Abstract:
Background:Lower procalcitonin (PCT) concentrations are associated with reduced risk of bacterial community-acquired pneumonia (CAP) in adults, but data in children are limited. Methods:We analyzed serum PCT concentrations from children hospitalized with radiographically confirmed CAP enrolled in the Centers for Disease Control and Prevention's Etiology of Pneumonia in the Community (EPIC) Study. Blood and respiratory specimens were tested using multiple pathogen detection methods for typical bacteria (eg, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus), atypical bacteria (Mycoplasma pneumoniae and Chlamydophila pneumoniae), and respiratory viruses. Multivariable regression was used to assess associations between PCT concentrations and etiology and severity. Results:Among 532 children (median age, 2.4 years; interquartile range [IQR], 1.0-6.3), patients with typical bacteria had higher PCT concentrations (±viruses; n = 54; median, 6.10; IQR, 0.84-22.79 ng/mL) than those with atypical bacteria (±viruses; n = 82; median, 0.10; IQR, 0.06-0.39 ng/mL), viral pathogens only (n = 349; median, 0.33; IQR, 0.12-1.35 ng/mL), or no pathogen detected (n = 47; median, 0.44; IQR, 0.10-1.83 ng/mL) (P < .001 for all). No child with PCT <0.1 ng/mL had typical bacteria detected. Procalcitonin <0.25 ng/mL featured a 96% negative predictive value (95% confidence interval [CI], 93-99), 85% sensitivity (95% CI, 76-95), and 45% specificity (95% CI, 40-50) in identifying children without typical bacterial CAP. Conclusions:Lower PCT concentrations in children hospitalized with CAP were associated with a reduced risk of typical bacterial detection and may help identify children who would not benefit from antibiotic treatment.
journal_name
J Pediatric Infect Dis Socjournal_title
Journal of the Pediatric Infectious Diseases Societyauthors
Stockmann C,Ampofo K,Killpack J,Williams DJ,Edwards KM,Grijalva CG,Arnold SR,McCullers JA,Anderson EJ,Wunderink RG,Self WH,Bramley A,Jain S,Pavia AT,Blaschke AJdoi
10.1093/jpids/piw091subject
Has Abstractpub_date
2018-02-19 00:00:00pages
46-53issue
1eissn
2048-7193issn
2048-7207pii
2966998journal_volume
7pub_type
杂志文章abstract::We determined the rates of community-acquired pneumonia (CAP)-associated hospitalizations and complications in Athens, over a period covering 4 years before and 4 years after the implementation of the 7-valent pneumococcal vaccine (PCV7) in Greece. PCV7 had no impact on pediatric CAP rates, whereas there was an increa...
journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章,评审
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abstract:BACKGROUND:The objective was to describe respiratory syncytial virus (RSV) hospitalizations in Alberta, Canada over a 13-year period with an emphasis on the incidence and risk factors for repeat hospitalizations attributable to new RSV infections. METHODS:This was a retrospective database analysis. The Alberta Health ...
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journal_title:Journal of the Pediatric Infectious Diseases Society
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Journal of the Pediatric Infectious Diseases Society
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更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Rotavirus is the most common cause of infectious diarrhea in children worldwide. Recent studies have described changes in the burden of all-cause gastroenteritis; however, there are limited data on the clinical and economic impact of rotavirus vaccine on cases of laboratory-confirmed rotavirus disease. METH...
journal_title:Journal of the Pediatric Infectious Diseases Society
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abstract:BACKGROUND:Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics. METHODS:We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diag...
journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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更新日期:2017-11-24 00:00:00
abstract:Background:Evaluation for neonatal sepsis routinely includes performing both aerobic and anaerobic blood cultures despite our lack of knowledge of the true incidence of anaerobic bacteremia in this age group and the consequences of not performing these paired cultures. Methods:We performed a retrospective review of al...
journal_title:Journal of the Pediatric Infectious Diseases Society
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journal_title:Journal of the Pediatric Infectious Diseases Society
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abstract:Background:Data on long-term toxicity of antiretroviral therapy (ART) in HIV-infected children are sparse. PENPACT-1 was an open-label trial in which HIV-infected children were assigned randomly to receive protease inhibitor (PI)- or nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based ART. Methods:We examined ...
journal_title:Journal of the Pediatric Infectious Diseases Society
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