Abstract:
:The acute apoptotic response to genotoxic carcinogens animal model has been extensively used to assess the ability of drugs and natural products like dietary components to promote apoptosis in the colon and protect against colorectal cancer (CRC). This work aimed to use this model to identify the main chemopreventative agent in extracts from an Australian mollusc Dicathais orbita, while simultaneously providing information on their potential in vivo toxicity. After 2 weeks of daily oral gavage with bioactive extracts and purified brominated indoles, mice were injected with the chemical carcinogen azoxymethane (AOM; 10 mg/kg) and then killed 6 hours later. Efficacy was evaluated using immunohistochemical and hematoxylin staining, and toxicity was assessed via hematology, blood biochemistry, and liver histopathology. Comparison of saline- and AOM-injected controls revealed that potential toxic side effects can be interpreted from blood biochemistry and hematology using this short-term model, although AOM negatively affected the ability to detect histopathological effects in the liver. Purified 6-bromoisatin was identified as the main cancer preventive agent in the Muricidae extract, significantly enhancing apoptosis and reducing cell proliferation in the colonic crypts at 0.05 mg/g. There was no evidence of liver toxicity associated with 6-bromoisatin, whereas 0.1 mg/g of the brominated indole tyrindoleninone led to elevated aspartate aminotransferase levels and a reduction in red blood cells. As tyrindoleninone is converted to 6-bromoisatin by oxidation, this information will assist in the optimization and quality control of a chemopreventative nutraceutical from Muricidae. In conclusion, preliminary data on in vivo safety can be simultaneously collected when testing the efficacy of new natural products, such as 6-bromoisatin from Muricidae molluscs for early stage prevention of colon cancer.
journal_name
Integr Cancer Therjournal_title
Integrative cancer therapiesauthors
Esmaeelian B,Benkendorff K,Le Leu RK,Abbott CAdoi
10.1177/1534735417699880subject
Has Abstractpub_date
2018-06-01 00:00:00pages
248-262issue
2eissn
1534-7354issn
1552-695Xjournal_volume
17pub_type
杂志文章abstract::The large majority of clinical prostate cancers remain dependent on androgen receptor (AR) activity for proliferation even as they lose their responsiveness to androgen deprivation or antagonism. AR activity can be maintained in these circumstances by increased AR synthesis--often reflecting increased NF-κB activation...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414534728
更新日期:2014-09-01 00:00:00
abstract::Altered expression of a cytosolic flavoenzyme NAD(P)H:quinone oxidoreductase-1 (NQO1) has been seen in many human tumors. Its remarkable overexpression in cholangiocarcinoma (CCA; an aggressive malignancy of the biliary duct system) was associated with poor prognosis and short survival of the patients. Inhibition of N...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418820444
更新日期:2019-01-01 00:00:00
abstract::Many plant products are known to exert antioxidative effects by quenching various free radicals and singlet molecular oxygen. Andrographis paniculata (Kalmegh) is used extensively in the Indian traditional system of medicine as a hepatoprotective and hepatostimulative agent and has been reported to have antioxidant ef...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735407305985
更新日期:2007-09-01 00:00:00
abstract::Background The role of whole grains, refined cereals, and legumes in preventing or initiating colorectal cancer (CRC) is still uncertain. The aim of this study is to examine the possible association between the consumption of whole grains, refined cereals, and legumes and the risk of developing CRC among Jordanian pop...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415620010
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Malignant pleural effusion (MPE) is a common complication in most malignancies. Despite its frequent occurrence, current knowledge of MPE remains limited and the effect of the management is still unsatisfying. Traditional Chinese medicine (TCM) external treatment has unique advantages, such as quicker effica...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1534735416660193
更新日期:2017-12-01 00:00:00
abstract:AIM:To introduce the application of wheel balance cancer therapy (WBCT) in cancer treatment through an intensive study of a representative patient. METHOD:A 59-year-old, female patient who was a secondhand smoker and who carried no significant medical and family history was diagnosed with T1N0M1 (stage 4) lung adenoca...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410371479
更新日期:2010-06-01 00:00:00
abstract::In recent years, there has been an increased interest in complementary and alternative medicine (CAM) use among people with cancer. Many are looking for informed advice and desire communication with their physicians about CAM use. Communication is crucial in establishing trust with patients, gathering information, add...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735410363706
更新日期:2010-06-01 00:00:00
abstract::Introduction:Viscum album L extracts (VA) are frequently used in integrative oncology. Aim of this study was to evaluate the impact of add-on VA applications on various patient-reported outcome measures. Methods: A longitudinal real-world study was conducted, using data from the Network Oncology clinical registry. Pri...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420917211
更新日期:2020-01-01 00:00:00
abstract::Eupatorin is a polymethoxy flavone extracted from Orthosiphon stamineus and was reported to exhibit cytotoxic effects on several cancer cell lines. However, its effect as an anti-breast cancer agent in vivo has yet to be determined. This study aims to elucidate the potential of eupatorin as an anti-breast cancer agent...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420935625
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Xerostomia (dry mouth) causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food. Many cancer patients have complained of xerostomia induced by cancer therapy. OBJECTIVE:The aim of this systematic review is to assess the efficacy of herbal med...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417728336
更新日期:2018-06-01 00:00:00
abstract::The effectiveness of traditional herbal medicine (THM) as treatment for nasopharyngeal cancer (NPC) has not been clearly demonstrated. The aim of this study is to assess the effectiveness of THM as adjunctive therapies for NPC using the results of randomized controlled trials (RCTs). Five electronic databases, includi...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,meta分析,评审
doi:10.1177/1534735415572881
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Because of advances in medical treatment, the survival of cancer patients is prolonged. In line with the prolonged survival time of cancer the incidence of second primary cancer has increased. There is currently no effective way to prevent the occurrence of secondary primary cancer (SPC). OBJECTIVES:The aim...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419834353
更新日期:2019-01-01 00:00:00
abstract:HYPOTHESIS:Anorexia and cancer cachexia produce significant loss of adipose tissue and muscle mass and eventually reduce survival in cancer patients. STUDY DESIGN:This phase II study was conducted to assess the efficacy and the safety of an herbal decoction with Astragali radix in patients with anorexia in advanced ca...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409359180
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Due to the limitations and side effects of conventional cancer treatment, especially in relation to quality of life (QOL), patients are increasingly utilizing complementary and alternative medicine (CAM) to supplement health-related outcomes. However, evidence for the safety and efficacy of such treatments i...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735411413268
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Jiedu Sangen Decoction (JSD), a traditional Chinese medicine formula, has been widely applied in the treatment of gastrointestinal cancer, especially in colorectal cancer. Our study mainly aimed to assess the combined efficacy of Jiedu Sangen aqueous extract (JSAE) and a PD-L1 inhibitor (PI) in colon cancer ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420972486
更新日期:2020-01-01 00:00:00
abstract::The protective effect of Andrograhis paniculata and andrographolide (ANDLE) against cyclophosphamide (CTX)-induced urothelial toxicity was investigated in this study. Pretreatment of Swiss albino mice with A paniculata extract (10 mg/dose/animal intraperitoneally [ip]) and ANDLE (500 microg/dose/animal ip) could signi...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735406291984
更新日期:2006-09-01 00:00:00
abstract::Total alkaloids is an active ingredient of the natural plant Rubus alceifolius Poir, commonly used for the treatment of various cancers. Antitumor effects may be mediated through anti-angiogenic mechanisms. As such, the goal of the present study was to investigate and evaluate the effect of total alkaloids in Rubus al...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414547109
更新日期:2014-11-01 00:00:00
abstract::Breast cancer is the most frequently diagnosed cancer of women in North America. Despite advances in treatment that have reduced mortality, breast cancer remains the second leading cause of cancer induced death. Several well established tools are used to screen for breast cancer including clinical breast exams, mammog...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735408326171
更新日期:2009-03-01 00:00:00
abstract:UNLABELLED:BACKGROUND AND HYPOTHESES: Postcancer cognitive impairment (PCCI) is observed in a substantial number of breast cancer survivors, persisting for as long as 20 years in some subgroups. Although compensatory strategies are frequently suggested, no restorative interventions have yet been identified. This study ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735413477192
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:This study portrays the characteristics of patients who attended an integrative oncology clinic at a large comprehensive cancer center and evaluated whether this service addressed patients' concerns about complementary and integrative medicine (CIM). METHODS:Patient information was collected prior to an int...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410378663
更新日期:2010-09-01 00:00:00
abstract::The circadian production of melatonin by the pineal gland during the night provides an inhibitory signal to tissue-isolated steroid receptor SR+ and - MCF-7 human breast cancer xenografts in female nude rats. A pivotal mechanism for melatonin's anticancer effects in vivo involves a melatonin receptor-mediated inhibiti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409352320
更新日期:2009-12-01 00:00:00
abstract::Toona sinensis (TS) is one of the most popular vegetarian dishes in Taiwan. It has been shown to exhibit antioxidant, antiangiogenic, antiatherosclerotic, and anticancer properties. In this study, we demonstrated the ability of aqueous leaf extracts from TS to promote immune responses in BALB/c mice and to exhibit ant...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416642863
更新日期:2017-09-01 00:00:00
abstract::Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of s...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735403002002005
更新日期:2003-06-01 00:00:00
abstract::Antineoplastic agents induce oxidative stress in biological systems. During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that can attack many cellular targets. These products of oxidative stress can slow cell cycle progression of cancer cells and cause cel...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735404270335
更新日期:2004-12-01 00:00:00
abstract::Background: Integrative oncology has proven to be a useful approach to control cancer symptoms and improve the quality of life (QoL) and overall health of patients, delivering integrated patient care at both physical and emotional levels. The objective of this randomized trial was to evaluate the effects of a triple i...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420924757
更新日期:2020-01-01 00:00:00
abstract::Studies show an important relationship between vitamin D and malignancies, both in prevention and treatment. The extraskeletal actions of vitamin D relevant to oncology include being proapoptotic, antimetastatic, antiangiogenic, antiinflammatory, prodifferentiating, and immunomodulating. Widespread and severe vitamin ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735408319062
更新日期:2008-06-01 00:00:00
abstract::Although localized colon cancer is often successfully treated with surgery, advanced disease requires aggressive systemic therapy that has lower effectiveness. Approximately 30% to 75% of patients with colon cancer use complementary and alternative medicine (CAM), but there is limited formal evidence of survival effic...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735411406539
更新日期:2011-09-01 00:00:00
abstract::Extracts of milk thistle have been recognized for centuries as "liver tonics" and are well-known to prevent or reverse hepatotoxicity of reactive drug metabolites or naturally occurring toxins. Milk thistle extracts are now under intense study in the experimental therapeutics of cancer for chemoprevention, treatment, ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735407301825
更新日期:2007-06-01 00:00:00
abstract::Nausea and vomiting are among the most common and distressing side effects of chemotherapy. Additional antiemetic drugs are urgently needed to effectively manage and ameliorate chemotherapy-induced nausea and vomiting (CINV). The efficacy of ginger as an antiemetic modality for ameliorating CINV has not been establish...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,随机对照试验
doi:10.1177/1534735417753541
更新日期:2018-09-01 00:00:00
abstract::Circadian rhythms are endogenous biological clocks that govern fundamental physiological and behavioral functions. Consequently, perturbations of these rhythms have been associated with pathogenic conditions, such as depression, diabetes, and cancer. CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcripti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409352084
更新日期:2009-12-01 00:00:00