Abstract:
:This review discusses a set of experimental results that support the existence of extended strand displacement events during budding yeast lagging strand DNA synthesis. Starting from introducing the mechanisms and factors involved in leading and lagging strand DNA synthesis and some aspects of the architecture of the eukaryotic replisome, we discuss studies on bacterial, bacteriophage and viral DNA polymerases with potent strand displacement activities. We describe proposed pathways of Okazaki fragment processing via short and long flaps, with a focus on experimental results obtained in Saccharomyces cerevisiae that suggest the existence of frequent and extended strand displacement events during eukaryotic lagging strand DNA synthesis, and comment on their implications for genome integrity.
journal_name
Genes (Basel)journal_title
Genesauthors
Giannattasio M,Branzei Ddoi
10.3390/genes10020167subject
Has Abstractpub_date
2019-02-21 00:00:00issue
2issn
2073-4425pii
genes10020167journal_volume
10pub_type
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