Abstract:
:Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns. Incorrect nutritional habits and lifestyle practices have been directly linked to cancer incidence. Nutrients with antioxidant activity inhibit cancer cells development, destroying them through oxidative stress and apoptosis. α-tocopherol, the potent antioxidant form of vitamin E is a known scavenger of free radicals. In vitro study exhibited effective antitumor activity of α-tocopherol on ORL-48 at 2.5 ± 0.42 µg/mL. Cisplatin exhibited stronger activity at 1.0 ± 0.15 µg/mL, but unlike α-tocopherol it exhibited cytotoxicity on normal human epidermal keratinocytes at very low concentration (<0.1 µg/mL). Despite the lower potency of α-tocopherol, signs of apoptosis such as the shrinkage of cells and appearance of apoptotic bodies were observed much earlier than cisplatin in time lapse microscopy. No apoptotic vesicles were formed with cisplatin, instead an increased population of cells in the holoclone form which may suggest different induction mechanisms between both agents. High accumulation of cells in the G0/G1 phase were observed through TUNEL and annexin V-biotin assays, while the exhibition of ultrastructural changes of the cellular structures verified the apoptotic mode of cell death by both agents. Both cisplatin and α-tocopherol displayed cell cycle arrest at the Sub G0 phase. α-tocopherol thus, showed potential as an antitumour agent for the treatment of oral cancer and merits further research.
journal_name
Integr Cancer Therjournal_title
Integrative cancer therapiesauthors
Zulkapli R,Abdul Razak F,Zain RBdoi
10.1177/1534735416675950subject
Has Abstractpub_date
2017-09-01 00:00:00pages
414-425issue
3eissn
1534-7354issn
1552-695Xjournal_volume
16pub_type
杂志文章abstract::Gastric cancer (GC) is a malignancy with few effective treatment options after metastasis occurs. Quercetin (Qu) intake has been associated with reduced incidence and slow development of GC, probably due to its anti-proliferative and apoptotic effects, but it is unclear whether Qu can inhibit the metastatic activity. ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417696702
更新日期:2018-06-01 00:00:00
abstract::In recent years, there has been an increased interest in complementary and alternative medicine (CAM) use among people with cancer. Many are looking for informed advice and desire communication with their physicians about CAM use. Communication is crucial in establishing trust with patients, gathering information, add...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735410363706
更新日期:2010-06-01 00:00:00
abstract::The circadian production of melatonin by the pineal gland during the night provides an inhibitory signal to tissue-isolated steroid receptor SR+ and - MCF-7 human breast cancer xenografts in female nude rats. A pivotal mechanism for melatonin's anticancer effects in vivo involves a melatonin receptor-mediated inhibiti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409352320
更新日期:2009-12-01 00:00:00
abstract::Cancer traditionally has been explained by the biomedical model; however, it is limited in comprehensively accounting for all factors in this disease. Recently, it has been suggested that a broader theoretical framework that includes psychosocial components in cancer is needed to complement the traditional approach. T...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735402238188
更新日期:2002-12-01 00:00:00
abstract:GANODERMA LUCIDU:spore (GLS), an over-the-counter herbal supplement, is widely used by cancer patients in China. Although preclinical studies have shown it to be safe, complete safety data on GLS is still lacking. In this article, we report 5 cases of gastrointestinal cancer that were treated with GLS plus multiple str...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735413510022
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:Physical activity (PA) is important in lung cancer. OBJECTIVES:To investigate PA levels and health-related quality of life (HRQoL) of patients with lung cancer in China and compare this to a similar cohort in Australia. METHODS:Prospective cohort study. 71 patients from China (group CH) and 90 patients f...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417699513
更新日期:2018-06-01 00:00:00
abstract::The acute apoptotic response to genotoxic carcinogens animal model has been extensively used to assess the ability of drugs and natural products like dietary components to promote apoptosis in the colon and protect against colorectal cancer (CRC). This work aimed to use this model to identify the main chemopreventativ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417699880
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Because of advances in medical treatment, the survival of cancer patients is prolonged. In line with the prolonged survival time of cancer the incidence of second primary cancer has increased. There is currently no effective way to prevent the occurrence of secondary primary cancer (SPC). OBJECTIVES:The aim...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419834353
更新日期:2019-01-01 00:00:00
abstract::This study reports the antimigration, anti-invasive effect of glabridin, a flavonoid obtained from licorice, in human non-small cell lung cancer A549 cells. Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer cell migration and invasion of A549 cells. In addition, glabridin also decreased ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410384860
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is a lack of information on therapies recommended by naturopathic doctors (NDs) for lung and gastroesophageal cancer care. Study objectives were to: (1) identify the most common interventions considered for use by NDs; (2) identify interventions NDs recommend to support key therapeutic g...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418759420
更新日期:2018-09-01 00:00:00
abstract::This exploratory study is an attempt to define psychological attributes related to longer survival in patients with metastatic cancers. Previous published analyses have been limited in two ways. First, they have almost always been carried out on patients not receiving therapy; we have followed people receiving a year ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735402001002006
更新日期:2002-06-01 00:00:00
abstract::Hesperidin is a natural compound that has chemoprotective effects in tumor cell lines and protective effects against hematotoxicity induced by cyclophosphamide. The aim of this study was to evaluate the effect of hesperidin on the antitumor effect of cyclophosphamide in tumor-bearing mice. Administration of hesperidin...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735412448959
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:This study portrays the characteristics of patients who attended an integrative oncology clinic at a large comprehensive cancer center and evaluated whether this service addressed patients' concerns about complementary and integrative medicine (CIM). METHODS:Patient information was collected prior to an int...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410378663
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:Although the importance of spiritual issues to people with cancer is by now widely acknowledged, there has been almost no research on the value of interventions specifically designed to enhance the spiritual experience of these patients. The present report describes an exploratory study on the effects of a brie...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735405275648
更新日期:2005-06-01 00:00:00
abstract::Background: Integrative oncology has proven to be a useful approach to control cancer symptoms and improve the quality of life (QoL) and overall health of patients, delivering integrated patient care at both physical and emotional levels. The objective of this randomized trial was to evaluate the effects of a triple i...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420924757
更新日期:2020-01-01 00:00:00
abstract::Physical inactivity is a major concern in cancer patients despite the established preventative and therapeutic effects of regular physical exercise for this patient group. Sport not only plays an important role in supporting the development and maintenance of a physically active lifestyle but also is increasingly used...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419894063
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Xerostomia (dry mouth) causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food. Many cancer patients have complained of xerostomia induced by cancer therapy. OBJECTIVE:The aim of this systematic review is to assess the efficacy of herbal med...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417728336
更新日期:2018-06-01 00:00:00
abstract::Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investigated in the cultured human cervical gland carcinoma cells HeLa and cervical squ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416684551
更新日期:2018-03-01 00:00:00
abstract::Pancreatic cancer (PC) has a very low average survival, but its prognosis is further reduced in the case of metastatic spread. Medical therapy in these cases is the only applicable methodology in the international guidelines. During anticancer treatments, common side effects are nausea, vomiting, arthralgia, neuropath...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418755479
更新日期:2018-09-01 00:00:00
abstract::Vitamin D status has importance in the prevention and treatment of many malignancies. Patients with breast, colon, and lung malignancies with higher vitamin D status at the onset of treatment have an improved prognosis compared with those patients with a lower vitamin D status. Methods to improve vitamin D status are ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414537875
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Melatonin (MLT) is known to possess potent antioxidant, antiproliferative, immune-modulating, and hormone-modulating properties. Clinical evidence suggests that MLT may have a possible role in the treatment of cancer. The authors systematically reviewed the effects of MLT in conjunction with chemotherapy, ra...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,meta分析,评审
doi:10.1177/1534735411425484
更新日期:2012-12-01 00:00:00
abstract::A recurrence of cancer is a traumatic and stressful experience, and a number of approaches have been proposed to manage or treat the associated psychological distress. Meditative techniques such as mindfulness may be able to improve an individual's ability to cope with stressful life events such as cancer diagnosis or...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420908341
更新日期:2020-01-01 00:00:00
abstract:AIM:To introduce the application of wheel balance cancer therapy (WBCT) in cancer treatment through an intensive study of a representative patient. METHOD:A 59-year-old, female patient who was a secondhand smoker and who carried no significant medical and family history was diagnosed with T1N0M1 (stage 4) lung adenoca...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410371479
更新日期:2010-06-01 00:00:00
abstract::Introduction:Viscum album L extracts (VA) are frequently used in integrative oncology. Aim of this study was to evaluate the impact of add-on VA applications on various patient-reported outcome measures. Methods: A longitudinal real-world study was conducted, using data from the Network Oncology clinical registry. Pri...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420917211
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Sleep disturbance is the second most bothersome symptom in patients with cancer, and it can significantly impair their quality of life. The aim of this study was to investigate the efficacy and safety of the traditional herbal medicine Gamiguibi-tang (GGBT) in patients with cancer-related sleep disturbance. ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417734914
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Many botanical immunomodulators are used as adjuvants along with cancer chemotherapy. However, information on the impact of concurrent administration of such botanicals on pharmacokinetics of chemotherapy agents is inadequate. This study investigates inhibitory activities of 3 popular botanical adjuvants: ASPAR...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735413503551
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Malignant pleural effusion (MPE) is a common complication in most malignancies. Despite its frequent occurrence, current knowledge of MPE remains limited and the effect of the management is still unsatisfying. Traditional Chinese medicine (TCM) external treatment has unique advantages, such as quicker effica...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1534735416660193
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Complementary and alternative medicine (CAM) is becoming more common in medical practice, but little is known about the concurrent use of CAM and conventional treatment. Therefore, the aim was to investigate the types of CAM used and their prevalence in a regional patient cohort with breast cancer (BC). MET...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420983910
更新日期:2020-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide, and most chemotherapeutic drugs have limited success in treating this disease. Furthermore, some drugs show undesirable side effects due to the enrichment of cancer stem cells (CSCs) that are present, leading to resistance to conventional chemotherapy and tum...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414534462
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of participating in an integrative cancer care program at the Centre for Integrated Healing in Vancouver, British Columbia, on patients' lifestyle, quality of life, and overall well-being. STUDY DESIGN:A mixed-methods case study with a pre- and posttest design. No control group was uti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735407313395
更新日期:2008-03-01 00:00:00