Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness.

Abstract:

:Antineoplastic agents induce oxidative stress in biological systems. During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that can attack many cellular targets. These products of oxidative stress can slow cell cycle progression of cancer cells and cause cell cycle checkpoint arrest, effects that may interfere with the ability of anticancer drugs to kill cancer cells. The aldehydes may also inhibit drug-induced apoptosis (programmed cell death) by inactivating death receptors and inhibiting caspase activity. These effects would also diminish the efficacy of the treatment. The use of anti-oxidants during chemotherapy may enhance therapy by reducing the generation of oxidative stress-induced aldehydes.

journal_name

Integr Cancer Ther

authors

Conklin KA

doi

10.1177/1534735404270335

keywords:

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

294-300

issue

4

eissn

1534-7354

issn

1552-695X

pii

3/4/294

journal_volume

3

pub_type

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