Abstract:
BACKGROUND:Xerostomia (dry mouth) causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food. Many cancer patients have complained of xerostomia induced by cancer therapy. OBJECTIVE:The aim of this systematic review is to assess the efficacy of herbal medicine for the treatment of xerostomia in cancer patients. MATERIALS AND METHODS:Randomized controlled trials investigating the use of herbal medicines to treat xerostomia in cancer patients were included. We searched the following 12 databases without restrictions on time or language. The risk of bias was assessed using the Cochrane Risk of Bias Tool. RESULTS:Twenty-five randomized controlled trials involving 1586 patients met the inclusion criteria. A total of 24 formulas were examined in the included trials. Most of the included trials were insufficiently reported in the methodology section. Five formulas were shown to significantly improve the salivary flow rate compared to comparators. Regarding the grade of xerostomia, all formulas with the exception of a Dark Plum gargle solution with normal saline were significantly effective in reducing the severity of dry mouth. Adverse events were reported in 4 trials, and adverse effects of herbal medicine were reported in 3 trials. CONCLUSIONS:We found herbal medicines had potential benefits for improving salivary function and reducing the severity of dry mouth in cancer patients. However, methodological limitations and a relatively small sample size reduced the strength of the evidence. More high-quality trials reporting sufficient methodological data are warranted to enforce the strength of evidence regarding the effectiveness of herbal medicines.
journal_name
Integr Cancer Therjournal_title
Integrative cancer therapiesauthors
Park B,Noh H,Choi DJdoi
10.1177/1534735417728336subject
Has Abstractpub_date
2018-06-01 00:00:00pages
179-191issue
2eissn
1534-7354issn
1552-695Xjournal_volume
17pub_type
杂志文章abstract::Pancreatic cancer (PC) has a very low average survival, but its prognosis is further reduced in the case of metastatic spread. Medical therapy in these cases is the only applicable methodology in the international guidelines. During anticancer treatments, common side effects are nausea, vomiting, arthralgia, neuropath...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418755479
更新日期:2018-09-01 00:00:00
abstract::The aim of this study was to investigate the anticancer effect of a combination of D-fraction polysaccharide from Grifola frondosa (DFP) and vitamin C (VC) on hepatocellular carcinoma in vitro. DFP is a bioactive extract from the maitake mushroom. Anticancer activity was demonstrated using various concentrations of DF...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416644674
更新日期:2017-06-01 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide, and most chemotherapeutic drugs have limited success in treating this disease. Furthermore, some drugs show undesirable side effects due to the enrichment of cancer stem cells (CSCs) that are present, leading to resistance to conventional chemotherapy and tum...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414534462
更新日期:2014-11-01 00:00:00
abstract::Circadian rhythms are endogenous biological clocks that govern fundamental physiological and behavioral functions. Consequently, perturbations of these rhythms have been associated with pathogenic conditions, such as depression, diabetes, and cancer. CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcripti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409352084
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is a lack of information on therapies recommended by naturopathic doctors (NDs) for lung and gastroesophageal cancer care. Study objectives were to: (1) identify the most common interventions considered for use by NDs; (2) identify interventions NDs recommend to support key therapeutic g...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418759420
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Health care policies and guidelines that are clear and consistent with research evidence are important for maximizing clinical outcomes. To determine whether cancer centers in Canada and the United States had policies and/or guidelines about antioxidant use, and whether policies were aligned with the evidenc...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415572884
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To assess the effects of an 8-week stress management and health promotion program on women undergoing breast cancer chemotherapy treatment. Patients and methods A total of 61 patients were recruited in 2 cancer centers and were randomly assigned to the intervention program (n = 30) or control group (n = 31). ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,随机对照试验
doi:10.1177/1534735415598225
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Many botanical immunomodulators are used as adjuvants along with cancer chemotherapy. However, information on the impact of concurrent administration of such botanicals on pharmacokinetics of chemotherapy agents is inadequate. This study investigates inhibitory activities of 3 popular botanical adjuvants: ASPAR...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735413503551
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of participating in an integrative cancer care program at the Centre for Integrated Healing in Vancouver, British Columbia, on patients' lifestyle, quality of life, and overall well-being. STUDY DESIGN:A mixed-methods case study with a pre- and posttest design. No control group was uti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735407313395
更新日期:2008-03-01 00:00:00
abstract:INTRODUCTION:Increasingly physical activity (PA) is being recognized as an important outcome in non-small cell lung cancer (NSCLC). We investigated PA using novel global positioning system (GPS) tracking individuals with NSCLC and a group of similar-aged healthy individuals. METHODS:A prospective cross-sectional multi...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,多中心研究
doi:10.1177/1534735414542484
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Arthralgia affects postmenopausal women receiving aromatase inhibitors (AIs) for breast cancer. Given the existing evidence for electroacupuncture (EA) for treatment of osteoarthritis in the general population, this study aims to establish the feasibility of studying EA for treating AI-related arthralgia. P...
journal_title:Integrative cancer therapies
pub_type: 临床试验,杂志文章
doi:10.1177/1534735409332903
更新日期:2009-06-01 00:00:00
abstract::Although localized colon cancer is often successfully treated with surgery, advanced disease requires aggressive systemic therapy that has lower effectiveness. Approximately 30% to 75% of patients with colon cancer use complementary and alternative medicine (CAM), but there is limited formal evidence of survival effic...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735411406539
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Chemoradiotherapy-associated mucositis can manifest as pain, inflammation, dysphagia, diarrhea, weight loss, rectal bleeding, and infection. Mucositis is a major dose-limiting side effect of chemotherapy, affecting nutritional intake and oral and intestinal function. Despite several interventions being avail...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418794885
更新日期:2018-12-01 00:00:00
abstract::Besides honey, honeybees make a sticky substance (called propolis/bee glue) by mixing saliva with poplar tree resin and other botanical sources. It is known to be rich in bioactivities of which the anticancer activity is most studied. Caffeic acid phenethyl ester (CAPE) is a key anticancer component in New Zealand pro...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417753545
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:Although the importance of spiritual issues to people with cancer is by now widely acknowledged, there has been almost no research on the value of interventions specifically designed to enhance the spiritual experience of these patients. The present report describes an exploratory study on the effects of a brie...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735405275648
更新日期:2005-06-01 00:00:00
abstract::Physical inactivity is a major concern in cancer patients despite the established preventative and therapeutic effects of regular physical exercise for this patient group. Sport not only plays an important role in supporting the development and maintenance of a physically active lifestyle but also is increasingly used...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419894063
更新日期:2019-01-01 00:00:00
abstract::Studies show an important relationship between vitamin D and malignancies, both in prevention and treatment. The extraskeletal actions of vitamin D relevant to oncology include being proapoptotic, antimetastatic, antiangiogenic, antiinflammatory, prodifferentiating, and immunomodulating. Widespread and severe vitamin ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735408319062
更新日期:2008-06-01 00:00:00
abstract::Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418762537
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Conventional anticancer therapies still cause difficulties with selective eradication and accompanying side effects that reduce patients' quality of life (QOL). Fucoidan is extracted from seaweeds and has already exhibited broad bioactivities, including anticancer and anti-inflammatory properties, in basic s...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417692097
更新日期:2018-06-01 00:00:00
abstract::The large majority of clinical prostate cancers remain dependent on androgen receptor (AR) activity for proliferation even as they lose their responsiveness to androgen deprivation or antagonism. AR activity can be maintained in these circumstances by increased AR synthesis--often reflecting increased NF-κB activation...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414534728
更新日期:2014-09-01 00:00:00
abstract::Oncology is currently a sector of medical science with accelerated progress due to rapid technological development, the advancement in molecular biology, and the invention of many innovative therapies. Immunotherapy partially accounts for this advance, since it is increasingly playing an important role in the treatmen...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419827090
更新日期:2019-01-01 00:00:00
abstract::The acute apoptotic response to genotoxic carcinogens animal model has been extensively used to assess the ability of drugs and natural products like dietary components to promote apoptosis in the colon and protect against colorectal cancer (CRC). This work aimed to use this model to identify the main chemopreventativ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417699880
更新日期:2018-06-01 00:00:00
abstract::A considerable number of patients with cancer have used or are using the Gerson therapy, an alleged anticancer metabolic diet. However, there is almost no scientific support for this regimen. Hence, the present case review study of 6 patients with metastatic cancer who used the Gerson therapy aims at critically evalua...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735406298258
更新日期:2007-03-01 00:00:00
abstract::A recurrence of cancer is a traumatic and stressful experience, and a number of approaches have been proposed to manage or treat the associated psychological distress. Meditative techniques such as mindfulness may be able to improve an individual's ability to cope with stressful life events such as cancer diagnosis or...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420908341
更新日期:2020-01-01 00:00:00
abstract::Background: Chemotherapy-induced peripheral neuropathy (CIPN) has no cure, but acupuncture may provide relief through its known neuromodulation or neuroendocrine adjustment. This review aimed to assess the efficacy of acupuncture in treating CIPN. Method: A literature review following the PRISMA Statement was performe...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,meta分析
doi:10.1177/1534735419886662
更新日期:2019-01-01 00:00:00
abstract:AIM:To introduce the application of wheel balance cancer therapy (WBCT) in cancer treatment through an intensive study of a representative patient. METHOD:A 59-year-old, female patient who was a secondhand smoker and who carried no significant medical and family history was diagnosed with T1N0M1 (stage 4) lung adenoca...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410371479
更新日期:2010-06-01 00:00:00
abstract::Toona sinensis (TS) is one of the most popular vegetarian dishes in Taiwan. It has been shown to exhibit antioxidant, antiangiogenic, antiatherosclerotic, and anticancer properties. In this study, we demonstrated the ability of aqueous leaf extracts from TS to promote immune responses in BALB/c mice and to exhibit ant...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416642863
更新日期:2017-09-01 00:00:00
abstract::The protective effect of Andrograhis paniculata and andrographolide (ANDLE) against cyclophosphamide (CTX)-induced urothelial toxicity was investigated in this study. Pretreatment of Swiss albino mice with A paniculata extract (10 mg/dose/animal intraperitoneally [ip]) and ANDLE (500 microg/dose/animal ip) could signi...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735406291984
更新日期:2006-09-01 00:00:00
abstract::Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns. Incorrect nutritional habits and lifestyle practices have been dire...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416675950
更新日期:2017-09-01 00:00:00
abstract::Altered expression of a cytosolic flavoenzyme NAD(P)H:quinone oxidoreductase-1 (NQO1) has been seen in many human tumors. Its remarkable overexpression in cholangiocarcinoma (CCA; an aggressive malignancy of the biliary duct system) was associated with poor prognosis and short survival of the patients. Inhibition of N...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418820444
更新日期:2019-01-01 00:00:00