当前位置： SCI文献检索 > INTEGRATIVE CANCER THERAPIES期刊下所有文献 > Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-κb, PKC-δ, ERK1/2, and AMPKα.

Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-κb, PKC-δ, ERK1/2, and AMPKα.

Abstract：

:Gastric cancer (GC) is a malignancy with few effective treatment options after metastasis occurs. Quercetin (Qu) intake has been associated with reduced incidence and slow development of GC, probably due to its anti-proliferative and apoptotic effects, but it is unclear whether Qu can inhibit the metastatic activity. The urokinase plasminogen activator (uPA)/uPA receptor (uPAR) system plays an important role in cancer metastasis. In this study, we measured both uPA activity and uPAR expression in GC and pericarcinous tissues, and we investigated the correlation between uPAR expression and the migratory and invasive activities of various GC cell lines. GC BGC823 and AGS cells were subjected to treatment with 10 μM Qu for 72 hours and uPAR knockdown, alone or in combination, before evaluating cell metastasis. The results showed that uPA activity and uPAR expression were higher in GC tissues than in pericarcinous tissues. Migratory and invasive activities of GC cell lines positively correlated with uPAR expression. Qu treatment decreased BGC823 and AGS cell migration and invasion, accompanied by reduced uPA and uPAR protein expression. Both Qu treatment and uPAR knockdown decreased matrix metalloproteinase-2 and -9 activity and blocked Pak1-Limk1-cofilin signaling. Qu treatment was associated with inhibition of NF-κb, PKC-δ, and ERK1/2, and with AMPKα activation. Specific inhibitors of NF-κb, PKC, and ERK1/2, and an AMPKα activator suppressed uPA and uPAR expression in GC cells. Collectively, Qu showed an antimetastatic effect on GC cells via the interruption of uPA/uPAR function and modulation of NF-κb, PKC-δ, ERK1/2, and AMPKα. This suggests that Qu is a promising agent against GC metastasis.

journal_name

Integr Cancer Ther

journal_title

Integrative cancer therapies

authors

Li H,Chen C

doi

10.1177/1534735417696702

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

511-523

issue

2

eissn

1534-7354

issn

1552-695X

journal_volume

17

pub_type

杂志文章

相关文献

INTEGRATIVE CANCER THERAPIES文献大全
  • Simultaneous Assessment of the Efficacy and Toxicity of Marine Mollusc-Derived Brominated Indoles in an In Vivo Model for Early Stage Colon Cancer.

    abstract：:The acute apoptotic response to genotoxic carcinogens animal model has been extensively used to assess the ability of drugs and natural products like dietary components to promote apoptosis in the colon and protect against colorectal cancer (CRC). This work aimed to use this model to identify the main chemopreventativ...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735417699880

    authors： Esmaeelian B,Benkendorff K,Le Leu RK,Abbott CA

    更新日期：2018-06-01 00:00:00

  • Circadian stage-dependent inhibition of human breast cancer metabolism and growth by the nocturnal melatonin signal: consequences of its disruption by light at night in rats and women.

    abstract：:The circadian production of melatonin by the pineal gland during the night provides an inhibitory signal to tissue-isolated steroid receptor SR+ and - MCF-7 human breast cancer xenografts in female nude rats. A pivotal mechanism for melatonin's anticancer effects in vivo involves a melatonin receptor-mediated inhibiti...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735409352320

    authors： Blask DE,Dauchy RT,Brainard GC,Hanifin JP

    更新日期：2009-12-01 00:00:00

  • Per2 is a C/EBP target gene implicated in myeloid leukemia.

    abstract：:Circadian rhythms are endogenous biological clocks that govern fundamental physiological and behavioral functions. Consequently, perturbations of these rhythms have been associated with pathogenic conditions, such as depression, diabetes, and cancer. CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcripti...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735409352084

    authors： Gery S,Koeffler HP

    更新日期：2009-12-01 00:00:00

  • Physical Activity as a Nonpharmacological Symptom Management Approach in Myeloproliferative Neoplasms: Recommendations for Future Research.

    abstract：PURPOSE:Essential thrombocythemia, polycythemia vera, and myelofibrosis are rare chronic hematological malignancies known as myeloproliferative neoplasms (MPNs) and are characterized by deregulated myeloid lineage cell production, splenomegaly, and heterogeneous symptom profiles. MPN patients suffer from a significant ...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章,评审

    doi：10.1177/1534735416661417

    authors： Eckert R,Huberty J,Gowin K,Mesa R,Marks L

    更新日期：2017-12-01 00:00:00

  • Feasibility trial of electroacupuncture for aromatase inhibitor--related arthralgia in breast cancer survivors.

    abstract：BACKGROUND:Arthralgia affects postmenopausal women receiving aromatase inhibitors (AIs) for breast cancer. Given the existing evidence for electroacupuncture (EA) for treatment of osteoarthritis in the general population, this study aims to establish the feasibility of studying EA for treating AI-related arthralgia. P...

    journal_title：Integrative cancer therapies

    pub_type： 临床试验,杂志文章

    doi：10.1177/1534735409332903

    authors： Mao JJ,Bruner DW,Stricker C,Farrar JT,Xie SX,Bowman MA,Pucci D,Han X,DeMichele A

    更新日期：2009-06-01 00:00:00

  • Herbal Medicine for Xerostomia in Cancer Patients: A Systematic Review of Randomized Controlled Trials.

    abstract：BACKGROUND:Xerostomia (dry mouth) causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food. Many cancer patients have complained of xerostomia induced by cancer therapy. OBJECTIVE:The aim of this systematic review is to assess the efficacy of herbal med...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735417728336

    authors： Park B,Noh H,Choi DJ

    更新日期：2018-06-01 00:00:00

  • Inhibition to Epithelial-Mesenchymal Transition and Metastatic Potential In Colorectal Cancer Cell By Combination of Traditional Chinese Medicine Formulation Jiedu Sangen Decoction and PD-L1 Inhibitor.

    abstract：BACKGROUND:Jiedu Sangen Decoction (JSD), a traditional Chinese medicine formula, has been widely applied in the treatment of gastrointestinal cancer, especially in colorectal cancer. Our study mainly aimed to assess the combined efficacy of Jiedu Sangen aqueous extract (JSAE) and a PD-L1 inhibitor (PI) in colon cancer ...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735420972486

    authors： Shan F,Sun L,Zhang L,Guo K,Yan Q,Feng G,Zhu Y,Shen M,Ruan S

    更新日期：2020-01-01 00:00:00

  • A comparative review of thermography as a breast cancer screening technique.

    abstract：:Breast cancer is the most frequently diagnosed cancer of women in North America. Despite advances in treatment that have reduced mortality, breast cancer remains the second leading cause of cancer induced death. Several well established tools are used to screen for breast cancer including clinical breast exams, mammog...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章,评审

    doi：10.1177/1534735408326171

    authors： Kennedy DA,Lee T,Seely D

    更新日期：2009-03-01 00:00:00

  • Colon cancer survival with herbal medicine and vitamins combined with standard therapy in a whole-systems approach: ten-year follow-up data analyzed with marginal structural models and propensity score methods.

    abstract：:Although localized colon cancer is often successfully treated with surgery, advanced disease requires aggressive systemic therapy that has lower effectiveness. Approximately 30% to 75% of patients with colon cancer use complementary and alternative medicine (CAM), but there is limited formal evidence of survival effic...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735411406539

    authors： McCulloch M,Broffman M,van der Laan M,Hubbard A,Kushi L,Abrams DI,Gao J,Colford JM Jr

    更新日期：2011-09-01 00:00:00

  • Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells.

    abstract：:Previous studies have shown that soybean fermentation products can act as cancer chemoprevention or therapeutic agents. In this study, the anticancer activities of a fermentation product of soybean, black bean, and green bean mixture (BN999) were investigated. We found that BN999 inhibited the growth of human breast c...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735412458828

    authors： Chia JS,Du JL,Wu MS,Hsu WB,Chiang CP,Sun A,Lu JJ,Wang WB

    更新日期：2013-05-01 00:00:00

  • Antimetastatic effects of Celastrus orbiculatus on human gastric adenocarcinoma by inhibiting epithelial-mesenchymal transition and NF-κB/snail signaling pathway.

    abstract：AIM OF THE STUDY:Celastrus orbiculatus has been used as a folk medicine in China for the treatment of many diseases. In the laboratory, the ethyl acetate extract of Celastrus orbiculatus (COE) displays a wide range of anticancer functions. However, the inhibition of the metastasis mechanism of COE in gastric cancer cel...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735415572880

    authors： Zhu Y,Liu Y,Qian Y,Dai X,Yang L,Chen J,Guo S,Hisamitsu T

    更新日期：2015-05-01 00:00:00

  • Traditional herbal medicine as adjunctive therapy for nasopharyngeal cancer: a systematic review and meta-analysis.

    abstract：:The effectiveness of traditional herbal medicine (THM) as treatment for nasopharyngeal cancer (NPC) has not been clearly demonstrated. The aim of this study is to assess the effectiveness of THM as adjunctive therapies for NPC using the results of randomized controlled trials (RCTs). Five electronic databases, includi...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章,meta分析,评审

    doi：10.1177/1534735415572881

    authors： Kim W,Lee WB,Lee J,Min BI,Lee H,Cho SH

    更新日期：2015-05-01 00:00:00

  • Ganoderma lucidum spore induced CA72-4 elevation in gastrointestinal cancer: a five-case report.

    abstract：GANODERMA LUCIDU:spore (GLS), an over-the-counter herbal supplement, is widely used by cancer patients in China. Although preclinical studies have shown it to be safe, complete safety data on GLS is still lacking. In this article, we report 5 cases of gastrointestinal cancer that were treated with GLS plus multiple str...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735413510022

    authors： Yan B,Meng X,Shi J,Qin Z,Wei P,Lao L

    更新日期：2014-03-01 00:00:00

  • Integrating spirituality into a group psychological therapy program for cancer patients.

    abstract：PURPOSE:Although the importance of spiritual issues to people with cancer is by now widely acknowledged, there has been almost no research on the value of interventions specifically designed to enhance the spiritual experience of these patients. The present report describes an exploratory study on the effects of a brie...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735405275648

    authors： Cunningham AJ

    更新日期：2005-06-01 00:00:00

  • Use of Complementary Traditional Chinese Medicines by Adult Cancer Patients in Taiwan: A Nationwide Population-Based Study.

    abstract：BACKGROUND:Many patients with cancer seek complementary and alternative medicine treatments. We investigated the use of traditional Chinese medicine (TCM) by adult cancer patients in Taiwan. METHODS:We reviewed the Registry for Catastrophic Illness Patients Database of Taiwan, and included all adult patients diagnosed...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735417716302

    authors： Kuo YT,Chang TT,Muo CH,Wu MY,Sun MF,Yeh CC,Yen HR

    更新日期：2018-06-01 00:00:00

  • Extracellular-to-Intracellular Fluid Volume Ratio as a Prognostic Factor for Survival in Patients With Metastatic Cancer.

    abstract：PURPOSE:This study aimed to investigate whether the extracellular-to-intracellular fluid volume (E/I) ratio can predict survival in patients with metastatic cancer. METHODS:Clinical data were collected from April 2016 to March 2018. Patients aged ≥19 years with metastatic solid tumor were eligible. Bioimpedance analys...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735419847285

    authors： Lee JY,Ryu HS,Yoon SS,Kim EH,Yoon SW

    更新日期：2019-01-01 00:00:00

  • Effects of Vitamin D Use on Health-Related Quality of Life of Breast Cancer Patients in Early Survivorship.

    abstract：BACKGROUND:Vitamin D supplements may prevent recurrence, prolong survival, and improve mood for women with breast cancer, although evidence for these effects is preliminary. METHODS:This report describes vitamin D supplement use by 553 breast cancer patient/survivors (193 who used a naturopathic oncology [NO] provider...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735418822056

    authors： Andersen MR,Sweet E,Hager S,Gaul M,Dowd F,Standish LJ

    更新日期：2019-01-01 00:00:00

  • Influence of a Multidisciplinary Program of Diet, Exercise, and Mindfulness on the Quality of Life of Stage IIA-IIB Breast Cancer Survivors.

    abstract：:Background: Integrative oncology has proven to be a useful approach to control cancer symptoms and improve the quality of life (QoL) and overall health of patients, delivering integrated patient care at both physical and emotional levels. The objective of this randomized trial was to evaluate the effects of a triple i...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735420924757

    authors： Ruiz-Vozmediano J,Löhnchen S,Jurado L,Recio R,Rodríguez-Carrillo A,López M,Mustieles V,Expósito M,Arroyo-Morales M,Fernández MF

    更新日期：2020-01-01 00:00:00

  • Attachment and cancer: a conceptual integration.

    abstract：:Cancer traditionally has been explained by the biomedical model; however, it is limited in comprehensively accounting for all factors in this disease. Recently, it has been suggested that a broader theoretical framework that includes psychosocial components in cancer is needed to complement the traditional approach. T...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章,评审

    doi：10.1177/1534735402238188

    authors： Tacón AM

    更新日期：2002-12-01 00:00:00

  • A Proposed Revision of the International Classification of Diseases, 11th Revision, Chapter 26.

    abstract：:In 2019, the World Health Assembly approved the International Classification of Diseases, 11th Revision (ICD-11), which included a traditional medicine chapter. This means that traditional medicine (TM) is incorporated into the mainstream medicine of the world. For TM to contribute to human health, the role of ICD-11,...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735420908334

    authors： Choi SH

    更新日期：2020-01-01 00:00:00

  • Detoxifying cancer causing agents to prevent cancer.

    abstract：:Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of s...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章,评审

    doi：10.1177/1534735403002002005

    authors： Hanausek M,Walaszek Z,Slaga TJ

    更新日期：2003-06-01 00:00:00

  • Shedding light on vitamin D and integrative oncology.

    abstract：:Studies show an important relationship between vitamin D and malignancies, both in prevention and treatment. The extraskeletal actions of vitamin D relevant to oncology include being proapoptotic, antimetastatic, antiangiogenic, antiinflammatory, prodifferentiating, and immunomodulating. Widespread and severe vitamin ...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735408319062

    authors： Cantor I

    更新日期：2008-06-01 00:00:00

  • A Polyphenol-Rich Extract From Muscadine Grapes Inhibits Triple-Negative Breast Tumor Growth.

    abstract：:Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that tends to affect young women and has a high propensity to metastasize. No targeted treatments are available for this type of breast cancer due to a lack of estrogen or progesterone receptors or overexpression of human epidermal growth f...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735420917444

    authors： Collard M,Gallagher PE,Tallant EA

    更新日期：2020-01-01 00:00:00

  • Total alkaloids of Rubus alceifolius Poir shows anti-angiogenic activity in vivo and in vitro.

    abstract：:Total alkaloids is an active ingredient of the natural plant Rubus alceifolius Poir, commonly used for the treatment of various cancers. Antitumor effects may be mediated through anti-angiogenic mechanisms. As such, the goal of the present study was to investigate and evaluate the effect of total alkaloids in Rubus al...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735414547109

    authors： Zhao J,Lin W,Zhuang Q,Zhong X,Cao Z,Hong Z,Peng J

    更新日期：2014-11-01 00:00:00

  • Therapeutic actions of melatonin in cancer: possible mechanisms.

    abstract：:Melatonin is a phylogenetically well-preserved molecule with diverse physiological functions. In addition to its well-known regulatory control of the sleep/wake cycle, as well as circadian rhythms generally, melatonin is involved in immunomodulation, hematopoiesis, and antioxidative processes. Recent human and animal ...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章,评审

    doi：10.1177/1534735408322846

    authors： Srinivasan V,Spence DW,Pandi-Perumal SR,Trakht I,Cardinali DP

    更新日期：2008-09-01 00:00:00

  • Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury.

    abstract：:Many plant products are known to exert antioxidative effects by quenching various free radicals and singlet molecular oxygen. Andrographis paniculata (Kalmegh) is used extensively in the Indian traditional system of medicine as a hepatoprotective and hepatostimulative agent and has been reported to have antioxidant ef...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735407305985

    authors： Trivedi NP,Rawal UM,Patel BP

    更新日期：2007-09-01 00:00:00

  • The Inhibition Kinetics and Potential Anti-Migration Activity of NQO1 Inhibitory Coumarins on Cholangiocarcinoma Cells.

    abstract：:Altered expression of a cytosolic flavoenzyme NAD(P)H:quinone oxidoreductase-1 (NQO1) has been seen in many human tumors. Its remarkable overexpression in cholangiocarcinoma (CCA; an aggressive malignancy of the biliary duct system) was associated with poor prognosis and short survival of the patients. Inhibition of N...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735418820444

    authors： Khunluck T,Kukongviriyapan V,Senggunprai L,Duangarsong W,Prawan A

    更新日期：2019-01-01 00:00:00

  • Hesperidin inhibits cyclophosphamide-induced tumor growth delay in mice.

    abstract：:Hesperidin is a natural compound that has chemoprotective effects in tumor cell lines and protective effects against hematotoxicity induced by cyclophosphamide. The aim of this study was to evaluate the effect of hesperidin on the antitumor effect of cyclophosphamide in tumor-bearing mice. Administration of hesperidin...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735412448959

    authors： Hosseinimehr SJ,Jalayer Z,Naghshvar F,Mahmoudzadeh A

    更新日期：2012-09-01 00:00:00

  • Protective effect of Andrographis paniculata and andrographolide on cyclophosphamide-induced urothelial toxicity.

    abstract：:The protective effect of Andrograhis paniculata and andrographolide (ANDLE) against cyclophosphamide (CTX)-induced urothelial toxicity was investigated in this study. Pretreatment of Swiss albino mice with A paniculata extract (10 mg/dose/animal intraperitoneally [ip]) and ANDLE (500 microg/dose/animal ip) could signi...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735406291984

    authors： Sheeja K,Kuttan G

    更新日期：2006-09-01 00:00:00

  • Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral Squamous Carcinoma Cells ORL-48.

    abstract：:Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns. Incorrect nutritional habits and lifestyle practices have been dire...

    journal_title：Integrative cancer therapies

    pub_type： 杂志文章

    doi：10.1177/1534735416675950

    authors： Zulkapli R,Abdul Razak F,Zain RB

    更新日期：2017-09-01 00:00:00