Carnosine Inhibits the Proliferation of Human Cervical Gland Carcinoma Cells Through Inhibiting Both Mitochondrial Bioenergetics and Glycolysis Pathways and Retarding Cell Cycle Progression.

Abstract:

:Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investigated in the cultured human cervical gland carcinoma cells HeLa and cervical squamous carcinoma cells SiHa. The results showed that carnosine exerted a significant inhibitory effect on the proliferation of HeLa cells, whereas its inhibitory action on the proliferation of SiHa cells was much weaker. Carnosine decreased the ATP content through inhibiting both mitochondrial respiration and glycolysis pathways in cultured HeLa cells but not SiHa cells. Carnosine reduced the activities of isocitrate dehydrogenase and malate dehydrogenase in TCA (tricarboxylic acid) cycle and the activities of mitochondrial electron transport chain complex I, II, III, and IV in HeLa cells but not SiHa cells. Carnosine also decreased the mRNA and protein expression levels of ClpP, which plays a key role in maintaining the mitochondrial function in HeLa cells. In addition, carnosine induced G1 arrest by inhibiting the G1-S phase transition in both HeLa and SiHa cells. Taken together, these findings suggest that carnosine has a strong inhibitory action on the proliferation of human cervical gland carcinoma cells rather than cervical squamous carcinoma cells. Mitochondrial bioenergetics and glycolysis pathways and cell cycle may be involved in the carnosine action on the cell proliferation in cultured human cervical gland carcinoma cells HeLa.

journal_name

Integr Cancer Ther

authors

Bao Y,Ding S,Cheng J,Liu Y,Wang B,Xu H,Shen Y,Lyu J

doi

10.1177/1534735416684551

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

80-91

issue

1

eissn

1534-7354

issn

1552-695X

journal_volume

17

pub_type

杂志文章
  • Evaluation of an Integrative Care Program in Pediatric Oncology.

    abstract::Purpose: This article discusses the results of an evaluation of the one-year implementation period of an integrative care program at a pediatric oncology ward, which consists of integrative care treatments offered three times a week to the patients. The guiding questions are how the model was implemented, which factor...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735420928393

    authors: Stritter W,Rutert B,Eggert A,Längler A,Holmberg C,Seifert G

    更新日期:2020-01-01 00:00:00

  • Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies.

    abstract::Extracts of milk thistle have been recognized for centuries as "liver tonics" and are well-known to prevent or reverse hepatotoxicity of reactive drug metabolites or naturally occurring toxins. Milk thistle extracts are now under intense study in the experimental therapeutics of cancer for chemoprevention, treatment, ...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/1534735407301825

    authors: Kroll DJ,Shaw HS,Oberlies NH

    更新日期:2007-06-01 00:00:00

  • Survey of Policies and Guidelines on Antioxidant Use for Cancer Prevention, Treatment, and Survivorship in North American Cancer Centers: What Do Institutions Perceive as Evidence?

    abstract:BACKGROUND:Health care policies and guidelines that are clear and consistent with research evidence are important for maximizing clinical outcomes. To determine whether cancer centers in Canada and the United States had policies and/or guidelines about antioxidant use, and whether policies were aligned with the evidenc...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735415572884

    authors: Hong G,White J,Zhong L,Carlson LE

    更新日期:2015-07-01 00:00:00

  • The life and times of John Beard, DSc (1858-1924).

    abstract::The British developmental biologist John Beard, DSc (1858-1924) is little remembered today. Yet, he made outstanding contributions to the life sciences. Beard deserves to be included among the leading biologists of the late 19th and early 20th century. He has been hailed as a forerunner of the present-day theory of th...

    journal_title:Integrative cancer therapies

    pub_type: 传,历史文章,杂志文章

    doi:10.1177/1534735408326174

    authors: Moss RW

    更新日期:2008-12-01 00:00:00

  • Physical Activity Behavior After a Diagnosis of Lung Cancer Differs Between Countries: An Observational Cohort Study.

    abstract:INTRODUCTION:Physical activity (PA) is important in lung cancer. OBJECTIVES:To investigate PA levels and health-related quality of life (HRQoL) of patients with lung cancer in China and compare this to a similar cohort in Australia. METHODS:Prospective cohort study. 71 patients from China (group CH) and 90 patients f...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735417699513

    authors: Ni J,Denehy L,Feng J,Xu L,Wu Y,Granger CL

    更新日期:2018-06-01 00:00:00

  • Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury.

    abstract::Many plant products are known to exert antioxidative effects by quenching various free radicals and singlet molecular oxygen. Andrographis paniculata (Kalmegh) is used extensively in the Indian traditional system of medicine as a hepatoprotective and hepatostimulative agent and has been reported to have antioxidant ef...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735407305985

    authors: Trivedi NP,Rawal UM,Patel BP

    更新日期:2007-09-01 00:00:00

  • Physical activity measured using global positioning system tracking in non-small cell lung cancer: an observational study.

    abstract:INTRODUCTION:Increasingly physical activity (PA) is being recognized as an important outcome in non-small cell lung cancer (NSCLC). We investigated PA using novel global positioning system (GPS) tracking individuals with NSCLC and a group of similar-aged healthy individuals. METHODS:A prospective cross-sectional multi...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,多中心研究

    doi:10.1177/1534735414542484

    authors: Granger CL,Denehy L,McDonald CF,Irving L,Clark RA

    更新日期:2014-11-01 00:00:00

  • A Proposed Revision of the International Classification of Diseases, 11th Revision, Chapter 26.

    abstract::In 2019, the World Health Assembly approved the International Classification of Diseases, 11th Revision (ICD-11), which included a traditional medicine chapter. This means that traditional medicine (TM) is incorporated into the mainstream medicine of the world. For TM to contribute to human health, the role of ICD-11,...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735420908334

    authors: Choi SH

    更新日期:2020-01-01 00:00:00

  • Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells.

    abstract::Previous studies have shown that soybean fermentation products can act as cancer chemoprevention or therapeutic agents. In this study, the anticancer activities of a fermentation product of soybean, black bean, and green bean mixture (BN999) were investigated. We found that BN999 inhibited the growth of human breast c...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735412458828

    authors: Chia JS,Du JL,Wu MS,Hsu WB,Chiang CP,Sun A,Lu JJ,Wang WB

    更新日期:2013-05-01 00:00:00

  • Efficacy of Ginger in Ameliorating Acute and Delayed Chemotherapy-Induced Nausea and Vomiting Among Patients With Lung Cancer Receiving Cisplatin-Based Regimens: A Randomized Controlled Trial.

    abstract::Nausea and vomiting are among the most common and distressing side effects of chemotherapy. Additional antiemetic drugs are urgently needed to effectively manage and ameliorate chemotherapy-induced nausea and vomiting (CINV). The efficacy of ginger as an antiemetic modality for ameliorating CINV has not been establish...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1534735417753541

    authors: Li X,Qin Y,Liu W,Zhou XY,Li YN,Wang LY

    更新日期:2018-09-01 00:00:00

  • Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats.

    abstract::Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of ...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735418762537

    authors: Wang C,Shi S,Chen Q,Lin S,Wang R,Wang S,Chen C

    更新日期:2018-09-01 00:00:00

  • Simultaneous Assessment of the Efficacy and Toxicity of Marine Mollusc-Derived Brominated Indoles in an In Vivo Model for Early Stage Colon Cancer.

    abstract::The acute apoptotic response to genotoxic carcinogens animal model has been extensively used to assess the ability of drugs and natural products like dietary components to promote apoptosis in the colon and protect against colorectal cancer (CRC). This work aimed to use this model to identify the main chemopreventativ...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735417699880

    authors: Esmaeelian B,Benkendorff K,Le Leu RK,Abbott CA

    更新日期:2018-06-01 00:00:00

  • Immunotherapy of Cancer: Developments and Reference Points, an Unorthodox Approach.

    abstract::Oncology is currently a sector of medical science with accelerated progress due to rapid technological development, the advancement in molecular biology, and the invention of many innovative therapies. Immunotherapy partially accounts for this advance, since it is increasingly playing an important role in the treatmen...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735419827090

    authors: Nikolaou M,Nikolaou G,Digklia A,Pontas C,Tsoukalas N,Kyrgias G,Tolia M

    更新日期:2019-01-01 00:00:00

  • Naturopathic Oncology Care for Thoracic Cancers: A Practice Survey.

    abstract:BACKGROUND AND OBJECTIVES:There is a lack of information on therapies recommended by naturopathic doctors (NDs) for lung and gastroesophageal cancer care. Study objectives were to: (1) identify the most common interventions considered for use by NDs; (2) identify interventions NDs recommend to support key therapeutic g...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735418759420

    authors: Seely D,Ennis JK,McDonell E,Zhao L

    更新日期:2018-09-01 00:00:00

  • Attachment and cancer: a conceptual integration.

    abstract::Cancer traditionally has been explained by the biomedical model; however, it is limited in comprehensively accounting for all factors in this disease. Recently, it has been suggested that a broader theoretical framework that includes psychosocial components in cancer is needed to complement the traditional approach. T...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/1534735402238188

    authors: Tacón AM

    更新日期:2002-12-01 00:00:00

  • Bursera copallifera Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines.

    abstract::Plants from the Bursera genus are widely distributed in the tropical dry forests of Mexico. In traditional medicine, extracts from different species of Bursera have been used for a wide range of biological activities, including the treatment of cancer-related symptoms. Compounds present in the Bursera genus include li...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735418766416

    authors: Domínguez F,Maycotte P,Acosta-Casique A,Rodríguez-Rodríguez S,Moreno DA,Ferreres F,Flores-Alonso JC,Delgado-López MG,Pérez-Santos M,Anaya-Ruiz M

    更新日期:2018-09-01 00:00:00

  • Can a cancer program-sponsored spiritual event meet with acceptance from patients and other attendees?

    abstract:BACKGROUND:While many cancer patients derive strength from spiritual or religious faith, concern often remains regarding how different patient subgroups and other community members might react to faith-based services when sponsored by a secular health care organization. METHODS:"A Sacred Gathering for Those Touched by...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735405278640

    authors: Dann NJ,Higby DJ,Mertens WC

    更新日期:2005-09-01 00:00:00

  • Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells.

    abstract::The aim of this study was to investigate the anticancer effect of a combination of D-fraction polysaccharide from Grifola frondosa (DFP) and vitamin C (VC) on hepatocellular carcinoma in vitro. DFP is a bioactive extract from the maitake mushroom. Anticancer activity was demonstrated using various concentrations of DF...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735416644674

    authors: Zhao F,Wang YF,Song L,Jin JX,Zhang YQ,Gan HY,Yang KH

    更新日期:2017-06-01 00:00:00

  • Inhibition to Epithelial-Mesenchymal Transition and Metastatic Potential In Colorectal Cancer Cell By Combination of Traditional Chinese Medicine Formulation Jiedu Sangen Decoction and PD-L1 Inhibitor.

    abstract:BACKGROUND:Jiedu Sangen Decoction (JSD), a traditional Chinese medicine formula, has been widely applied in the treatment of gastrointestinal cancer, especially in colorectal cancer. Our study mainly aimed to assess the combined efficacy of Jiedu Sangen aqueous extract (JSAE) and a PD-L1 inhibitor (PI) in colon cancer ...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735420972486

    authors: Shan F,Sun L,Zhang L,Guo K,Yan Q,Feng G,Zhu Y,Shen M,Ruan S

    更新日期:2020-01-01 00:00:00

  • Optimal mode for maximal aerobic exercise testing in breast cancer survivors.

    abstract:PURPOSE:To determine which mode of exercise is preferred by breast cancer survivors and to evaluate this response between graded exercise testing on a treadmill and on a cycle ergometer. METHODS:Twelve breast cancer survivors completed 2 maximal aerobic stress tests on separate days. The women completed a ramp protoco...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1534735411433202

    authors: Dolan LB,Lane K,McKenzie DC

    更新日期:2012-12-01 00:00:00

  • Exercise preconditioning provides long-term protection against early chronic doxorubicin cardiotoxicity.

    abstract::Acute doxorubicin (DOX) cardiotoxicity can be attenuated by exercise preconditioning, but little is known of whether this cardioprotection continues beyond 10 days post-DOX administration. The purpose of this study was to determine the effects of exercise preconditioning on early chronic DOX-induced cardiotoxicity. Ma...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735410392577

    authors: Hydock DS,Lien CY,Jensen BT,Schneider CM,Hayward R

    更新日期:2011-03-01 00:00:00

  • A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part I): Methods and Results.

    abstract::Animal-assisted interventions (AAIs) use human-animal interactions to positive effect in various contexts including cancer care. As the first installment of a 2-part series, this systematic literature review focuses on the research methods and quantitative results of AAI studies in oncology. We find methodological con...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735420943278

    authors: Holder TRN,Gruen ME,Roberts DL,Somers T,Bozkurt A

    更新日期:2020-01-01 00:00:00

  • Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients.

    abstract::Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tis...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735416676584

    authors: Larouche D,Hanna M,Chang SL,Jacob S,Têtu B,Diorio C

    更新日期:2017-12-01 00:00:00

  • A comparative review of thermography as a breast cancer screening technique.

    abstract::Breast cancer is the most frequently diagnosed cancer of women in North America. Despite advances in treatment that have reduced mortality, breast cancer remains the second leading cause of cancer induced death. Several well established tools are used to screen for breast cancer including clinical breast exams, mammog...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/1534735408326171

    authors: Kennedy DA,Lee T,Seely D

    更新日期:2009-03-01 00:00:00

  • A model program: exercise intervention for cancer rehabilitation.

    abstract::Recent advances in cancer detection and treatment have resulted in an increase in the survival rate of individuals diagnosed with cancer. The increased survival rate brings new challenges for increasing the quality of life for cancer survivors. Debilitating side effects can result from the cancer itself and the cancer...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/153473540200100117

    authors: Schneider CM,Dennehy CA,Roozeboom M,Carter SD

    更新日期:2002-03-01 00:00:00

  • Therapeutic actions of melatonin in cancer: possible mechanisms.

    abstract::Melatonin is a phylogenetically well-preserved molecule with diverse physiological functions. In addition to its well-known regulatory control of the sleep/wake cycle, as well as circadian rhythms generally, melatonin is involved in immunomodulation, hematopoiesis, and antioxidative processes. Recent human and animal ...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/1534735408322846

    authors: Srinivasan V,Spence DW,Pandi-Perumal SR,Trakht I,Cardinali DP

    更新日期:2008-09-01 00:00:00

  • Toona sinensis Inhibits Murine Leukemia WEHI-3 Cells and Promotes Immune Response In Vivo.

    abstract::Toona sinensis (TS) is one of the most popular vegetarian dishes in Taiwan. It has been shown to exhibit antioxidant, antiangiogenic, antiatherosclerotic, and anticancer properties. In this study, we demonstrated the ability of aqueous leaf extracts from TS to promote immune responses in BALB/c mice and to exhibit ant...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735416642863

    authors: Yang HL,Thiyagarajan V,Liao JW,Chu YL,Chang CT,Huang PJ,Hsu CJ,Hseu YC

    更新日期:2017-09-01 00:00:00

  • Use of Complementary Traditional Chinese Medicines by Adult Cancer Patients in Taiwan: A Nationwide Population-Based Study.

    abstract:BACKGROUND:Many patients with cancer seek complementary and alternative medicine treatments. We investigated the use of traditional Chinese medicine (TCM) by adult cancer patients in Taiwan. METHODS:We reviewed the Registry for Catastrophic Illness Patients Database of Taiwan, and included all adult patients diagnosed...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735417716302

    authors: Kuo YT,Chang TT,Muo CH,Wu MY,Sun MF,Yeh CC,Yen HR

    更新日期:2018-06-01 00:00:00

  • Patient responses to Cytoluminescent Therapy for cancer: an investigative report of early experiences and adverse effects of an unconventional form of photodynamic therapy.

    abstract::Cytoluminescent Therapy (CLT) is an unconventional form of photodynamic therapy (PDT), utilizing a second-generation chlorophyll-derived photosensitizing agent and whole-body illumination. Starting in late 2002, CLT was administered in Ireland to 48 patients. Illumination with lasers and light-emitting diodes followed...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735403259325

    authors: Moss RW

    更新日期:2003-12-01 00:00:00

  • Protective effect of Andrographis paniculata and andrographolide on cyclophosphamide-induced urothelial toxicity.

    abstract::The protective effect of Andrograhis paniculata and andrographolide (ANDLE) against cyclophosphamide (CTX)-induced urothelial toxicity was investigated in this study. Pretreatment of Swiss albino mice with A paniculata extract (10 mg/dose/animal intraperitoneally [ip]) and ANDLE (500 microg/dose/animal ip) could signi...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735406291984

    authors: Sheeja K,Kuttan G

    更新日期:2006-09-01 00:00:00