Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells.

Abstract:

:Previous studies have shown that soybean fermentation products can act as cancer chemoprevention or therapeutic agents. In this study, the anticancer activities of a fermentation product of soybean, black bean, and green bean mixture (BN999) were investigated. We found that BN999 inhibited the growth of human breast cancer AU565 cells and prostate adenocarcinoma PC-3 cells but not that of normal human cells. BN999 induced apoptosis in various human cancer cells but not in normal human cells. BN999 treatment of AU565 cancer cells resulted in activation of calpain and caspase-8, -9, and -3, suggesting that BN999 induces apoptosis via receptor-, mitochondria-, and endoplasmic reticulum-mediated pathways. Finally, we showed that BN999 inhibited the growth of mouse CT-26 colon cancer xenografts in syngenic BALB/c mice without causing obvious side effects. Together, these data suggest that BN999 has potential to be used as a cancer chemoprevention or therapeutic agent.

journal_name

Integr Cancer Ther

authors

Chia JS,Du JL,Wu MS,Hsu WB,Chiang CP,Sun A,Lu JJ,Wang WB

doi

10.1177/1534735412458828

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

248-56

issue

3

eissn

1534-7354

issn

1552-695X

pii

1534735412458828

journal_volume

12

pub_type

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