Abstract:
:The large majority of clinical prostate cancers remain dependent on androgen receptor (AR) activity for proliferation even as they lose their responsiveness to androgen deprivation or antagonism. AR activity can be maintained in these circumstances by increased AR synthesis--often reflecting increased NF-κB activation; upregulation of signaling pathways that promote AR activity in the absence of androgens; and by emergence of AR mutations or splice variants lacking the ligand-binding domain, which render the AR constitutively active. Drugs targeting the N-terminal transactivating domain of the AR, some of which are now in preclinical development, can be expected to inhibit the activity not only of unmutated ARs but also of the mutant forms and splice variants selected for by androgen deprivation. Concurrent measures that suppress AR synthesis or boost AR turnover could be expected to complement the efficacy of such drugs. A number of nutraceuticals that show efficacy in prostate cancer xenograft models--including polyphenols from pomegranate, grape seed, and green tea, the crucifera metabolite diindolylmethane, and the hormone melatonin--have the potential to suppress AR synthesis via downregulation of NF-κB activity; clinical doses of salicylate may have analogous efficacy. The proteasomal turnover of the AR is abetted by diets with a high ratio of long-chain omega-3 to omega-6 fatty acids, which are beneficial in prostate cancer xenograft models; berberine and sulforaphane, by inhibiting AR's interaction with its chaperone Hsp90, likewise promote AR proteasomal degradation and retard growth of human prostate cancer in nude mice. Hinge region acetylation of the AR is required for optimal transactivational activity, and low micromolar concentrations of the catechin epigallocatechin-3-gallate (EGCG) can inhibit such acetylation--possibly explaining the ability of EGCG administration to suppress androgenic activity and cell proliferation in prostate cancer xenografts. Hence, it is proposed that regimens featuring an N-terminal domain-targeting drug, various nutraceuticals/drugs that downregulate NF-κB activity, and/or supplemental intakes of fish oil, berberine, sulforaphane, and EGCG have potential for blocking proliferation of prostate cancer by targeting its characteristic addiction to androgen receptor activity.
journal_name
Integr Cancer Therjournal_title
Integrative cancer therapiesauthors
McCarty MF,Hejazi J,Rastmanesh Rdoi
10.1177/1534735414534728subject
Has Abstractpub_date
2014-09-01 00:00:00pages
386-95issue
5eissn
1534-7354issn
1552-695Xpii
1534735414534728journal_volume
13pub_type
杂志文章abstract::Hesperidin is a natural compound that has chemoprotective effects in tumor cell lines and protective effects against hematotoxicity induced by cyclophosphamide. The aim of this study was to evaluate the effect of hesperidin on the antitumor effect of cyclophosphamide in tumor-bearing mice. Administration of hesperidin...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735412448959
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:Physical activity (PA) is important in lung cancer. OBJECTIVES:To investigate PA levels and health-related quality of life (HRQoL) of patients with lung cancer in China and compare this to a similar cohort in Australia. METHODS:Prospective cohort study. 71 patients from China (group CH) and 90 patients f...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417699513
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Xerostomia (dry mouth) causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food. Many cancer patients have complained of xerostomia induced by cancer therapy. OBJECTIVE:The aim of this systematic review is to assess the efficacy of herbal med...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417728336
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Health care policies and guidelines that are clear and consistent with research evidence are important for maximizing clinical outcomes. To determine whether cancer centers in Canada and the United States had policies and/or guidelines about antioxidant use, and whether policies were aligned with the evidenc...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415572884
更新日期:2015-07-01 00:00:00
abstract::The aim of this study was to investigate the anticancer effect of a combination of D-fraction polysaccharide from Grifola frondosa (DFP) and vitamin C (VC) on hepatocellular carcinoma in vitro. DFP is a bioactive extract from the maitake mushroom. Anticancer activity was demonstrated using various concentrations of DF...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416644674
更新日期:2017-06-01 00:00:00
abstract::Vitamin D status has importance in the prevention and treatment of many malignancies. Patients with breast, colon, and lung malignancies with higher vitamin D status at the onset of treatment have an improved prognosis compared with those patients with a lower vitamin D status. Methods to improve vitamin D status are ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414537875
更新日期:2014-09-01 00:00:00
abstract::This meta-analysis evaluates the clinical evidence for the addition of traditional medicines (TMs) to oxaliplatin-based regimens for colorectal cancer (CRC) in terms of tumor response rate (TRR). Eight electronic databases were searched for randomized controlled trials of oxaliplatin-based chemotherapy combined with T...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,meta分析
doi:10.1177/1534735415596424
更新日期:2016-03-01 00:00:00
abstract:UNLABELLED:BACKGROUND AND HYPOTHESES: Postcancer cognitive impairment (PCCI) is observed in a substantial number of breast cancer survivors, persisting for as long as 20 years in some subgroups. Although compensatory strategies are frequently suggested, no restorative interventions have yet been identified. This study ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735413477192
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of participating in an integrative cancer care program at the Centre for Integrated Healing in Vancouver, British Columbia, on patients' lifestyle, quality of life, and overall well-being. STUDY DESIGN:A mixed-methods case study with a pre- and posttest design. No control group was uti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735407313395
更新日期:2008-03-01 00:00:00
abstract::Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of s...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735403002002005
更新日期:2003-06-01 00:00:00
abstract:PURPOSE:Although the importance of spiritual issues to people with cancer is by now widely acknowledged, there has been almost no research on the value of interventions specifically designed to enhance the spiritual experience of these patients. The present report describes an exploratory study on the effects of a brie...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735405275648
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Malignant pleural effusion (MPE) is a common complication in most malignancies. Despite its frequent occurrence, current knowledge of MPE remains limited and the effect of the management is still unsatisfying. Traditional Chinese medicine (TCM) external treatment has unique advantages, such as quicker effica...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1534735416660193
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Arthralgia affects postmenopausal women receiving aromatase inhibitors (AIs) for breast cancer. Given the existing evidence for electroacupuncture (EA) for treatment of osteoarthritis in the general population, this study aims to establish the feasibility of studying EA for treating AI-related arthralgia. P...
journal_title:Integrative cancer therapies
pub_type: 临床试验,杂志文章
doi:10.1177/1534735409332903
更新日期:2009-06-01 00:00:00
abstract::Background: Integrative oncology has proven to be a useful approach to control cancer symptoms and improve the quality of life (QoL) and overall health of patients, delivering integrated patient care at both physical and emotional levels. The objective of this randomized trial was to evaluate the effects of a triple i...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420924757
更新日期:2020-01-01 00:00:00
abstract::Animal-assisted interventions (AAIs) use human-animal interactions to positive effect in various contexts including cancer care. As the first installment of a 2-part series, this systematic literature review focuses on the research methods and quantitative results of AAI studies in oncology. We find methodological con...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420943278
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is a lack of information on therapies recommended by naturopathic doctors (NDs) for lung and gastroesophageal cancer care. Study objectives were to: (1) identify the most common interventions considered for use by NDs; (2) identify interventions NDs recommend to support key therapeutic g...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418759420
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To determine which mode of exercise is preferred by breast cancer survivors and to evaluate this response between graded exercise testing on a treadmill and on a cycle ergometer. METHODS:Twelve breast cancer survivors completed 2 maximal aerobic stress tests on separate days. The women completed a ramp protoco...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,随机对照试验
doi:10.1177/1534735411433202
更新日期:2012-12-01 00:00:00
abstract::Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418762537
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To assess the effects of an 8-week stress management and health promotion program on women undergoing breast cancer chemotherapy treatment. Patients and methods A total of 61 patients were recruited in 2 cancer centers and were randomly assigned to the intervention program (n = 30) or control group (n = 31). ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,随机对照试验
doi:10.1177/1534735415598225
更新日期:2016-06-01 00:00:00
abstract::The British developmental biologist John Beard, DSc (1858-1924) is little remembered today. Yet, he made outstanding contributions to the life sciences. Beard deserves to be included among the leading biologists of the late 19th and early 20th century. He has been hailed as a forerunner of the present-day theory of th...
journal_title:Integrative cancer therapies
pub_type: 传,历史文章,杂志文章
doi:10.1177/1534735408326174
更新日期:2008-12-01 00:00:00
abstract::The circadian production of melatonin by the pineal gland during the night provides an inhibitory signal to tissue-isolated steroid receptor SR+ and - MCF-7 human breast cancer xenografts in female nude rats. A pivotal mechanism for melatonin's anticancer effects in vivo involves a melatonin receptor-mediated inhibiti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409352320
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Conventional anticancer therapies still cause difficulties with selective eradication and accompanying side effects that reduce patients' quality of life (QOL). Fucoidan is extracted from seaweeds and has already exhibited broad bioactivities, including anticancer and anti-inflammatory properties, in basic s...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417692097
更新日期:2018-06-01 00:00:00
abstract:AIM OF THE STUDY:Celastrus orbiculatus has been used as a folk medicine in China for the treatment of many diseases. In the laboratory, the ethyl acetate extract of Celastrus orbiculatus (COE) displays a wide range of anticancer functions. However, the inhibition of the metastasis mechanism of COE in gastric cancer cel...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415572880
更新日期:2015-05-01 00:00:00
abstract::Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns. Incorrect nutritional habits and lifestyle practices have been dire...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416675950
更新日期:2017-09-01 00:00:00
abstract::Background The role of whole grains, refined cereals, and legumes in preventing or initiating colorectal cancer (CRC) is still uncertain. The aim of this study is to examine the possible association between the consumption of whole grains, refined cereals, and legumes and the risk of developing CRC among Jordanian pop...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415620010
更新日期:2016-09-01 00:00:00
abstract::Gastric cancer (GC) is a malignancy with few effective treatment options after metastasis occurs. Quercetin (Qu) intake has been associated with reduced incidence and slow development of GC, probably due to its anti-proliferative and apoptotic effects, but it is unclear whether Qu can inhibit the metastatic activity. ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417696702
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Increasing physical activity (PA) is safe and beneficial in lung cancer (LC) patients. Advanced-stage LC patients are under-studied and have worse symptoms and quality of life (QoL). We evaluated the feasibility of monitoring step count in advanced LC as well as potential correlations between P...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416684016
更新日期:2018-03-01 00:00:00
abstract:GANODERMA LUCIDU:spore (GLS), an over-the-counter herbal supplement, is widely used by cancer patients in China. Although preclinical studies have shown it to be safe, complete safety data on GLS is still lacking. In this article, we report 5 cases of gastrointestinal cancer that were treated with GLS plus multiple str...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735413510022
更新日期:2014-03-01 00:00:00
abstract::This study reports the antimigration, anti-invasive effect of glabridin, a flavonoid obtained from licorice, in human non-small cell lung cancer A549 cells. Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer cell migration and invasion of A549 cells. In addition, glabridin also decreased ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410384860
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Due to the limitations and side effects of conventional cancer treatment, especially in relation to quality of life (QOL), patients are increasingly utilizing complementary and alternative medicine (CAM) to supplement health-related outcomes. However, evidence for the safety and efficacy of such treatments i...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735411413268
更新日期:2012-06-01 00:00:00