Abstract:
:Rapeseed contains glucosinolates, a toxic group of sulfur-containing glucosides, which play critical roles in defense against herbivores and microbes. However, the presence of glucosinolates in rapeseed reduces the value of the meal as feed for livestock. We performed association mapping of seed glucosinolate (GS) content using the 60K Brassica Infinium single nucleotide polymorphism (SNP) array in 520 oilseed rape accessions. A total of 11 peak SNPs significantly associated with GS content were detected in growing seasons of 2013 and 2014 and were located on B. napus chromosomes A08, A09, C03, and C09, respectively. Two associated regions of GS content covered by these markers were further verified, and three B. napus homologous genes involved in the biosynthesis and accumulation of GS were identified. These genes were multigene family members and were distributed on different chromosomes. Moreover, two genes (BnGRT2 and BnMYB28) associated with GS content were validated by the qRT-PCR analysis of their expression profiles. The further identification and functionalization of these genes will provide useful insight into the mechanism underlying GS biosynthesis and allocation in B. napus, and the associated SNPs markers could be helpful for molecular maker-assisted breeding for low seed GS in B. napus.
journal_name
Genes (Basel)journal_title
Genesauthors
Qu CM,Li SM,Duan XJ,Fan JH,Jia LD,Zhao HY,Lu K,Li JN,Xu XF,Wang Rdoi
10.3390/genes6041215subject
Has Abstractpub_date
2015-11-18 00:00:00pages
1215-29issue
4issn
2073-4425pii
genes6041215journal_volume
6pub_type
杂志文章相关文献
Genes文献大全abstract::The sea lamprey (Petromyzon marinus) is one of few vertebrate species known to reproducibly eliminate large fractions of its genome during normal embryonic development. This germline-specific DNA is lost in the form of large fragments, including entire chromosomes, and available evidence suggests that DNA elimination ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100832
更新日期:2019-10-22 00:00:00
abstract::Gene expression in the brain is dramatically regulated by a variety of stimuli. While the role of neural activity has been extensively studied, less is known about the effects of metabolism and nutrition on transcriptional control mechanisms in the brain. Extracellular signals are integrated at the chromatin level thr...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11070742
更新日期:2020-07-03 00:00:00
abstract::Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and a γ-secretase. It has been hypothesised that partial inhibition of BACE1 in individuals with a high risk of developing Alzheimer's disease ma...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10090705
更新日期:2019-09-12 00:00:00
abstract::Lower levels of physical activity (PA) have been associated with increased risk of cardiovascular disease. Worldwide, there is a shift towards a lifestyle with less PA, posing a serious threat to public health. One of the suggested mechanisms behind the association between PA and disease development is through systemi...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10110908
更新日期:2019-11-07 00:00:00
abstract::During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus laevis; this review will focus primarily on studies of this model organ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10110895
更新日期:2019-11-06 00:00:00
abstract::Information on the biochemical pathways of carbon and energy metabolism in representatives of the deep lineage bacterial phylum Deferribacteres are scarce. Here, we report the results of the sequencing and analysis of the high-quality draft genome of the thermophilic chemolithoautotrophic anaerobe Deferribacter autotr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10110849
更新日期:2019-10-26 00:00:00
abstract::Genetic dissection of yield components and seed mineral-nutrient is crucial for understanding plant physiological and biochemical processes and alleviate nutrient malnutrition. Sesame (Sesamum indicum L.) is an orphan crop that harbors rich allelic repertoire for seed mineral-nutrients. Here, we harness this wide dive...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101221
更新日期:2020-10-18 00:00:00
abstract::This article explores the mechanism of miR-194 on the proliferation and apoptosis of Aβ1-42-transduced hippocampal neurons. Aβ1-42-transduced hippocampal neuron model was established by inducing hippocampal neurons with Aβ1-42. MTT assay and flow cytometry were used to detect the viability and apoptosis of hippocampal...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10040313
更新日期:2019-04-21 00:00:00
abstract::Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability and autism spectrum disorder, and among those with fragile X syndrome, approximately 1/3rd meet a threshold for an autism spectrum disorder (ASD) diagnosis. Previous functional imaging studies of fragile X syndrome have typically fo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10121052
更新日期:2019-12-17 00:00:00
abstract::Root nodule symbioses (nodulation) and whole genome duplication (WGD, polyploidy) are both important phenomena in the legume family (Leguminosae). Recently, it has been proposed that polyploidy may have played a critical role in the origin or refinement of nodulation. However, while nodulation and polyploidy have been...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120357
更新日期:2017-11-30 00:00:00
abstract::Xyloglucan endotransglycosylase/hydrolase (XTH) is a cell-wall-modifying enzyme participating in diverse cell morphogenetic processes and adaptation to stress. In this study, 48 XTH genes were identified from two pineapple (Ananas comosus) cultivars ('F153' and 'MD2') and designated Ac(F153)XTH1 to -24 and Ac(MD2)XTH1...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10070537
更新日期:2019-07-16 00:00:00
abstract::Modulated electromagnetic fields (wEMFs), as generated by modern communication technologies, have raised concerns about adverse health effects. The International Agency for Research on Cancer (IARC) classifies them as "possibly carcinogenic to humans" (Group 2B), yet, the underlying molecular mechanisms initiating and...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11040347
更新日期:2020-03-25 00:00:00
abstract::Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050476
更新日期:2020-04-27 00:00:00
abstract::Segments of the genome enriched in repetitive sequences still present a challenge and are omitted in genome assemblies. For that reason, the exact composition of DNA sequences underlying the heterochromatic regions and the active centromeres are still unexplored for many organisms. The centromere is a crucial region o...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060695
更新日期:2020-06-24 00:00:00
abstract::The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derive...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101192
更新日期:2020-10-14 00:00:00
abstract::While methods for detecting SNVs and indels in circulating tumor DNA (ctDNA) with hybridization capture-based next-generation sequencing (NGS) have been available, copy number variations (CNVs) detection is more challenging. Here, we present a method enabling CNV detection from a 150-gene panel using a very low amount...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10110926
更新日期:2019-11-14 00:00:00
abstract::Meiosis yields haploid gametes following two successive divisions of a germ cell in the absence of intervening DNA replication. Balanced segregation of homologous chromosomes in Meiosis I is aided by a proteinaceous structure, the synaptonemal complex (SC). The objective of this study was to determine total average au...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes1030505
更新日期:2010-12-15 00:00:00
abstract::Variants of the LOXHD1 gene, which are expressed in hair cells of the cochlea and vestibule, have been reported to cause a progressive form of autosomal recessive non-syndromic hereditary hearing loss, DFNB77. In this study, genetic screening was conducted on 8074 Japanese hearing loss patients utilizing massively par...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100735
更新日期:2019-09-23 00:00:00
abstract::Olfaction, which is mediated by olfactory receptor (OR) genes, is essential in the daily life of fish, especially in foraging. However, Chinese perch (Siniperca chuatsi) is believed to prey with reliance on vision and lateral sensation, but not on olfaction. Therefore, understanding the evolutionary dynamics of the Ch...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020178
更新日期:2019-02-25 00:00:00
abstract::Lactobacillus ruminis is a commensal motile lactic acid bacterium living in the intestinal tract of humans and animals. Although a few genomes of L. ruminis were published, most of them were animal derived. To explore the genetic diversity and potential niche-specific adaptation changes of L. ruminis, in the current w...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010070
更新日期:2020-01-08 00:00:00
abstract::In the frog genus Pseudis, previous works found a sex-linked heteromorphism of the PcP190 satellite DNA in the nucleolus organizer region (NOR)-bearing chromosome pairs of Pseudis bolbodactyla and Pseudis tocantins, which possess a ZZ/ZW sex determination system. A pericentromeric inversion was inferred to have occurr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020160
更新日期:2019-02-19 00:00:00
abstract::Mitogen-activated protein kinase (MAPK) signaling pathway plays key roles in sensing extracellular signals and transmitting them from the cell membrane to the nucleus in response to various environmental stimuli. A MAPKKK protein CgMck1 in Colletotrichum gloeosporioides was characterized. Phenotypic analyses of the ∆C...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9110543
更新日期:2018-11-08 00:00:00
abstract::In addition to its wide geographical distribution, osteoglossiform fishes represent one of the most ancient freshwater teleost lineages; making it an important group for systematic and evolutionary studies. These fishes had a Gondwanan origin and their past distribution may have contributed to the diversity present in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060306
更新日期:2018-06-19 00:00:00
abstract::Illumina and nanopore sequencing technologies are powerful tools that can be used to determine the bacterial composition of complex microbial communities. In this study, we compared nasal microbiota results at genus level using both Illumina and nanopore 16S rRNA gene sequencing. We also monitored the progression of n...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11091105
更新日期:2020-09-21 00:00:00
abstract::Marek's Disease is a lymphoproliferative disease of chickens caused by Marek's Disease Virus. Similar to other herpesviruses, Marek's Disease Virus (MDV) encodes its own small non-coding regulatory RNAs termed microRNAs (miRNAs). We previously found that the expression profile of these viral miRNAs is affected by vacc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020115
更新日期:2019-02-05 00:00:00
abstract::Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9020115
更新日期:2018-02-21 00:00:00
abstract::Epigenetic modifications are a mechanism conveying environmental information to subsequent generations via parental germ lines. Research on epigenetic responses to environmental changes in wild mammals has been widely neglected, as well as studies that compare responses to changes in different environmental factors. H...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10010004
更新日期:2018-12-21 00:00:00
abstract::Juvenile open angle glaucoma (JOAG), which is an uncommon form of primary open angle glaucoma, is a clinically and genetically heterogeneous disorder. We report on a family with a recessively inherited form of JOAG. The proband has a superior and an inferior never fiber layer thinning in both the eyes and the nasal vi...
journal_title:Genes
pub_type:
doi:10.3390/genes9110527
更新日期:2018-10-30 00:00:00
abstract::Although genome-wide association studies (GWAS) have identified several hundred loci associated with autoimmune diseases, their mechanistic insights are still poorly understood. The human genome is more complex than single nucleotide polymorphisms (SNPs) that are interrogated by GWAS arrays. Apart from SNPs, it also c...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes9080377
更新日期:2018-07-27 00:00:00
abstract::Transcriptional regulation of the genome arguably provides the basis for the anatomical elaboration and dynamic operation of the human brain. It logically follows that genetic variations affecting gene transcription contribute to mental health disorders, including autism spectrum disorder (ASD). A number of recent stu...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050535
更新日期:2020-05-11 00:00:00