abstract：BACKGROUND:In November 2020, the US Food and Drug Administration (FDA) provided Emergency Use Authorizations (EUA) for two novel virus-neutralizing monoclonal antibody therapies, bamlanivimab, and REGN-COV2 (casirivimab plus imdevimab), for the treatment of mild to moderate COVID-19 in adolescents and adults in specifi...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Wolf J,Abzug MJ,Wattier RL,Sue PK,Vora SB,Zachariah P,Dulek DE,Waghmare A,Olivero R,Downes KJ,James SH,Pinninti SG,Yarbrough A,Aldrich ML,MacBrayne CE,Soma VL,Grapentine SP,Oliveira CR,Hayes M,Kimberlin DW,Jones S

更新日期：2021-01-03 00:00:00

abstract：BACKGROUND:While fluoroquinolones are commonly used in adults, the use in children has been low. Since 2000, there were 3 US Food and Drug Administration (FDA) Boxed warnings regarding fluoroquinolones (2008, 2013, and 2016). Our objective was to describe the use of fluoroquinolones in children and assess the impact of...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Ross RK,Gerber JS,Willis ZI,Hersh AL,Kinlaw AC

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012-2019 based on national surveillance. METHO...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Kang HJ,Yoon Y,Lee YP,Kim HJ,Lee DY,Lee JW,Hyeon JY,Yoo JS,Lee S,Kang C,Choi W,Han MG

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:A moderate to severe (M/S) influenza clinical endpoint has been proposed in children, defined as fever >39°C, otitis media, lower respiratory tract infection, or serious extrapulmonary manifestations. The objective of the study was to evaluate the M/S measure against clinically relevant outcomes including ho...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Rao S,Yanni E,Moss A,Lamb MM,Schuind A,Bekkat-Berkani R,Innis BL,Cotter J,Mistry RD,Asturias EJ

更新日期：2020-09-17 00:00:00

abstract：:Coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barré syndrome (GBS), followed by 5 adult Italian patients and anoth...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Khalifa M,Zakaria F,Ragab Y,Saad A,Bamaga A,Emad Y,Rasker JJ

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:Acute gastroenteritis (AGE) in hematopoietic cell transplant (HCT) patients causes significant morbidity and mortality. Data regarding the longitudinal assessment of infectious pathogens during symptomatic AGE and asymptomatic periods, particularly in children, are limited. We investigated the prevalence of ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Schuster JE,Johnston SH,Piya B,Dulek DE,Wikswo ME,McHenry R,Browne H,Gautam R,Bowen MD,Vinjé J,Payne DC,Azimi P,Selvarangan R,Halasa N,Englund JA

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:The 2017-2018 influenza season was of high severity. Circulating influenza strains change periodically, making it important to determine vaccine effectiveness on an annual basis, especially for susceptible populations. The primary aim of our study was to estimate the effectiveness of the influenza vaccine am...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Powell LN,Bégué RE

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:The objective was to describe respiratory syncytial virus (RSV) hospitalizations in Alberta, Canada over a 13-year period with an emphasis on the incidence and risk factors for repeat hospitalizations attributable to new RSV infections. METHODS:This was a retrospective database analysis. The Alberta Health ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Wong K,Robinson JL,Hawkes MT

更新日期：2020-07-24 00:00:00

abstract：BACKGROUND:Our goal was to characterize the epidemiology and clinical significance of congenital Zika virus (ZIKV) exposure by prospectively following a cohort of infants with possible congenital exposure through their first year of life. METHODS:We included infants born in New York City between 2016 and 2017 who had ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Lee EH,Cooper H,Iwamoto M,Lash M,Conners EE,Bloch D,Clark S,Hrusa G,Kubinson H,Paladini M,McGibbon E,Rakeman JL,Fine AD,Limberger RJ,Liu D,Slavinski S,New York City Department of Health and Mental Hygiene Zika Working Gro

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Children who develop malaria after returning to a setting in which the disease is not endemic are at high risk for critical delays in diagnosis and initiation of antimalarial therapy. We assessed the clinical impact of the implementation of malaria rapid diagnostic testing (RDT) on the management of children...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Enane LA,Sullivan KV,Spyridakis E,Feemster KA

更新日期：2020-07-13 00:00:00

abstract：:We report a case of disseminated tularemia in a previously healthy 8-month-old male. This case highlights an atypical presentation of tularemia with multisystem organ involvement. The diagnosis was complicated by concurrent primary cytomegalovirus infection. Bronchoalveolar lavage culture confirmed the diagnosis. The ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Stringham S,Green Hines A,Attebery J,Darwin L,Wachholtz A,Deschamp A,Choudhry O,Neemann K

更新日期：2020-06-14 00:00:00

abstract：BACKGROUND:Studies describing the activity of imipenem/relebactam against gram-negative bacilli (GNB) isolated from pediatric patients are lacking in the peer-reviewed literature. We address this deficiency by reporting on GNB tested against imipenem/relebactam as part of the Study for Monitoring Antimicrobial Resistan...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Karlowsky JA,Lob SH,Young K,Motyl MR,Sahm DF

更新日期：2020-06-14 00:00:00

abstract：BACKGROUND:Despite successes in lung transplantation, with infection as the leading cause of death in the first year following lung transplantation, there remains a lag in survival compared with other solid organ transplants. Infections that occur early after transplantation may impact short- and long-term outcomes in ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Onyearugbulem C,Coss-Bu J,Gazzaneo MC,Melicoff E,Das S,Lam F,Mallory GB,Munoz FM

更新日期：2020-06-13 00:00:00

abstract：:E-consults replace "curbside" interactions, facilitate provider-specialist communication, document within the medical record, and track relative value units (RVUs). Pediatric infectious diseases (PID) E-consults commonly relate to vaccines, exposures, diagnoses, and treatments. The documented RVU effort of 197 consecu...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Gonzalez BE,Sabella C,Esper FP,Daniels HL,Saracusa C,Boutros J,Foster CB

更新日期：2020-05-05 00:00:00

abstract：:The reduction in human immunodeficiency virus (HIV) transmission through breastmilk with maternal combination antiretroviral therapy (cART) has led many pregnant women living with HIV and healthcare providers to question exclusive formula feeding in resource-rich settings. Here, we describe cART prophylaxis in 3 breas...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Nashid N,Khan S,Loutfy M,MacGillivray J,Yudin MH,Campbell DM,Barozzino T,Baqi M,Read SE,Bitnun A

更新日期：2020-04-30 00:00:00

abstract：:Coronaviruses contribute to the burden of respiratory diseases in children, frequently manifesting in upper respiratory symptoms considered to be part of the "common cold." Recent epidemics of novel coronaviruses recognized in the 21st century have highlighted issues of zoonotic origins of transmissible respiratory vi...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Ogimi C,Kim YJ,Martin ET,Huh HJ,Chiu CH,Englund JA

更新日期：2020-04-30 00:00:00

abstract：:Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occu...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Higa N,Pelz A,Birch D,Beck IA,Sils T,Samson P,Bwakura-Dangarembizi M,Bolton-Moore C,Capparelli E,Chadwick E,Frenkel LM

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:P1093 is an ongoing phase I/II multicenter open-label study of dolutegravir plus an optimized background regimen in age-defined pediatric cohorts; here we report the long-term safety and virologic efficacy outcomes for the oldest cohort. METHODS:The study enrolled human immunodeficiency virus type 1 (HIV-1)...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Viani RM,Ruel T,Alvero C,Fenton T,Acosta EP,Hazra R,Townley E,Palumbo P,Buchanan AM,Vavro C,Singh R,Graham B,Anthony P,George K,Wiznia A,P1093 Study Team .

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics. METHODS:We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diag...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Wangrangsimakul T,Greer RC,Chanta C,Nedsuwan S,Blacksell SD,Day NPJ,Paris DH

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND:Cartridge-based nucleic acid amplification test (CB-NAAT) has been recommended for diagnosis of tuberculosis (TB) in children, but its wide use is limited by high cost and the need for well-equipped laboratories. This study was conducted in children with pulmonary TB to compare the diagnostic yield of TB-LAM...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Dayal R,Yadav A,Agarwal D,Kumar M,Kamal R,Singh D,Bhatnagar S

更新日期：2020-03-10 00:00:00

abstract：BACKGROUND:Respiratory viruses cause significant morbidity and death in infants; 99% of such deaths occur in resource-limited settings. Risk factors for initial and repeated respiratory viral infections in young infants in resource-limited settings have not been well described. METHODS:From 2011 to 2014, a birth cohor...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Boonyaratanakornkit J,Englund JA,Magaret AS,Bu Y,Tielsch JM,Khatry SK,Katz J,Kuypers J,Shrestha L,LeClerq SC,Steinhoff MC,Chu HY

更新日期：2020-02-28 00:00:00

abstract：:Little information on the efficacy and pharmacokinetics of letermovir among immunocompromised children is currently available. We describe here the use of letermovir in a 2-year-old immunocompromised child with ganciclovir-resistant cytomegalovirus disease who required extracorporeal membrane oxygenation. Detailed inf...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Pérez Marín M,Decosterd LA,Andre P,Buclin T,Mercier T,Murray K,Rizzi M,Meylan P,Jaton-Ogay K,Opota O,Gengler C,Perez MH,Natterer J,Asner SA

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Egypt has the highest prevalence of hepatitis C virus (HCV) infection. Anti-HCV antibodies were detectable in 3% of children in Upper Egypt. Our aim was to evaluate the efficacy of ledipasvir/sofosbuvir for chronic HCV genotype 4 in adolescents with/without hematological disorders and to determine the effect...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Makhlouf NA,Abdelmalek MO,Ibrahim ME,Abu-Faddan NH,Kheila AE,Mahmoud AA

更新日期：2020-02-15 00:00:00

abstract：:We performed a seroepidemiologic study of sera from children in Brooklyn, New York, before and after the implementation of prenatal chlamydial screening almost 20% of children aged ≤10 years in the prescreening group had anti-Chlamydia trachomatis immunoglobulin G compared with none in the postscreening group. ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Banniettis N,Wisecup K,Boland L,Watanabe I,Hammerschlag MR,Kohlhoff S

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Parechovirus A (PeV-A) is an important cause of sepsis and meningoencephalitis in neonates and young infants. Thus, identifying the source of PeV-A is essential for prevention; however, little is known regarding the spread of PeV-A among family members of PeV-A-infected neonates and young infants. METHODS:I...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Izumita R,Deuchi K,Aizawa Y,Habuka R,Watanabe K,Otsuka T,Saitoh A

更新日期：2019-12-27 00:00:00

abstract：:We conducted a retrospective study to evaluate suboptimal discharge antibiotic prescribing at a children's hospital and found that 27% of the prescriptions were suboptimal. Thirty-three percent of the patients who might have qualified for solid dosage forms received liquid dosages instead. Our findings suggest that op...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Olson J,Thorell EA,Hersh AL

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Single-nucleotide polymorphisms (SNPs) in the fucosyltransferase genes FUT2 and FUT3 have been associated with susceptibility to various infectious and inflammatory disorders. FUT variations influence the expression of human histo-blood group antigens (HBGAs) (H-type 1 and Lewis), which are highly expressed ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： King JR,Varadé J,Hammarström L

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, st...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Simon TD,Kronman MP,Whitlock KB,Browd SR,Holubkov R,Kestle JRW,Kulkarni AV,Langley M,Limbrick DD,Luerssen TG,Oakes J,Riva-Cambrin J,Rozzelle C,Shannon CN,Tamber M,Wellons Iii JC,Whitehead WE,Mayer-Hamblett N,Hydroceph

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Septic arthritis is a serious infection, but the results of blood and joint fluid cultures are often negative in children. We describe here the clinical features and management of culture-negative septic arthritis in children at our hospital and their outcomes. METHODS:We performed a retrospective review of...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Spyridakis E,Gerber JS,Schriver E,Grundmeier RW,Porsch EA,St Geme JW,Downes KJ

更新日期：2019-07-01 00:00:00

abstract：:We report here 18 cases of pediatric group A streptococcal toxic shock syndrome, associated clinical findings, and bacterial molecular genetic characteristics discovered through whole-genome sequencing. This comparative whole-genome sequencing revealed unique gene content (speK) and polymorphisms (dpiB) in emm87 group...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Deniskin R,Shah B,Muñoz FM,Flores AR

更新日期：2019-07-01 00:00:00

abstract：:The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice. Attention to 5 major areas hold the promise of making new antibiotics available for use in chil...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Noel GJ,Nambiar S,Bradley J,Clinical Trials Transformation Initiative’s Pediatric Antibiotic Drug Development Program.

更新日期：2019-03-28 00:00:00

abstract：Background:Pertussis is an important cause of hospitalization and death in infants too young to be vaccinated (aged <2 months). Limited data on infant pertussis have been reported from Central America. The aim of this study was to characterize acute respiratory illnesses (ARIs) attributable to Bordetella pertussis amon...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Phadke VK,McCracken JP,Kriss JL,Lopez MR,Lindblade KA,Bryan JP,Garcia ME,Funes CE,Omer SB

更新日期：2018-12-03 00:00:00

abstract：:Among newborns with congenital cytomegalovirus (CMV) infection from China, there was no difference in CMV viral load in saliva specimens dried and stored at room temperature compared with those kept wet and stored cold, even after longer storage time for the former than the later (74 vs 58 days, P = .02). ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Xu A,Wang S,Zhang W,Wang X,Wang T,Liu X,Wang H,Ma W,Amin M,Dollard S,Wang C

更新日期：2018-08-17 00:00:00

abstract：Background:Evaluation for neonatal sepsis routinely includes performing both aerobic and anaerobic blood cultures despite our lack of knowledge of the true incidence of anaerobic bacteremia in this age group and the consequences of not performing these paired cultures. Methods:We performed a retrospective review of al...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Messbarger N,Neemann K

更新日期：2018-08-17 00:00:00

abstract：Background:Trichosporonosis is an emerging and often fatal opportunistic fungal infection in immunocompromised patients, particularly those with hematologic malignancy, but data in children are lacking. Methods:We report here 3 cases of invasive infection caused by Trichosporon asahii in pediatric patients with acute ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Foster CE,Edwards MS,Brackett J,Schady DA,Healy CM,Baker CJ

更新日期：2018-08-17 00:00:00

abstract：Background:Solid organ transplant (SOT) recipients are at risk for invasive fungal disease (IFD). Data on IFD burden in pediatric patients are limited. We aimed to determine the incidence and outcome of IFD in a large cohort of pediatric patients who underwent SOT. Methods:A single-center cohort of pediatric patients ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Saxena S,Gee J,Klieger S,Kajon A,Petersen H,Zaoutis T,Fisher B

更新日期：2018-08-17 00:00:00

abstract：:Achieving rapid and meaningful improvement in healthcare requires the dissemination of quality improvement project results via publication. Doing this well requires detailed descriptions of the complex interventions and of the context in which the improvement took place. This report builds on the first 2 articles in t...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Schondelmeyer AC,Brower LH,Statile AM,White CM,Brady PW

更新日期：2018-08-17 00:00:00

abstract：:We examined the uptake of rotavirus vaccine and compared trends in acute gastroenteritis (AGE)-associated hospitalizations and outpatient visits among American Indian and Alaska Native (AI/AN) children aged <5 years before and after introduction of the rotavirus vaccine. The rates of AGE-associated hospitalization and...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Grytdal SP,Haberling DL,Kennedy JL,McCollum JT,Parashar UD

更新日期：2018-05-15 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a congenital disorder characterized by recurrent life-threatening bacterial and fungal infections and development of severe inflammation secondary to a congenital defect in 1 of the 5 phagocyte oxidase (phox) subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxi...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Connelly JA,Marsh R,Parikh S,Talano JA

更新日期：2018-05-09 00:00:00

abstract：:Pneumonia, most often caused by a respiratory virus, is common in childhood. Mycoplasma pneumoniae also is detected frequently, particularly in older children in the era of pneumococcal conjugate vaccination. Despite recommendations for β-lactam antibiotics, macrolide antibiotics, including erythromycin, clarithromyci...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Blyth CC,Gerber JS

更新日期：2018-02-19 00:00:00