Abstract:
:Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that tends to affect young women and has a high propensity to metastasize. No targeted treatments are available for this type of breast cancer due to a lack of estrogen or progesterone receptors or overexpression of human epidermal growth factor receptor type 2 overexpression. Currently, patients have no therapeutic options once standard of care is complete, indicating a need for safe and effective therapies to slow or prevent the progression of TNBC to metastatic disease. Studies showed that isolated polyphenols or polyphenol-rich muscadine grape extracts polyphenols inhibit the proliferation of various cancer cells including breast cancer. A proprietary muscadine grape extract (MGE) was administered to nude mice with human MDA-MB-231 TNBC atumors for 4 weeks to determine the effect of the extract on tumor growth. MGE decreased tumor volume in association with a reduction in the proliferative markers Ki67 and cyclin D1. To determine the molecular mechanisms for the MGE-induced reduction in tumor growth, mouse 4T1, MDA-MB-231, or human BT-549 TNBC cells were treated with MGE, and various signaling pathways were investigated. MGE reduced c-Met, differentially abrogated ERK/MAPK and AKT signaling, and decreased a downstream targets of ERK/MAPK and AKT pathways, cyclin D1. Cyclin D1 reduction was associated with retinoblastoma activation and cell cycle arrest in MDA-MB-231 TNBC cells. MGE-regulated molecular signaling pathways were functionally associated with a dose-dependent reduction in cell proliferation. The pluripotency of MGE and high index of safety and tolerability suggest that the extract may serve as a therapeutic to reduce TNBC progression to metastatic disease.
journal_name
Integr Cancer Therjournal_title
Integrative cancer therapiesauthors
Collard M,Gallagher PE,Tallant EAdoi
10.1177/1534735420917444subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1534735420917444eissn
1534-7354issn
1552-695Xjournal_volume
19pub_type
杂志文章abstract:PURPOSE:Many botanical immunomodulators are used as adjuvants along with cancer chemotherapy. However, information on the impact of concurrent administration of such botanicals on pharmacokinetics of chemotherapy agents is inadequate. This study investigates inhibitory activities of 3 popular botanical adjuvants: ASPAR...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735413503551
更新日期:2014-03-01 00:00:00
abstract:UNLABELLED:Objective Acquired chemoresistance is a major obstacle in the clinical management of ovarian cancer. Therefore, searching for alternative therapeutic modalities is urgently needed. Bitter melon (Momordica charantia) is a traditional dietary fruit, but its extract also shows potential medicinal values in huma...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415611747
更新日期:2016-09-01 00:00:00
abstract::Oncology is currently a sector of medical science with accelerated progress due to rapid technological development, the advancement in molecular biology, and the invention of many innovative therapies. Immunotherapy partially accounts for this advance, since it is increasingly playing an important role in the treatmen...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419827090
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Jiedu Sangen Decoction (JSD), a traditional Chinese medicine formula, has been widely applied in the treatment of gastrointestinal cancer, especially in colorectal cancer. Our study mainly aimed to assess the combined efficacy of Jiedu Sangen aqueous extract (JSAE) and a PD-L1 inhibitor (PI) in colon cancer ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420972486
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Health care policies and guidelines that are clear and consistent with research evidence are important for maximizing clinical outcomes. To determine whether cancer centers in Canada and the United States had policies and/or guidelines about antioxidant use, and whether policies were aligned with the evidenc...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735415572884
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:High-grade gliomas are the most common and invasive malignant brain tumors in adults, and they are almost universally fatal because of drug resistance and recurrence. In spite of the progress in adjuvant therapy (like temozolomide) and irradiation after surgery, no effective salvage therapy is currently avai...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414549623
更新日期:2014-11-01 00:00:00
abstract:HYPOTHESIS:Anorexia and cancer cachexia produce significant loss of adipose tissue and muscle mass and eventually reduce survival in cancer patients. STUDY DESIGN:This phase II study was conducted to assess the efficacy and the safety of an herbal decoction with Astragali radix in patients with anorexia in advanced ca...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735409359180
更新日期:2010-03-01 00:00:00
abstract::Background: Integrative oncology has proven to be a useful approach to control cancer symptoms and improve the quality of life (QoL) and overall health of patients, delivering integrated patient care at both physical and emotional levels. The objective of this randomized trial was to evaluate the effects of a triple i...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420924757
更新日期:2020-01-01 00:00:00
abstract::Hesperidin is a natural compound that has chemoprotective effects in tumor cell lines and protective effects against hematotoxicity induced by cyclophosphamide. The aim of this study was to evaluate the effect of hesperidin on the antitumor effect of cyclophosphamide in tumor-bearing mice. Administration of hesperidin...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735412448959
更新日期:2012-09-01 00:00:00
abstract::Background: Chemotherapy-induced peripheral neuropathy (CIPN) has no cure, but acupuncture may provide relief through its known neuromodulation or neuroendocrine adjustment. This review aimed to assess the efficacy of acupuncture in treating CIPN. Method: A literature review following the PRISMA Statement was performe...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,meta分析
doi:10.1177/1534735419886662
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Arthralgia affects postmenopausal women receiving aromatase inhibitors (AIs) for breast cancer. Given the existing evidence for electroacupuncture (EA) for treatment of osteoarthritis in the general population, this study aims to establish the feasibility of studying EA for treating AI-related arthralgia. P...
journal_title:Integrative cancer therapies
pub_type: 临床试验,杂志文章
doi:10.1177/1534735409332903
更新日期:2009-06-01 00:00:00
abstract::The protective effect of Andrograhis paniculata and andrographolide (ANDLE) against cyclophosphamide (CTX)-induced urothelial toxicity was investigated in this study. Pretreatment of Swiss albino mice with A paniculata extract (10 mg/dose/animal intraperitoneally [ip]) and ANDLE (500 microg/dose/animal ip) could signi...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735406291984
更新日期:2006-09-01 00:00:00
abstract::Introduction:Viscum album L extracts (VA) are frequently used in integrative oncology. Aim of this study was to evaluate the impact of add-on VA applications on various patient-reported outcome measures. Methods: A longitudinal real-world study was conducted, using data from the Network Oncology clinical registry. Pri...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420917211
更新日期:2020-01-01 00:00:00
abstract::A considerable number of patients with cancer have used or are using the Gerson therapy, an alleged anticancer metabolic diet. However, there is almost no scientific support for this regimen. Hence, the present case review study of 6 patients with metastatic cancer who used the Gerson therapy aims at critically evalua...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735406298258
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:This study aimed to investigate whether the extracellular-to-intracellular fluid volume (E/I) ratio can predict survival in patients with metastatic cancer. METHODS:Clinical data were collected from April 2016 to March 2018. Patients aged ≥19 years with metastatic solid tumor were eligible. Bioimpedance analys...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735419847285
更新日期:2019-01-01 00:00:00
abstract::Altered expression of a cytosolic flavoenzyme NAD(P)H:quinone oxidoreductase-1 (NQO1) has been seen in many human tumors. Its remarkable overexpression in cholangiocarcinoma (CCA; an aggressive malignancy of the biliary duct system) was associated with poor prognosis and short survival of the patients. Inhibition of N...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418820444
更新日期:2019-01-01 00:00:00
abstract::Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tis...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416676584
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Melatonin (MLT) is known to possess potent antioxidant, antiproliferative, immune-modulating, and hormone-modulating properties. Clinical evidence suggests that MLT may have a possible role in the treatment of cancer. The authors systematically reviewed the effects of MLT in conjunction with chemotherapy, ra...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,meta分析,评审
doi:10.1177/1534735411425484
更新日期:2012-12-01 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide, and most chemotherapeutic drugs have limited success in treating this disease. Furthermore, some drugs show undesirable side effects due to the enrichment of cancer stem cells (CSCs) that are present, leading to resistance to conventional chemotherapy and tum...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414534462
更新日期:2014-11-01 00:00:00
abstract::Antineoplastic agents induce oxidative stress in biological systems. During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that can attack many cellular targets. These products of oxidative stress can slow cell cycle progression of cancer cells and cause cel...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735404270335
更新日期:2004-12-01 00:00:00
abstract::Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418762537
更新日期:2018-09-01 00:00:00
abstract::Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns. Incorrect nutritional habits and lifestyle practices have been dire...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416675950
更新日期:2017-09-01 00:00:00
abstract::The large majority of clinical prostate cancers remain dependent on androgen receptor (AR) activity for proliferation even as they lose their responsiveness to androgen deprivation or antagonism. AR activity can be maintained in these circumstances by increased AR synthesis--often reflecting increased NF-κB activation...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414534728
更新日期:2014-09-01 00:00:00
abstract:GANODERMA LUCIDU:spore (GLS), an over-the-counter herbal supplement, is widely used by cancer patients in China. Although preclinical studies have shown it to be safe, complete safety data on GLS is still lacking. In this article, we report 5 cases of gastrointestinal cancer that were treated with GLS plus multiple str...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735413510022
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Increasing physical activity (PA) is safe and beneficial in lung cancer (LC) patients. Advanced-stage LC patients are under-studied and have worse symptoms and quality of life (QoL). We evaluated the feasibility of monitoring step count in advanced LC as well as potential correlations between P...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735416684016
更新日期:2018-03-01 00:00:00
abstract::Melatonin is a phylogenetically well-preserved molecule with diverse physiological functions. In addition to its well-known regulatory control of the sleep/wake cycle, as well as circadian rhythms generally, melatonin is involved in immunomodulation, hematopoiesis, and antioxidative processes. Recent human and animal ...
journal_title:Integrative cancer therapies
pub_type: 杂志文章,评审
doi:10.1177/1534735408322846
更新日期:2008-09-01 00:00:00
abstract::Cytoluminescent Therapy (CLT) is an unconventional form of photodynamic therapy (PDT), utilizing a second-generation chlorophyll-derived photosensitizing agent and whole-body illumination. Starting in late 2002, CLT was administered in Ireland to 48 patients. Illumination with lasers and light-emitting diodes followed...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735403259325
更新日期:2003-12-01 00:00:00
abstract::Total alkaloids is an active ingredient of the natural plant Rubus alceifolius Poir, commonly used for the treatment of various cancers. Antitumor effects may be mediated through anti-angiogenic mechanisms. As such, the goal of the present study was to investigate and evaluate the effect of total alkaloids in Rubus al...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735414547109
更新日期:2014-11-01 00:00:00
abstract::Animal-assisted interventions (AAIs) use human-animal interactions to positive effect in various contexts including cancer care. As the first installment of a 2-part series, this systematic literature review focuses on the research methods and quantitative results of AAI studies in oncology. We find methodological con...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735420943278
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Chemoradiotherapy-associated mucositis can manifest as pain, inflammation, dysphagia, diarrhea, weight loss, rectal bleeding, and infection. Mucositis is a major dose-limiting side effect of chemotherapy, affecting nutritional intake and oral and intestinal function. Despite several interventions being avail...
journal_title:Integrative cancer therapies
pub_type: 杂志文章
doi:10.1177/1534735418794885
更新日期:2018-12-01 00:00:00