Characterisation and pharmacological analysis of a crustacean G protein-coupled receptor: the red pigment-concentrating hormone receptor of Daphnia pulex.

abstract：:Biomarkers suitable for early diagnosis and monitoring disease progression are the cornerstone of developing disease-modifying treatments for neurodegenerative diseases such as Parkinson's disease (PD). Besides motor complications, PD is also characterized by deficits in visual processing. Here, we investigate how vir...

journal_title：Scientific reports

authors： Østergaard FG,Himmelberg MM,Laursen B,Siebner HR,Wade AR,Christensen KV

更新日期：2020-07-17 00:00:00

abstract：:Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and proteasome activities in frozen postmortem OFC tissue from 76 (...

journal_title：Scientific reports

authors： Bousman CA,Luza S,Mancuso SG,Kang D,Opazo CM,Mostaid MS,Cropley V,McGorry P,Shannon Weickert C,Pantelis C,Bush AI,Everall IP

更新日期：2019-02-19 00:00:00

abstract：:Targeting micrometer sized metal droplets with near-infrared sub-picosecond laser pulses generates intense stress-confined acoustic waves within the droplet. Spherical focusing amplifies their pressures. The rarefaction wave nucleates cavitation at the center of the droplet, which explosively expands with a repeatable...

journal_title：Scientific reports

authors： Krivokorytov MS,Zeng Q,Lakatosh BV,Vinokhodov AY,Sidelnikov YV,Kompanets VO,Krivtsun VM,Koshelev KN,Ohl CD,Medvedev VV

更新日期：2018-01-12 00:00:00

abstract：:VvhA, a virulent factor of Vibrio (V.) vulnificus, induces acute cell death in a destructive manner. Autophagy plays an important role in cell death, but the functional role of VvhA in autophagy-related cell death has not been elucidated yet. We found that rVvhA significantly increased LC3 puncta formation and autopha...

journal_title：Scientific reports

authors： Song EJ,Lee SJ,Lim HS,Kim JS,Jang KK,Choi SH,Han HJ

更新日期：2016-06-02 00:00:00

abstract：:Systemic lupus erythematosus (SLE) patients are vulnerable to infections. We aim to explore the approach to differentiate active infection from disease activity in pediatric SLE patients. Fifty pediatric SLE patients presenting with 185 clinical visits were collected. The associations between both clinical and laborat...

journal_title：Scientific reports

authors： Luo KL,Yang YH,Lin YT,Hu YC,Yu HH,Wang LC,Chiang BL,Lee JH

更新日期：2020-11-16 00:00:00

abstract：:Long-term monitoring of host-parasite interactions is important for understanding the consequences of infection on host fitness and population dynamics. In an eight-year survey of the loggerhead sea turtle (Caretta caretta) population nesting in Cabo Verde, we determined the spatiotemporal variation of Ozobranchus mar...

journal_title：Scientific reports

authors： Lockley EC,Fouda L,Correia SM,Taxonera A,Nash LN,Fairweather K,Reischig T,Durão J,Dinis H,Roque SM,Lomba JP,Dos Passos L,Cameron SJK,Stiebens VA,Eizaguirre C

更新日期：2020-10-29 00:00:00

abstract：:Data on post stroke outcomes in developing countries are scarce due to uncoordinated healthcare delivery systems. In Malaysia, the national stroke clinical practice guideline does not address transfer of care and longer term post stroke care beyond tertiary care. Hence, post stroke care delivery may be delivered at ei...

journal_title：Scientific reports

authors： Abdul Aziz AF,Ali MF,Yusof MF,Che' Man Z,Sulong S,Aljunid SM

更新日期：2018-12-19 00:00:00

abstract：:Recent studies have reported the ectopic expression of olfactory receptors (ORs) in non-olfactory tissues, however, their physiological roles were not well elucidated. ORs are expressed in and function in different types of cancers. Here, we identified that the H3K9me2 levels of several OR promoters decreased during d...

journal_title：Scientific reports

authors： Jung H,Chae YC,Kim JY,Jeong OS,Kook H,Seo SB

更新日期：2017-04-07 00:00:00

abstract：:Although lizards are often described as having robust neurogenic abilities, only a handful of the more than 6300 species have been explored. Here, we provide the first evidence of homeostatic neurogenesis in the leopard gecko (Eublepharis macularius). We focused our study on the medial cortex, homologue of the mammali...

journal_title：Scientific reports

authors： McDonald RP,Vickaryous MK

更新日期：2018-06-25 00:00:00

abstract：:Naturally occurring metals and metalloids [metal(loid)s] are essential for the physiological functioning of wildlife; however, environmental contamination by metal(loid) and plastic pollutants is a health hazard. Metal(loid)s may interact with plastic in the environment and there is mixed evidence about whether plasti...

journal_title：Scientific reports

authors： Roman L,Kastury F,Petit S,Aleman R,Wilcox C,Hardesty BD,Hindell MA

更新日期：2020-10-22 00:00:00

abstract：:The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representi...

journal_title：Scientific reports

authors： Gehring TV,Luksys G,Sandi C,Vasilaki E

更新日期：2015-10-01 00:00:00

abstract：:Hbs1, which is homologous to the GTPase eRF3, is a small G protein implicated in mRNA quality control. It interacts with a translation-release factor 1-like protein Dom34/Pelota to direct decay of mRNAs with ribosomal stalls. Although both proteins are evolutionarily conserved in eukaryotes, the biological function of...

journal_title：Scientific reports

authors： Li Z,Yang F,Xuan Y,Xi R,Zhao R

更新日期：2019-03-01 00:00:00

abstract：:In this report we have evaluated radiation effective dose received by patients during ECG-gated CCTA examinations based on gender, heart rate, tube voltage protocol and body mass index (BMI). A total of 1,824 patients were retrospectively recruited (1,139 men and 685 women) and they were divided into Group 1 (CCTA wit...

journal_title：Scientific reports

authors： Sabarudin A,Siong TW,Chin AW,Hoong NK,Karim MKA

更新日期：2019-03-13 00:00:00

abstract：:Oxytocin has a conserved role in regulating animal social behaviour including parental-offspring interactions. Recently an oxytocin-like neuropeptide, nematocin, and its cognate receptors have been identified in the nematode Caenorhabditis elegans. We provide evidence for a pheromone signal produced by C. elegans larv...

journal_title：Scientific reports

authors： Scott E,Hudson A,Feist E,Calahorro F,Dillon J,de Freitas R,Wand M,Schoofs L,O'Connor V,Holden-Dye L

更新日期：2017-08-31 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Ayaz Ahmed KB,Raman T,Veerappan A

更新日期：2018-03-20 00:00:00

abstract：:Radiotherapy (RT) is one of the most frequently used methods for cancer treatment. Despite remarkable advancements in RT techniquesthe treatment of radioresistant tumours (i.e. high-grade gliomas) is not yet satisfactory. Finding novel approaches less damaging for normal tissues is of utmost importance. This would mak...

journal_title：Scientific reports

authors： Lamirault C,Doyère V,Juchaux M,Pouzoulet F,Labiod D,Dendale R,Patriarca A,Nauraye C,Le Dudal M,Jouvion G,Hardy D,Massioui NE,Prezado Y

更新日期：2020-08-11 00:00:00

abstract：:This study aimed to explore the effects of radiochemotherapy on the neurocognitive function of patients with high-grade gliomas (HGG). The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA), event-related potential P300 (ERP-P300), and specific MRI parameters were compared, and the associations...

journal_title：Scientific reports

authors： Bian Y,Meng L,Peng J,Li J,Wei R,Huo L,Yang H,Wang Y,Fu J,Shen L,Hong J

更新日期：2019-04-12 00:00:00

abstract：:A dusty thermal vacuum chamber (DTVC) containing a regolith simulant bed is essential for testing equipment and techniques related to lunar surface exploration. Space agencies have been reluctant to operate a DTVC because of the challenge of controlling soil disturbance of the lunar regolith simulant bed during pumpin...

journal_title：Scientific reports

authors： Go GH,Lee J,Chung T,Ryu BH,Jin H,Zhuang L,Shin HS,Kim JH,Yun TS

更新日期：2021-01-21 00:00:00

abstract：:The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary compon...

journal_title：Scientific reports

authors： Enevold C,Nielsen CH,Molbo D,Lund R,Bendtzen K,Fiehn N-,Holmstrup P

更新日期：2019-04-18 00:00:00

abstract：:The polychaetous annelid Neanthes acuminata complex has a widespread distribution, with the California population referred to as N. arenaceodentata. The reproductive pattern in this complex is unique, in that the female reproduces once and then dies, whereas the male can reproduce up to nine times. The male incubates ...

journal_title：Scientific reports

authors： Chandramouli KH,Reish D,Zhang H,Qian PY,Ravasi T

更新日期：2015-09-04 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Röttgerding F,Wagemakers A,Koetsveld J,Fingerle V,Kirschfink M,Hovius JW,Zipfel PF,Wallich R,Kraiczy P

更新日期：2019-05-02 00:00:00

abstract：:Secondary bacterial infections increase morbidity and mortality of influenza A virus (IAV) infections. Bacteria are able to invade due to virus-induced depletion of alveolar macrophages (AMs), but this is not the only contributing factor. By analyzing a kinetic model, we uncovered a nonlinear initial dose threshold th...

journal_title：Scientific reports

authors： Smith AM,Smith AP

更新日期：2016-12-15 00:00:00

abstract：:This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative con...

journal_title：Scientific reports

authors： BaSalamah MA,Abdelghany AH,El-Boshy M,Ahmad J,Idris S,Refaat B

更新日期：2018-03-19 00:00:00

abstract：:Isopods of the genus Idotea have an unusual ability to feed on algae containing high amounts of chemical defense molecules, such as species of the genera Fucus and Ulva. In this study, we compared gene expression patterns of Idotea balthica individuals fed with Fucus vesiculosus to individuals fed with Ulva lactuca. W...

journal_title：Scientific reports

authors： De Wit P,Yamada K,Panova M,André C,Johannesson K

更新日期：2018-11-14 00:00:00

abstract：:Common reference values of arterial stiffness indices could be effective screening tool in detecting vascular phenotypes at risk. However, populations of the same ethnicity may differ in vascular phenotype due to different environmental pressure. We examined applicability of normative equations for central augmentatio...

journal_title：Scientific reports

authors： Jeroncic A,Gunjaca G,Mrsic DB,Mudnic I,Brizic I,Polasek O,Boban M

更新日期：2016-05-27 00:00:00

abstract：:OVGP1 is the major non-serum glycoprotein in the oviduct fluid at the time of fertilization and early embryo development. Its activity differs among species. Here, we show that the C-terminal region of recombinant OVGP1 regulates its binding to the extracellular zona pellucida and affects its activity during fertiliza...

journal_title：Scientific reports

authors： Algarra B,Han L,Soriano-Úbeda C,Avilés M,Coy P,Jovine L,Jiménez-Movilla M

更新日期：2016-09-07 00:00:00

abstract：:Basal-like breast cancer (BLBC) is associated with a poor clinical outcome due to the few treatment options and absence of effective targeted agents. Here, we show that malic enzyme 1 (ME1) is dramatically upregulated in BLBC due to ME1 copy number amplification. ME1 expression increases glucose uptake and lactate pro...

journal_title：Scientific reports

authors： Liao R,Ren G,Liu H,Chen X,Cao Q,Wu X,Li J,Dong C

更新日期：2018-11-13 00:00:00

abstract：:Thermoelectrics is a challenging issue for modern and future energy conversion and recovery technology. Carbon nanotubes are promising active thermoelectic materials owing to their narrow bandgap energy and high charge carrier mobility, and they can be integrated into flexible thermoelectrics that can recover any wast...

journal_title：Scientific reports

authors： Nonoguchi Y,Ohashi K,Kanazawa R,Ashiba K,Hata K,Nakagawa T,Adachi C,Tanase T,Kawai T

更新日期：2013-11-26 00:00:00

abstract：:Although most models suggest continental Antarctica was covered by ice during the Last Glacial Maximum (LGM) it has been speculated that endemic species of soil invertebrates could have survived the Pleistocene at high elevation habitats protruding above the ice sheets. We analyzed a series of soil samples from differ...

journal_title：Scientific reports

authors： Lyons WB,Deuerling K,Welch KA,Welch SA,Michalski G,Walters WW,Nielsen U,Wall DH,Hogg I,Adams BJ

更新日期：2016-05-18 00:00:00

abstract：:Erwinia tracheiphila is a bacterial plant pathogen that causes a fatal wilt infection in some cucurbit crop plants. Wilt symptoms are thought to be caused by systemic bacterial colonization through xylem that impedes sap flow. However, the genetic determinants of within-plant movement are unknown for this pathogen spe...

journal_title：Scientific reports

authors： Rocha J,Shapiro LR,Kolter R

更新日期：2020-12-10 00:00:00