Macrolides in Children With Community-Acquired Pneumonia: Panacea or Placebo?

abstract：:Children presenting to an emergency department following an animal bite were found to be at risk for infection if they had puncture wounds, crush wounds, or were bitten by a cat. Of the infected wounds that were cultured, methicillin-resistant Staphylococcus aureus was not isolated as a pathogen. ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Ogden RK Jr,Hedican EB,Stach LM,Herigon JC,Jackson MA,Newland JG

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Despite successes in lung transplantation, with infection as the leading cause of death in the first year following lung transplantation, there remains a lag in survival compared with other solid organ transplants. Infections that occur early after transplantation may impact short- and long-term outcomes in ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Onyearugbulem C,Coss-Bu J,Gazzaneo MC,Melicoff E,Das S,Lam F,Mallory GB,Munoz FM

更新日期：2020-06-13 00:00:00

abstract：BACKGROUND:Egypt has the highest prevalence of hepatitis C virus (HCV) infection. Anti-HCV antibodies were detectable in 3% of children in Upper Egypt. Our aim was to evaluate the efficacy of ledipasvir/sofosbuvir for chronic HCV genotype 4 in adolescents with/without hematological disorders and to determine the effect...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Makhlouf NA,Abdelmalek MO,Ibrahim ME,Abu-Faddan NH,Kheila AE,Mahmoud AA

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:Invasive mold infections (IMIs) are a leading cause of mortality in immunocompromised children, yet there has never been an international epidemiologic investigation of pediatric IMIs. METHODS:This international, prospective cohort study was performed to characterize the epidemiology, antifungal therapy, an...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Wattier RL,Dvorak CC,Hoffman JA,Brozovich AA,Bin-Hussain I,Groll AH,Castagnola E,Knapp KM,Zaoutis TE,Gustafsson B,Sung L,Berman D,Halasa NB,Abzug MJ,Velegraki A,Sharma TS,Fisher BT,Steinbach WJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The genetic makeup of circulating Staphylococcus aureus (SA) populations varies by region. The extent to which SA virulence determinants contribute to the severity of pediatric infections is poorly understood. The study objective was to describe the genetic population of invasive SA (ISA) isolates from child...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Suryadevara M,Clark AE,Wolk DM,Carman A,Rosenbaum PF,Shaw J

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Single-nucleotide polymorphisms (SNPs) in the fucosyltransferase genes FUT2 and FUT3 have been associated with susceptibility to various infectious and inflammatory disorders. FUT variations influence the expression of human histo-blood group antigens (HBGAs) (H-type 1 and Lewis), which are highly expressed ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： King JR,Varadé J,Hammarström L

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:While fluoroquinolones are commonly used in adults, the use in children has been low. Since 2000, there were 3 US Food and Drug Administration (FDA) Boxed warnings regarding fluoroquinolones (2008, 2013, and 2016). Our objective was to describe the use of fluoroquinolones in children and assess the impact of...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Ross RK,Gerber JS,Willis ZI,Hersh AL,Kinlaw AC

更新日期：2020-12-30 00:00:00

abstract：:Achieving rapid and meaningful improvement in healthcare requires the dissemination of quality improvement project results via publication. Doing this well requires detailed descriptions of the complex interventions and of the context in which the improvement took place. This report builds on the first 2 articles in t...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Schondelmeyer AC,Brower LH,Statile AM,White CM,Brady PW

更新日期：2018-08-17 00:00:00

abstract：Background:Solid organ transplant (SOT) recipients are at risk for invasive fungal disease (IFD). Data on IFD burden in pediatric patients are limited. We aimed to determine the incidence and outcome of IFD in a large cohort of pediatric patients who underwent SOT. Methods:A single-center cohort of pediatric patients ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Saxena S,Gee J,Klieger S,Kajon A,Petersen H,Zaoutis T,Fisher B

更新日期：2018-08-17 00:00:00

abstract：:We report a case of disseminated tularemia in a previously healthy 8-month-old male. This case highlights an atypical presentation of tularemia with multisystem organ involvement. The diagnosis was complicated by concurrent primary cytomegalovirus infection. Bronchoalveolar lavage culture confirmed the diagnosis. The ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Stringham S,Green Hines A,Attebery J,Darwin L,Wachholtz A,Deschamp A,Choudhry O,Neemann K

更新日期：2020-06-14 00:00:00

abstract：Background:Pertussis is an important cause of hospitalization and death in infants too young to be vaccinated (aged <2 months). Limited data on infant pertussis have been reported from Central America. The aim of this study was to characterize acute respiratory illnesses (ARIs) attributable to Bordetella pertussis amon...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Phadke VK,McCracken JP,Kriss JL,Lopez MR,Lindblade KA,Bryan JP,Garcia ME,Funes CE,Omer SB

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:Parainfluenza virus (PIV), a common pediatric pathogen, is associated with significant morbidity in immunocompromised (IC) hosts. DAS181, a novel sialidase fusion protein inhibitor, seems to be effective against PIV in vitro and in vivo; its use in IC children has not been evaluated. METHODS:Patients were d...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Waghmare A,Wagner T,Andrews R,Smith S,Kuypers J,Boeckh M,Moss R,Englund JA

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Our goal was to characterize the epidemiology and clinical significance of congenital Zika virus (ZIKV) exposure by prospectively following a cohort of infants with possible congenital exposure through their first year of life. METHODS:We included infants born in New York City between 2016 and 2017 who had ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Lee EH,Cooper H,Iwamoto M,Lash M,Conners EE,Bloch D,Clark S,Hrusa G,Kubinson H,Paladini M,McGibbon E,Rakeman JL,Fine AD,Limberger RJ,Liu D,Slavinski S,New York City Department of Health and Mental Hygiene Zika Working Gro

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Despite a high burden of staphylococcal skin disease in children and high incidence of Staphylococcus aureus bacteremia in adult Indigenous populations in northern Australia, there are few studies describing incidence or clinical information of invasive S aureus (ISA) infections in children. METHODS:We cond...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Engelman D,Hofer A,Davis JS,Carapetis JR,Baird RW,Giffard PM,Holt DC,Tong SY

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Endothelial activation may contribute to development of severe disease from Plasmodium falciparum infection, but optimal markers of endothelial activation in severe malaria, the extent of endothelial activation in asymptomatic infection, and the effect of blood group O on endothelial activation have not been...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Park GS,Ireland KF,Opoka RO,John CC

更新日期：2012-03-01 00:00:00

abstract：:We studied the effect of azithromycin (AZM) on macrophage responses to pneumococci. We found that exposure of pneumococci to AZM led to reduced tumor necrosis factor (TNF) secretion by macrophages; this effect was observed in response to both AZM-susceptible and AZM-resistant (AZM-R) pneumococci. ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Ingram K,Marker M,Meals E,Talati AJ,Spentzas T,English BK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Parechovirus A (PeV-A) is an important cause of sepsis and meningoencephalitis in neonates and young infants. Thus, identifying the source of PeV-A is essential for prevention; however, little is known regarding the spread of PeV-A among family members of PeV-A-infected neonates and young infants. METHODS:I...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Izumita R,Deuchi K,Aizawa Y,Habuka R,Watanabe K,Otsuka T,Saitoh A

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Farmer C,Yehia BR,Fleishman JA,Rutstein R,Mathews WC,Nijhawan A,Moore RD,Gebo KA,Agwu AL,HIV Research Network.

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Respiratory viruses cause significant morbidity and death in infants; 99% of such deaths occur in resource-limited settings. Risk factors for initial and repeated respiratory viral infections in young infants in resource-limited settings have not been well described. METHODS:From 2011 to 2014, a birth cohor...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Boonyaratanakornkit J,Englund JA,Magaret AS,Bu Y,Tielsch JM,Khatry SK,Katz J,Kuypers J,Shrestha L,LeClerq SC,Steinhoff MC,Chu HY

更新日期：2020-02-28 00:00:00

abstract：:We conducted a survey of pediatric members of the Emerging Infections Network regarding outpatient parenteral antimicrobial therapy (OPAT) practices and clinical decision making about OPAT initiation. We identified substantial variation in characteristics and resources of pediatric OPAT practices. Opportunities to imp...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Banerjee R,Beekmann SE,Doby EH,Polgreen PM,Rathore MH,Hersh AL

更新日期：2014-03-01 00:00:00

abstract：:We determined the rates of community-acquired pneumonia (CAP)-associated hospitalizations and complications in Athens, over a period covering 4 years before and 4 years after the implementation of the 7-valent pneumococcal vaccine (PCV7) in Greece. PCV7 had no impact on pediatric CAP rates, whereas there was an increa...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Lagousi T,Papadatou I,Kopsidas I,Critselis E,Theodoridou M,Spoulou V

更新日期：2015-09-01 00:00:00

abstract：:Little information on the efficacy and pharmacokinetics of letermovir among immunocompromised children is currently available. We describe here the use of letermovir in a 2-year-old immunocompromised child with ganciclovir-resistant cytomegalovirus disease who required extracorporeal membrane oxygenation. Detailed inf...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Pérez Marín M,Decosterd LA,Andre P,Buclin T,Mercier T,Murray K,Rizzi M,Meylan P,Jaton-Ogay K,Opota O,Gengler C,Perez MH,Natterer J,Asner SA

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:Prevention strategies for cytomegalovirus (CMV) in pediatric transplant recipients are sparsely reported. A hybrid strategy that combines prophylaxis with preemptive therapy using serial CMV viral load monitoring is an emerging option. We report our clinical outcomes with a hybrid strategy in pediatric heart...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Lin A,Worley S,Brubaker J,Boyle G,Nasman C,Sabella C,Danziger-Isakov LA

更新日期：2012-12-01 00:00:00

abstract：:Among newborns with congenital cytomegalovirus (CMV) infection from China, there was no difference in CMV viral load in saliva specimens dried and stored at room temperature compared with those kept wet and stored cold, even after longer storage time for the former than the later (74 vs 58 days, P = .02). ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Xu A,Wang S,Zhang W,Wang X,Wang T,Liu X,Wang H,Ma W,Amin M,Dollard S,Wang C

更新日期：2018-08-17 00:00:00

abstract：BACKGROUND:Enteroviruses (EVs) occur frequently worldwide and are known to be associated with a broad spectrum of clinical manifestations from mild syndromes to neurological disease. To understand the epidemiology of EV in Korea, we characterized EV-infected cases during 2012-2019 based on national surveillance. METHO...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Kang HJ,Yoon Y,Lee YP,Kim HJ,Lee DY,Lee JW,Hyeon JY,Yoo JS,Lee S,Kang C,Choi W,Han MG

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:The 2017-2018 influenza season was of high severity. Circulating influenza strains change periodically, making it important to determine vaccine effectiveness on an annual basis, especially for susceptible populations. The primary aim of our study was to estimate the effectiveness of the influenza vaccine am...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Powell LN,Bégué RE

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:The clinical and economic outcomes associated with pediatric antimicrobial stewardship programs (ASPs) and other supplemental antimicrobial stewardship (AS) interventions have not been well described or reviewed. METHODS:We performed a systematic review using PubMed to identify studies with any of the follo...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Smith MJ,Gerber JS,Hersh AL

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:As antiretroviral therapy (ART) allows the world's 2.3 million human immunodeficiency virus (HIV)-infected children to grow and thrive, these children need to be informed of their HIV status. Neither the prevalence of disclosure to children nor its impact has been evaluated in most resource-limited settings....

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Turissini ML,Nyandiko WM,Ayaya SO,Marete I,Mwangi A,Chemboi V,Warui L,Vreeman RC

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Septic arthritis is a serious infection, but the results of blood and joint fluid cultures are often negative in children. We describe here the clinical features and management of culture-negative septic arthritis in children at our hospital and their outcomes. METHODS:We performed a retrospective review of...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Spyridakis E,Gerber JS,Schriver E,Grundmeier RW,Porsch EA,St Geme JW,Downes KJ

更新日期：2019-07-01 00:00:00

abstract：:Across 12 consecutive influenza seasons in Utah, medically-attended visits for laboratory-confirmed influenza infection peaked first among older children (12-18 years). Peak activity in older children preceded that of children 0-4 years by more than 2 days and that of peak activity among adults ≥65 years by more than ...

journal_title：Journal of the Pediatric Infectious Diseases Society

authors： Stockmann C,Pavia AT,Hersh AL,Spigarelli MG,Castle B,Korgenski K,Byington CL,Ampofo K

更新日期：2014-06-01 00:00:00