Evaluation of Discharge Antibiotic Prescribing at a Freestanding Children's Hospital: Opportunities for Stewardship.

abstract：BACKGROUND:A moderate to severe (M/S) influenza clinical endpoint has been proposed in children, defined as fever >39°C, otitis media, lower respiratory tract infection, or serious extrapulmonary manifestations. The objective of the study was to evaluate the M/S measure against clinically relevant outcomes including ho...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Rao S,Yanni E,Moss A,Lamb MM,Schuind A,Bekkat-Berkani R,Innis BL,Cotter J,Mistry RD,Asturias EJ

更新日期：2020-09-17 00:00:00

abstract：:We studied the effect of azithromycin (AZM) on macrophage responses to pneumococci. We found that exposure of pneumococci to AZM led to reduced tumor necrosis factor (TNF) secretion by macrophages; this effect was observed in response to both AZM-susceptible and AZM-resistant (AZM-R) pneumococci. ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Ingram K,Marker M,Meals E,Talati AJ,Spentzas T,English BK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Data on human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection among children in Africa are limited. We evaluated the seroprevalence of both viruses among healthy, HIV-uninfected children and HIV-infected children in the Kilimanjaro region of northern Tanzania....

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Muro FJ,Fiorillo SP,Sakasaka P,Odhiambo C,Reddy EA,Cunningham CK,Buchanan AM

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Despite a high burden of staphylococcal skin disease in children and high incidence of Staphylococcus aureus bacteremia in adult Indigenous populations in northern Australia, there are few studies describing incidence or clinical information of invasive S aureus (ISA) infections in children. METHODS:We cond...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Engelman D,Hofer A,Davis JS,Carapetis JR,Baird RW,Giffard PM,Holt DC,Tong SY

更新日期：2014-12-01 00:00:00

abstract：:Actinomycetes are Gram-positive bacteria that can be part of the normal human flora of the gastrointestinal, pulmonary, and genital tract. Infections are rare, slowly progressing and most commonly affect the cervicofacial region. Actinomyces israelii is the most frequently isolated species but a number of other specie...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Walther K,Bruder E,Goldenberger D,Mayr J,Schaad UB,Ritz N

更新日期：2015-09-01 00:00:00

abstract：:Coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barré syndrome (GBS), followed by 5 adult Italian patients and anoth...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Khalifa M,Zakaria F,Ragab Y,Saad A,Bamaga A,Emad Y,Rasker JJ

更新日期：2020-09-17 00:00:00

abstract：:We performed a seroepidemiologic study of sera from children in Brooklyn, New York, before and after the implementation of prenatal chlamydial screening almost 20% of children aged ≤10 years in the prescreening group had anti-Chlamydia trachomatis immunoglobulin G compared with none in the postscreening group. ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Banniettis N,Wisecup K,Boland L,Watanabe I,Hammerschlag MR,Kohlhoff S

更新日期：2020-01-20 00:00:00

abstract：Background:Pertussis is an important cause of hospitalization and death in infants too young to be vaccinated (aged <2 months). Limited data on infant pertussis have been reported from Central America. The aim of this study was to characterize acute respiratory illnesses (ARIs) attributable to Bordetella pertussis amon...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Phadke VK,McCracken JP,Kriss JL,Lopez MR,Lindblade KA,Bryan JP,Garcia ME,Funes CE,Omer SB

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:Rotavirus is the most common cause of infectious diarrhea in children worldwide. Recent studies have described changes in the burden of all-cause gastroenteritis; however, there are limited data on the clinical and economic impact of rotavirus vaccine on cases of laboratory-confirmed rotavirus disease. METH...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Guerra AH,Stockmann C,Pavia AT,Hersh AL,Thorell EA,Weng HY,Korgenski K,Byington CL,Ampofo K

更新日期：2012-12-01 00:00:00

abstract：:The Advisory Committee on Immunization Practices (ACIP) consists of medical and public health experts who develop recommendations on vaccine use in the United States. The ACIP meets 3 times per year, and members and Centers for Disease Control (CDC) staff present findings and discuss vaccine research, vaccine effectiv...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Schuster JE,O'Leary S,Kimberlin DW

更新日期：2016-12-01 00:00:00

abstract：Background:Children undergoing CIC frequently have positive urine culture results and receive many antimicrobial agents. Subsequently, this population is at high risk for infections caused by antimicrobial-resistant bacteria. Resistant pathogens, such as vancomycin-resistant Enterococcus (VRE), carbapenem-resistant Ent...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Forster CS,Courter J,Jackson EC,Mortensen JE,Haslam DB

更新日期：2017-11-24 00:00:00

abstract：:The reduction in human immunodeficiency virus (HIV) transmission through breastmilk with maternal combination antiretroviral therapy (cART) has led many pregnant women living with HIV and healthcare providers to question exclusive formula feeding in resource-rich settings. Here, we describe cART prophylaxis in 3 breas...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Nashid N,Khan S,Loutfy M,MacGillivray J,Yudin MH,Campbell DM,Barozzino T,Baqi M,Read SE,Bitnun A

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:Prevention strategies for cytomegalovirus (CMV) in pediatric transplant recipients are sparsely reported. A hybrid strategy that combines prophylaxis with preemptive therapy using serial CMV viral load monitoring is an emerging option. We report our clinical outcomes with a hybrid strategy in pediatric heart...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Lin A,Worley S,Brubaker J,Boyle G,Nasman C,Sabella C,Danziger-Isakov LA

更新日期：2012-12-01 00:00:00

abstract：:Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the grow...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Pana ZD,Roilides E,Warris A,Groll AH,Zaoutis T

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Studies describing the activity of imipenem/relebactam against gram-negative bacilli (GNB) isolated from pediatric patients are lacking in the peer-reviewed literature. We address this deficiency by reporting on GNB tested against imipenem/relebactam as part of the Study for Monitoring Antimicrobial Resistan...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Karlowsky JA,Lob SH,Young K,Motyl MR,Sahm DF

更新日期：2020-06-14 00:00:00

abstract：Introduction:Antimicrobial use is decreasing across freestanding children's hospitals, predominantly in institutions with antimicrobial stewardship programs (ASPs) in place. A highly effective ASP should effect a greater decrease in use than predicted by existing trends. Antimicrobial stewardship programs depend on cli...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Willis ZI,Gillon J,Xu M,Slaughter JC,Di Pentima MC

更新日期：2017-11-24 00:00:00

abstract：:The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice. Attention to 5 major areas hold the promise of making new antibiotics available for use in chil...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Noel GJ,Nambiar S,Bradley J,Clinical Trials Transformation Initiative’s Pediatric Antibiotic Drug Development Program.

更新日期：2019-03-28 00:00:00

abstract：BACKGROUND:The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Farmer C,Yehia BR,Fleishman JA,Rutstein R,Mathews WC,Nijhawan A,Moore RD,Gebo KA,Agwu AL,HIV Research Network.

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, st...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Simon TD,Kronman MP,Whitlock KB,Browd SR,Holubkov R,Kestle JRW,Kulkarni AV,Langley M,Limbrick DD,Luerssen TG,Oakes J,Riva-Cambrin J,Rozzelle C,Shannon CN,Tamber M,Wellons Iii JC,Whitehead WE,Mayer-Hamblett N,Hydroceph

更新日期：2019-07-01 00:00:00

abstract：:We report a case of disseminated tularemia in a previously healthy 8-month-old male. This case highlights an atypical presentation of tularemia with multisystem organ involvement. The diagnosis was complicated by concurrent primary cytomegalovirus infection. Bronchoalveolar lavage culture confirmed the diagnosis. The ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Stringham S,Green Hines A,Attebery J,Darwin L,Wachholtz A,Deschamp A,Choudhry O,Neemann K

更新日期：2020-06-14 00:00:00

abstract：BACKGROUND:Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics. METHODS:We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diag...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Wangrangsimakul T,Greer RC,Chanta C,Nedsuwan S,Blacksell SD,Day NPJ,Paris DH

更新日期：2020-04-30 00:00:00

abstract：:We determined the rates of community-acquired pneumonia (CAP)-associated hospitalizations and complications in Athens, over a period covering 4 years before and 4 years after the implementation of the 7-valent pneumococcal vaccine (PCV7) in Greece. PCV7 had no impact on pediatric CAP rates, whereas there was an increa...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Lagousi T,Papadatou I,Kopsidas I,Critselis E,Theodoridou M,Spoulou V

更新日期：2015-09-01 00:00:00

abstract：:Frontline clinicians caring for hospitalized children typically knew the indication for antimicrobial therapy but less often knew the current day or planned duration of therapy or of plans for intravenous to oral conversion. Night shift clinicians were less likely to know day of therapy and duration of therapy than da...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Larru B,Sulieman SE,Localio R,Ross RK,Sharland M,Zaoutis TE,Gerber JS

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:As antiretroviral therapy (ART) allows the world's 2.3 million human immunodeficiency virus (HIV)-infected children to grow and thrive, these children need to be informed of their HIV status. Neither the prevalence of disclosure to children nor its impact has been evaluated in most resource-limited settings....

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Turissini ML,Nyandiko WM,Ayaya SO,Marete I,Mwangi A,Chemboi V,Warui L,Vreeman RC

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Despite successes in lung transplantation, with infection as the leading cause of death in the first year following lung transplantation, there remains a lag in survival compared with other solid organ transplants. Infections that occur early after transplantation may impact short- and long-term outcomes in ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Onyearugbulem C,Coss-Bu J,Gazzaneo MC,Melicoff E,Das S,Lam F,Mallory GB,Munoz FM

更新日期：2020-06-13 00:00:00

abstract：BACKGROUND:While fluoroquinolones are commonly used in adults, the use in children has been low. Since 2000, there were 3 US Food and Drug Administration (FDA) Boxed warnings regarding fluoroquinolones (2008, 2013, and 2016). Our objective was to describe the use of fluoroquinolones in children and assess the impact of...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Ross RK,Gerber JS,Willis ZI,Hersh AL,Kinlaw AC

更新日期：2020-12-30 00:00:00

abstract：:Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occu...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Higa N,Pelz A,Birch D,Beck IA,Sils T,Samson P,Bwakura-Dangarembizi M,Bolton-Moore C,Capparelli E,Chadwick E,Frenkel LM

更新日期：2020-04-30 00:00:00

abstract：:We conducted a survey of pediatric members of the Emerging Infections Network regarding outpatient parenteral antimicrobial therapy (OPAT) practices and clinical decision making about OPAT initiation. We identified substantial variation in characteristics and resources of pediatric OPAT practices. Opportunities to imp...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Banerjee R,Beekmann SE,Doby EH,Polgreen PM,Rathore MH,Hersh AL

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Respiratory viruses cause significant morbidity and death in infants; 99% of such deaths occur in resource-limited settings. Risk factors for initial and repeated respiratory viral infections in young infants in resource-limited settings have not been well described. METHODS:From 2011 to 2014, a birth cohor...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Boonyaratanakornkit J,Englund JA,Magaret AS,Bu Y,Tielsch JM,Khatry SK,Katz J,Kuypers J,Shrestha L,LeClerq SC,Steinhoff MC,Chu HY

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Septic arthritis is a serious infection, but the results of blood and joint fluid cultures are often negative in children. We describe here the clinical features and management of culture-negative septic arthritis in children at our hospital and their outcomes. METHODS:We performed a retrospective review of...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Spyridakis E,Gerber JS,Schriver E,Grundmeier RW,Porsch EA,St Geme JW,Downes KJ

更新日期：2019-07-01 00:00:00