Abstract:
:Background The role of whole grains, refined cereals, and legumes in preventing or initiating colorectal cancer (CRC) is still uncertain. The aim of this study is to examine the possible association between the consumption of whole grains, refined cereals, and legumes and the risk of developing CRC among Jordanian population. Methods A validated food frequency questionnaire was used to collect dietary data with regard to intake of whole grains, refined cereals, and legumes. A total of 220 diagnosed CRC participants and 281 CRC-free control participants matched by age, gender, occupation, and marital status were recruited. Logistic regression was used to estimate the odds of developing CRC in relation to the consumption of different types of whole grains, refined cereals, and legumes. Results The odds ratio (OR) for developing CRC among cases consumed refined wheat bread at all meals was 3.1 compared with controls (95% CI: 1.2-7.9, P-Trend = 0.001); whereas the OR associated with whole wheat bread was 0.44 (95% CI: 0.22-0.92, P-Trend = 0.001). The statistical evaluation for daily consumption of rice suggested a direct association with the risk of developing CRC, OR = 3.0 (95% CI: 0.27-33.4, P-Trend = 0.020). Weekly consumption of macaroni was associated with CRC with OR of 2.4 (95% CI: 1.1-5.3, P-Trend = 0.001). The consumption of corn, bulgur, lentils, and peas suggested a protective trend, although the trend was not statistically significant. Conclusion This study provides additional indicators of the protective role of whole grains and suggests a direct association between consumption of refined grains and higher possibility for developing CRC.
journal_name
Integr Cancer Therjournal_title
Integrative cancer therapiesauthors
Tayyem RF,Bawadi HA,Shehadah I,Agraib LM,Al-Awwad NJ,Heath DD,Bani-Hani KEdoi
10.1177/1534735415620010subject
Has Abstractpub_date
2016-09-01 00:00:00pages
318-25issue
3eissn
1534-7354issn
1552-695Xpii
1534735415620010journal_volume
15pub_type
杂志文章abstract::Antineoplastic agents induce oxidative stress in biological systems. During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that can attack many cellular targets. These products of oxidative stress can slow cell cycle progression of cancer cells and cause cel...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
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abstract::Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammati...
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abstract::Background: Chemotherapy-induced peripheral neuropathy (CIPN) has no cure, but acupuncture may provide relief through its known neuromodulation or neuroendocrine adjustment. This review aimed to assess the efficacy of acupuncture in treating CIPN. Method: A literature review following the PRISMA Statement was performe...
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journal_title:Integrative cancer therapies
pub_type: 杂志文章,meta分析,评审
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更新日期:2012-12-01 00:00:00
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journal_title:Integrative cancer therapies
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-06-01 00:00:00
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journal_title:Integrative cancer therapies
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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