Abstract:
:Scutellaria baicalensis Georgi (Lamiaceae) is the source of the well-known traditional Chinese medicine "HuangQin" (Radix Scutellariae). Natural sources of S. baicalensis are rapidly declining due to high market demand and overexploitation. Moreover, the commercial products of Radix Scutellariae have often been found to contain adulterants in recent years, which may give rise to issues regarding drug efficacy and safety. In this study, we developed valuable chloroplast molecular resources by comparing intraspecific and interspecific chloroplast genome. The S. baicalensis chloroplast genome is a circular molecule consisting of two single-copy regions separated by a pair of inverted repeats. Comparative analyses of three Scutellaria chloroplast genomes revealed six variable regions (trnH-psbA, trnK-rps16, petN-psbM, trnT-trnL, petA-psbJ, and ycf1) that could be used as DNA barcodes. There were 25 single nucleotide polymorphisms(SNPs) and 29 indels between the two S. baicalensis genotypes. All of the indels occurred within non-coding regions. Phylogenetic analysis suggested that Scutellarioideae is a sister taxon to Lamioideae. These resources could be used to explore the variation present in Scutellaria populations and for further evolutionary, phylogenetic, barcoding and genetic engineering studies, in addition to effective exploration and conservation of S. baicalensis.
journal_name
Genes (Basel)journal_title
Genesauthors
Jiang D,Zhao Z,Zhang T,Zhong W,Liu C,Yuan Q,Huang Ldoi
10.3390/genes8090227subject
Has Abstractpub_date
2017-09-13 00:00:00issue
9issn
2073-4425pii
genes8090227journal_volume
8pub_type
杂志文章相关文献
Genes文献大全abstract::During speciation-with-gene-flow, a transition from single-locus to multi-locus processes can occur, as strong coupling of multiple loci creates a barrier to gene flow. Testing predictions about such transitions with empirical data requires building upon past theoretical work and the continued development of quantitat...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060274
更新日期:2018-05-24 00:00:00
abstract::This review discusses a set of experimental results that support the existence of extended strand displacement events during budding yeast lagging strand DNA synthesis. Starting from introducing the mechanisms and factors involved in leading and lagging strand DNA synthesis and some aspects of the architecture of the ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10020167
更新日期:2019-02-21 00:00:00
abstract::Rapeseed contains glucosinolates, a toxic group of sulfur-containing glucosides, which play critical roles in defense against herbivores and microbes. However, the presence of glucosinolates in rapeseed reduces the value of the meal as feed for livestock. We performed association mapping of seed glucosinolate (GS) con...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes6041215
更新日期:2015-11-18 00:00:00
abstract::RabGTPase activating proteins (RabGAP) are responsible for directing the deactivation of vesicular trafficking master regulators associated to plant development, the RabGTPase proteins. Recently, RabGAPs were identified in Arabidopsis and rice, but studies were not yet reported in tomato. Herein, we identified 24 RabG...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090638
更新日期:2019-08-23 00:00:00
abstract::Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. Triploid trout as sterile do not invest an energy in gametogenesis and continue to grow, whereas fertile diploid individuals suffer from declines in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070786
更新日期:2020-07-13 00:00:00
abstract::The plant circadian clock coordinates environmental signals with internal processes including secondary metabolism, growth, flowering, and volatile emission. Plant tissues are specialized in different functions, and petals conceal the sexual organs while attracting pollinators. Here we analyzed the transcriptional str...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10110860
更新日期:2019-10-30 00:00:00
abstract::This article explores the mechanism of miR-194 on the proliferation and apoptosis of Aβ1-42-transduced hippocampal neurons. Aβ1-42-transduced hippocampal neuron model was established by inducing hippocampal neurons with Aβ1-42. MTT assay and flow cytometry were used to detect the viability and apoptosis of hippocampal...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10040313
更新日期:2019-04-21 00:00:00
abstract::: The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar proteins being encoded in the cell nuclear genome and traffick...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9080412
更新日期:2018-08-14 00:00:00
abstract::(1) Background: Autoimmune thyroid diseases (AITDs) are female predominant and much attention has been focused on G protein-coupled receptor 174 (GPR174) and integral membrane protein 2A (ITM2A) on the X chromosome as Grave's disease (GD) susceptible locus. (2) Methods: We genotyped four single nucleotide polymorphism...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11080858
更新日期:2020-07-27 00:00:00
abstract::Ferns are a representative clade in plant evolution although underestimated in the genomic era. Ceratopteris richardii is an emergent model for developmental processes in ferns, yet a complete scheme of the different growth stages is necessary. Here, we present a developmental analysis, at the tissue and cellular leve...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11121455
更新日期:2020-12-04 00:00:00
abstract::The yeast Exophiala dermatitidis exhibits high resistance to γ-radiation in comparison to many other fungi. Several aspects of this phenotype have been characterized, including its dependence on homologous recombination for the repair of radiation-induced DNA damage, and the transcriptomic response invoked by acute γ-...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101128
更新日期:2020-09-25 00:00:00
abstract::Due to its extraordinary longevity and wide distribution, the ocean quahog Arctica islandica has become an important species model in both aging and environmental change research. Notwithstanding that, most genetic studies on ocean quahogs have been focused on fishery related, phylogeographic and phylogenetic aspects ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060299
更新日期:2018-06-13 00:00:00
abstract::Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex traits. Our aim was to test the extent to which a population with a former history of geographic isolation and religious endogamy, and currently with one of the highest fert...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8050133
更新日期:2017-05-04 00:00:00
abstract::In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE) enable predefined nucleotide exchanges in genomic sequences without generating DNA double strand breaks. Here, we employed BE and PE mRNAs in conjunction with chemically synthesized sgRNAs and pegRNAs for efficient editing of human i...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050511
更新日期:2020-05-06 00:00:00
abstract::Pleurotus tuoliensis (Pt) and P. eryngii var. eryngii (Pe) are important edible mushrooms. The epigenetic and gene expression signatures characterizing major developmental transitions in these two mushrooms remain largely unknown. Here, we report global analyses of DNA methylation and gene expression in both mushrooms...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10060465
更新日期:2019-06-17 00:00:00
abstract::Epigenetic modifications are a mechanism conveying environmental information to subsequent generations via parental germ lines. Research on epigenetic responses to environmental changes in wild mammals has been widely neglected, as well as studies that compare responses to changes in different environmental factors. H...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10010004
更新日期:2018-12-21 00:00:00
abstract::Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6040957
更新日期:2015-09-30 00:00:00
abstract:BACKGROUND:Anthocyanin pigmentation characterizes a number of tissues of Citrus and its relatives. The gain and loss of pigmentation is intriguing and is inherited variously among species. METHODS:Citrus germplasm was used to investigate the anthocyanin pigmentation of tissues never before considered, including stamen...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070807
更新日期:2020-07-16 00:00:00
abstract::Coat color dilution corresponds to a specific pigmentation phenotype that leads to a dilution of wild type pigments. It affects both eumelanin and pheomelanin containing melanosomes. The mode of inheritance of the dilution phenotype is autosomal recessive. Candidate gene approaches focused on the melanophilin (MLPH) g...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9090430
更新日期:2018-08-23 00:00:00
abstract::Oral vaccination is a practical method for the active immunization of farmed fish in the matter of animal welfare and handling costs. However, it always shows insufficient protective immunity, mainly due to antigen degradation in the gastrointestinal tract (GIT). Bacillus subtilis spores have been shown to be able to ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111351
更新日期:2020-11-14 00:00:00
abstract::n/a. ...
journal_title:Genes
pub_type: 杂志文章,已发布勘误
doi:10.3390/genes8030091
更新日期:2017-03-03 00:00:00
abstract::There is an ongoing worldwide coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, confirmatory diagnosis is by reverse transcription polymerase chain reaction (RT-PCR), typically taking several hours and requiring a molecular laboratory to pe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060664
更新日期:2020-06-18 00:00:00
abstract::Pseudomonas savastanoi pv. savastanoi is the causal agent of Olive knot disease, relying on the Type Three Secretion System (TTSS) for its pathogenicity. In this regard, nothing was known about the two other pathovars belonging to this species, pv. nerii and pv. fraxini, characterized by a different host range. Here w...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes2040957
更新日期:2011-11-25 00:00:00
abstract::Preimplantation genetic testing (PGT) has evolved into a well-established alternative to invasive prenatal diagnosis, even though genetic testing of single or few cells is quite challenging. PGT-M is in theory available for any monogenic disorder for which the disease-causing locus has been unequivocally identified. I...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11080871
更新日期:2020-07-31 00:00:00
abstract::Approximately 150 fungal species are considered as primary pathogens of humans and animals[...]. ...
journal_title:Genes
pub_type: 社论
doi:10.3390/genes10020136
更新日期:2019-02-12 00:00:00
abstract::Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85-90% reactivate telomerase, while 10-15% use the alternative lengthening of telomeres (ALT). Due to anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism to ALT; in fact, the co-existence between b...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070834
更新日期:2020-07-21 00:00:00
abstract::Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes8110299
更新日期:2017-10-30 00:00:00
abstract::Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone acetylation can directly affect chromatin structure by neutralising char...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes3020320
更新日期:2012-05-29 00:00:00
abstract::There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of linc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8080203
更新日期:2017-08-18 00:00:00
abstract::Cyclocarya paliurus (Batal.) Iljinskaja, a unique species growing in southern China, is a multi-function tree species with medicinal, healthcare, material, and ornamental values. So far, sexual reproduction is the main method for extensive cultivation of C. paliurus plantations, but this is limited by low seed plumpne...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100818
更新日期:2019-10-17 00:00:00