus Disease 2019 in a Child.

    abstract：:Coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barré syndrome (GBS), followed by 5 adult Italian patients and anoth...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piaa086

    authors： Khalifa M,Zakaria F,Ragab Y,Saad A,Bamaga A,Emad Y,Rasker JJ

    更新日期：2020-09-17 00:00:00

  • Risk of Repeated Admissions for Respiratory Syncytial Virus in a Cohort of >10 000 Hospitalized Children.

    abstract：BACKGROUND:The objective was to describe respiratory syncytial virus (RSV) hospitalizations in Alberta, Canada over a 13-year period with an emphasis on the incidence and risk factors for repeat hospitalizations attributable to new RSV infections. METHODS:This was a retrospective database analysis. The Alberta Health ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piaa077

    authors： Wong K,Robinson JL,Hawkes MT

    更新日期：2020-07-24 00:00:00

  • Infectious Causes of Acute Gastroenteritis in US Children Undergoing Allogeneic Hematopoietic Cell Transplant: A Longitudinal, Multicenter Study.

    abstract：BACKGROUND:Acute gastroenteritis (AGE) in hematopoietic cell transplant (HCT) patients causes significant morbidity and mortality. Data regarding the longitudinal assessment of infectious pathogens during symptomatic AGE and asymptomatic periods, particularly in children, are limited. We investigated the prevalence of ...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/piz063

    authors： Schuster JE,Johnston SH,Piya B,Dulek DE,Wikswo ME,McHenry R,Browne H,Gautam R,Bowen MD,Vinjé J,Payne DC,Azimi P,Selvarangan R,Halasa N,Englund JA

    更新日期：2020-09-17 00:00:00

  • Molecular Characterization of Invasive Staphylococcus aureus Infection in Central New York Children: Importance of Two Clonal Groups and Inconsistent Presence of Selected Virulence Determinants.

    abstract：BACKGROUND:The genetic makeup of circulating Staphylococcus aureus (SA) populations varies by region. The extent to which SA virulence determinants contribute to the severity of pediatric infections is poorly understood. The study objective was to describe the genetic population of invasive SA (ISA) isolates from child...

    journal_title：Journal of the Pediatric Infectious Diseases Society

    pub_type： 杂志文章

    doi：10.1093/jpids/pis087

    authors： Suryadevara M,Clark AE,Wolk DM,Carman A,Rosenbaum PF,Shaw J

    更新日期：2013-03-01 00:00:00