Abstract:
:The circadian production of melatonin by the pineal gland during the night provides an inhibitory signal to tissue-isolated steroid receptor SR+ and - MCF-7 human breast cancer xenografts in female nude rats. A pivotal mechanism for melatonin's anticancer effects in vivo involves a melatonin receptor-mediated inhibition of linoleic acid (LA) uptake and its metabolism to mitogenically active 13-hydroxyoctadecadienoic acid (13-HODE). Exposure of (SR-) xenograft-bearing rats to increasing intensities of polychromatic white light at night suppresses melatonin while increasing tumor growth rates, DNA content, [3H]thymidine incorporation into DNA, LA uptake, 13-HODE formation, cAMP levels and ERK1/2 activation a dose-dependent manner. Similar effects occur in SR- human breast cancer xenografts perfused in situ with melatonin-depleted blood from healthy female subjects after their exposure to a single bright intensity (2800 lux) of polychromatic light at night. Additionally, SR- human breast cancer xenografts exhibit robust circadian rhythms of LA uptake, 13-HODE formation and proliferative activity. Exposure of xenograft-bearing rats to dim light at night results in the complete elimination of these rhythms which culminates in unfettered, high rates of tumor metabolism and growth. The organization of tumor metabolism and growth within circadian time structure by the oncostatic melatonin signal helps create a balance between the cancer and its host that is disrupted by host exposure to light at night. This biological mechanism may partially explain the higher risk of breast and other cancers in women working rotating night shifts and possibly others who also experience prolonged exposure to light at night.
journal_name
Integr Cancer Therjournal_title
Integrative cancer therapiesauthors
Blask DE,Dauchy RT,Brainard GC,Hanifin JPdoi
10.1177/1534735409352320subject
Has Abstractpub_date
2009-12-01 00:00:00pages
347-53issue
4eissn
1534-7354issn
1552-695Xpii
8/4/347journal_volume
8pub_type
杂志文章abstract::The large majority of clinical prostate cancers remain dependent on androgen receptor (AR) activity for proliferation even as they lose their responsiveness to androgen deprivation or antagonism. AR activity can be maintained in these circumstances by increased AR synthesis--often reflecting increased NF-κB activation...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414534728
更新日期:2014-09-01 00:00:00
abstract::Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammati...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419846400
更新日期:2019-01-01 00:00:00
abstract::Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418762537
更新日期:2018-09-01 00:00:00
abstract:AIM:To introduce the application of wheel balance cancer therapy (WBCT) in cancer treatment through an intensive study of a representative patient. METHOD:A 59-year-old, female patient who was a secondhand smoker and who carried no significant medical and family history was diagnosed with T1N0M1 (stage 4) lung adenoca...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410371479
更新日期:2010-06-01 00:00:00
abstract::The use of multiple drugs in cancer therapy increases the efficacy of the potential therapeutic effects. In this study, the authors investigated the adjuvant effects of an ethanol extract of solid-state cultivated Taiwanofungus camphoratus (TCEE) and amphotericin B (AmB) in the human cancer cell lines RPMI7951 and MG6...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735412442379
更新日期:2013-03-01 00:00:00
abstract::Altered expression of a cytosolic flavoenzyme NAD(P)H:quinone oxidoreductase-1 (NQO1) has been seen in many human tumors. Its remarkable overexpression in cholangiocarcinoma (CCA; an aggressive malignancy of the biliary duct system) was associated with poor prognosis and short survival of the patients. Inhibition of N...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418820444
更新日期:2019-01-01 00:00:00
abstract::Breast cancer is the most frequently diagnosed cancer of women in North America. Despite advances in treatment that have reduced mortality, breast cancer remains the second leading cause of cancer induced death. Several well established tools are used to screen for breast cancer including clinical breast exams, mammog...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735408326171
更新日期:2009-03-01 00:00:00
abstract::Studies show an important relationship between vitamin D and malignancies, both in prevention and treatment. The extraskeletal actions of vitamin D relevant to oncology include being proapoptotic, antimetastatic, antiangiogenic, antiinflammatory, prodifferentiating, and immunomodulating. Widespread and severe vitamin ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735408319062
更新日期:2008-06-01 00:00:00
abstract::The aim of this study was to investigate the anticancer effect of a combination of D-fraction polysaccharide from Grifola frondosa (DFP) and vitamin C (VC) on hepatocellular carcinoma in vitro. DFP is a bioactive extract from the maitake mushroom. Anticancer activity was demonstrated using various concentrations of DF...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416644674
更新日期:2017-06-01 00:00:00
abstract::Purpose Fatigue is an important problem in children receiving intensive chemotherapy and hematopoietic stem cell transplantation (HSCT). Exercise may be an effective intervention for fatigue. Individualized yoga represents an ideal intervention because it can be tailored according to an individual child's needs. Littl...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416630806
更新日期:2016-09-01 00:00:00
abstract::Purpose: We evaluate longitudinal changes in symptom clusters and core burdensome symptoms in breast cancer patients who participated in the OptiTrain trial. Methods: 240 women were randomized to 16 weeks of supervised exercise (RT-HIIT or AT-HIIT) or usual care (UC) during adjuvant chemotherapy. Symptom clusters were...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420905003
更新日期:2020-01-01 00:00:00
abstract:HYPOTHESIS:Anorexia and cancer cachexia produce significant loss of adipose tissue and muscle mass and eventually reduce survival in cancer patients. STUDY DESIGN:This phase II study was conducted to assess the efficacy and the safety of an herbal decoction with Astragali radix in patients with anorexia in advanced ca...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409359180
更新日期:2010-03-01 00:00:00
abstract::Toona sinensis (TS) is one of the most popular vegetarian dishes in Taiwan. It has been shown to exhibit antioxidant, antiangiogenic, antiatherosclerotic, and anticancer properties. In this study, we demonstrated the ability of aqueous leaf extracts from TS to promote immune responses in BALB/c mice and to exhibit ant...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416642863
更新日期:2017-09-01 00:00:00
abstract::Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns. Incorrect nutritional habits and lifestyle practices have been dire...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416675950
更新日期:2017-09-01 00:00:00
abstract::In 2019, the World Health Assembly approved the International Classification of Diseases, 11th Revision (ICD-11), which included a traditional medicine chapter. This means that traditional medicine (TM) is incorporated into the mainstream medicine of the world. For TM to contribute to human health, the role of ICD-11,...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420908334
更新日期:2020-01-01 00:00:00
abstract::Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of s...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735403002002005
更新日期:2003-06-01 00:00:00
abstract::A recurrence of cancer is a traumatic and stressful experience, and a number of approaches have been proposed to manage or treat the associated psychological distress. Meditative techniques such as mindfulness may be able to improve an individual's ability to cope with stressful life events such as cancer diagnosis or...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420908341
更新日期:2020-01-01 00:00:00
abstract::Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tis...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416676584
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:This study aimed to investigate whether the extracellular-to-intracellular fluid volume (E/I) ratio can predict survival in patients with metastatic cancer. METHODS:Clinical data were collected from April 2016 to March 2018. Patients aged ≥19 years with metastatic solid tumor were eligible. Bioimpedance analys...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419847285
更新日期:2019-01-01 00:00:00
abstract::Animal-assisted interventions (AAIs) use human-animal interactions to positive effect in various contexts including cancer care. As the first installment of a 2-part series, this systematic literature review focuses on the research methods and quantitative results of AAI studies in oncology. We find methodological con...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420943278
更新日期:2020-01-01 00:00:00
abstract::Eupatorin is a polymethoxy flavone extracted from Orthosiphon stamineus and was reported to exhibit cytotoxic effects on several cancer cell lines. However, its effect as an anti-breast cancer agent in vivo has yet to be determined. This study aims to elucidate the potential of eupatorin as an anti-breast cancer agent...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420935625
更新日期:2020-01-01 00:00:00
abstract::Physical inactivity is a major concern in cancer patients despite the established preventative and therapeutic effects of regular physical exercise for this patient group. Sport not only plays an important role in supporting the development and maintenance of a physically active lifestyle but also is increasingly used...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419894063
更新日期:2019-01-01 00:00:00
abstract::The effectiveness of traditional herbal medicine (THM) as treatment for nasopharyngeal cancer (NPC) has not been clearly demonstrated. The aim of this study is to assess the effectiveness of THM as adjunctive therapies for NPC using the results of randomized controlled trials (RCTs). Five electronic databases, includi...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,meta分析,评审
doi:10.1177/1534735415572881
更新日期:2015-05-01 00:00:00
abstract::For more than 200 years, biomedicine has approached the treatment of disease by studying disease processes (patho-genesis), inferring causal connections and developing specific approaches for therapeutically interfering with those processes. This pathogenic approach has been highly successful in acute and traumatic di...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735406295565
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Xerostomia (dry mouth) causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food. Many cancer patients have complained of xerostomia induced by cancer therapy. OBJECTIVE:The aim of this systematic review is to assess the efficacy of herbal med...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417728336
更新日期:2018-06-01 00:00:00
abstract::Pancreatic cancer (PC) has a very low average survival, but its prognosis is further reduced in the case of metastatic spread. Medical therapy in these cases is the only applicable methodology in the international guidelines. During anticancer treatments, common side effects are nausea, vomiting, arthralgia, neuropath...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418755479
更新日期:2018-09-01 00:00:00
abstract::In recent years, there has been an increased interest in complementary and alternative medicine (CAM) use among people with cancer. Many are looking for informed advice and desire communication with their physicians about CAM use. Communication is crucial in establishing trust with patients, gathering information, add...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735410363706
更新日期:2010-06-01 00:00:00
abstract::Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investigated in the cultured human cervical gland carcinoma cells HeLa and cervical squ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416684551
更新日期:2018-03-01 00:00:00
abstract::Total alkaloids is an active ingredient of the natural plant Rubus alceifolius Poir, commonly used for the treatment of various cancers. Antitumor effects may be mediated through anti-angiogenic mechanisms. As such, the goal of the present study was to investigate and evaluate the effect of total alkaloids in Rubus al...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414547109
更新日期:2014-11-01 00:00:00
abstract::Although localized colon cancer is often successfully treated with surgery, advanced disease requires aggressive systemic therapy that has lower effectiveness. Approximately 30% to 75% of patients with colon cancer use complementary and alternative medicine (CAM), but there is limited formal evidence of survival effic...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735411406539
更新日期:2011-09-01 00:00:00