Abstract:
Background:Evaluation for neonatal sepsis routinely includes performing both aerobic and anaerobic blood cultures despite our lack of knowledge of the true incidence of anaerobic bacteremia in this age group and the consequences of not performing these paired cultures. Methods:We performed a retrospective review of all blood cultures performed for neonates in a children's hospital. Clinically significant pathogens were defined as microorganisms that rarely are considered to be contaminants, that were recovered from multiple blood cultures or sites, or were considered significant according to the patient's attending physician. The chart of every patient with positive culture results was reviewed for patient characteristics. Results:A total of 662 culture sets among 403 patients were obtained between November 1, 2013, and April 30, 2015. A clinically significant organism was isolated from 64 (9.7%) culture sets from 25 patients (1.9% contamination rate). A total of 56 organisms were isolated; 35 (62.5%) grew from both the aerobic and anaerobic bottles, 19 (33.9%) grew from the anaerobic bottle alone, and 2 (3.6%) grew from the aerobic bottle alone. One (0.2%) obligate anaerobic bacterium (Clostridium symbiosum) was identified. Conclusions:Although the incidence of anaerobic bacteremia in neonates is rare, anaerobic culture remains important in this population, given the increased yield of both aerobic and facultative anaerobic organisms isolated from anaerobic blood culture bottles.
journal_name
J Pediatric Infect Dis Socjournal_title
Journal of the Pediatric Infectious Diseases Societyauthors
Messbarger N,Neemann Kdoi
10.1093/jpids/pix088subject
Has Abstractpub_date
2018-08-17 00:00:00pages
e65-e69issue
3eissn
2048-7193issn
2048-7207pii
4641896journal_volume
7pub_type
杂志文章abstract:Background:Pertussis is an important cause of hospitalization and death in infants too young to be vaccinated (aged <2 months). Limited data on infant pertussis have been reported from Central America. The aim of this study was to characterize acute respiratory illnesses (ARIs) attributable to Bordetella pertussis amon...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pix081
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:Respiratory viruses cause significant morbidity and death in infants; 99% of such deaths occur in resource-limited settings. Risk factors for initial and repeated respiratory viral infections in young infants in resource-limited settings have not been well described. METHODS:From 2011 to 2014, a birth cohor...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piy107
更新日期:2020-02-28 00:00:00
abstract::Coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barré syndrome (GBS), followed by 5 adult Italian patients and anoth...
journal_title:Journal of the Pediatric Infectious Diseases Society
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doi:10.1093/jpids/piaa086
更新日期:2020-09-17 00:00:00
abstract:BACKGROUND:Rotavirus is the most common cause of infectious diarrhea in children worldwide. Recent studies have described changes in the burden of all-cause gastroenteritis; however, there are limited data on the clinical and economic impact of rotavirus vaccine on cases of laboratory-confirmed rotavirus disease. METH...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis058
更新日期:2012-12-01 00:00:00
abstract::Perinatal screening for Trypanosoma cruzi in a cohort of 4000 predominantly Hispanic women in southern Texas revealed that Chagas disease occurs with sufficient frequency (0.25%) that targeted perinatal screening should be considered to identify infected mothers and infants at risk for congenital infection. ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit056
更新日期:2015-03-01 00:00:00
abstract:Key points:The effectiveness of pentavalent rotavirus vaccine against rotavirus-associated hospitalization was more than 90% 4 years after introduction into the national immunization program in Finland. A major impact on hospitalization for all-cause gastroenteritis was observed also. Background:Rotavirus vaccination ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piw061
更新日期:2017-11-24 00:00:00
abstract::We determined the rates of community-acquired pneumonia (CAP)-associated hospitalizations and complications in Athens, over a period covering 4 years before and 4 years after the implementation of the 7-valent pneumococcal vaccine (PCV7) in Greece. PCV7 had no impact on pediatric CAP rates, whereas there was an increa...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit088
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics. METHODS:We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diag...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piz014
更新日期:2020-04-30 00:00:00
abstract::Although cryptococcal meningitis is uncommon in children and rare in neonates, it does occur. We highlight circumstances in which the diagnosis should be considered and methods required to confirm the diagnosis in young patients. ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis037
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Prevention strategies for cytomegalovirus (CMV) in pediatric transplant recipients are sparsely reported. A hybrid strategy that combines prophylaxis with preemptive therapy using serial CMV viral load monitoring is an emerging option. We report our clinical outcomes with a hybrid strategy in pediatric heart...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis056
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Although long treatment courses of outpatient antimicrobials are often used in pediatric patients, few data exist regarding the frequency of adverse events (AEs) associated with these medications. METHODS:We performed a retrospective cohort study of all patients seen in the Infectious Diseases clinic at a t...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piu037
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012-2019 based on national surveillance. METHO...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa111
更新日期:2020-11-05 00:00:00
abstract::Pneumonia, most often caused by a respiratory virus, is common in childhood. Mycoplasma pneumoniae also is detected frequently, particularly in older children in the era of pneumococcal conjugate vaccination. Despite recommendations for β-lactam antibiotics, macrolide antibiotics, including erythromycin, clarithromyci...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/pix083
更新日期:2018-02-19 00:00:00
abstract:BACKGROUND:Shiga toxin (Stx)-producing Escherichia coli (STECs) are the most common cause of acute renal failure in children. The present study evaluated a 10-year STEC polymerase chain reaction screening regimen in children. METHODS:All routine stool culture specimens from patients below 10 years of age (n = 10 342) ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piv003
更新日期:2016-06-01 00:00:00
abstract::Actinomycetes are Gram-positive bacteria that can be part of the normal human flora of the gastrointestinal, pulmonary, and genital tract. Infections are rare, slowly progressing and most commonly affect the cervicofacial region. Actinomyces israelii is the most frequently isolated species but a number of other specie...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/piu096
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:In theory, active surveillance of methicillin-resistant Staphylococcus aureus (MRSA) reduces MRSA spread by identifying all MRSA-colonized patients and placing them under contact precautions. In October 2007, Illinois mandated active MRSA surveillance in all intensive care units, including neonatal intensive...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piv050
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The clinical and economic outcomes associated with pediatric antimicrobial stewardship programs (ASPs) and other supplemental antimicrobial stewardship (AS) interventions have not been well described or reviewed. METHODS:We performed a systematic review using PubMed to identify studies with any of the follo...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/piu141
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:As antiretroviral therapy (ART) allows the world's 2.3 million human immunodeficiency virus (HIV)-infected children to grow and thrive, these children need to be informed of their HIV status. Neither the prevalence of disclosure to children nor its impact has been evaluated in most resource-limited settings....
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit024
更新日期:2013-06-01 00:00:00
abstract::We conducted a retrospective study to evaluate suboptimal discharge antibiotic prescribing at a children's hospital and found that 27% of the prescriptions were suboptimal. Thirty-three percent of the patients who might have qualified for solid dosage forms received liquid dosages instead. Our findings suggest that op...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piy127
更新日期:2019-12-27 00:00:00
abstract::Plasma posaconazole exposure was assessed in 13 children who underwent a hematopoietic stem cell transplant. The median dosage was 12.5 mg/kg per day, divided into 3 doses. Of these 13 patients, 46.2% (6) and 30.8% (4) achieved concentrations higher than 0.7 and 1.25 mg/L, respectively. In children at high risk, a hig...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piw087
更新日期:2017-11-24 00:00:00
abstract:BACKGROUND:Endothelial activation may contribute to development of severe disease from Plasmodium falciparum infection, but optimal markers of endothelial activation in severe malaria, the extent of endothelial activation in asymptomatic infection, and the effect of blood group O on endothelial activation have not been...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis010
更新日期:2012-03-01 00:00:00
abstract::Children presenting to an emergency department following an animal bite were found to be at risk for infection if they had puncture wounds, crush wounds, or were bitten by a cat. Of the infected wounds that were cultured, methicillin-resistant Staphylococcus aureus was not isolated as a pathogen. ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis096
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piu102
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The objective was to describe respiratory syncytial virus (RSV) hospitalizations in Alberta, Canada over a 13-year period with an emphasis on the incidence and risk factors for repeat hospitalizations attributable to new RSV infections. METHODS:This was a retrospective database analysis. The Alberta Health ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa077
更新日期:2020-07-24 00:00:00
abstract::We conducted a survey of pediatric members of the Emerging Infections Network regarding outpatient parenteral antimicrobial therapy (OPAT) practices and clinical decision making about OPAT initiation. We identified substantial variation in characteristics and resources of pediatric OPAT practices. Opportunities to imp...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis137
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The genetic makeup of circulating Staphylococcus aureus (SA) populations varies by region. The extent to which SA virulence determinants contribute to the severity of pediatric infections is poorly understood. The study objective was to describe the genetic population of invasive SA (ISA) isolates from child...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis087
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:This study was designed to determine whether an automated hospital-based influenza vaccination screening program leveraging the electronic medical record (EMR) increases vaccination rates. METHODS:We performed a retrospective cohort study of all children ≥6 months old admitted to medical, surgical, rehabili...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit044
更新日期:2014-03-01 00:00:00
abstract::We examined the uptake of rotavirus vaccine and compared trends in acute gastroenteritis (AGE)-associated hospitalizations and outpatient visits among American Indian and Alaska Native (AI/AN) children aged <5 years before and after introduction of the rotavirus vaccine. The rates of AGE-associated hospitalization and...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pix098
更新日期:2018-05-15 00:00:00
abstract:Background:Trichosporonosis is an emerging and often fatal opportunistic fungal infection in immunocompromised patients, particularly those with hematologic malignancy, but data in children are lacking. Methods:We report here 3 cases of invasive infection caused by Trichosporon asahii in pediatric patients with acute ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/pix031
更新日期:2018-08-17 00:00:00
abstract::The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice. Attention to 5 major areas hold the promise of making new antibiotics available for use in chil...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/piy001
更新日期:2019-03-28 00:00:00