Abstract:
BACKGROUND:The 2017-2018 influenza season was of high severity. Circulating influenza strains change periodically, making it important to determine vaccine effectiveness on an annual basis, especially for susceptible populations. The primary aim of our study was to estimate the effectiveness of the influenza vaccine among children. Secondary aims were to assess the effect of previous season vaccination and intraseasonal waning of immunity. METHODS:Children 6 months to 17 years of age tested for influenza during the 2017-2018 season were included. Clinical charts were reviewed, and immunization status was confirmed via the Louisiana Immunization Registry. Influenza vaccine effectiveness (IVE) was estimated in a test-negative design by comparing vaccination status of influenza-positive vs influenza-negative cases. RESULTS:A total of 3595 children were included, 26% of whom tested positive for influenza, mostly type A (79%); 15% had received an influenza vaccine prior to illness: 8% among the influenza-positive and 17% among influenza-negative cases (P <.0001). IVE for the 2017-2018 influenza season was 52% overall (95% confidence interval, 38%-62%), 49% for influenza A, and 60% for influenza B. While receiving current year (2017-2018) vaccine had the most effect, receiving the previous year (2016-2017) vaccine had a small benefit and no interference. We found no evidence of waning immunity of the vaccine for the 2017-2018 season. CONCLUSIONS:IVE was moderate for children. Previous year vaccination had a small but significant benefit and there was no evidence of waning immunity in our cohort. Ongoing national and local surveillance is important to understand the benefit of influenza vaccination.
journal_name
J Pediatric Infect Dis Socjournal_title
Journal of the Pediatric Infectious Diseases Societyauthors
Powell LN,Bégué REdoi
10.1093/jpids/piz077subject
Has Abstractpub_date
2020-09-17 00:00:00pages
468-473issue
4eissn
2048-7193issn
2048-7207pii
5644294journal_volume
9pub_type
杂志文章abstract::Across 12 consecutive influenza seasons in Utah, medically-attended visits for laboratory-confirmed influenza infection peaked first among older children (12-18 years). Peak activity in older children preceded that of children 0-4 years by more than 2 days and that of peak activity among adults ≥65 years by more than ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit004
更新日期:2014-06-01 00:00:00
abstract::We report a case of disseminated tularemia in a previously healthy 8-month-old male. This case highlights an atypical presentation of tularemia with multisystem organ involvement. The diagnosis was complicated by concurrent primary cytomegalovirus infection. Bronchoalveolar lavage culture confirmed the diagnosis. The ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa066
更新日期:2020-06-14 00:00:00
abstract::Children presenting to an emergency department following an animal bite were found to be at risk for infection if they had puncture wounds, crush wounds, or were bitten by a cat. Of the infected wounds that were cultured, methicillin-resistant Staphylococcus aureus was not isolated as a pathogen. ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis096
更新日期:2013-12-01 00:00:00
abstract::Among 66 antiretroviral-naive children aged <3 years with human immunodeficiency virus (HIV) or coinfected with HIV and tuberculosis and initiating efavirenz-based antiretroviral therapy (ART), non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance was detected before ART in 5 (7.6%). Virologic failure occu...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piz038
更新日期:2020-04-30 00:00:00
abstract:BACKGROUND:The genetic makeup of circulating Staphylococcus aureus (SA) populations varies by region. The extent to which SA virulence determinants contribute to the severity of pediatric infections is poorly understood. The study objective was to describe the genetic population of invasive SA (ISA) isolates from child...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pis087
更新日期:2013-03-01 00:00:00
abstract:Background:Solid organ transplant (SOT) recipients are at risk for invasive fungal disease (IFD). Data on IFD burden in pediatric patients are limited. We aimed to determine the incidence and outcome of IFD in a large cohort of pediatric patients who underwent SOT. Methods:A single-center cohort of pediatric patients ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pix041
更新日期:2018-08-17 00:00:00
abstract::The Advisory Committee on Immunization Practices (ACIP) consists of medical and public health experts who develop recommendations on vaccine use in the United States. The ACIP meets 3 times per year, and members and Centers for Disease Control (CDC) staff present findings and discuss vaccine research, vaccine effectiv...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piw057
更新日期:2016-12-01 00:00:00
abstract::Coronaviruses contribute to the burden of respiratory diseases in children, frequently manifesting in upper respiratory symptoms considered to be part of the "common cold." Recent epidemics of novel coronaviruses recognized in the 21st century have highlighted issues of zoonotic origins of transmissible respiratory vi...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/piaa037
更新日期:2020-04-30 00:00:00
abstract::Little information on the efficacy and pharmacokinetics of letermovir among immunocompromised children is currently available. We describe here the use of letermovir in a 2-year-old immunocompromised child with ganciclovir-resistant cytomegalovirus disease who required extracorporeal membrane oxygenation. Detailed inf...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piz033
更新日期:2020-02-28 00:00:00
abstract:Key points:The effectiveness of pentavalent rotavirus vaccine against rotavirus-associated hospitalization was more than 90% 4 years after introduction into the national immunization program in Finland. A major impact on hospitalization for all-cause gastroenteritis was observed also. Background:Rotavirus vaccination ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piw061
更新日期:2017-11-24 00:00:00
abstract::E-consults replace "curbside" interactions, facilitate provider-specialist communication, document within the medical record, and track relative value units (RVUs). Pediatric infectious diseases (PID) E-consults commonly relate to vaccines, exposures, diagnoses, and treatments. The documented RVU effort of 197 consecu...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa041
更新日期:2020-05-05 00:00:00
abstract:BACKGROUND:Our goal was to characterize the epidemiology and clinical significance of congenital Zika virus (ZIKV) exposure by prospectively following a cohort of infants with possible congenital exposure through their first year of life. METHODS:We included infants born in New York City between 2016 and 2017 who had ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piz027
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Data on human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection among children in Africa are limited. We evaluated the seroprevalence of both viruses among healthy, HIV-uninfected children and HIV-infected children in the Kilimanjaro region of northern Tanzania....
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit018
更新日期:2013-12-01 00:00:00
abstract::We determined the rates of community-acquired pneumonia (CAP)-associated hospitalizations and complications in Athens, over a period covering 4 years before and 4 years after the implementation of the 7-valent pneumococcal vaccine (PCV7) in Greece. PCV7 had no impact on pediatric CAP rates, whereas there was an increa...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pit088
更新日期:2015-09-01 00:00:00
abstract:Background:Trichosporonosis is an emerging and often fatal opportunistic fungal infection in immunocompromised patients, particularly those with hematologic malignancy, but data in children are lacking. Methods:We report here 3 cases of invasive infection caused by Trichosporon asahii in pediatric patients with acute ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/pix031
更新日期:2018-08-17 00:00:00
abstract:BACKGROUND:Despite a high burden of staphylococcal skin disease in children and high incidence of Staphylococcus aureus bacteremia in adult Indigenous populations in northern Australia, there are few studies describing incidence or clinical information of invasive S aureus (ISA) infections in children. METHODS:We cond...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piu013
更新日期:2014-12-01 00:00:00
abstract::Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the grow...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/pix046
更新日期:2017-09-01 00:00:00
abstract::We examined the uptake of rotavirus vaccine and compared trends in acute gastroenteritis (AGE)-associated hospitalizations and outpatient visits among American Indian and Alaska Native (AI/AN) children aged <5 years before and after introduction of the rotavirus vaccine. The rates of AGE-associated hospitalization and...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pix098
更新日期:2018-05-15 00:00:00
abstract::Children with healthcare-associated Clostridium difficile infection were identified. The incidence increased from 3.2/10,000 patient days in 2007 to 5.2/10,000 patient days in 2011 (p < 0.001). Of 169 isolates, the most common North American Pulsed-Field (NAP) types were NAP4 (n = 43; (25.4%), and NAP1 (n = 25;14.8%) ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piv011
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Parainfluenza virus (PIV), a common pediatric pathogen, is associated with significant morbidity in immunocompromised (IC) hosts. DAS181, a novel sialidase fusion protein inhibitor, seems to be effective against PIV in vitro and in vivo; its use in IC children has not been evaluated. METHODS:Patients were d...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piu039
更新日期:2015-06-01 00:00:00
abstract::We report here 18 cases of pediatric group A streptococcal toxic shock syndrome, associated clinical findings, and bacterial molecular genetic characteristics discovered through whole-genome sequencing. This comparative whole-genome sequencing revealed unique gene content (speK) and polymorphisms (dpiB) in emm87 group...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piy069
更新日期:2019-07-01 00:00:00
abstract::Among newborns with congenital cytomegalovirus (CMV) infection from China, there was no difference in CMV viral load in saliva specimens dried and stored at room temperature compared with those kept wet and stored cold, even after longer storage time for the former than the later (74 vs 58 days, P = .02). ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piy048
更新日期:2018-08-17 00:00:00
abstract:BACKGROUND:Shiga toxin (Stx)-producing Escherichia coli (STECs) are the most common cause of acute renal failure in children. The present study evaluated a 10-year STEC polymerase chain reaction screening regimen in children. METHODS:All routine stool culture specimens from patients below 10 years of age (n = 10 342) ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piv003
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Invasive mold infections (IMIs) are a leading cause of mortality in immunocompromised children, yet there has never been an international epidemiologic investigation of pediatric IMIs. METHODS:This international, prospective cohort study was performed to characterize the epidemiology, antifungal therapy, an...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,多中心研究
doi:10.1093/jpids/piu074
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012-2019 based on national surveillance. METHO...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa111
更新日期:2020-11-05 00:00:00
abstract::Actinomycetes are Gram-positive bacteria that can be part of the normal human flora of the gastrointestinal, pulmonary, and genital tract. Infections are rare, slowly progressing and most commonly affect the cervicofacial region. Actinomyces israelii is the most frequently isolated species but a number of other specie...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
doi:10.1093/jpids/piu096
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Septic arthritis is a serious infection, but the results of blood and joint fluid cultures are often negative in children. We describe here the clinical features and management of culture-negative septic arthritis in children at our hospital and their outcomes. METHODS:We performed a retrospective review of...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piy034
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The objective was to describe respiratory syncytial virus (RSV) hospitalizations in Alberta, Canada over a 13-year period with an emphasis on the incidence and risk factors for repeat hospitalizations attributable to new RSV infections. METHODS:This was a retrospective database analysis. The Alberta Health ...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa077
更新日期:2020-07-24 00:00:00
abstract:BACKGROUND:In November 2020, the US Food and Drug Administration (FDA) provided Emergency Use Authorizations (EUA) for two novel virus-neutralizing monoclonal antibody therapies, bamlanivimab, and REGN-COV2 (casirivimab plus imdevimab), for the treatment of mild to moderate COVID-19 in adolescents and adults in specifi...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/piaa175
更新日期:2021-01-03 00:00:00
abstract:Background:Evaluation for neonatal sepsis routinely includes performing both aerobic and anaerobic blood cultures despite our lack of knowledge of the true incidence of anaerobic bacteremia in this age group and the consequences of not performing these paired cultures. Methods:We performed a retrospective review of al...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
doi:10.1093/jpids/pix088
更新日期:2018-08-17 00:00:00