Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury.

Abstract:

:Many plant products are known to exert antioxidative effects by quenching various free radicals and singlet molecular oxygen. Andrographis paniculata (Kalmegh) is used extensively in the Indian traditional system of medicine as a hepatoprotective and hepatostimulative agent and has been reported to have antioxidant effects against different hepatotoxins. The present study aims to analyze antioxidant properties of an active component, andrographolide (ANDLE), extracted from A paniculata. This study investigates the effect of andrographolide on the hepatocellular antioxidant defense system and lipid peroxidation of control mice, mice treated with hexachlorocyclohexane (BHC) only, and andrographolide + BHC. Glutathione (GSH), glutathione-s-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GSH-Px), gamma-glutamyl transpeptidase (gamma-GTP), superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation (LPO) are studied by spectrophotometric methods. The BHC experimental model forms an irreversible liver tumor in male mice. The activities of GSH, GR, GSH-Px, SOD, and CAT show significant (P

journal_name

Integr Cancer Ther

authors

Trivedi NP,Rawal UM,Patel BP

doi

10.1177/1534735407305985

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

271-80

issue

3

eissn

1534-7354

issn

1552-695X

pii

6/3/271

journal_volume

6

pub_type

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