Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements.

abstract：:The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often lethal respiratory illness in humans, and no vaccines or specific treatments are available. Infections are initiated via binding of the MERS-CoV spike (S) glycoprotein to sialosides and dipeptidyl-peptidase 4 (the attachment and entry ...

journal_title：Nature structural & molecular biology

authors： Park YJ,Walls AC,Wang Z,Sauer MM,Li W,Tortorici MA,Bosch BJ,DiMaio F,Veesler D

更新日期：2019-12-01 00:00:00

abstract：:Three recent studies converged on a specific protein-protein interface between TPP1 and telomerase as being crucial for the regulation of both telomerase recruitment and processivity in mammalian cells. An equivalent interaction appears to exist in budding yeast, making this a nearly universal means of telomerase regu...

journal_title：Nature structural & molecular biology

authors： Lue NF,Yu EY,Lei M

更新日期：2013-01-01 00:00:00

abstract：:The ≥ 10³⁰ bacteriophages on Earth relentlessly drive adaptive coevolution, forcing the generation of protective mechanisms in their bacterial hosts. One such bacterial phage-resistance system, ToxIN, consists of a protein toxin (ToxN) that is inhibited in vivo by a specific RNA antitoxin (ToxI); however, the mechanis...

journal_title：Nature structural & molecular biology

authors： Blower TR,Pei XY,Short FL,Fineran PC,Humphreys DP,Luisi BF,Salmond GP

更新日期：2011-02-01 00:00:00

abstract：:Heat-shock transcription factor (HSF) family members function in stress protection and in human diseases including proteopathies, neurodegeneration and cancer. The mechanisms that drive distinct post-translational modifications, cofactor recruitment and target-gene activation for specific HSF paralogs are unknown. We ...

journal_title：Nature structural & molecular biology

authors： Jaeger AM,Pemble CW 4th,Sistonen L,Thiele DJ

更新日期：2016-02-01 00:00:00

abstract：:Chaperones, a group of proteins that assist the folding of other proteins, seem to work in a coordinated manner. Two major chaperone families are heat-shock protein families Hsp60 and Hsp70. Here we show for the first time the formation of a stable complex between chaperonin-containing TCP-1 (CCT) and Hsc70, two eukar...

journal_title：Nature structural & molecular biology

authors： Cuéllar J,Martín-Benito J,Scheres SH,Sousa R,Moro F,López-Viñas E,Gómez-Puertas P,Muga A,Carrascosa JL,Valpuesta JM

更新日期：2008-08-01 00:00:00

abstract：:We investigated co-transcriptional recruitment of pre-mRNA processing factors to human genes. Capping factors associate with paused RNA polymerase II (pol II) at the 5' ends of quiescent genes. They also track throughout actively transcribed genes and accumulate with paused polymerase in the 3' flanking region. The 3'...

journal_title：Nature structural & molecular biology

authors： Glover-Cutter K,Kim S,Espinosa J,Bentley DL

更新日期：2008-01-01 00:00:00

abstract：:Cells respond to changes in environmental conditions via orchestrated modifications in gene expression. For example, in response to heat shock, cells execute a program of gene-specific transcriptional activation and repression. Although the activation of genes upon heat shock has been widely studied, the mechanism of ...

journal_title：Nature structural & molecular biology

authors： Allen TA,Von Kaenel S,Goodrich JA,Kugel JF

更新日期：2004-09-01 00:00:00

abstract：:Myotonic dystrophy is an RNA gain-of-function disease caused by expanded CUG or CCUG repeats, which sequester the RNA binding protein MBNL1. Here we describe a newly discovered function for MBNL1 as a regulator of pre-miR-1 biogenesis and find that miR-1 processing is altered in heart samples from people with myotonic...

journal_title：Nature structural & molecular biology

authors： Rau F,Freyermuth F,Fugier C,Villemin JP,Fischer MC,Jost B,Dembele D,Gourdon G,Nicole A,Duboc D,Wahbi K,Day JW,Fujimura H,Takahashi MP,Auboeuf D,Dreumont N,Furling D,Charlet-Berguerand N

更新日期：2011-06-19 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature structural & molecular biology

authors： Weill L,Belloc E,Castellazzi CL,Méndez R

更新日期：2019-08-01 00:00:00

abstract：:The Rbfox family of splicing factors regulate alternative splicing during animal development and in disease, impacting thousands of exons in the maturing brain, heart and muscle. Rbfox proteins have long been known to bind to the RNA sequence GCAUG with high affinity and specificity, but just half of Rbfox binding sit...

journal_title：Nature structural & molecular biology

authors： Begg BE,Jens M,Wang PY,Minor CM,Burge CB

更新日期：2020-10-01 00:00:00

abstract：:Myosin V is a double-headed processive molecular motor that moves along an actin filament by taking 36-nm steps. Using optical trapping nanometry with high spatiotemporal resolution, we discovered that there are two possible pathways for the 36-nm steps, one with 12- and 24-nm substeps, in this order, and the other wi...

journal_title：Nature structural & molecular biology

authors： Uemura S,Higuchi H,Olivares AO,De La Cruz EM,Ishiwata S

更新日期：2004-09-01 00:00:00

abstract：:Thylakoid assembly 8 (THA8) is a pentatricopeptide repeat (PPR) RNA-binding protein required for the splicing of the transcript of ycf3, a gene involved in chloroplast thylakoid-membrane biogenesis. Here we report the identification of multiple THA8-binding sites in the ycf3 intron and present crystal structures of Br...

journal_title：Nature structural & molecular biology

authors： Ke J,Chen RZ,Ban T,Zhou XE,Gu X,Tan MH,Chen C,Kang Y,Brunzelle JS,Zhu JK,Melcher K,Xu HE

更新日期：2013-12-01 00:00:00

abstract：:Frizzled planar cell polarity (PCP) signaling regulates cell motility in several tissues, including ommatidial rotation in Drosophila melanogaster. The Nemo kinase (Nlk in vertebrates) has also been linked to cell-motility regulation and ommatidial rotation but its mechanistic role(s) during rotation remain obscure. W...

journal_title：Nature structural & molecular biology

authors： Mirkovic I,Gault WJ,Rahnama M,Jenny A,Gaengel K,Bessette D,Gottardi CJ,Verheyen EM,Mlodzik M

更新日期：2011-06-01 00:00:00

abstract：:In bacteria, disassembly of the ribosome at the end of translation is facilitated by an essential protein factor termed ribosome recycling factor (RRF), which works in concert with elongation factor G. Here we describe the crystal structure of the Thermus thermophilus RRF bound to a 70S ribosomal complex containing a ...

journal_title：Nature structural & molecular biology

authors： Weixlbaumer A,Petry S,Dunham CM,Selmer M,Kelley AC,Ramakrishnan V

更新日期：2007-08-01 00:00:00

abstract：:Although tertiary folding of whole protein domains is prohibited by the cramped dimensions of the ribosomal tunnel, dynamic tertiary interactions may permit folding of small elementary units within the tunnel. To probe this possibility, we used a beta-hairpin and an alpha-helical hairpin from the cytosolic N terminus ...

journal_title：Nature structural & molecular biology

authors： Kosolapov A,Deutsch C

更新日期：2009-04-01 00:00:00

abstract：:Although t-loops protect telomeres, they are at risk of cleavage by Holliday junction (HJ) resolvases if branch migration converts the three-way t-loop junction into four-way HJs. T-loop cleavage is repressed by the TRF2 basic domain, which binds three- and four-way junctions and protects HJs in vitro. By replacing th...

journal_title：Nature structural & molecular biology

authors： Schmutz I,Timashev L,Xie W,Patel DJ,de Lange T

更新日期：2017-09-01 00:00:00

abstract：: ...

journal_title：Nature structural & molecular biology

authors： Horowitz S,Salmon L,Koldewey P,Ahlstrom LS,Martin R,Quan S,Afonine PV,van den Bedem H,Wang L,Xu Q,Trievel RC,Brooks CL 3rd,Bardwell JCA

更新日期：2018-11-01 00:00:00

abstract：:Microtubule-severing enzymes katanin, spastin and fidgetin are AAA ATPases important for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. Because of a lack of known 3D structures for these enzymes, their mechanism of action has remained poorly understood. Here we report the X-...

journal_title：Nature structural & molecular biology

authors： Zehr E,Szyk A,Piszczek G,Szczesna E,Zuo X,Roll-Mecak A

更新日期：2017-09-01 00:00:00

abstract：:The normally soluble TAR DNA-binding protein 43 (TDP-43) is found aggregated both in reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low-complexity domain (LCD) is believed to be involved in both types of aggregation. To uncover the structural origins of these two modes of β-sheet-ric...

journal_title：Nature structural & molecular biology

authors： Guenther EL,Cao Q,Trinh H,Lu J,Sawaya MR,Cascio D,Boyer DR,Rodriguez JA,Hughes MP,Eisenberg DS

更新日期：2018-06-01 00:00:00

abstract：:Jun dimerization protein-2 (JDP2) is a component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Here, we examine the functional mechanisms of JDP2 and show that it can inhibit p300-mediated acetylation of core histones in vitro and in vivo. Inhibition of histone...

journal_title：Nature structural & molecular biology

authors： Jin C,Kato K,Chimura T,Yamasaki T,Nakade K,Murata T,Li H,Pan J,Zhao M,Sun K,Chiu R,Ito T,Nagata K,Horikoshi M,Yokoyama KK

更新日期：2006-04-01 00:00:00

abstract：:During transcription, RNA polymerase II (Pol II) associates with the conserved elongation factor DSIF. DSIF renders the elongation complex stable and functions during Pol II pausing and RNA processing. We combined cryo-EM and X-ray crystallography to determine the structure of the mammalian Pol II-DSIF elongation comp...

journal_title：Nature structural & molecular biology

authors： Bernecky C,Plitzko JM,Cramer P

更新日期：2017-10-01 00:00:00

abstract：:The major structural components of HIV-1 are encoded as a single polyprotein, Gag, which is sufficient for virus particle assembly. Initially, Gag forms an approximately spherical shell underlying the membrane of the immature particle. After proteolytic maturation of Gag, the capsid (CA) domain of Gag reforms into a c...

journal_title：Nature structural & molecular biology

authors： Briggs JA,Simon MN,Gross I,Kräusslich HG,Fuller SD,Vogt VM,Johnson MC

更新日期：2004-07-01 00:00:00

abstract：:The Ca(2+) sensor synaptotagmin-1 is thought to trigger membrane fusion by binding to acidic membrane lipids and SNARE proteins. Previous work has shown that binding is mediated by electrostatic interactions that are sensitive to the ionic environment. However, the influence of divalent or polyvalent ions, at physiolo...

journal_title：Nature structural & molecular biology

authors： Park Y,Seo JB,Fraind A,Pérez-Lara A,Yavuz H,Han K,Jung SR,Kattan I,Walla PJ,Choi M,Cafiso DS,Koh DS,Jahn R

更新日期：2015-10-01 00:00:00

abstract：:Expansion of CAG/CTG trinucleotide repeats is associated with certain familial neurological disorders, including Huntington's disease. Increasing evidence suggests that formation of a stable DNA hairpin within CAG/CTG repeats during DNA metabolism contributes to their expansion. However, the molecular mechanism(s) by ...

journal_title：Nature structural & molecular biology

authors： Hou C,Chan NL,Gu L,Li GM

更新日期：2009-08-01 00:00:00

abstract：:Post-translational modification of proteins by ubiquitin (Ub) and Ub-like modifiers regulates DNA replication. We have previously shown that chromatin around replisomes is rich in SUMO and poor in Ub, whereas mature chromatin exhibits an opposite pattern. How this SUMO-rich, Ub-poor environment is maintained at sites ...

journal_title：Nature structural & molecular biology

authors： Lecona E,Rodriguez-Acebes S,Specks J,Lopez-Contreras AJ,Ruppen I,Murga M,Muñoz J,Mendez J,Fernandez-Capetillo O

更新日期：2016-04-01 00:00:00

abstract：:Despite growing appreciation of the importance of long noncoding RNAs (lncRNAs) in normal physiology and disease, our knowledge of cancer-related lncRNAs remains limited. By repurposing microarray probes, we constructed expression profiles of 10,207 lncRNA genes in approximately 1,300 tumors over four different cancer...

journal_title：Nature structural & molecular biology

authors： Du Z,Fei T,Verhaak RG,Su Z,Zhang Y,Brown M,Chen Y,Liu XS

更新日期：2013-07-01 00:00:00

abstract：:Although the two B-family human DNA polymerases, pol δ and pol ε, are responsible for the bulk of nuclear genome replication, at least 14 additional polymerases have roles in nuclear DNA repair and replication. In this issue, newly reported crystal structures of two specialized A-family polymerases, pol δ and pol ε, e...

journal_title：Nature structural & molecular biology

authors： Beard WA,Wilson SH

更新日期：2015-04-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression, including type I interferon production, by promoting host mRNA degradation and inhibiting host translation, in infected cells. We present evidence that nsp1 uses a novel, two-pronged strategy to inhibit host translation and gen...

journal_title：Nature structural & molecular biology

authors： Kamitani W,Huang C,Narayanan K,Lokugamage KG,Makino S

更新日期：2009-11-01 00:00:00

abstract：:The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into functional complexes. A recently discovered sorting and assembly machinery (SAM complex) is essential for integration and as...

journal_title：Nature structural & molecular biology

authors： Pfanner N,Wiedemann N,Meisinger C,Lithgow T

更新日期：2004-11-01 00:00:00

abstract：:The N-end rule pathway is a regulated proteolytic system that targets proteins containing destabilizing N-terminal residues (N-degrons) for ubiquitination and proteasomal degradation in eukaryotes. The N-degrons of type 1 substrates contain an N-terminal basic residue that is recognized by the UBR box domain of the E3...

journal_title：Nature structural & molecular biology

authors： Choi WS,Jeong BC,Joo YJ,Lee MR,Kim J,Eck MJ,Song HK

更新日期：2010-10-01 00:00:00