Abstract:
BACKGROUND:The genetic makeup of circulating Staphylococcus aureus (SA) populations varies by region. The extent to which SA virulence determinants contribute to the severity of pediatric infections is poorly understood. The study objective was to describe the genetic population of invasive SA (ISA) isolates from children in the Central New York (CNY) area and the prevalence of selected virulence genes. METHODS:Clinical and demographic information for hospitalized children <19 years of age with community-onset or community-associated ISA infections, determined from clinical microbiology records, was extracted from medical records from Upstate Golisano Children's Hospital in CNY. Antibiotic susceptibility was assessed, and available isolates were genotyped and tested for the presence of selected virulence determinants. Associations between clinical and laboratory findings were evaluated using standard statistical techniques. RESULTS:Ninety patients with ISA disease diagnosed between 2007 and 2010 were included in the study; 74% were due to methicillin-susceptible SA (MSSA). The most common clinical diagnosis was bacteremia. Fifty-seven of 90 isolates were available for further testing. The SA pulsed-field gel electrophoresis type, agr type, and clonal complexes most commonly isolated were USA300 (n = 25, 44%), agr1 (n = 30, 52%), and CC8 (n = 25, 44%), respectively. USA300 strains were more likely to be associated with deep abscesses (P = .007), whereas non-USA300 strains were associated with medical device infections (P = .018). Isolates from patients with deep abscesses and pneumonia were more likely to carry luk-PV genes (P = .023 and P = .051, respectively). CONCLUSIONS:MSSA remains an important problem of pediatric ISA infection in our region and results from genetically diverse SA populations.
journal_name
J Pediatric Infect Dis Socjournal_title
Journal of the Pediatric Infectious Diseases Societyauthors
Suryadevara M,Clark AE,Wolk DM,Carman A,Rosenbaum PF,Shaw Jdoi
10.1093/jpids/pis087subject
Has Abstractpub_date
2013-03-01 00:00:00pages
30-9issue
1eissn
2048-7193issn
2048-7207pii
pis087journal_volume
2pub_type
杂志文章abstract:BACKGROUND:Invasive mold infections (IMIs) are a leading cause of mortality in immunocompromised children, yet there has never been an international epidemiologic investigation of pediatric IMIs. METHODS:This international, prospective cohort study was performed to characterize the epidemiology, antifungal therapy, an...
journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,多中心研究
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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pub_type: 杂志文章
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journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
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journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
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更新日期:2018-02-19 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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pub_type: 杂志文章,评审
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