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The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity.

Abstract：

:To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the ~116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis genome due to a rapid amplification of long terminal repeat retrotransposons that occurred ~38 million years ago in concert with the uplift of the plateau. We also observe massive removal of thousands of genes related to the transport process and energy metabolism. O. sinensis displays considerable lineage-specific expansion of gene families functionally enriched in the adaptability of low-temperature of cold tolerance, fungal pathogenicity and specialized host infection. We detect signals of positive selection for genes involved in peroxidase and hypoxia to enable its highland adaptation. Resequencing and analyzing 31 whole genomes of O. sinensis, representing nearly all of its geographic range, exhibits latitude-based population divergence and nature selection for population inhabitation towards higher altitudes on the Qinghai-Tibetan Plateau.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Xia EH,Yang DR,Jiang JJ,Zhang QJ,Liu Y,Liu YL,Zhang Y,Zhang HB,Shi C,Tong Y,Kim C,Chen H,Peng YQ,Yu Y,Zhang W,Eichler EE,Gao LZ

doi

10.1038/s41598-017-01869-z

subject

Has Abstract

pub_date

2017-05-11 00:00:00

pages

1806

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01869-z

journal_volume

7

pub_type

杂志文章

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