Abstract:
:Oncology is currently a sector of medical science with accelerated progress due to rapid technological development, the advancement in molecular biology, and the invention of many innovative therapies. Immunotherapy partially accounts for this advance, since it is increasingly playing an important role in the treatment of cancer patients, bringing on a sense of hope and optimism through a series of clinical studies and cases with spectacular results. Immunotherapy, after the initial successes it experienced in the early 20th century, was forgotten after chemotherapy and radiotherapy prevailed and developed slowly in the background. Today, it is the new hope for cancer treatment, despite the unorthodox path it has followed. In this article, we study the course and key points of the discovery of immune-oncology from the oncologist's point of view. We also record the questions that have been posed about immunotherapy that sometimes lead to confusion or stalemate.
journal_name
Integr Cancer Therjournal_title
Integrative cancer therapiesauthors
Nikolaou M,Nikolaou G,Digklia A,Pontas C,Tsoukalas N,Kyrgias G,Tolia Mdoi
10.1177/1534735419827090subject
Has Abstractpub_date
2019-01-01 00:00:00pages
1534735419827090eissn
1534-7354issn
1552-695Xjournal_volume
18pub_type
杂志文章abstract:OBJECTIVE:To evaluate the impact of participating in an integrative cancer care program at the Centre for Integrated Healing in Vancouver, British Columbia, on patients' lifestyle, quality of life, and overall well-being. STUDY DESIGN:A mixed-methods case study with a pre- and posttest design. No control group was uti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735407313395
更新日期:2008-03-01 00:00:00
abstract::This study reports the antimigration, anti-invasive effect of glabridin, a flavonoid obtained from licorice, in human non-small cell lung cancer A549 cells. Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer cell migration and invasion of A549 cells. In addition, glabridin also decreased ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410384860
更新日期:2011-12-01 00:00:00
abstract::Toona sinensis (TS) is one of the most popular vegetarian dishes in Taiwan. It has been shown to exhibit antioxidant, antiangiogenic, antiatherosclerotic, and anticancer properties. In this study, we demonstrated the ability of aqueous leaf extracts from TS to promote immune responses in BALB/c mice and to exhibit ant...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416642863
更新日期:2017-09-01 00:00:00
abstract::The British developmental biologist John Beard, DSc (1858-1924) is little remembered today. Yet, he made outstanding contributions to the life sciences. Beard deserves to be included among the leading biologists of the late 19th and early 20th century. He has been hailed as a forerunner of the present-day theory of th...
journal_title:Integrative cancer therapies
pub_type: 传,历史文章,杂志文章
doi:10.1177/1534735408326174
更新日期:2008-12-01 00:00:00
abstract::This study hypothesizes that, bromelain (BL) acts as radiosensitizer of tumor cells and that it protects normal cells from radiation effects. In vitro and in vivo studies have been carried out to prove that assumption. In vitro MTT cell proliferation assay has shown that the irradiated Ehrlich ascites carcinoma (EAC) ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420950468
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Health care policies and guidelines that are clear and consistent with research evidence are important for maximizing clinical outcomes. To determine whether cancer centers in Canada and the United States had policies and/or guidelines about antioxidant use, and whether policies were aligned with the evidenc...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415572884
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Many patients with cancer seek complementary and alternative medicine treatments. We investigated the use of traditional Chinese medicine (TCM) by adult cancer patients in Taiwan. METHODS:We reviewed the Registry for Catastrophic Illness Patients Database of Taiwan, and included all adult patients diagnosed...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417716302
更新日期:2018-06-01 00:00:00
abstract::Background: Integrative oncology has proven to be a useful approach to control cancer symptoms and improve the quality of life (QoL) and overall health of patients, delivering integrated patient care at both physical and emotional levels. The objective of this randomized trial was to evaluate the effects of a triple i...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420924757
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:This study aimed to investigate whether the extracellular-to-intracellular fluid volume (E/I) ratio can predict survival in patients with metastatic cancer. METHODS:Clinical data were collected from April 2016 to March 2018. Patients aged ≥19 years with metastatic solid tumor were eligible. Bioimpedance analys...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419847285
更新日期:2019-01-01 00:00:00
abstract::Vitamin D status has importance in the prevention and treatment of many malignancies. Patients with breast, colon, and lung malignancies with higher vitamin D status at the onset of treatment have an improved prognosis compared with those patients with a lower vitamin D status. Methods to improve vitamin D status are ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414537875
更新日期:2014-09-01 00:00:00
abstract::Besides honey, honeybees make a sticky substance (called propolis/bee glue) by mixing saliva with poplar tree resin and other botanical sources. It is known to be rich in bioactivities of which the anticancer activity is most studied. Caffeic acid phenethyl ester (CAPE) is a key anticancer component in New Zealand pro...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735417753545
更新日期:2018-09-01 00:00:00
abstract:AIM OF THE STUDY:Celastrus orbiculatus has been used as a folk medicine in China for the treatment of many diseases. In the laboratory, the ethyl acetate extract of Celastrus orbiculatus (COE) displays a wide range of anticancer functions. However, the inhibition of the metastasis mechanism of COE in gastric cancer cel...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415572880
更新日期:2015-05-01 00:00:00
abstract::Carnosine has been demonstrated to play an antitumorigenic role in certain types of cancer. However, its underlying mechanism is unclear. In this study, the roles of carnosine in cell proliferation and its underlying mechanism were investigated in the cultured human cervical gland carcinoma cells HeLa and cervical squ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416684551
更新日期:2018-03-01 00:00:00
abstract::Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tis...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416676584
更新日期:2017-12-01 00:00:00
abstract::Cancer traditionally has been explained by the biomedical model; however, it is limited in comprehensively accounting for all factors in this disease. Recently, it has been suggested that a broader theoretical framework that includes psychosocial components in cancer is needed to complement the traditional approach. T...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735402238188
更新日期:2002-12-01 00:00:00
abstract::Circadian rhythms are endogenous biological clocks that govern fundamental physiological and behavioral functions. Consequently, perturbations of these rhythms have been associated with pathogenic conditions, such as depression, diabetes, and cancer. CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcripti...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409352084
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:Essential thrombocythemia, polycythemia vera, and myelofibrosis are rare chronic hematological malignancies known as myeloproliferative neoplasms (MPNs) and are characterized by deregulated myeloid lineage cell production, splenomegaly, and heterogeneous symptom profiles. MPN patients suffer from a significant ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735416661417
更新日期:2017-12-01 00:00:00
abstract::In recent years, there has been an increased interest in complementary and alternative medicine (CAM) use among people with cancer. Many are looking for informed advice and desire communication with their physicians about CAM use. Communication is crucial in establishing trust with patients, gathering information, add...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735410363706
更新日期:2010-06-01 00:00:00
abstract:HYPOTHESIS:Anorexia and cancer cachexia produce significant loss of adipose tissue and muscle mass and eventually reduce survival in cancer patients. STUDY DESIGN:This phase II study was conducted to assess the efficacy and the safety of an herbal decoction with Astragali radix in patients with anorexia in advanced ca...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409359180
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:Although the importance of spiritual issues to people with cancer is by now widely acknowledged, there has been almost no research on the value of interventions specifically designed to enhance the spiritual experience of these patients. The present report describes an exploratory study on the effects of a brie...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735405275648
更新日期:2005-06-01 00:00:00
abstract::A recurrence of cancer is a traumatic and stressful experience, and a number of approaches have been proposed to manage or treat the associated psychological distress. Meditative techniques such as mindfulness may be able to improve an individual's ability to cope with stressful life events such as cancer diagnosis or...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420908341
更新日期:2020-01-01 00:00:00
abstract::Breast cancer is the most frequently diagnosed cancer of women in North America. Despite advances in treatment that have reduced mortality, breast cancer remains the second leading cause of cancer induced death. Several well established tools are used to screen for breast cancer including clinical breast exams, mammog...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735408326171
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Jiedu Sangen Decoction (JSD), a traditional Chinese medicine formula, has been widely applied in the treatment of gastrointestinal cancer, especially in colorectal cancer. Our study mainly aimed to assess the combined efficacy of Jiedu Sangen aqueous extract (JSAE) and a PD-L1 inhibitor (PI) in colon cancer ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420972486
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:This study portrays the characteristics of patients who attended an integrative oncology clinic at a large comprehensive cancer center and evaluated whether this service addressed patients' concerns about complementary and integrative medicine (CIM). METHODS:Patient information was collected prior to an int...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735410378663
更新日期:2010-09-01 00:00:00
abstract::Background The role of whole grains, refined cereals, and legumes in preventing or initiating colorectal cancer (CRC) is still uncertain. The aim of this study is to examine the possible association between the consumption of whole grains, refined cereals, and legumes and the risk of developing CRC among Jordanian pop...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415620010
更新日期:2016-09-01 00:00:00
abstract::Eupatorin is a polymethoxy flavone extracted from Orthosiphon stamineus and was reported to exhibit cytotoxic effects on several cancer cell lines. However, its effect as an anti-breast cancer agent in vivo has yet to be determined. This study aims to elucidate the potential of eupatorin as an anti-breast cancer agent...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420935625
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Malignant pleural effusion (MPE) is a common complication in most malignancies. Despite its frequent occurrence, current knowledge of MPE remains limited and the effect of the management is still unsatisfying. Traditional Chinese medicine (TCM) external treatment has unique advantages, such as quicker effica...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1534735416660193
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Increasing physical activity (PA) is safe and beneficial in lung cancer (LC) patients. Advanced-stage LC patients are under-studied and have worse symptoms and quality of life (QoL). We evaluated the feasibility of monitoring step count in advanced LC as well as potential correlations between P...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416684016
更新日期:2018-03-01 00:00:00
abstract::The large majority of clinical prostate cancers remain dependent on androgen receptor (AR) activity for proliferation even as they lose their responsiveness to androgen deprivation or antagonism. AR activity can be maintained in these circumstances by increased AR synthesis--often reflecting increased NF-κB activation...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414534728
更新日期:2014-09-01 00:00:00
abstract::Although localized colon cancer is often successfully treated with surgery, advanced disease requires aggressive systemic therapy that has lower effectiveness. Approximately 30% to 75% of patients with colon cancer use complementary and alternative medicine (CAM), but there is limited formal evidence of survival effic...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735411406539
更新日期:2011-09-01 00:00:00